A Highly Potent and Selective Caspase 1 Inhibitor that Utilizes a Key 3-Cyanopropanoic Acid Moiety

Identification and Optimization of Inhibitors of Trypanosomal Cysteine Proteases: Cruzain, Rhodesain, and TbCatB

(2010) Bryan T. Mott et al.   JOURNAL OF MEDICINAL CHEMISTRY

The inflammasome: a caspase-1-activation platform that regulates immune responses and disease pathogenesis

(2009) Luigi Franchi et al.   NATURE IMMUNOLOGY

The Caspase-1 Inflammasome: A Pilot of Innate Immune Responses

(2008) Hong Bing Yu et al.   Cell Host & Microbe

Caspases as therapeutic targets

(2008) B. Howley et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Development of Potent Purine-Derived Nitrile Inhibitors of the Trypanosomal Protease TbcatB

(2008) Jeremy P. Mallari et al.   JOURNAL OF MEDICINAL CHEMISTRY

Development of a Novel Pd-CatalyzedN-Acyl Vinylogous Carbamate Synthesis for the Key Intermediate of ICE Inhibitor VX-765

(2007) Gerald J. Tanoury et al.   ORGANIC LETTERS