Review
Biochemistry & Molecular Biology
Aaron Caccamise, Erik Van Newenhizen, John R. Mantsch
Summary: Stress plays a critical role in relapse susceptibility in individuals with substance use disorders, either directly triggering cocaine use or interacting with other stimuli to promote drug seeking behavior. The mechanisms of stress-triggered cocaine seeking involve various neural pathways and hormonal regulations.
JOURNAL OF NEUROCHEMISTRY
(2021)
Article
Neurosciences
Marco Venniro, Rosa A. M. Marino, Jonathan J. Chow, Daniele Caprioli, David H. Epstein, Leslie A. Ramsey, Yavin Shaham
Summary: This article discusses the role of social factors in addiction research using animal models. Social isolation promotes drug use and relapse, while social connections provide protection. The article summarizes the effects of different experimental procedures on opioids and psychostimulants, and suggests future research directions in the addiction field.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Substance Abuse
Violaine Mongeau-Perusse, Suzanne Brissette, Julie Bruneau, Patricia Conrod, Simon Dubreucq, Guillaume Gazil, Emmanuel Stip, Didier Jutras-Aswad
Summary: This study tested the efficacy of CBD for reducing craving and preventing relapse in people with CUD. However, the findings showed that CBD treatment did not reduce cocaine craving or relapse among participants being treated for CUD.
Article
Neurosciences
Sasha L. Fulton, Swarup Mitra, Ashley E. Lepack, Jennifer A. Martin, Andrew F. Stewart, Jacob Converse, Mason Hochstetler, David M. Dietz, Ian Maze
Summary: This study demonstrates the importance of the histone post-translational modification H3Q5dop in cocaine and heroin addiction, showing its role in persistent transcriptional events and plasticity in reward relevant brain regions.
NEUROPSYCHOPHARMACOLOGY
(2022)
Article
Psychiatry
Wenwen Shen, Longhui Li, Yue Liu, Xiaohu Xie, Weisheng Chen, Huifen Liu, Wenwu Zhang, Yu Liu, Haihang Yu, Wenhua Zhou
Summary: This study aimed to develop a measurement for the motivation for and against change in methamphetamine users in a compulsory detoxification setting. Motivations were grouped into three factors: the expectation to use drugs upon the completion of the program, the disagreement with the compulsory setting, and the motivation to quit drug use. The overall motivation was characterized by motivation against change rather than that for change.
FRONTIERS IN PSYCHIATRY
(2023)
Article
Substance Abuse
Mats Ekendahl, Patrik Karlsson
Summary: This article examines how craving is approached and handled in relapse prevention for addiction problems. Drawing upon STS and critical addiction research, the study analyzes how craving is enacted in manuals, training materials, and interviews with professionals. The findings reveal three collateral realities of craving: the materialization of craving, the transcendence of the individual, and the merging of treatment and everyday life. The data suggest that in RP, the brain, cognition, emotions, and behavior are perceived as intervention targets that individuals can transcend and control. This approach relies on the assumption that there are no clear-cut boundaries between identities, settings, or points in time. The article discusses the relevance and implications of treating craving as a stable object and the neoliberal governance of responsibilized individuals initiated by such interventions.
INTERNATIONAL JOURNAL OF DRUG POLICY
(2022)
Article
Cell Biology
Miguel A. Lujan, Brandon L. Oliver, Reana Young-Morrison, Sheila A. Engi, Lan-Yuan Zhang, Jennifer M. Wenzel, Yulong Li, Natalie E. Zlebnik, Joseph F. Cheer
Summary: Understanding mesolimbic dopamine adaptations underlying vulnerability to drug relapse is crucial but challenging due to technical limitations. In this study, the fluorescent sensor GrabDA was used to measure sub-second dopamine release in the nucleus accumbens of mice during self-administration. The findings reveal predictors of cue-induced reinstatement of cocaine seeking and sex-specific differences in cocaine-related dopamine responses. These insights shed light on the role of NAc dopamine signaling dynamics and sex in persistent cocaine seeking and relapse vulnerability.
Article
Neurosciences
Andrea Miuli, Giacomo d'Andrea, Mauro Pettorruso, Gianluca Mancusi, Alessio Mosca, Francesco Di Carlo, Giovanni Martinotti, Massimo di Giannantonio
Summary: This article discusses the potential role of Brain-Derived Neurotrophic Factor (BDNF) as a biomarker for the different stages of Cocaine Use Disorder (CUD) and its close relationship with the clinical course of CUD. The authors suggest that finding valuable biomarkers for CUD severity and disease stage could greatly benefit CUD patients.
CURRENT NEUROPHARMACOLOGY
(2022)
Article
Health Care Sciences & Services
Chieh-Liang Huang, Ping-Ho Chen, Hsien-Yuan Lane, Ing-Kang Ho, Chia-Min Chung
Summary: This study aimed to identify heroin addicts with specific genetic variants in their dopaminergic reward systems and found multiple genes associated with heroin use and craving scores. The results showed a dose-response relationship between the number of genetic risk alleles and heroin craving scores, suggesting potential implications for predicting relapse risk and developing targeted therapies for heroin addiction.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Multidisciplinary Sciences
Jasper A. Heinsbroek, Giuseppe Giannotti, Mitchel R. Mandel, Megan Josey, Gary Aston-Jones, Morgan H. James, Jamie Peters
Summary: The study found that heroin choice and relapse involve different neural pathways in the brain, but share a common addiction-limiting circuit in the IL-NAshell pathway. This suggests that different mechanisms may be at play during drug choice and relapse, highlighting the complexity of addiction behaviors.
NATURE COMMUNICATIONS
(2021)
Article
Psychology, Multidisciplinary
Hui-Ting Cai, Hong-Wei Zhang, Hui Zheng, Ting Xu, Lin Liu, Xu-Yan Ban, Jian-Zhong Di, Ti-Fei Yuan, Xiao-Dong Han
Summary: We developed and validated a picture library of Chinese foods (PLCF) to facilitate future investigations in food craving research, especially in Chinese cultural contexts. We collected 100 food images representing five subtypes of high-calorie foods, and had participants rate the images based on craving, familiarity, valence, and arousal. The results showed that images of salty foods and sugary drinks induced stronger cravings, particularly in individuals who met the criteria for food addiction.
FRONTIERS IN PSYCHOLOGY
(2023)
Article
Pharmacology & Pharmacy
Valentina Vengeliene, Rainer Spanagel
Summary: A deficiency in mGlu2 function is identified as a common pathological mechanism underlying alcohol-seeking and relapse behavior. The use of mGlu2/3 agonists and mGlu2 PAMs effectively reduces relapse-like behavior. These drugs may be a potential treatment option for alcohol-dependent patients.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Clinical Neurology
Jiaxin Li, Wei Jiang, Rongrong Zhu, Fusheng Fan, Fabing Fu, Dejun Wei, Shanshan Tang, Yang Tian, Jiajing Chen, Yuqing Li, Huixia Zhou, Li Wang, Dongmei Wang, Xiang-Yang Zhang
Summary: This study found that the prevalence of depression is significantly higher in methamphetamine-dependent men compared to the healthy Chinese population. Additionally, age, components of alexithymia, and drug craving are risk factors for depression in methamphetamine addicts.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Neurosciences
Jia-Ying Li, Yang-Jung Yu, Chun-Lin Su, Yu-Qi Shen, Chih-Hua Chang, Po-Wu Gean
Summary: Drug-associated conditioned cues promote drug-seeking behavior by recalling drug reward memory. Inhibition of the BLA-NAc neural projection can disrupt the consolidated methamphetamine-associated memory during reconsolidation. This study provides evidence that the BLA-NAc pathway is involved in the post-retrieval processing of drug-associated memory.
NEUROPSYCHOPHARMACOLOGY
(2023)
Article
Behavioral Sciences
Xiaoying Tan, Elizabeth Neslund, Zheng-Ming Ding
Summary: Relapse is a significant challenge in smoking cessation management. This study found that cotinine, a major metabolite of nicotine, induces sex-specific relapse to drug seeking in rats, suggesting that cotinine may contribute to relapse.
BEHAVIOURAL PHARMACOLOGY
(2022)
Article
Neurosciences
Peter R. Kufahl, Natalie A. Peartree, Krista L. Heintzelman, Maggie Chung, Janet L. Neisewander
Article
Behavioral Sciences
Ryan M. Bastle, Natalie A. Peartree, Julianna Goenaga, Kayla N. Hatch, Angela Henricks, Samantha Scott, Lauren E. Hood, Janet L. Neisewander
BEHAVIOURAL BRAIN RESEARCH
(2016)
Editorial Material
Veterinary Sciences
Felicia Duke, Kimberly Jen
Article
Neurosciences
Junshi Wang, Ryan M. Bastle, Caroline E. Bass, Ronald P. Hammer, Janet L. Neisewander, Ella M. Nikulina
Article
Biochemistry & Molecular Biology
Nathan S. Pentkowski, Bryan G. Harder, Samuel J. Brunwasser, Ryan M. Bastle, Natalie A. Peartree, Krishna Yanamandra, Matt D. Adams, Taleen Der-Ghazarian, Janet L. Neisewander
ACS CHEMICAL NEUROSCIENCE
(2014)
Article
Clinical Neurology
Lara A. Pockros-Burgess, Nathan S. Pentkowski, Taleen Der-Ghazarian, Janet L. Neisewander
INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY
(2014)
Review
Neurosciences
Janet L. Neisewander, Timothy H. C. Cheung, Nathan S. Pentkowski
Article
Veterinary Sciences
Felicia D. Duke, Travis D. Strong, Ellison Bentley, Richard R. Dubielzig
VETERINARY OPHTHALMOLOGY
(2013)
Article
Pathology
F. D. Duke, L. B. C. Teixeira, L. E. Galle, N. Green, R. R. Dubielzig
VETERINARY PATHOLOGY
(2015)
Editorial Material
Neurosciences
Janet L. Neisewer
BIOLOGICAL PSYCHIATRY
(2020)
Article
Psychiatry
Raul Garcia, Tien Le, Samantha N. Scott, Delaram Charmchi, Jamie M. L. Sprout, Nathan S. Pentkowski, Janet L. Neisewander
TRANSLATIONAL PSYCHIATRY
(2020)
Article
Biochemistry & Molecular Biology
Gregory L. Powell, Mark D. Namba, Annika Vannan, John Paul Bonadonna, Andrew Carlson, Rachel Mendoza, Peng-Jen Chen, Robert R. Luetdke, Benjamin E. Blass, Janet L. Neisewander
Article
Biology
Michela Dell'Orco, Amir Elyaderani, Annika Vannan, Shobana Sekar, Gregory Powell, Winnie S. Liang, Janet L. Neisewander, Nora Perrone-Bizzozero
Summary: The RNA-binding protein HuD plays a critical role in brain development, neurodegenerative diseases, and substance use disorders by regulating coding and non-coding RNA networks associated with neuronal differentiation and synaptic physiology.
Article
Neurosciences
Anaissa Ruiz-Tejada, Janet Neisewander, Christos S. Katsanos
Summary: Physical activity is beneficial for health, but only a small number of adults engage in regular physical activity. Further research is needed to understand the biological mechanisms of motivation and habit formation to enhance physical activity levels.
Article
Biochemistry & Molecular Biology
Leandro B. C. Teixeira, Kevin A. Buhr, Owen Bowie, Felicia D. Duke, T. Michael Nork, Richard R. Dubielzig, Gillian J. McLellan