Oxytosis/Ferroptosis—(Re-) Emerging Roles for Oxidative Stress-Dependent Non-apoptotic Cell Death in Diseases of the Central Nervous System

The role of Ca 2+ in cell death caused by oxidative glutamate toxicity and ferroptosis

(2018) Pamela Maher et al.   CELL CALCIUM

Potentiation of glutathione loss and nerve cell death by the transition metals iron and copper: Implications for age-related neurodegenerative diseases

(2018) Pamela Maher   FREE RADICAL BIOLOGY AND MEDICINE

Human hippocampal neurogenesis drops sharply in children to undetectable levels in adults

(2018) Shawn F. Sorrells et al.   NATURE

Postmortem MRI and histology demonstrate differential iron accumulation and cortical myelin organization in early- and late-onset Alzheimer's disease

(2018) Marjolein Bulk et al.   NEUROBIOLOGY OF AGING

Ferroptosis: A Novel Anti-tumor Action for Cisplatin

(2018) Jipeng Guo et al.   Cancer Research and Treatment

Bcl-x L knockout attenuates mitochondrial respiration and causes oxidative stress that is compensated by pentose phosphate pathway activity

(2017) Annika Pfeiffer et al.   FREE RADICAL BIOLOGY AND MEDICINE

Glutathione peroxidase 4-catalyzed reduction of lipid hydroperoxides in membranes: The polar head of membrane phospholipids binds the enzyme and addresses the fatty acid hydroperoxide group toward the redox center

(2017) Giorgio Cozza et al.   FREE RADICAL BIOLOGY AND MEDICINE

Worldwide demography of centenarians

(2017) Jean-Marie Robine et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Tau-mediated iron export prevents ferroptotic damage after ischemic stroke

(2017) Q-z Tuo et al.   MOLECULAR PSYCHIATRY

Alterations in neuronal control of body weight and anxiety behavior by glutathione peroxidase 4 deficiency

(2017) Sonja C. Schriever et al.   NEUROSCIENCE

Caregiver burden in amyotrophic lateral sclerosis: A systematic review

(2017) Jessica de Wit et al.   PALLIATIVE MEDICINE

Prevention of oxytosis-induced c-Raf down-regulation by (arylthio)cyclopentenone prostaglandins is neuroprotective

(2017) Shoko Shibata et al.   TOXICOLOGY

Bax and Bak Pores: Are We Closing the Circle?

(2017) Katia Cosentino et al.   TRENDS IN CELL BIOLOGY

Ferroptosis Inhibition: Mechanisms and Opportunities

(2017) Jose Pedro Friedmann Angeli et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Altered Synapse Stability in the Early Stages of Tauopathy

(2017) Johanna S. Jackson et al.   Cell Reports

The Tumor Suppressor p53 Limits Ferroptosis by Blocking DPP4 Activity

(2017) Yangchun Xie et al.   Cell Reports

BID links ferroptosis to mitochondrial cell death pathways

(2017) Sandra Neitemeier et al.   Redox Biology

Ablation of ferroptosis regulator glutathione peroxidase 4 in forebrain neurons promotes cognitive impairment and neurodegeneration

(2017) William Sealy Hambright et al.   Redox Biology

On the Mechanism of Cytoprotection by Ferrostatin-1 and Liproxstatin-1 and the Role of Lipid Peroxidation in Ferroptotic Cell Death

(2017) Omkar Zilka et al.   ACS Central Science

Calcium and Mitochondrial Reactive Oxygen Species Generation: How to Read the Facts

(2017) Vera Adam-Vizi et al.   JOURNAL OF ALZHEIMERS DISEASE

Dendritic Spine Pathology in Neurodegenerative Diseases

(2016) Jochen Herms et al.   Annual Review of Pathology-Mechanisms of Disease

Autophagy promotes ferroptosis by degradation of ferritin

(2016) Wen Hou et al.   Autophagy

Identification of ACSL4 as a biomarker and contributor of ferroptosis

(2016) Hua Yuan et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

An essential role for functional lysosomes in ferroptosis of cancer cells

(2016) S. Torii et al.   BIOCHEMICAL JOURNAL

Ferroptosis is an autophagic cell death process

(2016) Minghui Gao et al.   CELL RESEARCH

Identification and Successful Negotiation of a Metabolic Checkpoint in Direct Neuronal Reprogramming

(2016) Sergio Gascón et al.   Cell Stem Cell

An outline of necrosome triggers

(2016) Tom Vanden Berghe et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Synapse Dysfunction of Layer V Pyramidal Neurons Precedes Neurodegeneration in a Mouse Model of TDP-43 Proteinopathies

(2016) Emily E. Handley et al.   CEREBRAL CORTEX

Gadd45a is a heterochromatin relaxer that enhances iPS cell generation

(2016) Keshi Chen et al.   EMBO REPORTS

Oxidized arachidonic and adrenic PEs navigate cells to ferroptosis

(2016) Valerian E Kagan et al.   Nature Chemical Biology

ACSL4 dictates ferroptosis sensitivity by shaping cellular lipid composition

(2016) Sebastian Doll et al.   Nature Chemical Biology

Regulated necrosis: disease relevance and therapeutic opportunities

(2016) Marcus Conrad et al.   NATURE REVIEWS DRUG DISCOVERY

Ferroptosis, a newly characterized form of cell death in Parkinson's disease that is regulated by PKC

(2016) Bruce Do Van et al.   NEUROBIOLOGY OF DISEASE

Novel cystine transporter in renal proximal tubule identified as a missing partner of cystinuria-related plasma membrane protein rBAT/SLC3A1

(2016) Shushi Nagamori et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Activation ofSAT1engages polyamine metabolism with p53-mediated ferroptotic responses

(2016) Yang Ou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Peroxidation of polyunsaturated fatty acids by lipoxygenases drives ferroptosis

(2016) Wan Seok Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

RIPK1 mediates axonal degeneration by promoting inflammation and necroptosis in ALS

(2016) Yasushi Ito et al.   SCIENCE

Increased 12/15-Lipoxygenase Leads to Widespread Brain Injury Following Global Cerebral Ischemia

(2016) Kazim Yigitkanli et al.   Translational Stroke Research

U0126 Protects Cells against Oxidative Stress Independent of Its Function as a MEK Inhibitor

(2015) Qunxiang Ong et al.   ACS Chemical Neuroscience

The 5-Lipoxygenase Inhibitor Zileuton Confers Neuroprotection against Glutamate Oxidative Damage by Inhibiting Ferroptosis

(2015) Yang Liu et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Methods for determining the efficacy of radical-trapping antioxidants

(2015) Bo Li et al.   FREE RADICAL BIOLOGY AND MEDICINE

Ablation of the Ferroptosis Inhibitor Glutathione Peroxidase 4 in Neurons Results in Rapid Motor Neuron Degeneration and Paralysis

(2015) Liuji Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cystathionine Is a Novel Substrate of Cystine/Glutamate Transporter

(2015) Sho Kobayashi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Iron accumulation in the basal ganglia in Huntington's disease: cross-sectional data from the IMAGE-HD study

(2015) Juan F Domínguez D et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Glutaminolysis and Transferrin Regulate Ferroptosis

(2015) Minghui Gao et al.   MOLECULAR CELL

Iron and Neurodegeneration: Is Ferritinophagy the Link?

(2015) Giorgio Biasiotto et al.   MOLECULAR NEUROBIOLOGY

High nigral iron deposition in LRRK2 and Parkin mutation carriers using R2* relaxometry

(2015) Nadya Pyatigorskaya et al.   MOVEMENT DISORDERS

Ferroptosis as a p53-mediated activity during tumour suppression

(2015) Le Jiang et al.   NATURE

7T T2∗-weighted magnetic resonance imaging reveals cortical phase differences between early- and late-onset Alzheimer's disease

(2015) Sanneke van Rooden et al.   NEUROBIOLOGY OF AGING

Iron accumulation promotes TACE-mediated TNF-α secretion and neurodegeneration in a mouse model of ALS

(2015) Jae Keun Lee et al.   NEUROBIOLOGY OF DISEASE

Genomic approach to selective vulnerability of the hippocampus in brain ischemia–hypoxia

(2015) Rainald Schmidt-Kastner   NEUROSCIENCE

The Impact of Huntington Disease on Family Carers: a Literature Overview

(2015) Jan Domaradzki   Psychiatria Polska

Adult Neurogenesis in Humans

(2015) Olaf Bergmann et al.   Cold Spring Harbor Perspectives in Biology

Socioeconomic costs of amyotrophic lateral sclerosis according to staging system

(2015) Juyeon Oh et al.   Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration

Regulation of Ferroptotic Cancer Cell Death by GPX4

(2014) Wan Seok Yang et al.   CELL

CHAC1/MGC4504 Is a Novel Proapoptotic Component of the Unfolded Protein Response, Downstream of the ATF4-ATF3-CHOP Cascade

(2014) I. N. Mungrue et al.   JOURNAL OF IMMUNOLOGY

Ferrostatins Inhibit Oxidative Lipid Damage and Cell Death in Diverse Disease Models

(2014) Rachid Skouta et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Mixed Lineage Kinase Domain-like Protein MLKL Causes Necrotic Membrane Disruption upon Phosphorylation by RIP3

(2014) Huayi Wang et al.   MOLECULAR CELL

Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice

(2014) Jose Pedro Friedmann Angeli et al.   NATURE CELL BIOLOGY

Necroptosis Drives Motor Neuron Death in Models of Both Sporadic and Familial ALS

(2014) Diane B. Re et al.   NEURON

Suppression of STIM1 in the early stage after global ischemia attenuates the injury of delayed neuronal death by inhibiting store-operated calcium entry-induced apoptosis in rats

(2014) Ming Zhang et al.   NEUROREPORT

Prodromal Huntington Disease as a Model for Functional Compensation of Early Neurodegeneration

(2014) Kathrin Malejko et al.   PLoS One

Poly(ADP-ribose) polymerase-dependent energy depletion occurs through inhibition of glycolysis

(2014) S. A. Andrabi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cellular protection using Flt3 and PI3Kα inhibitors demonstrates multiple mechanisms of oxidative glutamate toxicity

(2014) Yunyi Kang et al.   Nature Communications

MLKL Compromises Plasma Membrane Integrity by Binding to Phosphatidylinositol Phosphates

(2014) Yves Dondelinger et al.   Cell Reports

Pharmacological inhibition of cystine–glutamate exchange induces endoplasmic reticulum stress and ferroptosis

(2014) Scott J Dixon et al.   eLife

Phosphoinositide 3-Kinases Upregulate System xc− via Eukaryotic Initiation Factor 2α and Activating Transcription Factor 4 – A Pathway Active in Glioblastomas and Epilepsy

(2013) Jan Lewerenz et al.   ANTIOXIDANTS & REDOX SIGNALING

Targeting Chelatable Iron as a Therapeutic Modality in Parkinson's Disease

(2013) David Devos et al.   ANTIOXIDANTS & REDOX SIGNALING

Mitochondrial function and energy metabolism in neuronal HT22 cells resistant to oxidative stress

(2013) Annika Pfeiffer et al.   BRITISH JOURNAL OF PHARMACOLOGY

Targeted Disruption of Glutathione Peroxidase 4 in Mouse Skin Epithelial Cells Impairs Postnatal Hair Follicle Morphogenesis that Is Partially Rescued through Inhibition of COX-2

(2013) Aniruddha Sengupta et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

The plasma membrane channel ORAI1 mediates detrimental calcium influx caused by endogenous oxidative stress

(2013) N Henke et al.   Cell Death & Disease

The Cystine/Glutamate Antiporter System xc− in Health and Disease: From Molecular Mechanisms to Novel Therapeutic Opportunities

(2012) Jan Lewerenz et al.   ANTIOXIDANTS & REDOX SIGNALING

Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death

(2012) Scott J. Dixon et al.   CELL

Mixed Lineage Kinase Domain-like Protein Mediates Necrosis Signaling Downstream of RIP3 Kinase

(2012) Liming Sun et al.   CELL

TRAIL induces necroptosis involving RIPK1/RIPK3-dependent PARP-1 activation

(2012) S Jouan-Lanhouet et al.   CELL DEATH AND DIFFERENTIATION

Maintenance of higher H2O2 levels, and its mechanism of action to induce growth in breast cancer cells: Important roles of bioactive catalase and PP2A

(2012) Suvajit Sen et al.   FREE RADICAL BIOLOGY AND MEDICINE

Gpx4 ablation in adult mice results in a lethal phenotype accompanied by neuronal loss in brain

(2012) Si-Eun Yoo et al.   FREE RADICAL BIOLOGY AND MEDICINE

Stromal Interaction Molecule 1 (STIM1) Is Involved in the Regulation of Mitochondrial Shape and Bioenergetics and Plays a Role in Oxidative Stress

(2012) Nadine Henke et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PANTHER in 2013: modeling the evolution of gene function, and other gene attributes, in the context of phylogenetic trees

(2012) Huaiyu Mi et al.   NUCLEIC ACIDS RESEARCH

Iron Accumulation in Deep Cortical Layers Accounts for MRI Signal Abnormalities in ALS: Correlating 7 Tesla MRI and Pathology

(2012) Justin Y. Kwan et al.   PLoS One

Glutamate Induces Mitochondrial Dynamic Imbalance and Autophagy Activation: Preventive Effects of Selenium

(2012) Santosh Kumari et al.   PLoS One

Programmed Cell Death in Animal Development and Disease

(2011) Yaron Fuchs et al.   CELL

BID regulates AIF-mediated caspase-independent necroptosis by promoting BAX activation

(2011) L Cabon et al.   CELL DEATH AND DIFFERENTIATION

Mutation of ATF4 mediates resistance of neuronal cell lines against oxidative stress by inducing xCT expression

(2011) J Lewerenz et al.   CELL DEATH AND DIFFERENTIATION

Charcot–Marie–Tooth disease CMT4A: GDAP1 increases cellular glutathione and the mitochondrial membrane potential

(2011) Rebecca Noack et al.   HUMAN MOLECULAR GENETICS

Oxidation of 3,4-Dihydroxyphenylacetaldehyde, a Toxic Dopaminergic Metabolite, to a Semiquinone Radical and anortho-Quinone

(2011) David G. Anderson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Loss of System xFormula Does Not Induce Oxidative Stress But Decreases Extracellular Glutamate in Hippocampus and Influences Spatial Working Memory and Limbic Seizure Susceptibility

(2011) D. De Bundel et al.   JOURNAL OF NEUROSCIENCE

Modulatory profiling identifies mechanisms of small molecule-induced cell death

(2011) A. J. Wolpaw et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Isotopic reinforcement of essential polyunsaturated fatty acids diminishes nigrostriatal degeneration in a mouse model of Parkinson's disease

(2011) Mikhail S. Shchepinov et al.   TOXICOLOGY LETTERS

Upregulation of Bax protein and increased DNA degradation in ALS spinal cord motor neurons

(2010) T. Ekegren et al.   ACTA NEUROLOGICA SCANDINAVICA

Blood-derived iron mediates free radical production and neuronal death in the hippocampal CA1 area following transient forebrain ischemia in rat

(2010) Ui Jin Park et al.   ACTA NEUROPATHOLOGICA

Evidence for the Involvement of Apoptosis-Inducing Factor–Mediated Caspase-Independent Neuronal Death in Alzheimer Disease

(2010) Wenfeng Yu et al.   AMERICAN JOURNAL OF PATHOLOGY

Evidence of Oxidant Damage in Huntington's Disease: Translational Strategies Using Antioxidants

(2010) Edward C. Stack et al.   Annals of the New York Academy of Sciences

Rescuing neurons in prion disease

(2010) Nicholas C. Verity et al.   BIOCHEMICAL JOURNAL

Compensation and Disease Severity on the Memory-Related Activations in Mild Cognitive Impairment

(2010) Francis Clément et al.   BIOLOGICAL PSYCHIATRY

Superoxide-dependent reduction of free Fe3+ and release of Fe2+ from ferritin by the physiologically-occurring Cu(I)–glutathione complex

(2010) Margarita E. Aliaga et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Extracellular hydrogen peroxide contributes to oxidative glutamate toxicity

(2010) Jong Seong Ha et al.   BRAIN RESEARCH

Critical role of the JNK-p53-GADD45α apoptotic cascade in mediating oxidative cytotoxicity in hippocampal neurons

(2010) Hye Joung Choi et al.   BRITISH JOURNAL OF PHARMACOLOGY

Necroptosis as an alternative form of programmed cell death

(2010) Dana E Christofferson et al.   CURRENT OPINION IN CELL BIOLOGY

A novel giant peroxisomal superoxide dismutase motif-containing protein

(2010) Diamandis Toutzaris et al.   FREE RADICAL BIOLOGY AND MEDICINE

Mechanism for the protective effect of resveratrol against oxidative stress-induced neuronal death

(2010) Masayuki Fukui et al.   FREE RADICAL BIOLOGY AND MEDICINE

System xc−and Thioredoxin Reductase 1 Cooperatively Rescue Glutathione Deficiency

(2010) Pankaj Kumar Mandal et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Verapamil Block of T-Type Calcium Channels

(2010) P. Bergson et al.   MOLECULAR PHARMACOLOGY

Pathophysiology and treatment of cystinuria

(2010) Josep Chillarón et al.   Nature Reviews Nephrology

Oxidative stress in Alzheimer disease: A possibility for prevention

(2010) David J. Bonda et al.   NEUROPHARMACOLOGY

Persistent cleavage and nuclear translocation of apoptosis-inducing factor in motor neurons in the spinal cord of sporadic amyotrophic lateral sclerosis patients

(2009) Noriyuki Shibata et al.   ACTA NEUROPATHOLOGICA

Activation of autophagy during glutamate-induced HT22 cell death

(2009) Hansoo Kim et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Oxidative stress in ALS: Key role in motor neuron injury and therapeutic target

(2009) Siân C. Barber et al.   FREE RADICAL BIOLOGY AND MEDICINE

The human brain in numbers: a linearly scaled-up primate brain

(2009) Suzana Herculano-Houzel   Frontiers in Human Neuroscience

Szt2, a novel gene for seizure threshold in mice

(2009) W. N. Frankel et al.   GENES BRAIN AND BEHAVIOR

Constitutive Reactive Oxygen Species Generation from Autophagosome/Lysosome in Neuronal Oxidative Toxicity

(2009) Chisato Kubota et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

12/15-Lipoxygenase targets neuronal mitochondria under oxidative stress

(2009) Stefanie Pallast et al.   JOURNAL OF NEUROCHEMISTRY

Dysregulation of Iron Homeostasis in the CNS Contributes to Disease Progression in a Mouse Model of Amyotrophic Lateral Sclerosis

(2009) S. Y. Jeong et al.   JOURNAL OF NEUROSCIENCE

An increase in intracellular Ca2+ is required for the activation of mitochondrial calpain to release AIF during cell death

(2008) E Norberg et al.   CELL DEATH AND DIFFERENTIATION

Bid-induced release of AIF from mitochondria causes immediate neuronal cell death

(2008) S Landshamer et al.   CELL DEATH AND DIFFERENTIATION

Glutathione Peroxidase 4 Senses and Translates Oxidative Stress into 12/15-Lipoxygenase Dependent- and AIF-Mediated Cell Death

(2008) Alexander Seiler et al.   Cell Metabolism

Synthetic Lethal Screening Identifies Compounds Activating Iron-Dependent, Nonapoptotic Cell Death in Oncogenic-RAS-Harboring Cancer Cells

(2008) Wan Seok Yang et al.   CHEMISTRY & BIOLOGY

Growth arrest and DNA damage-45 alpha (GADD45α)

(2008) A. Rosemary Siafakas et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Basal Levels of eIF2α Phosphorylation Determine Cellular Antioxidant Status by Regulating ATF4 and xCT Expression

(2008) Jan Lewerenz et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Constitutively Active Orphan G-protein-coupled Receptor GPR39 Protects from Cell Death by Increasing Secretion of Pigment Epithelium-derived Growth Factor

(2008) Sonja Dittmer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

ATF4 is an oxidative stress–inducible, prodeath transcription factor in neurons in vitro and in vivo

(2008) Philipp S. Lange et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The in vivo gene expression signature of oxidative stress

(2008) Eun-Soo Han et al.   PHYSIOLOGICAL GENOMICS

Opposing roles for caspase and calpain death proteases in l-glutamate-induced oxidative neurotoxicity

(2008) Lucy M. Elphick et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

The role of Bax in glutamate-induced nerve cell death

(2003) Richard Dargusch et al.   JOURNAL OF NEUROCHEMISTRY