Systematic review: cardiovascular safety profile of 5-HT4 agonists developed for gastrointestinal disorders

Metabolism of 4-Aminopiperidine Drugs by Cytochrome P450s: Molecular and Quantum Mechanical Insights into Drug Design

(2011) Hao Sun et al.   ACS Medicinal Chemistry Letters

Clinical trial: renzapride therapy for constipation-predominant irritable bowel syndrome - multicentre, randomized, placebo-controlled, double-blind study in primary healthcare setting

(2010) A. M. GEORGE et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

905 A Novel Gastrointestinal Prokinetic, ATI-7505, Increased Spontaneous Bowel Movements (Sbms) in a Phase II, Randomized, Placebo-Controlled Study of Patients With Chronic Idiopathic Constipation (CIC)

(2010) Monica Palme et al.   GASTROENTEROLOGY

Mosapride citrate (AS-4370), a new gastroproltinetic agent, is a partial 5-HT4 receptor agonist in the gut

(2010) N. YOSHIDA et al.   NEUROGASTROENTEROLOGY AND MOTILITY

5-HT4 receptor agonists: similar but not the same

(2010) J. H. De Maeyer et al.   NEUROGASTROENTEROLOGY AND MOTILITY

Review article: metoclopramide and tardive dyskinesia

(2009) A. S. RAO et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Selective desensitization of the 5-HT4receptor-mediated response in pig atrium but not in stomach

(2009) JH De Maeyer et al.   BRITISH JOURNAL OF PHARMACOLOGY

Functional characterization of contractions to tegaserod in human isolated proximal and distal coronary arteries

(2009) Kayi Y. Chan et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Lack of Association of Tegaserod With Adverse Cardiovascular Outcomes in a Matched Case-Control Study

(2009) Jeffrey L. Anderson et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY AND THERAPEUTICS

Pharmacology and Metabolism of Renzapride

(2009) Nicholas L Meyers et al.   Drugs in research & development

Clinical trial: the efficacy, impact on quality of life, and safety and tolerability of prucalopride in severe chronic constipation - a 12-week, randomized, double-blind, placebo-controlled study

(2008) E. M. M. QUIGLEY et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

5-HT4 receptor activation facilitates recovery from synaptic rundown and increases transmitter release from single varicosities of myenteric neurons

(2008) Jianhua Ren et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Treatment of Chronic Constipation: Current Pharmacologic Approaches and Future Directions

(2008) Jan Tack et al.   Clinical Gastroenterology and Hepatology

Identification of Patients with Non-D, Non-C Irritable Bowel Syndrome and Treatment with Renzapride: An Exploratory, Multicenter, Randomized, Double-Blind, Placebo-Controlled Clinical Trial

(2008) R. C. Spiller et al.   DIGESTIVE DISEASES AND SCIENCES

Identification of a novel 5-HT4 receptor splice variant (r5-HT4c1) and preliminary characterisation of specific 5-HT4a and 5-HT4b receptor antibodies

(2008) Alison M. Ray et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Renzapride: a new drug for the treatment of constipation in the irritable bowel syndrome

(2008) Emidio Scarpellini et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

T1322 Safety and Tolerability of Prucalopride (Resolor®) in Patients with Chronic Constipation: Pooled Data from Three Pivotal Phase III Studies

(2008) Jan F. Tack et al.   GASTROENTEROLOGY

T1389 TD-5108, a Selective 5-HT4 Agonist, Is Consistently Better Than Placebo Regardless of Response Definition in Patients with Chronic Constipation

(2008) Michael R. Goldberg et al.   GASTROENTEROLOGY

Prucalopride (Resolor) in the treatment of severe chronic constipation in patients dissatisfied with laxatives

(2008) J Tack et al.   GUT

Refining Insights into High-Affinity Drug Binding to the Human Ether-a-go-go-Related Gene Potassium Channel

(2008) J. C. Hancox et al.   MOLECULAR PHARMACOLOGY

The in vitro pharmacological profile of TD-5108, a selective 5-HT4 receptor agonist with high intrinsic activity

(2008) J. A. M. Smith et al.   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

The in vivo gastrointestinal activity of TD-5108, a selective 5-HT4 receptor agonist with high intrinsic activity

(2008) D. T. Beattie et al.   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

Development of drugs for gastrointestinal motor disorders: translating science to clinical need

(2008) g. j. sanger et al.   NEUROGASTROENTEROLOGY AND MOTILITY

Serotonergic signalling in the stomach and duodenum of patients with gastroparesis

(2008) n. van lelyveld et al.   NEUROGASTROENTEROLOGY AND MOTILITY

A Placebo-Controlled Trial of Prucalopride for Severe Chronic Constipation

(2008) Michael Camilleri et al.   NEW ENGLAND JOURNAL OF MEDICINE

Alternative splicing and exon duplication generates 10 unique porcine 5-HT4 receptor splice variants including a functional homofusion variant

(2008) Joris H. De Maeyer et al.   PHYSIOLOGICAL GENOMICS