Ferroptosis turns 10: Emerging mechanisms, physiological functions, and therapeutic applications

PKCβII phosphorylates ACSL4 to amplify lipid peroxidation to induce ferroptosis

(2022) Hai-Liang Zhang et al.   NATURE CELL BIOLOGY

Machine Learning Classifies Ferroptosis and Apoptosis Cell Death Modalities with TfR1 Immunostaining

(2022) Jenny Jin et al.   ACS Chemical Biology

CD8+ T cells and fatty acids orchestrate tumor ferroptosis and immunity via ACSL4

(2022) Peng Liao et al.   CANCER CELL

Targeting ferroptosis protects against experimental (multi)organ dysfunction and death

(2022) Samya Van Coillie et al.   Nature Communications

Ferroptosis: mechanisms, biology and role in disease

(2021) Xuejun Jiang et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

A pan-cancer study of selenoprotein genes as promising targets for cancer therapy

(2021) Wentao Wu et al.   BMC Medical Genomics

CD36-mediated ferroptosis dampens intratumoral CD8+ T cell effector function and impairs their antitumor ability

(2021) Xingzhe Ma et al.   Cell Metabolism

Differences in cell death in methionine versus cysteine depletion

(2021) Katherine F. Wallis et al.   ENVIRONMENTAL AND MOLECULAR MUTAGENESIS

Phospholipase iPLA2β averts ferroptosis by eliminating a redox lipid death signal

(2021) Wan-Yang Sun et al.   Nature Chemical Biology

mTORC1 couples cyst(e)ine availability with GPX4 protein synthesis and ferroptosis regulation

(2021) Yilei Zhang et al.   Nature Communications

Anti-ferroptotic mechanism of IL4i1-mediated amino acid metabolism

(2021) Leonie Zeitler et al.   eLife

DHODH-mediated ferroptosis defence is a targetable vulnerability in cancer

(2021) Chao Mao et al.   NATURE

Ferroptotic cell death triggered by conjugated linolenic acids is mediated by ACSL1

(2021) Alexander Beatty et al.   Nature Communications

Excess heme upregulates heme oxygenase 1 and promotes cardiac ferroptosis in mice with sickle cell disease

(2021) Archita Venugopal Menon et al.   BLOOD

Peroxidation of n-3 and n-6 polyunsaturated fatty acids in the acidic tumor environment leads to ferroptosis-mediated anticancer effects

(2021) Emeline Dierge et al.   Cell Metabolism

Heme oxygenase limits Mycobacterium marinum infection‐induced detrimental ferrostatin‐sensitive cell death in zebrafish

(2021) Kaiming Luo et al.   FEBS Journal

Selenium–GPX4 axis protects follicular helper T cells from ferroptosis

(2021) Yin Yao et al.   NATURE IMMUNOLOGY

Glutathione peroxidase 4–regulated neutrophil ferroptosis induces systemic autoimmunity

(2021) Pengchong Li et al.   NATURE IMMUNOLOGY

Genome-wide CRISPRi/a screens in human neurons link lysosomal failure to ferroptosis

(2021) Ruilin Tian et al.   NATURE NEUROSCIENCE

The iron chaperone and nucleic acid–binding activities of poly(rC)-binding protein 1 are separable and independently essential

(2021) Sarju J. Patel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

GOT1 inhibition promotes pancreatic cancer cell death by ferroptosis

(2021) Daniel M. Kremer et al.   Nature Communications

iPLA2β-mediated lipid detoxification controls p53-driven ferroptosis independent of GPX4

(2021) Delin Chen et al.   Nature Communications

Overexpression of ferroptosis defense enzyme Gpx4 retards motor neuron disease of SOD1G93A mice

(2021) Liuji Chen et al.   Scientific Reports

Ferroptotic stress promotes the accumulation of pro-inflammatory proximal tubular cells in maladaptive renal repair

(2021) Shintaro Ide et al.   eLife

Ferroptosis mediates selective motor neuron death in amyotrophic lateral sclerosis

(2021) Taide Wang et al.   CELL DEATH AND DIFFERENTIATION

Melatonin protects against PM2.5-induced lung injury by inhibiting ferroptosis of lung epithelial cells in a Nrf2-dependent manner

(2021) Fan Guohua et al.   ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY

Ferrostatin-1 obviates seizures and associated cognitive deficits in ferric chloride-induced posttraumatic epilepsy via suppressing ferroptosis

(2021) Kang-Ni Chen et al.   FREE RADICAL BIOLOGY AND MEDICINE

C-ferroptosis is an iron-dependent form of regulated cell death in cyanobacteria

(2021) Anabella Aguilera et al.   JOURNAL OF CELL BIOLOGY

Characterization of a patient-derived variant of GPX4 for precision therapy

(2021) Hengrui Liu et al.   Nature Chemical Biology

A roadmap to creating ferroptosis-based medicines

(2021) Kamyar Hadian et al.   Nature Chemical Biology

Syrian hamsters as a model of lung injury with SARS-CoV-2 infection: Pathologic, physiologic, and detailed molecular profiling

(2021) JOSEPH S. BEDNASH et al.   Translational Research

Plasticity of extrachromosomal and intrachromosomal BRAF amplifications in overcoming targeted therapy dosage challenges

(2021) Kai Song et al.   Cancer Discovery

Embryonal erythropoiesis and aging exploit ferroptosis

(2021) Hao Zheng et al.   Redox Biology

MLL4 mediates differentiation and tumor suppression through ferroptosis

(2021) Shaun Egolf et al.   Science Advances

Nanoprotection Against Retinal Pigment Epithelium Degeneration via Ferroptosis Inhibition

(2021) Zhimin Tang et al.   Small Methods

Protective Effects of Dexmedetomidine on Sepsis-Induced Vascular Leakage by Alleviating Ferroptosis via Regulating Metabolic Reprogramming

(2021) Han She et al.   Journal of Inflammation Research

Activation of pyroptosis and ferroptosis is involved in the hepatotoxicity induced by polystyrene microplastics in mice

(2021) Yingwen Mu et al.   CHEMOSPHERE

Radiation-Induced Lipid Peroxidation Triggers Ferroptosis and Synergizes with Ferroptosis Inducers

(2020) Ling F. Ye et al.   ACS Chemical Biology

The role of ferroptosis in ionizing radiation-induced cell death and tumor suppression

(2020) Guang Lei et al.   CELL RESEARCH

MDM2 and MDMX promote ferroptosis by PPARα-mediated lipid remodeling

(2020) Divya Venkatesh et al.   GENES & DEVELOPMENT

Energy-stress-mediated AMPK activation inhibits ferroptosis

(2020) Hyemin Lee et al.   NATURE CELL BIOLOGY

Cytochrome P450 oxidoreductase contributes to phospholipid peroxidation in ferroptosis

(2020) Yilong Zou et al.   Nature Chemical Biology

African-centric TP53 variant increases iron accumulation and bacterial pathogenesis but improves response to malaria toxin

(2020) Kumar Sachin Singh et al.   Nature Communications

Blockade of the Lysophosphatidylserine Lipase ABHD12 Potentiates Ferroptosis in Cancer Cells

(2020) Stefan G. Kathman et al.   ACS Chemical Biology

Ferroptosis contributes to developmental cell death in rice blast

(2020) Qing Shen et al.   NEW PHYTOLOGIST

Cysteine depletion induces pancreatic tumor ferroptosis in mice

(2020) Michael A. Badgley et al.   SCIENCE

Transferrin Receptor Is a Specific Ferroptosis Marker

(2020) Huizhong Feng et al.   Cell Reports

Dietary Lipids Induce Ferroptosis in Caenorhabditis elegans and Human Cancer Cells

(2020) Marcos A. Perez et al.   DEVELOPMENTAL CELL

New Probucol Analogues Inhibit Ferroptosis, Improve Mitochondrial Parameters, and Induce Glutathione Peroxidase in HT22 Cells

(2020) Diones Caeran Bueno et al.   MOLECULAR NEUROBIOLOGY

Metabolic determinants of cancer cell sensitivity to canonical ferroptosis inducers

(2020) Mariluz Soula et al.   Nature Chemical Biology

Changes in ferrous iron and glutathione promote ferroptosis and frailty in aging Caenorhabditis elegans

(2020) Nicole L Jenkins et al.   eLife

Lymph protects metastasizing melanoma cells from ferroptosis

(2020) Jessalyn M. Ubellacker et al.   NATURE

Plasticity of ether lipids promotes ferroptosis susceptibility and evasion

(2020) Yilong Zou et al.   NATURE

Ferroptosis occurs through an osmotic mechanism and propagates independently of cell rupture

(2020) Michelle Riegman et al.   NATURE CELL BIOLOGY

PLA2G6 guards placental trophoblasts against ferroptotic injury

(2020) Ofer Beharier et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ferroptotic pores induce Ca2+ fluxes and ESCRT-III activation to modulate cell death kinetics

(2020) Lohans Pedrera et al.   CELL DEATH AND DIFFERENTIATION

Non-canonical Glutamate-Cysteine Ligase Activity Protects against Ferroptosis

(2020) Yun Pyo Kang et al.   Cell Metabolism

3D Culture Models with CRISPR Screens Reveal Hyperactive NRF2 as a Prerequisite for Spheroid Formation via Regulation of Proliferation and Ferroptosis

(2020) Nobuaki Takahashi et al.   MOLECULAR CELL

Polyunsaturated fatty acid biosynthesis pathway determines ferroptosis sensitivity in gastric cancer

(2020) Ji-Yoon Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Oncogenic activation of PI3K-AKT-mTOR signaling suppresses ferroptosis via SREBP-mediated lipogenesis

(2020) Junmei Yi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Looking Back at the Early Stages of Redox Biology

(2020) Leopold Flohé   Antioxidants

Site-specific peroxidation modulates lipid bilayer mechanics

(2020) Choon-Peng Chng et al.   Extreme Mechanics Letters

Characterization of a rat monoclonal antibody raised against ferroptotic cells

(2020) Sho Kobayashi et al.   JOURNAL OF IMMUNOLOGICAL METHODS

A Genome-wide Haploid Genetic Screen Identifies Regulators of Glutathione Abundance and Ferroptosis Sensitivity

(2019) Jennifer Yinuo Cao et al.   Cell Reports

Chaperone-mediated autophagy is involved in the execution of ferroptosis

(2019) Zheming Wu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A major role for ferroptosis in Mycobacterium tuberculosis–induced cell death and tissue necrosis

(2019) Eduardo P. Amaral et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Selenium Drives a Transcriptional Adaptive Program to Block Ferroptosis and Treat Stroke

(2019) Ishraq Alim et al.   CELL

Artemisinin compounds sensitize cancer cells to ferroptosis by regulating iron homeostasis

(2019) Guo-Qing Chen et al.   CELL DEATH AND DIFFERENTIATION

CD8+ T cells regulate tumour ferroptosis during cancer immunotherapy

(2019) Weimin Wang et al.   NATURE

ALOX12 is required for p53-mediated tumour suppression through a distinct ferroptosis pathway

(2019) Bo Chu et al.   NATURE CELL BIOLOGY

Mechanistic basis for impaired ferroptosis in cells expressing the African-centric S47 variant of p53

(2019) Julia I-Ju Leu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Kinome screen of ferroptosis reveals a novel role of ATM in regulating iron metabolism

(2019) Po-Han Chen et al.   CELL DEATH AND DIFFERENTIATION

Intercellular interaction dictates cancer cell ferroptosis via NF2–YAP signalling

(2019) Jiao Wu et al.   NATURE

A GPX4-dependent cancer cell state underlies the clear-cell morphology and confers sensitivity to ferroptosis

(2019) Yilong Zou et al.   Nature Communications

A PCBP1–BolA2 chaperone complex delivers iron for cytosolic [2Fe–2S] cluster assembly

(2019) Sarju J. Patel et al.   Nature Chemical Biology

Radiotherapy and immunotherapy promote tumoral lipid oxidation and ferroptosis via synergistic repression of SLC7A11

(2019) Xueting Lang et al.   Cancer Discovery

Cu II (atsm) inhibits ferroptosis: implications for treatment of neurodegenerative disease

(2019) Authors Adam Southon et al.   BRITISH JOURNAL OF PHARMACOLOGY

FSP1 is a glutathione-independent ferroptosis suppressor

(2019) Sebastian Doll et al.   NATURE

The CoQ oxidoreductase FSP1 acts parallel to GPX4 to inhibit ferroptosis

(2019) Kirill Bersuker et al.   NATURE

Prominin2 Drives Ferroptosis Resistance by Stimulating Iron Export

(2019) Caitlin W. Brown et al.   DEVELOPMENTAL CELL

GTP Cyclohydrolase 1/Tetrahydrobiopterin Counteract Ferroptosis through Lipid Remodeling

(2019) Vanessa A. N. Kraft et al.   ACS Central Science

Determination of the Subcellular Localization and Mechanism of Action of Ferrostatins in Suppressing Ferroptosis

(2018) Michael M. Gaschler et al.   ACS Chemical Biology

Selenium Utilization by GPX4 Is Required to Prevent Hydroperoxide-Induced Ferroptosis

(2018) Irina Ingold et al.   CELL

Modeling the effects of lipid peroxidation during ferroptosis on membrane properties

(2018) Eran Agmon et al.   Scientific Reports

Resolving the Role of Lipoxygenases in the Initiation and Execution of Ferroptosis

(2018) Ron Shah et al.   ACS Central Science

Pseudomonas aeruginosa utilizes host polyunsaturated phosphatidylethanolamines to trigger theft-ferroptosis in bronchial epithelium

(2018) Haider H. Dar et al.   JOURNAL OF CLINICAL INVESTIGATION

BAP1 links metabolic regulation of ferroptosis to tumour suppression

(2018) Yilei Zhang et al.   NATURE CELL BIOLOGY

Tryparedoxin peroxidase-deficiency commits trypanosomes to ferroptosis-type cell death

(2018) Marta Bogacz et al.   eLife

Role of Mitochondria in Ferroptosis

(2018) Minghui Gao et al.   MOLECULAR CELL

Characterization of ferroptosis in murine models of hemochromatosis

(2017) Hao Wang et al.   HEPATOLOGY

Heat stress induces ferroptosis-like cell death in plants

(2017) Ayelén Mariana Distéfano et al.   JOURNAL OF CELL BIOLOGY

NFS1 undergoes positive selection in lung tumours and protects cells from ferroptosis

(2017) Samantha W. Alvarez et al.   NATURE

Drug-tolerant persister cancer cells are vulnerable to GPX4 inhibition

(2017) Matthew J. Hangauer et al.   NATURE

Dependency of a therapy-resistant state of cancer cells on a lipid peroxidase pathway

(2017) Vasanthi S. Viswanathan et al.   NATURE

Cysteine Dioxygenase 1 Mediates Erastin-Induced Ferroptosis in Human Gastric Cancer Cells

(2017) Shihui Hao et al.   NEOPLASIA

On the Mechanism of Cytoprotection by Ferrostatin-1 and Liproxstatin-1 and the Role of Lipid Peroxidation in Ferroptotic Cell Death

(2017) Omkar Zilka et al.   ACS Central Science

Five-Membered Ring Peroxide Selectively Initiates Ferroptosis in Cancer Cells

(2016) Rachel P. Abrams et al.   ACS Chemical Biology

Autophagy promotes ferroptosis by degradation of ferritin

(2016) Wen Hou et al.   Autophagy

Ferroptosis is an autophagic cell death process

(2016) Minghui Gao et al.   CELL RESEARCH

An African-specific polymorphism in theTP53gene impairs p53 tumor suppressor function in a mouse model

(2016) Matthew Jennis et al.   GENES & DEVELOPMENT

Oxidized arachidonic and adrenic PEs navigate cells to ferroptosis

(2016) Valerian E Kagan et al.   Nature Chemical Biology

ACSL4 dictates ferroptosis sensitivity by shaping cellular lipid composition

(2016) Sebastian Doll et al.   Nature Chemical Biology

Global survey of cell death mechanisms reveals metabolic regulation of ferroptosis

(2016) Kenichi Shimada et al.   Nature Chemical Biology

Peroxidation of polyunsaturated fatty acids by lipoxygenases drives ferroptosis

(2016) Wan Seok Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Glutathione peroxidase 4 and vitamin E cooperatively prevent hepatocellular degeneration

(2016) Bradley A. Carlson et al.   Redox Biology

A Mitochondrial-Targeted Nitroxide Is a Potent Inhibitor of Ferroptosis

(2016) Tanja Krainz et al.   ACS Central Science

Human Haploid Cell Genetics Reveals Roles for Lipid Metabolism Genes in Nonapoptotic Cell Death

(2015) Scott J. Dixon et al.   ACS Chemical Biology

Loss of cysteinyl-tRNA synthetase (CARS) induces the transsulfuration pathway and inhibits ferroptosis induced by cystine deprivation

(2015) M Hayano et al.   CELL DEATH AND DIFFERENTIATION

Activation of the p62-Keap1-NRF2 pathway protects against ferroptosis in hepatocellular carcinoma cells

(2015) Xiaofang Sun et al.   HEPATOLOGY

Glutaminolysis and Transferrin Regulate Ferroptosis

(2015) Minghui Gao et al.   MOLECULAR CELL

Ferroptosis as a p53-mediated activity during tumour suppression

(2015) Le Jiang et al.   NATURE

Regulation of Ferroptotic Cancer Cell Death by GPX4

(2014) Wan Seok Yang et al.   CELL

Ferrostatins Inhibit Oxidative Lipid Damage and Cell Death in Diverse Disease Models

(2014) Rachid Skouta et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice

(2014) Jose Pedro Friedmann Angeli et al.   NATURE CELL BIOLOGY

Pharmacological inhibition of cystine–glutamate exchange induces endoplasmic reticulum stress and ferroptosis

(2014) Scott J Dixon et al.   eLife

Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death

(2012) Scott J. Dixon et al.   CELL

Mechanisms of Oxidative Glutamate Toxicity: The Glutamate/Cystine Antiporter System xc¯ as a Neuroprotective Drug Target

(2012) Philipp Albrecht et al.   CNS & Neurological Disorders-Drug Targets

Modulatory profiling identifies mechanisms of small molecule-induced cell death

(2011) A. J. Wolpaw et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Glutathione Peroxidase 4 Senses and Translates Oxidative Stress into 12/15-Lipoxygenase Dependent- and AIF-Mediated Cell Death

(2008) Alexander Seiler et al.   Cell Metabolism

Synthetic Lethal Screening Identifies Compounds Activating Iron-Dependent, Nonapoptotic Cell Death in Oncogenic-RAS-Harboring Cancer Cells

(2008) Wan Seok Yang et al.   CHEMISTRY & BIOLOGY