Article
Chemistry, Multidisciplinary
J. Daniel Bailey, Edward Helbling, Amey Mankar, Matthew Stirling, Fred Hicks, David K. Leahy
Summary: Reducing or eliminating organic solvent use in pharmaceutical manufacturing is a highly effective way to reduce environmental, health, and safety impacts. The process described utilizing primarily water-based methods significantly reduces material inputs and organic solvent use, while surprisingly using less water and improving overall yield compared to traditional methods.
Review
Biochemistry & Molecular Biology
Muthmainah Muthmainah, Andrea Gogos, Priya Sumithran, Robyn M. Brown
Summary: Orexins play a crucial role in regulating eating behavior beyond homeostatic feeding, including reward and motivation. Studies have shown the involvement of orexins in hedonic and appetitive behavior towards palatable food. There is a bias towards studies involving male subjects in the literature, highlighting the need for future research to include female subjects.
JOURNAL OF NEUROCHEMISTRY
(2021)
Article
Pharmacology & Pharmacy
Dae Young Lee, Hee Eun Kang
Summary: This study validated a quantitative assay for DA-6886 in rat plasma and evaluated its pharmacokinetics and tissue distribution in rats. The results showed that DA-6886 distributed extensively in the liver, kidney, lung, and digestive tract, and exhibited nonlinear pharmacokinetics after oral administration.
Article
Biology
Karin H. Olsson, Roi Gurka, Roi Holzman
Summary: This study investigates suction-feeding in fishes using the concept of dynamic similarity. The research finds that feeding strikes of different fish species have distinct hydrodynamic regimes, and there are unique hydrodynamic adaptive peaks associated with different types of fish. The scaling of dynamic similarity across fish species, body sizes, and feeding guilds suggests that fundamental hydrodynamic principles govern the trophic evolution of suction-feeding in fishes.
PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Ryo Yamamoto, Tetsufumi Ito, Takafumi Furuyama, Munenori Ono, Nobuo Kato
Summary: Accumulating evidence suggests that the serotonergic system in the amygdala plays a significant role in affective states. This study aimed to identify the specific subtype of 5-HT receptors responsible for modulating excitatory transmission in the lateral amygdala. The results show that 5-HT1B receptors are involved in the attenuation of excitatory synaptic currents in principal neurons of the lateral amygdala.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Review
Biochemistry & Molecular Biology
Ruijie Jin, Shanbin Sun, Yang Hu, Hongfei Zhang, Xiangrong Sun
Summary: Dopamine is a neurotransmitter involved in various physiological functions. This paper explores the mechanisms of neuropeptides in regulating food intake through the reward system, specifically through dopaminergic neurons projecting from the VTA to the NAc. The study of these neuropeptides can contribute to identifying therapeutic targets for metabolic disorders such as obesity.
NEUROCHEMICAL RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Alejandro Castro-Alvarez, Emigdio Chavez-Angel, Ronald Nelson
Summary: This study analyzed a series of active compounds in the 5-HT4 receptor using quantitative structure-activity relationship, leading to the design of novel 5-HT4 partial agonists with potential biological activity. The research provided new insights for the design and development of new therapeutic options for neurodegenerative disorders like Alzheimer's disease.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Pharmacology & Pharmacy
Ulrich Gergs, Tobias Brueckner, Britt Hofmann, Joachim Neumann
Summary: The study revealed that lowering temperature can increase arrhythmias in mice overexpressing the human 5-HT4 receptor in their cardiac myocytes, suggesting a potential link between 5-HT4 receptors and hypothermia-induced arrhythmias in human patients.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Agronomy
Ramunas Antanaitis, Vida Juozaitiene, Gediminas Urbonavicius, Dovile Malasauskiene, Mindaugas Televicius, Mingaudas Urbutis, Walter Baumgartner
Summary: The study shows that lameness in fresh dairy cows has an impact on ingestive behaviors biomarkers such as rumination time, eating time, etc. The response of cows to lameness diagnosis varies greatly in terms of feeding behavior indicators.
Article
Neurosciences
Pierre Lecouflet, Candice M. Roux, Brigitte Potier, Marianne Leger, Elie Brunet, Jean-Marie Billard, Pascale Schumann-Bard, Thomas Freret
Summary: Activation of the 5-HT4R has been shown to impact LTP within the hippocampal CA1 area through modulation of GABAergic neurotransmission. The study also revealed the involvement of GABA(B) receptor in this regulatory process.
Article
Pharmacology & Pharmacy
Andrey Sequeira-Cordero, Juan C. Brenes
Summary: The study focused on the time-dependent neurochemical changes induced by amphetamine which revealed region and dose-dependent alterations in gene expression. Individual differences in neurotransmission and gene expression in brain pathways may influence behavioral sensitization to amphetamine.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Gastroenterology & Hepatology
John R. Konen, Melody M. Haag, Daria Guseva, Molly Hurd, Alisha A. Linton, Brigitte Lavoie, Colleen B. Kerrigan, Emily Joyce, Stephan C. Bischoff, Steve Swann, Luana Griffin, Jun Matsukawa, Matthew D. Falk, Tony S. Gibson, Grant W. Hennig, Jill Wykosky, Gary M. Mawe
Summary: Stimulation of epithelial 5-HT(4)Rs can enhance propulsive motility, indicating mucosal 5-HT(4)Rs may represent a safe and effective therapeutic target for constipation treatment.
NEUROGASTROENTEROLOGY AND MOTILITY
(2021)
Article
Biochemistry & Molecular Biology
Ulrich Gergs, Timo Gerigk, Jonas Wittschier, Constanze T. Schmidbaur, Clara Rottger, Mareen Mahnkopf, Hanna Edler, Hartmut Wache, Joachim Neumann
Summary: The study found that cardiac function is affected by 5-HT4 receptor overexpression under pathophysiological conditions, with potential benefits or drawbacks depending on the type of stress. 5-HT4 receptor overexpression influenced the response of the heart to hypoxia and ischemia, as well as cardiac hypertrophy.
Article
Biochemistry & Molecular Biology
Hannes Jacob, Pauline Braekow, Rebecca Schwarz, Christian Hoehm, Uwe Kirchhefer, Britt Hofmann, Joachim Neumann, Ulrich Gergs
Summary: Ergotamine is a tryptamine-related alkaloid used to treat migraines. It has positive inotropic effects on both 5-HT4-serotonin receptors and H-2-histamine receptors in the human heart.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Eri Kitayama, Maki Kimura, Takehito Ouchi, Masahiro Furusawa, Yoshiyuki Shibukawa
Summary: This study investigated the dynamics of intracellular cAMP in cultured human odontoblasts to understand the detailed expression patterns and role of the intracellular cAMP signaling pathway. The results showed the presence of G(alpha)s protein and various receptors (IP, 5-HT4, D-1, A(2A), and VIP) in odontoblasts. Activation of these receptors increased intracellular cAMP levels by activating AC, and this increase was inhibited by an AC inhibitor and receptor antagonists.
Article
Neurosciences
J. Amigo, A. Diaz, F. Pilar-Cuellar, R. Vidal, A. Martin, V. Compan, A. Pazos, E. Castro
Article
Cell Biology
Alexandra Jean, Laetitia Laurent, Sabira Delaunay, Stephane Doly, Nicole Dusticier, David Linden, Rachael Neve, Luc Maroteaux, Andre Nieoullon, Valerie Compan
Article
Pharmacology & Pharmacy
Joel Bockaert, Sylvie Claeysen, Valerie Compan, Aline Dumuis
CURRENT OPINION IN PHARMACOLOGY
(2011)
Article
Endocrinology & Metabolism
Gerard Alonso, Evelyne Galibert, Vera Boulay, Anne Guillou, Alexandra Jean, Valerie Compan, Gilles Guillon
Article
Biotechnology & Applied Microbiology
Christine Manrique, Valerie Compan, Celine Rosselet, Sylvie Gustave Dit Duflo
JOURNAL OF BIOTECHNOLOGY
(2009)
Article
Neurosciences
Joel Bockaert, Sylvie Claeysen, Valerie Compan, Aline Dumuis
Article
Endocrinology & Metabolism
Cecilia Ratner, Anders Ettrup, Marco Bueter, Mette E. Haahr, Valerie Compan, Carel W. Le Roux, Barry Levin, Henrik H. Hansen, Gitte M. Knudsen
Article
Multidisciplinary Sciences
Karine Toupet, Valerie Compan, Carole Crozet, Chantal Mourton-Gilles, Nadine Mestre-Frances, Francoise Ibos, Pierre Corbeau, Jean-Michel Verdier, Veronique Perrier
Article
Multidisciplinary Sciences
Luis Segu, Marie-Jose Lecomte, Mathieu Wolff, Julie Santamaria, Rene Hen, Aline Dumuis, Sylvie Berrard, Joel Bockaert, Marie-Christine Buhot, Valerie Compan
Article
Pharmacology & Pharmacy
Lisa L. Dupont, Ken R. Bracke, Joris H. De Maeyer, Valerie Compan, Guy E. Joos, Romain A. Lefebvre, Guy G. Brusselle
PULMONARY PHARMACOLOGY & THERAPEUTICS
(2014)
Review
Clinical Neurology
Valerie Compan
Article
Multidisciplinary Sciences
Alexandra Jean, Gregory Conductier, Christine Manrique, Constantin Bouras, Philippe Berta, Ren Hen, Yves Charnay, Joel Bockaert, Valerie Compan
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2007)
Article
Neurosciences
Gregory Conductier, Nicole Dusticier, Guillaume Lucas, Francine Cote, Guy Debonnel, Annie Daszuta, Aline Dumuis, Andre Nieoullon, Rene Hen, Joel Bockaert, Valerie Compan
EUROPEAN JOURNAL OF NEUROSCIENCE
(2006)
Article
Biochemistry & Molecular Biology
PA Keller, V Compan, J Bockaert, JP Giacobino, Y Charnay, C Bouras, F Assimacopoulos-Jeannet