Actin cytoskeleton vulnerability to disulfide stress mediates disulfidptosis

A targetable CoQ-FSP1 axis drives ferroptosis- and radiation-resistance in KEAP1 inactive lung cancers

(2022) Pranavi Koppula et al.   Nature Communications

A ferroptosis defense mechanism mediated by glycerol-3-phosphate dehydrogenase 2 in mitochondria

(2022) Shiqi Wu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ferroptosis: mechanisms, biology and role in disease

(2021) Xuejun Jiang et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

mTORC1 couples cyst(e)ine availability with GPX4 protein synthesis and ferroptosis regulation

(2021) Yilei Zhang et al.   Nature Communications

DHODH-mediated ferroptosis defence is a targetable vulnerability in cancer

(2021) Chao Mao et al.   NATURE

Ferroptosis as a mechanism to mediate p53 function in tumor radiosensitivity

(2021) Guang Lei et al.   ONCOGENE

KEAP1 deficiency drives glucose dependency and sensitizes lung cancer cells and tumors to GLUT inhibition

(2021) Pranavi Koppula et al.   iScience

A Quantitative Tissue-Specific Landscape of Protein Redox Regulation during Aging

(2020) Haopeng Xiao et al.   CELL

The role of ferroptosis in ionizing radiation-induced cell death and tumor suppression

(2020) Guang Lei et al.   CELL RESEARCH

Energy-stress-mediated AMPK activation inhibits ferroptosis

(2020) Hyemin Lee et al.   NATURE CELL BIOLOGY

H2A monoubiquitination links glucose availability to epigenetic regulation of the endoplasmic reticulum stress response and cancer cell death

(2020) Yilei Zhang et al.   CANCER RESEARCH

Cystine transporter regulation of pentose phosphate pathway dependency and disulfide stress exposes a targetable metabolic vulnerability in cancer

(2020) Xiaoguang Liu et al.   NATURE CELL BIOLOGY

Cystine transporter SLC7A11/xCT in cancer: ferroptosis, nutrient dependency, and cancer therapy

(2020) Pranavi Koppula et al.   Protein & Cell

Regulation of H2A ubiquitination and SLC7A11 expression by BAP1 and PRC1

(2019) Yilei Zhang et al.   CELL CYCLE

The molecular machinery of regulated cell death

(2019) Daolin Tang et al.   CELL RESEARCH

Identifying chemogenetic interactions from CRISPR screens with drugZ

(2019) Medina Colic et al.   Genome Medicine

BAP1 links metabolic regulation of ferroptosis to tumour suppression

(2018) Yilei Zhang et al.   NATURE CELL BIOLOGY

STIM2 interacts with AMPK and regulates calcium-induced AMPK activation

(2018) Anoop Singh Chauhan et al.   FASEB JOURNAL

The glutamate/cystine antiporter SLC7A11/xCT enhances cancer cell dependency on glucose by exporting glutamate

(2017) Pranavi Koppula et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Landscape of Histone Modifications in a High-Fat Diet-Induced Obese (DIO) Mouse Model

(2017) Litong Nie et al.   MOLECULAR & CELLULAR PROTEOMICS

BAP1 inhibits the ER stress gene regulatory network and modulates metabolic stress response

(2017) Fangyan Dai et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Energy stress-induced lncRNA FILNC1 represses c-Myc-mediated energy metabolism and inhibits renal tumor development

(2017) Zhen-Dong Xiao et al.   Nature Communications

lncRNANBR2modulates cancer cell sensitivity to phenformin through GLUT1

(2016) Xiaowen Liu et al.   CELL CYCLE

Identification and Optimization of the First Highly Selective GLUT1 Inhibitor BAY-876

(2016) Holger Siebeneicher et al.   ChemMedChem

LncRNA NBR2 engages a metabolic checkpoint by regulating AMPK under energy stress

(2016) Xiaowen Liu et al.   NATURE CELL BIOLOGY

The Perseus computational platform for comprehensive analysis of (prote)omics data

(2016) Stefka Tyanova et al.   NATURE METHODS

Cystinosis: a review

(2016) Mohamed A. Elmonem et al.   Orphanet Journal of Rare Diseases

BAF180 regulates cellular senescence and hematopoietic stem cell homeostasis through p21

(2016) Hyemin Lee et al.   Oncotarget

Cystinuria: current concepts and future directions

(2015) Daniel J. Castro Pereira et al.   CLINICAL NEPHROLOGY

FoxO Transcription Factors Promote AKT Ser473 Phosphorylation and Renal Tumor Growth in Response to Pharmacologic Inhibition of the PI3K–AKT Pathway

(2014) Aifu Lin et al.   CANCER RESEARCH

Metabolic determinants of cancer cell sensitivity to glucose limitation and biguanides

(2014) Kıvanç Birsoy et al.   NATURE

The FoxO–BNIP3 axis exerts a unique regulation of mTORC1 and cell survival under energy stress

(2013) A Lin et al.   ONCOGENE

Peroxiredoxin 1 and its role in cell signaling

(2011) Carola A. Neumann et al.   CELL CYCLE

Global quantification of mammalian gene expression control

(2011) Björn Schwanhäusser et al.   NATURE

Comparative Analysis of Cleavable Azobenzene-Based Affinity Tags for Bioorthogonal Chemical Proteomics

(2010) Yu-Ying Yang et al.   CHEMISTRY & BIOLOGY

Lkb1 regulates quiescence and metabolic homeostasis of haematopoietic stem cells

(2010) Boyi Gan et al.   NATURE

Sugar-free approaches to cancer cell killing

(2010) N El Mjiyad et al.   ONCOGENE