Article
Biochemistry & Molecular Biology
Jelena Nikolic, Katarina Vukojevic, Violeta Soljic, Josip Miskovic, Martina Orlovic Vlaho, Mirna Saraga-Babic, Natalija Filipovic
Summary: We studied the expression of serotonin receptors 5-HT1A, 5-HT2A, and 5-HT3A at different stages of fetal lung development. The receptors were strongly expressed in the epithelium of the proximal airways and vascular walls during early and mid-fetal development. In the later stages, they were also expressed in type I and type II pneumocytes. The expression of 5-HT2A decreased while 5-HT3A expression increased toward the final stage of lung development.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, Research & Experimental
Jinyu Li, Xiaohui Xu, Jiane Liu, Yunqing Chen, Shengxi Jin, Guangmin Zhang, Shulan Yin, Jingqi Wang, Kangqi Tian, Xiaoyang Luan, Xiaohua Tan, Xiangzhong Zhao, Na Zhang, Zheng Wang
Summary: N-Acetylglucosamine (NAG) has a protective effect in lung injury, improving pulmonary function and attenuating pulmonary fibrosis. It functions by targeting immune cells and regulating stem cell proliferation.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Plant Sciences
Ji-hong Yuan, Yu Ma, Ling-hong Yuan, Jing-jing Gong, Ling-li Xu, Lv Wang, Yong-mei Jin
Summary: This study investigates whether baicalein can attenuate lung fibrosis by regulating lung fibroblast senescence. The results suggest that baicalein can mitigate lung fibrosis, fibroblast senescence, and activation of the TGF-beta 1/Smad signaling pathway.
PHARMACEUTICAL BIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Hee Jin Park, Ok-Yi Jeong, Sung Hak Chun, Yun Hong Cheon, Mingyo Kim, Suhee Kim, Sang-Il Lee
Summary: The study found that butyrate has potential therapeutic effects in a mouse model of SSc and human dermal fibroblasts, by modulating intestinal microbiota, controlling macrophage differentiation, and inhibiting proinflammatory gene expression, thus improving fibrosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Ziwen Wang, Long Chen, Yu Huang, Min Luo, Huilan Wang, Zhongyong Jiang, Jiancheng Zheng, Zeyu Yang, Zelin Chen, Chi Zhang, Lei Long, Yawei Wang, Xueru Li, Fengying Liao, Yibo Gan, Peng Luo, Yunsheng Liu, Yu Wang, XuTan, Ziyuan Zhou, Aihua Zhang, Chunmeng Shi
Summary: This study reveals the metabolic alterations of fibroblasts in idiopathic pulmonary fibrosis, showing upregulation of glycolysis and downregulation of fatty acid oxidation due to succinate accumulation. Targeting succinate dehydrogenase with a near-infrared dye, IR-780, effectively inhibits fibrosis development. Targeting metabolic dysregulation could be a potential therapeutic approach for IPF.
Article
Pharmacology & Pharmacy
Coralie Mergault, Fanny Lisee, Victor Tiroille, Melia Magnien, Christelle Parent, Woodys Lenga Mabonda, Damien Sizaret, Madeleine Jaillet, Bruno Crestani, Sylvain Marchand-Adam, Laurent Plantier
Summary: The study found that the expression of the Arp2/3 complex was increased in profibrotic environments in vitro and in vivo. Inhibition of the Arp2/3 complex repressed ACTA2 and COL1 expression and blocked the Akt/phospho-GSK3 beta/beta-catenin/MRTF-A pathway in lung fibroblasts. CK666 demonstrated antifibrotic properties in the lung in vivo.
BRITISH JOURNAL OF PHARMACOLOGY
(2022)
Article
Cell Biology
Hemant Joshi, Alison Almgren-Bell, Edgar P. Anaya, Elizabeth M. Todd, Steven J. Van Dyken, Anushree Seth, Katherine M. McIntire, Srikanth Singamaneni, Fayyaz Sutterwala, Sharon C. Morley
Summary: The actin-bundling protein L-plastin (LPL) plays a crucial role in the activation of the NLRP3 inflammasome, which is involved in IL-1 beta production. LPL stabilizes the interactions between ASC and the kinase Pyk2, enabling ASC oligomerization during NLRP3 assembly.
Article
Immunology
Xiaohe Li, Ling Ma, Yuli Wei, Jinying Gu, Jingjing Liang, Shimeng Li, Yunyao Cui, Rui Liu, Hui Huang, Cheng Yang, Honggang Zhou
Summary: Cabozantinib shows potential as a treatment for acute lung injury and pulmonary fibrosis by improving pathological state, reducing inflammation, inhibiting fibrosis, and regulating key signaling pathways such as TLR4/NF-kappa B/NLRP3 and TGF-131/Smad3.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Cell Biology
Alessandro Ianni, Michael Hofmann, Poonam Kumari, Shahriar Tarighi, Hamza M. Al-Tamari, Andre Goergens, Bernd Giebel, Hendrik Nolte, Marcus Krueger, Isabelle Salwig, Soni Savai Pullamsetti, Andreas Guenther, Andre Schneider, Thomas Braun
Summary: Idiopathic pulmonary fibrosis (IPF) is a highly aggressive and poorly understood lung disease, with lung epithelial cells playing a critical role in its initiation and progression. NUMB protein is necessary for the pathological activation of beta-catenin signaling in lung epithelial cells following bleomycin-induced injury. Depletion of Numb and Numblike reduces fibrotic lesion accumulation, preserves lung function, and increases survival rates in mice treated with bleomycin.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Cell Biology
Abdulrahman Ibrahim, Alessandra Ciullo, Chang Li, Akbarshakh Akhmerov, Kiel Peck, K. C. Jones-Ungerleider, Ashley Morris, Alberto Marchevsky, Eduardo Marban, Ahmed Gamal Ibrahim
Summary: ASTEX has been shown to have potential immunomodulatory and antifibrotic properties in treating lung injury, as evidenced by reduced cytokine expression, improved survival, and decreased fibrotic burden in lung tissue.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Physiology
Evgenia Dobrinskikh, Alani M. Estrella, Corinne E. Hennessy, Naoko Hara, Marvin Schwarz, Jonathan S. Kurche, Ivana Yang, David A. Schwartz
Summary: IPF is an incurable genetic disease affecting 5 million people worldwide, with the MUCSB promoter variant rs35705950 as the main genetic risk factor. A study on genetically divergent mouse strains showed that Muc5b expression had varying effects on bleomycin-induced lung injury, suggesting other factors may work with or independent of Muc5b to promote lung fibrosis. These findings indicate the potential for further research to identify genes and molecules interacting with Muc5b in causing lung fibrosis.
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
(2021)
Article
Pharmacology & Pharmacy
Xiaohua Xie, Xiaofeng Wu, Dongsheng Zhao, Ying Liu, Qiyue Du, Yitian Li, Yaping Xu, Yuhang Li, Yan Qiu, Yungang Yang
Summary: Fluvoxamine exhibits therapeutic activities in IPF by inhibiting fibroblast activation and migration, reducing inflammation and excessive extracellular matrix production, and improving pulmonary function.
PHARMACOLOGICAL RESEARCH
(2023)
Article
Oncology
Werner E. G. Mueller, Meik Neufurth, Shunfeng Wang, Heinz C. Schroder, Xiaohong Wang
Summary: Bleomycin (BLM) is a medication used to treat cancer, but its side effects, such as pulmonary fibrosis, can be reduced by co-administration with inorganic polyphosphate (polyP), potentially through upregulating the gene for BLM hydrolase. This study may also have implications for using BLM in COVID-19 patients, as polyP prevents the binding of SARS-CoV-2 to host cells.
Article
Pathology
Hasan Yousefi-Manesh, Tayebeh Noori, Mohammad Hossein Asgardoon, Mohammad Hasan Derakhshan, Seyed Mohammad Tavangar, Mohammad Sheibani, Samira Shirooie, Ahmad Reza Dehpour
Summary: The study found that dapsone has therapeutic effects on idiopathic pulmonary fibrosis through its anti-inflammatory and anti-oxidative stress properties and reduction of the toxic effects of bleomycin.
EXPERIMENTAL AND MOLECULAR PATHOLOGY
(2022)
Article
Medicine, Research & Experimental
Hadi Kalantar, Elahe Sadeghi, Farhad Abolnezhadian, Mehdi Goudarzi, Ali Asghar Hemmati, Zahra Basir, Mojtaba Kalantar
Summary: The study showed that carnosol has protective effects against bleomycin-induced pulmonary fibrosis in rats, reducing oxidative stress and inflammation significantly, and improving the histopathological changes in lung tissues.
Article
Oncology
Amina Jouida, Marissa O'Callaghan, Cormac Mc Carthy, Aurelie Fabre, Parthiban Nadarajan, Michael P. Keane
Summary: Exosomes, as extracellular vesicles, have gained attention as potential sources of information on tumor detection and regulation of tumor progression and metastasis. This study found that exosomes from NSCLC patients with EGFR mutations could induce invasion by promoting hybrid EMT, highlighting their role in metastasis formation and establishment of the pre-metastatic niche.
Article
Critical Care Medicine
Raphael Borie, Marie Pierre Debray, Alexis F. Guedon, Arsene Mekinian, Louis Terriou, Valentin Lacombe, Estibaliz Lazaro, Aurore Meyer, Alexis Mathian, Samuel Ardois, Guillaume Vial, Thomas Moulinet, Benjamin Terrier, Yvan Jamilloux, Mael Heiblig, Jean-David Bouaziz, Eve Zakine, Roderau Outh, Sylvie Groslerons, Adrien Bigot, Edouard Flamarion, Marie Kostine, Pierrick Henneton, Sebastien Humbert, Arnaud Constantin, Maxime Samson, Nadine Magy Bertrand, Pascal Biscay, Celine Dieval, Herve Lobbes, Juliette Jeannel, Amelie Servettaz, Leo Adelaide, Julie Graveleau, Benjamin de Sainte-Marie, Joris Galland, Vivien Guillotin, Eugenie Duroyon, Marie Temple, Rim Bourguiba, Sophie Georgin Lavialle, Olivier Kosmider, Alexandra Audemard-Verger
Summary: VEXAS syndrome is a newly identified autoinflammatory disorder related to somatic UBA1 mutations, with a high prevalence of lung involvement.
Article
Pathology
Diarmuid O'Connor, Aurelie Fabre, David Gibbons
Summary: This study aimed to analyze the effectiveness of our respiratory cytology coding system by calculating the estimated risk of malignancy (ROM) and rates of each diagnostic category. The results showed that our ROM rates were consistent with other international studies, and our rates of diagnostic accuracy were in line with international standards, providing valuable information for the development of the WHO-IARC IAC joint project.
Article
Dermatology
Aoife Granahan, Aurelie Fabre, Aisling Ryan, Aoife Lally
Summary: We present a clinicopathological case of a patient who experienced rapid growth of a nonpigmented nodule on the chest wall. There was no personal or family history of skin disease or cutaneous malignancy.
CLINICAL AND EXPERIMENTAL DERMATOLOGY
(2023)
Article
Respiratory System
Raphael Borie, Caroline Kannengiesser, Katerina Antoniou, Francesco Bonella, Bruno Crestani, Aurelie Fabre, Antoine Froidure, Liam Galvin, Matthias Griese, Jan C. Grutters, Maria Molina-Molina, Venerino Poletti, Antje Prasse, Elisabetta Renzoni, Jasper van der Smagt, Coline H. M. van Moorsel
Summary: The discovery of gene mutations that cause pulmonary fibrosis confirms the genetic predisposition to this condition. While genetic sequencing is already part of routine clinical practice for familial pulmonary fibrosis cases in some countries, it has not been widely incorporated into interstitial lung disease services and lacks international consensus.
EUROPEAN RESPIRATORY JOURNAL
(2023)
Article
Respiratory System
Julie Mankikian, Agnes Caille, Martine Reynaud-Gaubert, Marie-Sara Agier, Julien Bermudez, Philippe Bonniaud, Raphael Borie, Pierre-Yves Brillet, Jacques Cadranel, Isabelle Court-Fortune, Bruno Crestani, Marie-Pierre Debray, Emmanuel Gomez, Anne Gondouin, Sandrine Hirschi-Santelmo, Dominique Israel-Biet, Stephane Jouneau, Karine Juvin, Julie Leger, Mallorie Kerjouan, Charles-Hugo Marquette, Jean-Marc Naccache, Hilario Nunes, Laurent Plantier, Gregoire Prevot, Sebastien Quetant, Julie Traclet, Victor Valentin, Yurdagul Uzunhan, Lidwine Wemeau-Stervinou, Theodora Bejan-Angoulvant, Vincent Cottin, Sylvain Marchand-Adam
Summary: The combination of rituximab and MMF was found to be more effective than MMF alone in the treatment of ILD with a NSIP pattern. However, the use of this combination should be cautious due to the risk of viral infection.
EUROPEAN RESPIRATORY JOURNAL
(2023)
Article
Pathology
Daniel M. Di Capua, William Shanahan, Michele Bourke, Navneet Ramlaul, Josh Appel, Aoife Canney, Neil G. Docherty, Erinn McGrath, Eabha Ring, Fiona Jones, Marie Boyle, Janet McCormack, Tom Gallagher, Emir Hoti, Niamh Nolan, John D. Ryan, Diarmaid D. Houlihan, Aurelie Fabre
Summary: The study compares the clinical course, treatment outcomes, and tumor characteristics of patients with HFE-HCC and those without HFE-HCC. It finds that HFE-HCC patients have a more aggressive disease progression and tumors with increased expression of progenitor markers. The study suggests that transplant should be considered at an earlier stage for patients with HFE-HCC.
JOURNAL OF CLINICAL PATHOLOGY
(2023)
Letter
Respiratory System
Pierre Le Guen, Raphael Borie, Marie Legendre, Clairelyne Dupin, Laetitia Dunogeant, Sebastien Ottaviani, Marie-Pierre Debray, Aurelie Cazes, Philippe Dieude, Caroline Kannengiesser, Bruno Crestani
Article
Respiratory System
Elsa Moncomble, Gaelle Weisenburger, Clement Picard, Tristan Degot, Martine Reynaud-Gaubert, Ana Nieves, Jean Francois Mornex, Gaelle Dauriat, Jonathan Messika, Cendrine Godet, Sandrine Hirschi, Jerome Le Pavec, Raphael Borie, Pierre Mordant, Brice Lortat-Jacob, Herve Mal, Vincent Bunel
Summary: A multi-center nationwide retrospective study in France shows that continuing antifibrotic agents (AFAs) treatment before lung transplantation (LTx) does not increase the risk of post-operative airway, bleeding, or wound complications. In fact, it may be associated with reduced rates of primary graft dysfunction and 90-day mortality.
Article
Respiratory System
Axelle Mabo, Raphael Borie, Lidwine Wemeau-Stervinou, Yurdaguel Uzunhan, Emmanuel Gomez, Gregoire Prevot, Martine Reynaud-Gaubert, Julie Traclet, Emmanuel Bergot, Jacques Cadranel, Sylvain Marchand-Adam, Anne Bergeron, Elodie Blanchard, Benjamin Bondue, Philippe Bonniaud, Arnaud Bourdin, Pierre Regis Burgel, Sandrine Hirschi, Charles Hugo Marquette, Sebastien Quetant, Hilario Nunes, Cecile Chenivesse, Bruno Crestani, Yoann Guirriec, Delphine Monnier, Cedric Menard, Pierre Tattevin, Vincent Cottin, David Luque Paz, Stephane Jouneau
Summary: This study investigated the characteristics and clinical outcomes of patients diagnosed with autoimmune pulmonary alveolar proteinosis (aPAP) and identified risk factors associated with opportunistic infections. The results showed that a large proportion of patients developed infections, including opportunistic infections, with Nocardia spp being the main pathogen. Male gender was found to be associated with opportunistic infections. The study highlights the importance of systematically searching for slow-growing bacteria in bronchoalveolar lavage or whole lung lavage.
Letter
Respiratory System
Spyros A. Papiris, Ilaria Campo, Francesca Mariani, Maria Kallieri, Lykourgos Kolilekas, Andriana I. Papaioannou, Efsun Gonca Chousein, Erdogan Cetinkaya, Francesco Bonella, Raphael Borie, Maria Kokosi, Thomas Pickworth, Maria Molina-Molina, Merce Gasa, Elzbieta Radzikowska, Justyna Fijolek, Stephane Jouneau, Emmanuel Gomez, Cormac McCarthy, Elisabeth Bendstrup, Wojciech J. Piotrowski, Rishi Pabary, Alice Hadchouel, Nathalie Coolen-Allou, Tiago Alfaro, Carlos Robalo Cordeiro, Elvira-Markela Antonogiannaki, Ioannis P. Tomos, Despoina Papakosta, Theodoros Kontakiotis, Panagiota Panagiotou, Konstantinos Douros, Andrea Schams, Sara Lettieri, Vassiliki Papaevangelou, Christina Kanaka-Gantenbein, Anna Karakatsani, Stelios Loukides, Ulrich Costabel, Bruno Crestani, Cliff Morgan, Ryushi Tazawa, Andrew Bush, Matthias Griese, Effrosyni D. Manali
Article
Pediatrics
Julie Cassibba, Ralph Epaud, Laureline Berteloot, Sabrina Aberbache, Lauren Bitton, Camille Fletcher, Manon Fleury, Celine Delestrain, Harriet Corvol, Alix de Becdelievre, Raphael Borie, Marie Legendre, Aurore Coulomb l'Hermine, Camille Louvrier, Celine Lustremant, Meryem Sari Hassoun, Chiara Sileo, Alice Hadchouel, Nadia Nathan
Summary: The study found that multidisciplinary team meetings (MDTm) for childhood interstitial lung disease (chILD) can improve the diagnosis and management of the disease, increasing physician confidence in handling these cases.
PEDIATRIC PULMONOLOGY
(2023)
Article
Pediatrics
Nicol Bernardinello, Matthias Griese, Raphael Borie, Paolo Spagnolo
Summary: Childhood interstitial lung disease (chILD) is a group of diseases characterized by lung parenchymal abnormalities and clinical symptoms. Timely and accurate diagnosis is crucial for treatment and prognosis. Current treatments are mainly supportive care and anti-inflammatory drugs, but there is no cure. Research in this field is limited, and most treatments are based on case series with few randomized trials.
Article
Respiratory System
Emilie Lissavalid, Antoine Khalil, Ghassen Soussi, Marie-Pierre Debray, Alice Guyard, Vincent Bunel, Raphael Borie, Pierre Mordant, Aurelie Cazes, Gerard Zalcman, Valerie Gounant
Summary: This study evaluated the diagnostic accuracy and safety of CT-guided transthoracic lung biopsies (TTLB) for nodules <= 20 mm versus nodules >20 mm. The results showed that there were more conclusive biopsies in the >20 mm lesion group compared to <= 20 mm lesion group. The overall accuracy of diagnosing malignant lesions after first TTLB was slightly lower for <= 20 mm lesions, and pneumothorax requiring drainage was more common in this group. The only variable significantly associated with diagnostic failure in the <= 20 mm lesion group was the radiologist's experience.