Review
Immunology
Ying Qin, Wei Zhao
Summary: The NLRP3 inflammasome is a crucial complex involved in inflammation, and posttranslational modifications of NLRP3 play critical roles in controlling inflammation severity. Various modifications, including phosphorylation, ubiquitination, and SUMOylation, can affect the activity, stability, and localization of NLRP3, as well as its association with other inflammasome components. This review provides an overview of NLRP3 PTMs and their roles in controlling inflammation, as well as potential anti-inflammatory drugs targeting NLRP3 PTMs.
EUROPEAN JOURNAL OF IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Yeon-Ji Park, Niranjan Dodantenna, Yonghyeon Kim, Tae-Hwan Kim, Ho-Soo Lee, Young-Suk Yoo, June Heo, Jae-Ho Lee, Myung-Hee Kwon, Ho Chul Kang, Jong-Soo Lee, Hyeseong Cho
Summary: The NLRP3 inflammasome is activated through mitochondria-mediated ubiquitination by the E3 ligase MARCH5. Knockout of MARCH5 leads to an impaired secretion of IL-1β and IL-18 in myeloid cells, as well as a decreased mortality rate upon infection. MARCH5-dependent NLRP3 ubiquitination is essential for NLRP3-NEK7 complex formation and NLRP3 oligomerization.
Article
Immunology
Lu Yang, Yuzhen Huang, Fengxi Chen, Yan Wang, Kunhan Su, Ming Zhao, Weiwei Tao, Wanli Liu
Summary: This study aimed to investigate the molecular mechanisms through which berberine treats depression and reduces inflammation. The results suggest that berberine effectively alleviates depressive symptoms, suppresses the expression of genes associated with the NLRP3 inflammasome, and reduces hippocampal neuronal functional damage in CUMS mice. Further studies showed that knockdown of Trim65 reversed the effects of berberine and increased NLRP3 inflammasome activity, and an important binding site (K285) was identified.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Yueke Lin, Xiaoting Lv, Caiyu Sun, Yanlin Sun, Min Yang, Dapeng Ma, Weiqiang Jing, Yunxue Zhao, Yeping Cheng, Haocheng Xuan, Lihui Han
Summary: This study reveals a novel regulatory mechanism of NLRP3 via TRIM50 and suggests that modulating TRIM50 might represent a therapeutic strategy for NLRP3-dependent pathologies.
Review
Immunology
Zhilei Wang, Guang Xu, Zhiyong Li, Xiaohe Xiao, Jianyuan Tang, Zhaofang Bai
Summary: This article summarizes the role and mechanism of active ingredients such as licochalcone A, echinatin, isoliquiritigenin, and glycyrrhizin in Glycyrrhiza in targeting the NLRP3 inflammasome and treating related inflammatory diseases.
JOURNAL OF INFLAMMATION RESEARCH
(2022)
Review
Cell Biology
Julien Moretti, J. Magarian Blander
Summary: Inflammasomes are crucial multiprotein complexes that activate inflammatory responses by detecting danger signals. The activation of NLRP3 inflammasome is diverse and complex, involving both canonical and noncanonical pathways. Despite recent advances in understanding, some aspects of NLRP3 inflammasome still require further exploration.
JOURNAL OF LEUKOCYTE BIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Mahbuba Akther, Md Ezazul Haque, Jooho Park, Tae-Bong Kang, Kwang-Ho Lee
Summary: Activation of the NLRP3 inflammasome is a critical event in the release of inflammatory cytokines and has become a prime target for resolving inflammatory disorders. The regulation of ubiquitination and deubiquitination during NLRP3 inflammasome activation has emerged as a potential therapeutic target.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Chemistry, Medicinal
Cheng Shi, Xiangyu Zhang, Xiaowei Chi, Yi Ran Zhou, Weiping Lyu, Tongfei Gao, Jiaxu Zhou, Yanming Chen, Chuxiao Yi, Xiaojiao Sun, Liangren Zhang, Zhenming Liu
Summary: This study identified a series of NLRP3 inhibitors using a self-developed machine learning model. CSC-6 was validated as the hit molecule with optimal activity and it inhibits NLRP3 activation by blocking ASC oligomerization. In vivo experiments demonstrated that CSC-6 effectively reduces the symptoms of NLRP3 overactivation-mediated diseases.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Review
Cell Biology
Zhangwang Li, Xinyue Chen, Junjie Tao, Ao Shi, Jing Zhang, Peng Yu
Summary: Exosomes play a unique and critical role as signal molecules vector in various diseases, particularly in immune progression. However, the mechanisms and clinical treatment related to exosomes and NLRP3 are still not fully understood.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Review
Immunology
Bhesh Raj Sharma, Thirumala-Devi Kanneganti
Summary: The NLRP3 inflammasome plays diverse roles in cancer and metabolic diseases, being involved in the release of inflammatory cytokines and inflammatory cell death upon activation. While inflammatory cytokines contribute to chronic inflammation and disease pathogenesis, fine tuning NLRP3 activity is crucial for maintaining cellular health.
Review
Medicine, Research & Experimental
Xu Zheng, Dan Zhao, Ye Jin, Yang Liu, Da Liu
Summary: The NLRP3 inflammasome plays a crucial role in the innate immune system and is associated with the development of various gynecological diseases. Inhibitors of NLRP3 inflammasome have therapeutic potential in maintaining cellular and tissue health, but excessive use can lead to adverse effects.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Review
Oncology
Xueyan Shi, Sichuang Tan, Sipin Tan
Summary: The NLRP3 inflammasome plays a crucial role in sepsis by promoting immune defense and inflammatory responses through its activation pathway.
MOLECULAR MEDICINE REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Yuxin Lin, Zibo Li, Yicheng Wang, Tian Tian, Penghui Jia, Yu Ye, Miao He, Zixiao Yang, Chunmei Li, Deyin Guo, Panpan Hou
Summary: This study identifies a novel autophagy cargo receptor, CCDC50, which negatively regulates NLRP3 inflammasome assembly and the release of related inflammatory factors by degrading NLRP3. CCDC50 deficiency results in upregulation of signaling pathways associated with autoinflammatory diseases and enhances gut inflammation response.
Article
Biochemistry & Molecular Biology
Yuxin Lin, Zibo Li, Yicheng Wang, Tian Tian, Penghui Jia, Yu Ye, Miao He, Zixiao Yang, Chunmei Li, Deyin Guo, Panpan Hou
Summary: The NLRP3-directed inflammasome complex plays a crucial role in host defense against microbial infection and monitoring cellular damage. However, its hyperactivation is implicated in the pathogenesis of inflammatory diseases, such as inflammatory bowel disease (IBD). Autophagy and autophagy-related genes are closely linked to NLRP3-mediated inflammation in these diseases. This study reveals that CCDC50, a novel autophagy cargo receptor, negatively regulates NLRP3 inflammasome assembly and suppresses the release of pro-caspase-1 and interleukin 1 beta (IL-1 beta) by promoting autophagic degradation of NLRP3. Knockdown of CCDC50 leads to upregulation of signaling pathways associated with autoinflammatory diseases, and CCDC50 deficiency enhances proinflammatory cytokine response triggered by various NLRP3 stimuli. Furthermore, mice lacking CCDC50 are more susceptible to DSS-induced colitis and exhibit more severe gut inflammation with elevated NLRP3 inflammasome activity, emphasizing the protective role of CCDC50 in controlling gut inflammation.
Review
Biochemistry & Molecular Biology
Tan Zhang, Shuzhe Ding, Ru Wang
Summary: NLRP3 is a crucial pattern recognition receptor in the innate immune system, with mitochondria playing a key role in inflammasome activation. Exercise is considered an important intervention to regulate immune responses, with different types of training impacting NLRP3 inflammasome activation differently.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Nutrition & Dietetics
Si Chen, Mengyi Yang, Rui Wang, Xiuqin Fan, Tiantian Tang, Ping Li, Xinhui Zhou, Kemin Qi
Summary: This study found that dietary folic acid supplementation inhibited weight gain and regulated gene expression related to fat and energy metabolism in obese mice by affecting gut microbiota. However, folic acid supplementation had almost no effect on weight and gene expression in germ-free mice.
EUROPEAN JOURNAL OF NUTRITION
(2022)
Article
Nutrition & Dietetics
Xuanyi Liu, Qiaoyu Shi, Xiuqin Fan, Hang Chen, Na Chen, Yurong Zhao, Kemin Qi
Summary: This study found that maternal polyunsaturated fatty acids (PUFAs) are correlated with telomere length (TL) and DNA methylation of the telomerase reverse transcriptase (TERT) promoter in offspring. In cord blood cells, low concentrations of certain fatty acids were associated with shortened TL, while in the placenta, the same fatty acid concentrations were associated with TL reduction. Additionally, concentrations of docosahexaenoic acid (DHA) and total n-3 PUFAs in maternal erythrocytes were positively associated with DNA methylation of the TERT promoter in cord blood.
FRONTIERS IN NUTRITION
(2022)
Article
Pediatrics
Rongqiang Yang, Hao Ding, Jing Shan, Xiaole Li, Jian Zhang, Guanghui Liu, Hong Zheng, Yu Su, Hongyang Yao, Kemin Qi
Summary: This study found that supplementation of n-3 polyunsaturated fatty acids (n-3 PUFAs) through parenteral fish oil emulsions can increase erythrocyte DHA content and may have beneficial effects on preventing severe ROP in preterm infants.
Article
Nutrition & Dietetics
Ping Li, Yuhui Chen, Jieyun Song, Lailai Yan, Tiantian Tang, Rui Wang, Xiuqin Fan, Yurong Zhao, Kemin Qi
Summary: The study showed that maternal supplementation of DHA-rich n-3 PUFAs in early and middle pregnancy can reduce infant BMI at birth and affect the distribution of PUFAs in colostrum. Multiple SNPs were significantly correlated with the distribution of n-6 and n-3 PUFAs in colostrum, with cumulative effects on PUFA distribution.
NUTRITION & METABOLISM
(2022)
Article
Microbiology
Ping Li, Xuelian Chang, Xiaoyu Chen, Chuan Wang, Yu Shang, Dongyi Zheng, Kemin Qi
Summary: This study found that early-life antibiotic exposure is positively associated with childhood overweight and obesity, possibly through its impact on the composition of gut microbiota. These findings provide a theoretical basis for personalized antibiotic exposure to achieve fairness in public health.
ANNALS OF CLINICAL MICROBIOLOGY AND ANTIMICROBIALS
(2022)
Article
Cell & Tissue Engineering
Ping Li, Yang Wang, Pei Li, Yuan-Lin Liu, Wei-Jiang Liu, Xiao-Yu Chen, Tian-Tian Tang, Ke-Min Qi, Yi Zhang
Summary: Maternal inappropriate dietary calcium intake during pregnancy and lactation may affect the adipogenic differentiation potential of male offspring's bone mesenchymal stem cells (BMSCs) and aggravate high-fat-diet-induced obesity through interference with adipogenic differentiation gene expressions and the regulation of the Wnt/β-catenin signaling pathway.
WORLD JOURNAL OF STEM CELLS
(2022)
Article
Nutrition & Dietetics
Muhan Li, Qiaoyu Shi, Xueyi Jiang, Xuanyi Liu, Wei Han, Xiuqin Fan, Ping Li, Kemin Qi
Summary: Paternal supplementation of n-3 PUFAs before conception improves brain development and function in offspring, and affects gene imprinting. This finding suggests the potential of paternal nutritional intervention to address mental health issues in subsequent generations.
FRONTIERS IN NUTRITION
(2022)
Article
Nutrition & Dietetics
Ping Li, Yang Wang, Pei Li, Xiaoyu Chen, Yuanlin Liu, Lanlan Zha, Yi Zhang, Kemin Qi
Summary: Maternal deficiency in vitamin D intake during pregnancy and lactation aggravates gut microbiota dysbiosis and contributes to obesity progression in male offspring by affecting genes associated with barrier function, inflammation, and lipid transportation. Adequate early-life vitamin D intake plays a significant role in preventing later obesity.
Article
Nutrition & Dietetics
Qiaoyu Shi, Xuanyi Liu, Xiuqin Fan, Rui Wang, Kemin Qi
Summary: This study found that the paternal dietary ratio of n-6: n-3 PUFAs affects offspring leptin expression and associated gene imprinting, and maintaining optimal leptin pattern in a sex-specific manner through multiple generations may be beneficial for the long-term health of the offspring.
FRONTIERS IN NUTRITION
(2022)
Article
Nutrition & Dietetics
Wei Han, Muhan Li, Mengyi Yang, Si Chen, Yuanyuan Lu, Tiantian Tang, Rui Wang, Chenguang Zhang, Kemin Qi
Summary: This study investigated the effects of folic acid on body weight gain in obesity and gut microbiota-associated branched-chain amino acids (BCAAs) and mitochondrial function. The results showed that folic acid supplementation reversed the negative effects of high-fat diet on body weight gain, BCAA concentrations, and gene expression related to mitochondrial function in conventional mice. However, folic acid supplementation had little effect on BCAA concentrations and gene expression in germ-free mice. The study also found a correlation between adipose and hepatic mitochondrial DNA C/N ratio and BCAA concentrations, which were closely associated with specific gut bacteria.
JOURNAL OF NUTRITIONAL SCIENCE AND VITAMINOLOGY
(2023)
Review
Pediatrics
Qiaoyu Shi, Kemin Qi
Summary: Most research has focused on the effects of maternal influences on offspring's health, but it has become clear that paternal environmental factors also play a significant role. This article aims to explore the impact of male health and environmental exposure on offspring development and health, as well as the mechanisms behind paternal programming. Evidence suggests that paternal nutrition, lifestyle, and age can increase the risk of negative outcomes in offspring, both through genetic/epigenetic effects and the maternal uterine environment. Further research is needed to confirm these findings with well-designed human studies, as most evidence is currently based on animal research.
PEDIATRIC INVESTIGATION
(2023)
Article
Food Science & Technology
Rui Wang, Xiuqin Fan, Yuanyuan Lu, Dawei Chen, Yunfeng Zhao, Kemin Qi
Summary: This study found that high-fat diet-induced obesity disrupts bile acids balance, providing evidence for the potential use of acetic acid as a treatment. Acetic acid supplementation promotes the synthesis of specific types of bile acids in the liver and reduces their excretion in feces, thus restoring bile acids balance.
CURRENT RESEARCH IN FOOD SCIENCE
(2022)
Article
Microbiology
Ping Li, Xuelian Chang, Xiaoyu Chen, Tiantian Tang, Yajing Liu, Yu Shang, Kemin Qi
Summary: The colonization of gut microbiota in infants undergoes dynamic changes during the first two years of life and is influenced by various factors. This study analyzed the microbiota data of 30 healthy breast-feeding mother-infant pairs and found that the diversity of gut microbiota increased significantly from six months to two years of age. The proportions of different bacterial phyla and genera also showed dynamic trends. Maternal and infant characteristics were found to be associated with the composition of gut microbiota.
JOURNAL OF MICROBIOLOGY
(2022)
Article
Food Science & Technology
Ping Li, Xiaoyu Chen, Yuhui Chen, Tianyi Teng, Xiuqin Fan, Tiantian Tang, Rui Wang, Yurong Zhao, Kemin Qi
Summary: The study indicates that maternal exogenous DHA-rich n-3 PUFAs intake during early and mid-pregnancy can prevent obesity development in Chinese Han infants before 2 years by modulating DNA methylation states of obesity-associated genes.
FOOD & NUTRITION RESEARCH
(2021)
