Microglia-derived ASC specks cross-seed amyloid-β in Alzheimer’s disease

ASC filament formation serves as a signal amplification mechanism for inflammasomes

(2016) Mathias S. Dick et al.   Nature Communications

Association Between Genetic Traits for Immune-Mediated Diseases and Alzheimer Disease

(2016) Jennifer S. Yokoyama et al.   JAMA Neurology

Conserved epigenomic signals in mice and humans reveal immune basis of Alzheimer’s disease

(2015) Elizabeta Gjoneska et al.   NATURE

Innate immunity in Alzheimer's disease

(2015) Michael T Heneka et al.   NATURE IMMUNOLOGY

Three dimensions of the amyloid hypothesis: time, space and 'wingmen'

(2015) Erik S Musiek et al.   NATURE NEUROSCIENCE

Prion Pathogenesis in the Absence of NLRP3/ASC Inflammasomes

(2015) Mario Nuvolone et al.   PLoS One

Aβ seeds resist inactivation by formaldehyde

(2014) Sarah K. Fritschi et al.   ACTA NEUROPATHOLOGICA

Prion-like Polymerization Underlies Signal Transduction in Antiviral Immune Defense and Inflammasome Activation

(2014) Xin Cai et al.   CELL

Unified Polymerization Mechanism for the Assembly of ASC-Dependent Inflammasomes

(2014) Alvin Lu et al.   CELL

The NLRP3 inflammasome is released as a particulate danger signal that amplifies the inflammatory response

(2014) Alberto Baroja-Mazo et al.   NATURE IMMUNOLOGY

The adaptor ASC has extracellular and 'prionoid' activities that propagate inflammation

(2014) Bernardo S Franklin et al.   NATURE IMMUNOLOGY

Alzheimer’s Disease Genetics: From the Bench to the Clinic

(2014) Celeste M. Karch et al.   NEURON

Polarization of the Effects of Autoimmune and Neurodegenerative Risk Alleles in Leukocytes

(2014) T. Raj et al.   SCIENCE

Integrated Systems Approach Identifies Genetic Nodes and Networks in Late-Onset Alzheimer’s Disease

(2013) Bin Zhang et al.   CELL

Canonical Nlrp3 Inflammasome Links Systemic Low-Grade Inflammation to Functional Decline in Aging

(2013) Yun-Hee Youm et al.   Cell Metabolism

Tracking pathophysiological processes in Alzheimer's disease: an updated hypothetical model of dynamic biomarkers

(2013) Clifford R Jack et al.   LANCET NEUROLOGY

Self-propagation of pathogenic protein aggregates in neurodegenerative diseases

(2013) Mathias Jucker et al.   NATURE

Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease

(2013) Jean-Charles Lambert et al.   NATURE GENETICS

PPAR /RXR -Induced and CD36-Mediated Microglial Amyloid-  Phagocytosis Results in Cognitive Improvement in Amyloid Precursor Protein/Presenilin 1 Mice

(2012) M. Yamanaka et al.   JOURNAL OF NEUROSCIENCE

NLRP3 is activated in Alzheimer’s disease and contributes to pathology in APP/PS1 mice

(2012) Michael T. Heneka et al.   NATURE

NLRP6 Inflammasome Regulates Colonic Microbial Ecology and Risk for Colitis

(2011) Eran Elinav et al.   CELL

Extracellular phosphorylation of the amyloid β-peptide promotes formation of toxic aggregates during the pathogenesis of Alzheimer's disease

(2011) Sathish Kumar et al.   EMBO JOURNAL

α-secretase mediated conversion of the amyloid precursor protein derived membrane stub C99 to C83 limits Aβ generation

(2009) Sebastian Jäger et al.   JOURNAL OF NEUROCHEMISTRY

A new amyloid β variant favoring oligomerization in Alzheimer's-type dementia

(2008) Takami Tomiyama et al.   ANNALS OF NEUROLOGY