Lysosomal Zn2+ release triggers rapid, mitochondria-mediated, non-apoptotic cell death in metastatic melanoma

Atomic insights into ML-SI3 mediated human TRPML1 inhibition

(2021) Philip Schmiege et al.   STRUCTURE

Small-molecule activation of lysosomal TRP channels ameliorates Duchenne muscular dystrophy in mouse models

(2020) Lu Yu et al.   Science Advances

Mitochondria-lysosome contacts regulate mitochondrial Ca2+dynamics via lysosomal TRPML1

(2020) Wesley Peng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ST3GAL1 is a target of the SOX2-GLI1 transcriptional complex and promotes melanoma metastasis through AXL

(2020) Silvia Pietrobono et al.   Nature Communications

HRAS‐driven cancer cells are vulnerable to TRPML1 inhibition

(2019) Jewon Jung et al.   EMBO REPORTS

The lysosomal TRPML1 channel regulates triple negative breast cancer development by promoting mTORC1 and purinergic signaling pathways

(2019) Mengnan Xu et al.   CELL CALCIUM

Rapamycin directly activates lysosomal mucolipin TRP channels independent of mTOR

(2019) Xiaoli Zhang et al.   PLOS BIOLOGY

Sub-nanomolar sensitive GZnP3 reveals TRPML1-mediated neuronal Zn2+ signals

(2019) Taylor F. Minckley et al.   Nature Communications

Lysosomal membrane permeabilization as a cell death mechanism in cancer cells

(2018) Ana Serrano-Puebla et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Role of Mitochondria in Ferroptosis

(2018) Minghui Gao et al.   MOLECULAR CELL

The lysosome as a cellular centre for signalling, metabolism and quality control

(2018) Rosalie E. Lawrence et al.   NATURE CELL BIOLOGY

Lysosomal Ion Channels as Decoders of Cellular Signals

(2018) Ping Li et al.   TRENDS IN BIOCHEMICAL SCIENCES

Human TRPML1 channel structures in open and closed conformations

(2017) Philip Schmiege et al.   NATURE

Microenvironmental autophagy promotes tumour growth

(2017) Nadja S. Katheder et al.   NATURE

Stem cell-released oncolytic herpes simplex virus has therapeutic efficacy in brain metastatic melanomas

(2017) Wanlu Du et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Emerging Hallmarks of Cancer Metabolism

(2016) Natalya N. Pavlova et al.   Cell Metabolism

Lysosomes in cancer—living on the edge (of the cell)

(2016) Saara Hämälistö et al.   CURRENT OPINION IN CELL BIOLOGY

Resistance to combination BRAF and MEK inhibition in metastatic melanoma: Where to next?

(2016) Sarah J. Welsh et al.   EUROPEAN JOURNAL OF CANCER

Subtype-specific accumulation of intracellular zinc pools is associated with the malignant phenotype in breast cancer

(2016) Paige Chandler et al.   Molecular Cancer

A molecular mechanism to regulate lysosome motility for lysosome positioning and tubulation

(2016) Xinran Li et al.   NATURE CELL BIOLOGY

MCOLN1 is a ROS sensor in lysosomes that regulates autophagy

(2016) Xiaoli Zhang et al.   Nature Communications

The endoplasmic reticulum, not the pH gradient, drives calcium refilling of lysosomes

(2016) Abigail G Garrity et al.   eLife

Targeting the lysosome in cancer

(2015) Shengfu Piao et al.   Annals of the New York Academy of Sciences

Lysosomal calcium signalling regulates autophagy through calcineurin and TFEB

(2015) Diego L. Medina et al.   NATURE CELL BIOLOGY

Lysosome-related Organelles as Mediators of Metal Homeostasis

(2014) Crysten E. Blaby-Haas et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cellular Zinc Levels Are Modulated by TRPML1-TMEM163 Interaction

(2014) Math P. Cuajungco et al.   TRAFFIC

Zinc-dependent lysosomal enlargement in TRPML1-deficient cells involves MTF-1 transcription factor and ZnT4 (Slc30a4) transporter

(2013) Ira Kukic et al.   BIOCHEMICAL JOURNAL

Transformation-Associated Changes in Sphingolipid Metabolism Sensitize Cells to Lysosomal Cell Death Induced by Inhibitors of Acid Sphingomyelinase

(2013) Nikolaj H.T. Petersen et al.   CANCER CELL

Chelators for investigating zinc metalloneurochemistry

(2013) Robert J Radford et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

A TRP Channel in the Lysosome Regulates Large Particle Phagocytosis via Focal Exocytosis

(2013) Mohammad Samie et al.   DEVELOPMENTAL CELL

Vemurafenib and radiation therapy in melanoma brain metastases

(2013) Ashwatha Narayana et al.   JOURNAL OF NEURO-ONCOLOGY

Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death

(2012) Scott J. Dixon et al.   CELL

Cancer-associated lysosomal changes: friends or foes?

(2012) T Kallunki et al.   ONCOGENE

Autophagy inhibitor Lys05 has single-agent antitumor activity and reproduces the phenotype of a genetic autophagy deficiency

(2012) Q. McAfee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lipid storage disorders block lysosomal trafficking by inhibiting a TRP channel and lysosomal calcium release

(2012) Dongbiao Shen et al.   Nature Communications

Mucolipins: Intracellular TRPML1-3 channels

(2010) Xiping Cheng et al.   FEBS LETTERS

Zinc Dyshomeostasis Is Linked with the Loss of Mucolipidosis IV-associated TRPML1 Ion Channel

(2010) Jonathan L. Eichelsdoerfer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

V-ATPase inhibitors and implication in cancer treatment

(2009) Mario Pérez-Sayáns et al.   CANCER TREATMENT REVIEWS

Genes that mediate breast cancer metastasis to the brain

(2009) Paula D. Bos et al.   NATURE

Lysosome biogenesis and lysosomal membrane proteins: trafficking meets function

(2009) Paul Saftig et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Classification of cell death: recommendations of the Nomenclature Committee on Cell Death 2009

(2008) G Kroemer et al.   CELL DEATH AND DIFFERENTIATION

The type IV mucolipidosis-associated protein TRPML1 is an endolysosomal iron release channel

(2008) Xian-Ping Dong et al.   NATURE