Review
Biochemistry & Molecular Biology
Jieon Lee, Diana Avramets, Byungsun Jeon, Hyunah Choo
Summary: Recent studies suggest that 5-HT7R could be a potential therapeutic target for the treatment of neurodevelopmental disorders by affecting neuronal morphology and modulating behavioral symptoms, offering a new approach to treating NDDs.
Article
Multidisciplinary Sciences
Diana E. Mitchell, Soledad Miranda-Rottmann, Maxime Blanchard, Roberto Araya
Summary: Layer 5 pyramidal neurons in autism spectrum disorders (ASD) exhibit impaired integration of sensory inputs, contrary to the traditional belief of sensory hypersensitivity. Fragile X syndrome (FXS), the most common genetic cause of ASD, shows sublinear summation of subthreshold excitatory inputs. Knockdown of the regulatory beta 4 subunit of BK channels rescued this impairment, suggesting a differential dysfunction in the integration of feedforward sensory and feedback predictive inputs in FXS and potentially other forms of ASD.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Neurosciences
Lara Costa, Alessandra Tempio, Enza Lacivita, Marcello Leopoldo, Lucia Ciranna
Summary: The study demonstrates that Cdk5 modulates hippocampal synaptic plasticity, with 5-HT7 receptors requiring Cdk5 to regulate synaptic plasticity and rescue abnormal plasticity in Fmr1 KO neurons. This suggests that Cdk5 could be a novel target in Fragile X Syndrome.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2021)
Article
Neurosciences
Antonella Comitato, Enza Lacivita, Marcello Leopoldo, Rita Bardoni
Summary: The 5-HT7 receptors play an important role in synaptic modulation, particularly in synaptic inhibition, in the dorsal horn of the spinal cord. The stronger impact on synaptic inhibition suggests that these receptors may have an anti-nociceptive role in the spinal cord of naive animals.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2022)
Review
Neurosciences
Rita Bardoni
Summary: The role of 5-HT7 receptors in modulating pain perception has been explored through in vivo studies using different pain models. While most studies have reported an antinociceptive effect of 5-HT7 receptor activation, some researchers have suggested a pronociceptive action. The discrepancies in the results could be explained by differences in pain models, animal species and gender, receptor types, agonists, and route of administration. This mini-review summarizes the main findings and discusses the expression patterns, cellular mechanisms, alterations in receptor function, and the future perspectives of 5-HT7 receptors in the pain system.
CURRENT NEUROPHARMACOLOGY
(2023)
Review
Clinical Neurology
Ramkumar Aishworiya, Dragana Protic, Randi Hagerman
Summary: There is increasing recognition of the heterogeneity of origin of cases of autism spectrum disorder (ASD), with genetic etiology identified in 20-40% of cases. The Fragile X premutation state is a newly discovered disease state associated with various disorders, including ASD, and understanding molecular mechanisms may facilitate targeted treatments in the future.
JOURNAL OF NEUROLOGY
(2022)
Article
Environmental Sciences
Xing Zhang, Dongmeng Mei, Yongfang Li, Mingdan You, Da Wang, Dianqi Yao, Yuanyuan Xu, Lingling Zhai, Yi Wang
Summary: This study aimed to investigate whether exposure to arsenic during pregnancy and lactation leads to autism-like behaviors in offspring mice. The results showed that perinatal exposure to arsenic caused abnormal social behaviors and repetitive behaviors in male offspring mice, along with anxiety-like behaviors and learning and memory impairments. Immunofluorescence staining and western blotting revealed that perinatal exposure to arsenic resulted in decreases of synaptic density in the cortex, hippocampus, and cerebellum, which may contribute to the autism-like behaviors observed in offspring.
Review
Psychiatry
Khaleel A. Razak, Devin K. Binder, Iryna M. Ethell
Summary: This study explored the association between autism spectrum disorders and sensory processing disorders, as well as the neural correlates of Fragile X Syndrome. Findings indicated that individuals with Fragile X Syndrome often exhibit atypical sensory processing, including auditory hypersensitivity. By analyzing Fmr1 KO mice, the study revealed the neural mechanisms underlying auditory hypersensitivity and proposed new therapeutic approaches.
FRONTIERS IN PSYCHIATRY
(2021)
Review
Biochemistry & Molecular Biology
Ansoo Lee, Hyunah Choo, Byungsun Jeon
Summary: Autism spectrum disorder is a group of neurodevelopmental disorders characterized by repetitive behaviors and difficulties with social interaction and communication. Existing drugs can alleviate some symptoms, but not the core symptoms. Serotonin receptors have emerged as potential therapeutic targets for ASD treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Dragana D. Protic, Ramkumar Aishworiya, Maria Jimena Salcedo-Arellano, Si Jie Tang, Jelena Milisavljevic, Filip Mitrovic, Randi J. Hagerman, Dejan B. Budimirovic
Summary: FXS is a neurodevelopmental disorder that can be improved through early diagnosis and interventions targeting behavior symptoms.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Neurosciences
Francisco Altimiras, Jose Antonio Garcia, Ismael Palacios-Garcia, Michael J. Hurley, Robert Deacon, Bernardo Gonzalez, Patricia Cogram
Summary: The study found alterations in the gut microbiome of Fragile X syndrome (FXS) mouse model, including metabolic pathways associated with autism. This suggests a potential association of the gut microbiome with FXS, opening new possibilities for exploring reliable treatments and non-invasive biomarkers.
FRONTIERS IN NEUROSCIENCE
(2021)
Review
Psychiatry
Edgard Verdura, Laura Perez-Cano, Ruben Sabido-Vera, Emre Guney, Jean-Marc Hyvelin, Lynn Durham, Baltazar Gomez-Mancilla
Summary: Fragile X syndrome (FXS) is characterized by clinical, genetic, and therapeutic response heterogeneity, emphasizing the need for precision medicine-based treatments. The high genetic and phenotypic heterogeneity in FXS poses challenges in drug development. Precision medicine approaches, by accurately stratifying patients and defining drug responder profiles, have the potential to improve clinical trial success rates and benefit a larger number of patients with neurodevelopmental disorders.
FRONTIERS IN PSYCHIATRY
(2021)
Article
Psychology, Multidisciplinary
Angela John Thurman, Amanda Dimachkie Nunnally
Summary: This study compared joint attention between preschool-aged boys with autism and fragile X syndrome (FXS). While joint attention appeared similar, differences were observed after controlling for other factors, particularly in language and anxiety symptoms.
FRONTIERS IN PSYCHOLOGY
(2022)
Article
Psychology, Developmental
Angel Belle C. Dy, Lourdes Bernadette S. Tanchanco, Jenica Clarisse Y. Sy, Myla Dominicina Levantino, Randi J. Hagerman
Summary: This study aimed to determine the presence of FXS or premutation carriers among Filipino children with autism and describe the phenotypic characteristics of the identified cases.
JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
(2023)
Article
Biochemistry & Molecular Biology
Motohiro Okada, Ryusuke Matsumoto, Yoshimasa Yamamoto, Kouji Fukuyama
Summary: This study investigated the effects of lurasidone, vortioxetine, and escitalopram on 5-HT7R function and found that chronic administration of these drugs leads to downregulation of 5-HT7R in the thalamus. Furthermore, it was observed that vortioxetine and lurasidone induce more rapid downregulation of 5-HT7R through direct inhibition, while escitalopram's downregulation is slower due to its indirect elevation of extracellular serotonin levels.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Developmental Biology
C. M. Bonaccorso, M. Spatuzza, B. Di Marco, A. Gloria, G. Barrancotto, A. Cupo, S. A. Musumeci, S. D'Antoni, B. Bardoni, M. V. Catania
INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE
(2015)
Article
Biochemistry & Molecular Biology
Thomas Maurin, Mireille Melko, Sabiha Abekhoukh, Olfa Khalfallah, Laetitia Davidovic, Marielle Jarjat, Simona D'Antoni, Maria Vincenza Catania, Herve Moine, Elias Bechara, Barbara Bardoni
NUCLEIC ACIDS RESEARCH
(2015)
Article
Behavioral Sciences
Lara Costa, Lara M. Sardone, Enza Lacivita, Marcello Leopoldo, Lucia Ciranna
FRONTIERS IN BEHAVIORAL NEUROSCIENCE
(2015)
Article
Neurosciences
Barbara Di Marco, Carmela M. Bonaccorso, Elisabetta Aloisi, Simona D'Antoni, Maria V. Catania
CNS & NEUROLOGICAL DISORDERS-DRUG TARGETS
(2016)
Article
Pharmacology & Pharmacy
Gian Marco Leggio, Maria Vincenza Catania, Daniela Puzzo, Michela Spatuzza, Rosalia Pellitteri, Walter Gulisano, Sebastiano Alfio Torrisi, Giovanni Giurdanella, Cateno Piazza, Agata Rita Impellizzeri, Lucia Gozzo, Andrea Navarria, Claudio Bucolo, Ferdinando Nicoletti, Agostino Palmeri, Salvatore Salomone, Agata Copani, Filippo Caraci, Filippo Drago
PHARMACOLOGICAL RESEARCH
(2016)
Article
Neurosciences
S. D'Antoni, E. Ranno, M. Spatuzza, S. Cavallaro, M. V. Catania
NEUROTOXICITY RESEARCH
(2017)
Article
Multidisciplinary Sciences
Elisabetta Aloisi, Katy Le Corf, Julien Dupuis, Pei Zhang, Melanie Ginger, Virginie Labrousse, Michela Spatuzza, Matthias Georg Haberl, Lara Costa, Ryuichi Shigemoto, Anke Tappe-Theodor, Filippo Drago, Pier Vincenzo Piazza, Christophe Mulle, Laurent Groc, Lucia Ciranna, Maria Vincenza Catania, Andreas Frick
NATURE COMMUNICATIONS
(2017)
Meeting Abstract
Clinical Neurology
E. Aloisi, J. P. Dupuis, M. Haberl, F. Drago, L. Groc, M. V. Catania, A. Frick
EUROPEAN NEUROPSYCHOPHARMACOLOGY
(2014)
Review
Behavioral Sciences
Simona D'Antoni, Michela Spatuzza, Carmela M. Bonaccorso, Sebastiano A. Musumeci, Lucia Ciranna, Ferdinando Nicoletti, Kimberly M. Huber, Maria Vincenza Catania
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2014)
Article
Neurosciences
Lara Costa, Lara Maria Sardone, Carmela Maria Bonaccorso, Simona D'Antoni, Michela Spatuzza, Walter Gulisano, Maria Rosaria Tropea, Daniela Puzzo, Marcello Leopoldo, Enza Lacivita, Maria Vincenza Catania, Lucia Ciranna
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2018)
Article
Biochemistry & Molecular Biology
Simona D'Antoni, Lidia de Bari, Daniela Valenti, Marina Borro, Carmela Maria Bonaccorso, Maurizio Simmaco, Rosa Anna Vacca, Maria Vincenza Catania
BIOLOGICAL CHEMISTRY
(2020)
Article
Neurosciences
Lara Costa, Alessandra Tempio, Enza Lacivita, Marcello Leopoldo, Lucia Ciranna
Summary: The study demonstrates that Cdk5 modulates hippocampal synaptic plasticity, with 5-HT7 receptors requiring Cdk5 to regulate synaptic plasticity and rescue abnormal plasticity in Fmr1 KO neurons. This suggests that Cdk5 could be a novel target in Fragile X Syndrome.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2021)
Article
Neurosciences
B. Di Marco, P. Dell'Albani, S. D'Antoni, M. Spatuzza, C. M. Bonaccorso, S. A. Musumeci, F. Drago, B. Bardoni, M. V. Catania
Summary: The study found a novel modulatory role of mGlu5 receptor in SGs formation, providing new perspectives for understanding cellular response to stress in FXS pathophysiology.
NEUROBIOLOGY OF DISEASE
(2021)
Article
Neurosciences
Luisa Di Menna, Rosamaria Orlando, Giovanna 'Errico, Roxana Paula Ginerete, Agata Machaczka, Carmela Maria Bonaccorso, Andrea Arena, Michela Spatuzza, Roberta Celli, Marika Alborghetti, Eleonora Ciocca, Anna Rita Zuena, Mariarosaria Scioli, Valeria Bruno, Giuseppe Battaglia, Ferdinando Nicoletti, Maria Vincenza Catania
Summary: The involvement of mGlu5 receptors in monogenic autism has been supported by various studies, but there is a lack of research on the canonical signal transduction pathway activated by these receptors in mouse models of autism. In this study, we developed a method to assess PI hydrolysis in vivo and found that mGlu5 receptor-mediated PI hydrolysis was impaired in different brain regions of mice modeling Angelman syndrome and fragile-X syndrome. These findings provide the first evidence that the canonical transduction pathway of mGlu5 receptors is downregulated in mouse models of monogenic autism.
Article
Psychology, Developmental
Antonio Gennaro Nicotera, Randi Jenssen Hagerman, Maria Vincenza Catania, Serafino Buono, Santo Di Nuovo, Elisa Maria Liprino, Emanuela Stracuzzi, Stefania Giusto, Giuseppina Di Vita, Sebastiano Antonino Musumeci
JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
(2019)