The 5-HT2C receptor agonist WAY-163909 decreases impulsivity in the 5-choice serial reaction time test

Increased impulsivity is observed across a number of neuropsychiatric and neurodegenerative diseases. Preclinical evidence has demonstrated that antagonism of the serotonin 5-HT2C receptor may act to increase impulsivity, leading to the hypothesis that an agonist may exert reciprocal effects and attenuate impulsive behavior [1]. The 5-HT2C agonist. WAY-163909, was evaluated in the present paper using a variable stimulus duration and inter-trial interval manipulation in the 5-choice serial reaction time test designed to increase impulsivity and decrease attention. WAY-163909 treatment selectively and dose-dependently decreased impulsivity suggesting that agonism of the 5-HT2C receptor may be useful for modulating impulsivity in disease states where impulsivity is a pathological feature. (c) 2007 Elsevier B.V. All rights reserved.