Receptor-interacting protein kinase 1 (RIPK1) as a therapeutic target

RIP1 kinase activity is critical for skin inflammation but not for viral propagation

(2020) Joshua D. Webster et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China

(2020) Chaolin Huang et al.   LANCET

Sequential activation of necroptosis and apoptosis cooperates to mediate vascular and neural pathology in stroke

(2020) Masanori Gomi Naito et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Response to inhibition of receptor‐interacting protein kinase 1 (RIPK1) in active plaque psoriasis: a randomized placebo‐controlled study

(2020) Kathleen Weisel et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Inhibition of Necroptosis Rescues SAH-Induced Synaptic Impairments in Hippocampus via CREB-BDNF Pathway

(2019) Chunlei Yang et al.   Frontiers in Neuroscience

OTULIN deficiency in ORAS causes cell type‐specific LUBAC degradation, dysregulated TNF signalling and cell death

(2019) Rune Busk Damgaard et al.   EMBO Molecular Medicine

RIP1 inhibition blocks inflammatory diseases but not tumor growth or metastases

(2019) Snahel Patel et al.   CELL DEATH AND DIFFERENTIATION

A20 prevents inflammasome-dependent arthritis by inhibiting macrophage necroptosis through its ZnF7 ubiquitin-binding domain

(2019) Apostolos Polykratis et al.   NATURE CELL BIOLOGY

Targeting RIPK1 for the treatment of human diseases

(2019) Alexei Degterev et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cell Death and Inflammation – A Vital but Dangerous Liaison

(2019) Nieves Peltzer et al.   TRENDS IN IMMUNOLOGY

Identification of a RIP1 Kinase Inhibitor Clinical Candidate (GSK3145095) for the Treatment of Pancreatic Cancer

(2019) Philip A. Harris et al.   ACS Medicinal Chemistry Letters

Serine 25 phosphorylation inhibits RIPK1 kinase-dependent cell death in models of infection and inflammation

(2019) Yves Dondelinger et al.   Nature Communications

Potent and selective inhibitors of receptor-interacting protein kinase 1 that lack an aromatic back pocket group

(2019) Gregory L. Hamilton et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Molecular Recognition of M1-Linked Ubiquitin Chains by Native and Phosphorylated UBAN Domains

(2019) Lina Herhaus et al.   JOURNAL OF MOLECULAR BIOLOGY

A rare functional variant of SHARPIN attenuates the inflammatory response and associates with increased risk of late-onset Alzheimer’s disease

(2019) Yuya Asanomi et al.   MOLECULAR MEDICINE

Low TNFAIP3 expression in psoriatic skin promotes disease susceptibility and severity

(2019) Nahla Yassin Sahlol et al.   PLoS One

Sepsis: Inflammation Is a Necessary Evil

(2019) Christina Nedeva et al.   Frontiers in Cell and Developmental Biology

Integrative analysis of genome‐wide association study and expression quantitative trait loci datasets identified various immune cell‐related pathways for rheumatoid arthritis

(2019) Ping Li et al.   ANNALS OF HUMAN GENETICS

DNL 104, a Centrally Penetrant RIPK 1 Inhibitor, Inhibits RIP 1 Kinase Phosphorylation in a Randomized Phase I Ascending Dose Study in Healthy Volunteers

(2019) Hendrika W. Grievink et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Cleavage of RIPK1 by caspase-8 is crucial for limiting apoptosis and necroptosis

(2019) Kim Newton et al.   NATURE

Multiple sclerosis genomic map implicates peripheral immune cells and microglia in susceptibility

(2019)   SCIENCE

A20 protects cells from TNF-induced apoptosis through linear ubiquitin-dependent and -independent mechanisms

(2019) Dario Priem et al.   Cell Death & Disease

Infliximab therapy for inflammatory colitis in an infant with NEMO deficiency

(2019) Hasibe Artac et al.   IMMUNOLOGIC RESEARCH

Activity of caspase-8 determines plasticity between cell death pathways

(2019) Kim Newton et al.   NATURE

Necrosome complex detected in granulovacuolar degeneration is associated with neuronal loss in Alzheimer’s disease

(2019) Marta J. Koper et al.   ACTA NEUROPATHOLOGICA

Mutations that prevent caspase cleavage of RIPK1 cause autoinflammatory disease

(2019) Najoua Lalaoui et al.   NATURE

A dominant autoinflammatory disease caused by non-cleavable variants of RIPK1

(2019) Panfeng Tao et al.   NATURE

Association of Tumor Necrosis Factor Alpha-Induced Protein 3 Interacting Protein 1 (TNIP1) Gene Polymorphism (rs7708392) with Lupus Nephritis in Egyptian Patients

(2018) Mohamed Moustafa Rizk et al.   BIOCHEMICAL GENETICS

A Role for Receptor-Interacting Protein Kinase-1 in Neutrophil Extracellular Trap Formation in Patients with Systemic Lupus Erythematosus: a Preliminary Study

(2018) Ruru Guo et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Necroptosis in development and diseases

(2018) Bing Shan et al.   GENES & DEVELOPMENT

Infantile Onset Intractable Inflammatory Bowel Disease Due to Novel Heterozygous Mutations in TNFAIP3 (A20)

(2018) Cuifang Zheng et al.   INFLAMMATORY BOWEL DISEASES

RIP kinase 1–dependent endothelial necroptosis underlies systemic inflammatory response syndrome

(2018) Matija Zelic et al.   JOURNAL OF CLINICAL INVESTIGATION

Inhibition of regulated necrosis attenuates receptor-interacting protein kinase 1–mediated ischemia-reperfusion injury after lung transplantation

(2018) Takashi Kanou et al.   JOURNAL OF HEART AND LUNG TRANSPLANTATION

Discovery of 7-Oxo-2,4,5,7-tetrahydro-6H-pyrazolo[3,4-c]pyridine Derivatives as Potent, Orally Available, and Brain-Penetrating Receptor Interacting Protein 1 (RIP1) Kinase Inhibitors: Analysis of Structure–Kinetic Relationships

(2018) Masato Yoshikawa et al.   JOURNAL OF MEDICINAL CHEMISTRY

Ubiquitin-Mediated Regulation of RIPK1 Kinase Activity Independent of IKK and MK2

(2018) Alessandro Annibaldi et al.   MOLECULAR CELL

Necrostatin-1 Improves Long-term Functional Recovery Through Protecting Oligodendrocyte Precursor Cells After Transient Focal Cerebral Ischemia in Mice

(2018) Yingzhu Chen et al.   NEUROSCIENCE

Death-domain dimerization-mediated activation of RIPK1 controls necroptosis and RIPK1-dependent apoptosis

(2018) Huyan Meng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulation of a distinct activated RIPK1 intermediate bridging complex I and complex II in TNFα-mediated apoptosis

(2018) Palak Amin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

BiallelicRIPK1mutations in humans cause severe immunodeficiency, arthritis, and intestinal inflammation

(2018) Delphine Cuchet-Lourenço et al.   SCIENCE

Inhibition of necroptosis attenuates lung injury and improves survival in neonatal sepsis

(2018) Alexandra C. Bolognese et al.   SURGERY

Pharmacological Inhibition of Necroptosis Protects from Dopaminergic Neuronal Cell Death in Parkinson’s Disease Models

(2018) Angelo Iannielli et al.   Cell Reports

Inhibiting RIPK1 Limits Neuroinflammation and Alleviates Postoperative Cognitive Impairments in D-Galactose-Induced Aged Mice

(2018) Shangchun Duan et al.   Frontiers in Behavioral Neuroscience

The Role of Necroptosis in Cardiovascular Disease

(2018) Shi Zhe-Wei et al.   Frontiers in Pharmacology

Selective Modulation of TNF–TNFRs Signaling: Insights for Multiple Sclerosis Treatment

(2018) Valentina Pegoretti et al.   Frontiers in Immunology

Receptor-Interacting Protein Kinases 1 and 3, and Mixed Lineage Kinase Domain-Like Protein Are Activated by Sublytic Complement and Participate in Complement-Dependent Cytotoxicity

(2018) Michal Lusthaus et al.   Frontiers in Immunology

TBK1 Suppresses RIPK1-Driven Apoptosis and Inflammation during Development and in Aging

(2018) Daichao Xu et al.   CELL

Keratinocyte expression of A20/TNFAIP3 controls skin inflammation associated with atopic dermatitis and psoriasis

(2018) Michael Devos et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

OTULIN limits cell death and inflammation by deubiquitinating LUBAC

(2018) Klaus Heger et al.   NATURE

Elevated A20 promotes TNF-induced and RIPK1-dependent intestinal epithelial cell death

(2018) Ricard Garcia-Carbonell et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The pseudokinase MLKL activates PAD4-dependent NET formation in necroptotic neutrophils

(2018) Akshay A. D’Cruz et al.   Science Signaling

LRRK2 activation in idiopathic Parkinson’s disease

(2018) Roberto Di Maio et al.   Science Translational Medicine

RIP1 Kinase Drives Macrophage-Mediated Adaptive Immune Tolerance in Pancreatic Cancer

(2018) Wei Wang et al.   CANCER CELL

ABIN-1 heterozygosity sensitizes to innate immune response in both RIPK1-dependent and RIPK1-independent manner

(2018) Zhenyi Su et al.   CELL DEATH AND DIFFERENTIATION

TBK1 and IKKε prevent TNF-induced cell death by RIPK1 phosphorylation

(2018) Elodie Lafont et al.   NATURE CELL BIOLOGY

Necroptosis and RIPK1-mediated neuroinflammation in CNS diseases

(2018) Junying Yuan et al.   NATURE REVIEWS NEUROSCIENCE

Human RIPK1 deficiency causes combined immunodeficiency and inflammatory bowel diseases

(2018) Yue Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inhibiting RIP1 Improves Chronic Stress-Induced Cognitive Impairments in D-Galactose-Induced Aging Mice

(2018) Wenxiang Qing et al.   Frontiers in Behavioral Neuroscience

TRAF1 Signaling in Human Health and Disease

(2018) Maria I. Edilova et al.   Frontiers in Immunology

SPATA2 regulates the activation of RIPK1 by modulating linear ubiquitination

(2017) Ran Wei et al.   GENES & DEVELOPMENT

Necrostatin-1 Protects Against d-Galactosamine and Lipopolysaccharide-Induced Hepatic Injury by Preventing TLR4 and RAGE Signaling

(2017) Seok-Joo Kim et al.   INFLAMMATION

Autophagy protein ATG16L1 prevents necroptosis in the intestinal epithelium

(2017) Yu Matsuzawa-Ishimoto et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Discovery of a Highly Potent, Selective, and Metabolically Stable Inhibitor of Receptor-Interacting Protein 1 (RIP1) for the Treatment of Systemic Inflammatory Response Syndrome

(2017) Yan Ren et al.   JOURNAL OF MEDICINAL CHEMISTRY

Discovery of a First-in-Class Receptor Interacting Protein 1 (RIP1) Kinase Specific Clinical Candidate (GSK2982772) for the Treatment of Inflammatory Diseases

(2017) Philip A. Harris et al.   JOURNAL OF MEDICINAL CHEMISTRY

ABIN-1 regulates RIPK1 activation by linking Met1 ubiquitylation with Lys63 deubiquitylation in TNF-RSC

(2017) Slawomir A. Dziedzic et al.   NATURE CELL BIOLOGY

Necroptosis activation in Alzheimer's disease

(2017) Antonella Caccamo et al.   NATURE NEUROSCIENCE

Necroptosis controls NET generation and mediates complement activation, endothelial damage, and autoimmune vasculitis

(2017) Adrian Schreiber et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

RIPK1 mediates a disease-associated microglial response in Alzheimer’s disease

(2017) Dimitry Ofengeim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genetic correlation between amyotrophic lateral sclerosis and schizophrenia

(2017) Russell L. McLaughlin et al.   Nature Communications

Regulation of RIPK1 activation by TAK1-mediated phosphorylation dictates apoptosis and necroptosis

(2017) Jiefei Geng et al.   Nature Communications

Necroptosis regulated proteins expression is an early prognostic biomarker in patient with sepsis: a prospective observational study

(2017) Bing Wang et al.   Oncotarget

NF-κB Pathway in Autoinflammatory Diseases: Dysregulation of Protein Modifications by Ubiquitin Defines a New Category of Autoinflammatory Diseases

(2017) Ivona Aksentijevich et al.   Frontiers in Immunology

6E11, a highly selective inhibitor of Receptor-Interacting Protein Kinase 1, protects cells against cold hypoxia-reoxygenation injury

(2017) C. Delehouzé et al.   Scientific Reports

The Deubiquitinase OTULIN Is an Essential Negative Regulator of Inflammation and Autoimmunity

(2016) Rune Busk Damgaard et al.   CELL

RIPK3 deficiency or catalytically inactive RIPK1 provides greater benefit than MLKL deficiency in mouse models of inflammation and tissue injury

(2016) K Newton et al.   CELL DEATH AND DIFFERENTIATION

The Autophagy Machinery Controls Cell Death Switching between Apoptosis and Necroptosis

(2016) Megan L. Goodall et al.   DEVELOPMENTAL CELL

Challenges in the characterization of neutrophil extracellular traps: The truth is in the details

(2016) Paul H. Naccache et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

NEMO Prevents RIP Kinase 1-Mediated Epithelial Cell Death and Chronic Intestinal Inflammation by NF-κB-Dependent and -Independent Functions

(2016) Katerina Vlantis et al.   IMMUNITY

The Pseudokinase MLKL and the Kinase RIPK3 Have Distinct Roles in Autoimmune Disease Caused by Loss of Death-Receptor-Induced Apoptosis

(2016) Silvia Alvarez-Diaz et al.   IMMUNITY

RIPK1 and RIPK3 Kinases Promote Cell-Death-Independent Inflammation by Toll-like Receptor 4

(2016) Malek Najjar et al.   IMMUNITY

DNA-Encoded Library Screening Identifies Benzo[b][1,4]oxazepin-4-ones as Highly Potent and Monoselective Receptor Interacting Protein 1 Kinase Inhibitors

(2016) Philip A. Harris et al.   JOURNAL OF MEDICINAL CHEMISTRY

Biallelic hypomorphic mutations in a linear deubiquitinase define otulipenia, an early-onset autoinflammatory disease

(2016) Qing Zhou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Essential protective role of tumor necrosis factor receptor 2 in neurodegeneration

(2016) Yun Dong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

RIPK1 mediates axonal degeneration by promoting inflammation and necroptosis in ALS

(2016) Yasushi Ito et al.   SCIENCE

Role of necroptosis in autophagy signaling during hepatic ischemia and reperfusion

(2016) Jeong-Min Hong et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Holding RIPK1 on the Ubiquitin Leash in TNFR1 Signaling

(2016) Nieves Peltzer et al.   TRENDS IN CELL BIOLOGY

RIPK1 protects from TNF-α-mediated liver damage during hepatitis

(2016) Aveline Filliol et al.   Cell Death & Disease

Necroptosis in Niemann–Pick disease, type C1: a potential therapeutic target

(2016) A Cougnoux et al.   Cell Death & Disease

Whole-genome sequencing reveals important role for TBK1 and OPTN mutations in frontotemporal lobar degeneration without motor neuron disease

(2015) Cyril Pottier et al.   ACTA NEUROPATHOLOGICA

Necroptosis is a key pathogenic event in human and experimental murine models of non-alcoholic steatohepatitis

(2015) Marta B. Afonso et al.   CLINICAL SCIENCE

Caspase-8 Deficiency Presenting as Late-Onset Multi-Organ Lymphocytic Infiltration with Granulomas in two Adult Siblings

(2015) Julie Niemela et al.   JOURNAL OF CLINICAL IMMUNOLOGY

Human HOIP and LUBAC deficiency underlies autoinflammation, immunodeficiency, amylopectinosis, and lymphangiectasia

(2015) Bertrand Boisson et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Association of PELI1 polymorphisms in systemic lupus erythematosus susceptibility in a Chinese population

(2015) F-R Chen et al.   LUPUS

Loss-of-function mutations in TNFAIP3 leading to A20 haploinsufficiency cause an early-onset autoinflammatory disease

(2015) Qing Zhou et al.   NATURE GENETICS

The ubiquitin-modifying enzyme A20 restricts ubiquitination of the kinase RIPK3 and protects cells from necroptosis

(2015) Michio Onizawa et al.   NATURE IMMUNOLOGY

Neutrophils promote Alzheimer's disease–like pathology and cognitive decline via LFA-1 integrin

(2015) Elena Zenaro et al.   NATURE MEDICINE

Haploinsufficiency of TBK1 causes familial ALS and fronto-temporal dementia

(2015) Axel Freischmidt et al.   NATURE NEUROSCIENCE

Necrostatin-1 Ameliorates Intracerebral Hemorrhage-Induced Brain Injury in Mice Through Inhibiting RIP1/RIP3 Pathway

(2015) Xingfen Su et al.   NEUROCHEMICAL RESEARCH

Exome sequencing in amyotrophic lateral sclerosis identifies risk genes and pathways

(2015) E. T. Cirulli et al.   SCIENCE

Farm dust and endotoxin protect against allergy through A20 induction in lung epithelial cells

(2015) M. J. Schuijs et al.   SCIENCE

XIAP deficiency syndrome in humans

(2015) Sylvain Latour et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Structure Guided Design of Potent and Selective Ponatinib-Based Hybrid Inhibitors for RIPK1

(2015) Malek Najjar et al.   Cell Reports

Activation of Necroptosis in Multiple Sclerosis

(2015) Dimitry Ofengeim et al.   Cell Reports

RIPK3-Mediated Necroptosis Regulates Cardiac Allograft Rejection

(2014) A. Pavlosky et al.   AMERICAN JOURNAL OF TRANSPLANTATION

RIPK1 Regulates RIPK3-MLKL-Driven Systemic Inflammation and Emergency Hematopoiesis

(2014) James A. Rickard et al.   CELL

RIPK1 Blocks Early Postnatal Lethality Mediated by Caspase-8 and RIPK3

(2014) Christopher P. Dillon et al.   CELL

IKK-related genetic diseases: probing NF-κB functions in humans and other matters

(2014) Anna Senegas et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Cutting Edge: RIPK1 Kinase Inactive Mice Are Viable and Protected from TNF-Induced Necroptosis In Vivo

(2014) Apostolos Polykratis et al.   JOURNAL OF IMMUNOLOGY

Cutting Edge: RIP1 Kinase Activity Is Dispensable for Normal Development but Is a Key Regulator of Inflammation in SHARPIN-Deficient Mice

(2014) S. B. Berger et al.   JOURNAL OF IMMUNOLOGY

A20 deficiency causes spontaneous neuroinflammation in mice

(2014) Renata Guedes et al.   Journal of Neuroinflammation

A Crohn’s disease variant in Atg16l1 enhances its degradation by caspase 3

(2014) Aditya Murthy et al.   NATURE

Negative regulation of the NLRP3 inflammasome by A20 protects against arthritis

(2014) Lieselotte Vande Walle et al.   NATURE

RIPK1 maintains epithelial homeostasis by inhibiting apoptosis and necroptosis

(2014) Marius Dannappel et al.   NATURE

RIPK3 as a potential therapeutic target for Gaucher's disease

(2014) Einat B Vitner et al.   NATURE MEDICINE

Ischemic insults induce necroptotic cell death in hippocampal neurons through the up-regulation of endogenous RIP3

(2014) M. Vieira et al.   NEUROBIOLOGY OF DISEASE

Necroptosis Drives Motor Neuron Death in Models of Both Sporadic and Familial ALS

(2014) Diane B. Re et al.   NEURON

Atg16L1 T300A variant decreases selective autophagy resulting in altered cytokine signaling and decreased antibacterial defense

(2014) K. G. Lassen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

RIP1 suppresses innate immune necrotic as well as apoptotic cell death during mammalian parturition

(2014) W. J. Kaiser et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A20 controls intestinal homeostasis through cell-specific activities

(2014) Lars Vereecke et al.   Nature Communications

Necrostatin-1 protects against reactive oxygen species (ROS)-induced hepatotoxicity in acetaminophen-induced acute liver failure

(2014) Kenji Takemoto et al.   FEBS Open Bio

RIPK3-Mediated Necroptosis Promotes Donor Kidney Inflammatory Injury and Reduces Allograft Survival

(2013) A. Lau et al.   AMERICAN JOURNAL OF TRANSPLANTATION

A novel necroptosis inhibitor—necrostatin-21 and its SAR study

(2013) Zhijie Wu et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

OTULIN Antagonizes LUBAC Signaling by Specifically Hydrolyzing Met1-Linked Polyubiquitin

(2013) Kirstin Keusekotten et al.   CELL

XIAP deficiency is a mendelian cause of late-onset IBD

(2013) Carsten Speckmann et al.   GUT

ABIN1 Dysfunction as a Genetic Basis for Lupus Nephritis

(2013) D. J. Caster et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

The RIP1-Kinase Inhibitor Necrostatin-1 Prevents Osmotic Nephrosis and Contrast-Induced AKI in Mice

(2013) A. Linkermann et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Regulation of RIP1 kinase signalling at the crossroads of inflammation and cell death

(2013) Dimitry Ofengeim et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The FLIP Side of Life

(2013) J. Silke et al.   Science Signaling

Structural Basis of RIP1 Inhibition by Necrostatins

(2013) Tian Xie et al.   STRUCTURE

Discovery of Small Molecule RIP1 Kinase Inhibitors for the Treatment of Pathologies Associated with Necroptosis

(2013) Philip A. Harris et al.   ACS Medicinal Chemistry Letters

Association of two independent functional risk haplotypes inTNIP1with systemic lupus erythematosus

(2012) Indra Adrianto et al.   ARTHRITIS AND RHEUMATISM

Activity and specificity of necrostatin-1, small-molecule inhibitor of RIP1 kinase

(2012) A Degterev et al.   CELL DEATH AND DIFFERENTIATION

Absence of receptor interacting protein kinase 3 prevents ethanol-induced liver injury

(2012) Sanjoy Roychowdhury et al.   HEPATOLOGY

Rip1 (Receptor-interacting protein kinase 1) mediates necroptosis and contributes to renal ischemia/reperfusion injury

(2012) Andreas Linkermann et al.   KIDNEY INTERNATIONAL

TNF receptor 1 genetic risk mirrors outcome of anti-TNF therapy in multiple sclerosis

(2012) Adam P. Gregory et al.   NATURE

Host–microbe interactions have shaped the genetic architecture of inflammatory bowel disease

(2012) Luke Jostins et al.   NATURE

Immunodeficiency, autoinflammation and amylopectinosis in humans with inherited HOIL-1 and LUBAC deficiency

(2012) Bertrand Boisson et al.   NATURE IMMUNOLOGY

Programmed necrosis in acute kidney injury

(2012) A. Linkermann et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Challenges in Acute Ischemic Stroke Clinical Trials

(2012) Anthony J. Furlan   Current Cardiology Reports

Genome-wide meta-analysis identifies novel multiple sclerosis susceptibility loci

(2011) Nikolaos A. Patsopoulos et al.   ANNALS OF NEUROLOGY

SQSTM1 Mutations in Familial and Sporadic Amyotrophic Lateral Sclerosis

(2011) Faisal Fecto   ARCHIVES OF NEUROLOGY

Crohn disease: A current perspective on genetics, autophagy and immunity

(2011) Thaddeus S. Stappenbeck et al.   Autophagy

Keratinocyte-specific ablation of the NF-κB regulatory protein A20 (TNFAIP3) reveals a role in the control of epidermal homeostasis

(2011) S Lippens et al.   CELL DEATH AND DIFFERENTIATION

Sequencing of TNFAIP3 and association of variants with multiple autoimmune diseases

(2011) S L Musone et al.   GENES AND IMMUNITY

RIP Kinase-Dependent Necrosis Drives Lethal Systemic Inflammatory Response Syndrome

(2011) Linde Duprez et al.   IMMUNITY

TNFAIP3 Gene Polymorphisms Are Associated with Response to TNF Blockade in Psoriasis

(2011) Trilokraj Tejasvi et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

cIAPs Block Ripoptosome Formation, a RIP1/Caspase-8 Containing Intracellular Cell Death Complex Differentially Regulated by cFLIP Isoforms

(2011) Maria Feoktistova et al.   MOLECULAR CELL

Catalytic activity of the caspase-8–FLIPL complex inhibits RIPK3-dependent necrosis

(2011) Andrew Oberst et al.   NATURE

Linear ubiquitination prevents inflammation and regulates immune signalling

(2011) Björn Gerlach et al.   NATURE

A20 (TNFAIP3) deficiency in myeloid cells triggers erosive polyarthritis resembling rheumatoid arthritis

(2011) Mourad Matmati et al.   NATURE GENETICS

Association of a functional variant downstream of TNFAIP3 with systemic lupus erythematosus

(2011) Indra Adrianto et al.   NATURE GENETICS

Haploinsufficiency of TAB2 Causes Congenital Heart Defects in Humans

(2010) Bernard Thienpont et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Synergistic protective effects of humanin and necrostatin-1 on hypoxia and ischemia/reperfusion injury

(2010) Xingshun Xu et al.   BRAIN RESEARCH

A20 deficiency in B cells enhances B-cell proliferation and results in the development of autoantibodies

(2010) Nadine Hövelmeyer et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Enterocyte-specific A20 deficiency sensitizes to tumor necrosis factor–induced toxicity and experimental colitis

(2010) Lars Vereecke et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Mutations of optineurin in amyotrophic lateral sclerosis

(2010) Hirofumi Maruyama et al.   NATURE

Genome-wide analysis reveals mechanisms modulating autophagy in normal brain aging and in Alzheimer's disease

(2010) M. M. Lipinski et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Association of TNFAIP3 interacting protein 1, TNIP1 with systemic lupus erythematosus in a Japanese population: a case-control association study

(2010) Aya Kawasaki et al.   ARTHRITIS RESEARCH & THERAPY

Specific Recognition of Linear Ubiquitin Chains by NEMO Is Important for NF-κB Activation

(2009) Simin Rahighi et al.   CELL

A large-scale replication study identifies TNIP1, PRDM1, JAZF1, UHRF1BP1 and IL10 as risk loci for systemic lupus erythematosus

(2009) Vesela Gateva et al.   NATURE GENETICS

Genome-wide scan reveals association of psoriasis with IL-23 and NF-κB pathways

(2009) Rajan P Nair et al.   NATURE GENETICS

Structure–activity relationship study of a novel necroptosis inhibitor, necrostatin-7

(2008) Weihong Zheng et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Analysis of 17 autoimmune disease-associated variants in type 1 diabetes identifies 6q23/TNFAIP3 as a susceptibility locus

(2008) E Y M G Fung et al.   GENES AND IMMUNITY

Epidemiology of inflammatory bowel disease in a German twin cohort: Results of a nationwide study

(2008) Martina E. Spehlmann et al.   INFLAMMATORY BOWEL DISEASES

Necrostatin-1 Reduces Histopathology and Improves Functional Outcome after Controlled Cortical Impact in Mice

(2008) Zerong You et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

ABIN-1 is a ubiquitin sensor that restricts cell death and sustains embryonic development

(2008) Shigeru Oshima et al.   NATURE

Identification of RIP1 kinase as a specific cellular target of necrostatins

(2008) Alexei Degterev et al.   Nature Chemical Biology

Multiple polymorphisms in the TNFAIP3 region are independently associated with systemic lupus erythematosus

(2008) Stacy L Musone et al.   NATURE GENETICS