The Ubiquitin Ligase TRIP12 Limits PARP1 Trapping and Constrains PARP Inhibitor Efficiency

Published 2020 View Full Article

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Title
The Ubiquitin Ligase TRIP12 Limits PARP1 Trapping and Constrains PARP Inhibitor Efficiency
Authors
Keywords
genome instability, endogenous DNA lesions, replication stress, cancer, BRCA mutations, PARP inhibitors, PAR-targeted protein ubiquitylation, HECT-type ubiquitin ligases, synthetic lethality, personalized cancer therapy
Journal
Cell Reports
Volume 32, Issue 5, Pages 107985
Publisher
Elsevier BV
Online
2020-08-04
DOI
10.1016/j.celrep.2020.107985

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