Copper homeostasis and cuproptosis in cancer immunity and therapy

Copper-dependent autophagic degradation of GPX4 drives ferroptosis

(2023) Qian Xue et al.   Autophagy

A novel copper chelator for the suppression of colorectal cancer

(2023) Xiaolong Shi et al.   DRUG DEVELOPMENT RESEARCH

Tumor Microenvironment Responsive Hollow Nanoplatform for Triple Amplification of Oxidative Stress to Enhance Cuproptosis‐Based Synergistic Cancer Therapy

(2023) Weijun Xu et al.   Advanced Healthcare Materials

Cuproptosis-associated CDKN2A is targeted by plicamycin to regulate the microenvironment in patients with head and neck squamous cell carcinoma

(2023) Kaihui Fan et al.   Frontiers in Genetics

Cuproptosis-Related MiR-21-5p/FDX1 Axis in Clear Cell Renal Cell Carcinoma and Its Potential Impact on Tumor Microenvironment

(2023) Mingyue Xie et al.   Cells

Type-I AIE Photosensitizer Loaded Biomimetic System Boosting Cuproptosis to Inhibit Breast Cancer Metastasis and Rechallenge

(2023) Shipeng Ning et al.   ACS Nano

Cuproptosis Induced by ROS Responsive Nanoparticles with Elesclomol and Copper Combined with αPD‐L1 for Enhanced Cancer Immunotherapy

(2023) Boda Guo et al.   ADVANCED MATERIALS

4-Octyl itaconate inhibits aerobic glycolysis by targeting GAPDH to promote cuproptosis in colorectal cancer

(2023) Wenchang Yang et al.   BIOMEDICINE & PHARMACOTHERAPY

A novel cuproptosis-related gene signature to predict prognosis in Glioma

(2023) Mengyang Zhang et al.   BMC CANCER

Comprehensive analysis identifies cuproptosis-related gene DLAT as a potential prognostic and immunological biomarker in pancreatic adenocarcinoma

(2023) Xiaoling Zhang et al.   BMC CANCER

Cope with copper: From copper linked mechanisms to copper-based clinical cancer therapies

(2023) Xidi Wang et al.   CANCER LETTERS

Syphilis mimetic nanoparticles for cuproptosis-based synergistic cancer therapy via reprogramming copper metabolism

(2023) Jingzhe Zhang et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Ferroptosis inducers enhanced cuproptosis induced by copper ionophores in primary liver cancer

(2023) Weikai Wang et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Comprehensive analyses of cuproptosis-related gene CDKN2A on prognosis and immunologic therapy in human tumors

(2023) Di Zhang et al.   MEDICINE

Cuproptosis correlates with immunosuppressive tumor microenvironment based on pan-cancer multiomics and single-cell sequencing analysis

(2023) Yan Qin et al.   Molecular Cancer

A novel oncogene trigger transposable element derived‐1 promotes oral squamous cell carcinoma progression via evoking immune inhibition

(2023) Xue Qiao et al.   MOLECULAR CARCINOGENESIS

An integrative analysis reveals the prognostic value and potential functions of PSMD11 in hepatocellular carcinoma

(2023) Cong Zhang et al.   MOLECULAR CARCINOGENESIS

An Intelligent Cell-Derived Nanorobot Bridges Synergistic Crosstalk Between Sonodynamic Therapy and Cuproptosis to Promote Cancer Treatment

(2023) Kerong Chen et al.   Nano Letters

A druggable copper-signalling pathway that drives inflammation

(2023) Stéphanie Solier et al.   NATURE

Multimodal imaging findings in patients with glioblastoma with extensive coagulative necrosis related to regorafenib

(2023) Jan-Michael Werner et al.   NEURO-ONCOLOGY

FDX1-dependent and independent mechanisms of elesclomol-mediated intracellular copper delivery

(2023) Mohammad Zulkifli et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Multifaceted Roles of Copper Ions in Anticancer Nanomedicine

(2023) Siyuan Yang et al.   Advanced Healthcare Materials

Integrated machine learning and bioinformatic analyses used to construct a copper-induced cell death-related classifier for prognosis and immunotherapeutic response of hepatocellular carcinoma patients

(2023) Shuai Zhao et al.   Frontiers in Pharmacology

Roles of cuproptosis-related gene DLAT in various cancers: a bioinformatic analysis and preliminary verification on pro-survival autophagy

(2023) Qinjing Yang et al.   PeerJ

Integrated single-cell and bulk characterization of cuproptosis key regulator PDHB and association with tumor microenvironment infiltration in clear cell renal cell carcinoma

(2023) Jiajin Wu et al.   Frontiers in Immunology

TIGD1 Function as a Potential Cuproptosis Regulator Following a Novel Cuproptosis-Related Gene Risk Signature in Colorectal Cancer

(2023) Zhiwei Wu et al.   Cancers

DLAT as a Cuproptosis Promoter and a Molecular Target of Elesclomol in Hepatocellular Carcinoma

(2023) Fan Gao et al.   Current Medical Science

Copper-induced injectable hydrogel with nitric oxide for enhanced immunotherapy by amplifying immunogenic cell death and regulating cancer associated fibroblasts

(2023) Shuilin Shen et al.   Biomaterials Research

A tumor microenvironment-responsive core-shell tecto dendrimer nanoplatform for magnetic resonance imaging-guided and cuproptosis-promoted chemo-chemodynamic therapy

(2023) Cheng Ni et al.   Acta Biomaterialia

FDX1 regulates cellular protein lipoylation through direct binding to LIAS

(2023) Margaret B. Dreishpoon et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

In-situ fabrication of novel Au nanoclusters-Cu2+@sodium alginate/hyaluronic acid nanohybrid gels for cuproptosis enhanced photothermal/photodynamic/chemodynamic therapy via tumor microenvironment regulation

(2023) Zheng Yang et al.   JOURNAL OF COLLOID AND INTERFACE SCIENCE

Redox Homeostasis Disruptors Based on Metal‐Phenolic Network Nanoparticles for Chemo/Chemodynamic Synergistic Tumor Therapy through Activating Apoptosis and Cuproptosis

(2023) Fan Zhao et al.   Advanced Healthcare Materials

COMMD10 inhibits HIF1α/CP loop to enhance ferroptosis and radiosensitivity by disrupting Cu-Fe balance in hepatocellular carcinoma

(2022) Mi Yang et al.   JOURNAL OF HEPATOLOGY

Cysteine oxidation of copper transporter CTR1 drives VEGFR2 signalling and angiogenesis

(2022) Archita Das et al.   NATURE CELL BIOLOGY

Restoration of the Immunogenicity of Tumor Cells for Enhanced Cancer Therapy via Nanoparticle‐Mediated Copper Chaperone Inhibition

(2022) Feixiang Ding et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Compartmentalized metabolism supports midgestation mammalian development

(2022) Ashley Solmonson et al.   NATURE

Copper oxide nanoparticles trigger macrophage cell death with misfolding of Cu/Zn superoxide dismutase 1 (SOD1)

(2022) Govind Gupta et al.   Particle and Fibre Toxicology

Copper induces cell death by targeting lipoylated TCA cycle proteins

(2022) Peter Tsvetkov et al.   SCIENCE

Structure of the Wilson disease copper transporter ATP7B

(2022) Ryan M. Bitter et al.   Science Advances

Senolytic treatment reduces cell senescence and necroptosis in Sod1 knockout mice that is associated with reduced inflammation and hepatocellular carcinoma

(2022) Nidheesh Thadathil et al.   AGING CELL

Elesclomol elevates cellular and mitochondrial iron levels by delivering copper to the iron import machinery

(2022) Natalie M. Garza et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Copper ionophore elesclomol selectively targets GNAQ/11-mutant uveal melanoma

(2022) Yongyun Li et al.   ONCOGENE

Comprehensive Analysis of Cuproptosis-Related Genes in Immune Infiltration and Prognosis in Melanoma

(2022) Haozhen Lv et al.   Frontiers in Pharmacology

An Enzyme‐Engineered Nonporous Copper(I) Coordination Polymer Nanoplatform for Cuproptosis‐Based Synergistic Cancer Therapy

(2022) Yuzhi Xu et al.   ADVANCED MATERIALS

Glucose restriction induces ROS-AMPK-mediated CTR1 expression and increases cisplatin efficiency in NSCLC

(2022) Pengpeng Zhang et al.   CANCER LETTERS

Intestinal mucin is a chaperone of multivalent copper

(2022) Nava Reznik et al.   CELL

System analysis based on the cuproptosis-related genes identifies LIPT1 as a novel therapy target for liver hepatocellular carcinoma

(2022) Cheng Yan et al.   Journal of Translational Medicine

Functional spectrum and specificity of mitochondrial ferredoxins FDX1 and FDX2

(2022) Vinzent Schulz et al.   Nature Chemical Biology

Memo1 binds reduced copper ions, interacts with copper chaperone Atox1, and protects against copper-mediated redox activity in vitro

(2022) Xiaolu Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Copper binding leads to increased dynamics in the regulatory N-terminal domain of full-length human copper transporter ATP7B

(2022) Fredrik Orädd et al.   PLoS Computational Biology

Ferredoxin 1 is a cuproptosis-key gene responsible for tumor immunity and drug sensitivity: A pan-cancer analysis

(2022) Longfei Yang et al.   Frontiers in Pharmacology

Genome‐Wide CRISPR/Cas9 Library Screening Revealed Dietary Restriction of Glutamine in Combination with Inhibition of Pyruvate Metabolism as Effective Liver Cancer Treatment

(2022) Chunxue Yang et al.   Advanced Science

Disulfiram/Copper Induces Immunogenic Cell Death and Enhances CD47 Blockade in Hepatocellular Carcinoma

(2022) Xingxing Gao et al.   Cancers

Photothermally Triggered Copper Payload Release for Cuproptosis‐Promoted Cancer Synergistic Therapy

(2022) Jie Zhou et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Proteomics revealed the crosstalk between copper stress and cuproptosis, and explored the feasibility of curcumin as anticancer copper ionophore

(2022) Ying Yang et al.   FREE RADICAL BIOLOGY AND MEDICINE

Brain‐Targeted HFn‐Cu‐REGO Nanoplatform for Site‐Specific Delivery and Manipulation of Autophagy and Cuproptosis in Glioblastoma

(2022) Wenhui Jia et al.   Small

A new thinking: deciphering the aberrance and clinical implication of copper-death signatures in clear cell renal cell carcinoma

(2022) Aimin Jiang et al.   Cell and Bioscience

The mitochondrial Cu+ transporter PiC2 (SLC25A3) is a target of MTF1 and contributes to the development of skeletal muscle in vitro

(2022) Cat McCann et al.   Frontiers in Molecular Biosciences

SUCLA2-coupled regulation of GLS succinylation and activity counteracts oxidative stress in tumor cells

(2021) Yingying Tong et al.   MOLECULAR CELL

SOD1 regulates ribosome biogenesis in KRAS mutant non-small cell lung cancer

(2021) Xiaowen Wang et al.   Nature Communications

Helichrysetin inhibits gastric cancer growth by targeting c-Myc/PDHK1 axis-mediated energy metabolism reprogramming

(2021) Ping Wang et al.   ACTA PHARMACOLOGICA SINICA

Antimycin A-induced mitochondrial dysfunction regulates inflammasome signaling in human retinal pigment epithelial cells

(2021) Eveliina Korhonen et al.   EXPERIMENTAL EYE RESEARCH

Elesclomol-induced increase of mitochondrial reactive oxygen species impairs glioblastoma stem-like cell survival and tumor growth

(2021) Mariachiara Buccarelli et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Elesclomol induces copper‐dependent ferroptosis in colorectal cancer cells via degradation of ATP7A

(2021) Wei Gao et al.   Molecular Oncology

ZNF711 down-regulation promotes CISPLATIN resistance in epithelial ovarian cancer via interacting with JHDM2A and suppressing SLC31A1 expression

(2021) Geyan Wu et al.   EBioMedicine

SIRT5 functions as a tumor suppressor in renal cell carcinoma by reversing the Warburg effect

(2021) Liu Yihan et al.   Journal of Translational Medicine

Calcineurin inactivation inhibits pyruvate dehydrogenase complex activity and induces the Warburg effect

(2021) Jianong Zhang et al.   ONCOGENE

Copper depletion modulates mitochondrial oxidative phosphorylation to impair triple negative breast cancer metastasis

(2021) Divya Ramchandani et al.   Nature Communications

Inflammation mobilizes copper metabolism to promote colon tumorigenesis via an IL-17-STEAP4-XIAP axis

(2020) Yun Liao et al.   Nature Communications

Dihydrolipoamide dehydrogenase regulates cystine deprivation-induced ferroptosis in head and neck cancer

(2020) Daiha Shin et al.   Redox Biology

Disrupting Mitochondrial Copper Distribution Inhibits Leukemic Stem Cell Self-Renewal

(2020) Rashim Pal Singh et al.   Cell Stem Cell

Copper Oxide Nanoparticles Induce Oxidative DNA Damage and Cell Death via Copper Ion-Mediated P38 MAPK Activation in Vascular Endothelial Cells

(2020) Hui He et al.   International Journal of Nanomedicine

PTBP1 modulates osteosarcoma chemoresistance to cisplatin by regulating the expression of the copper transporter SLC31A1

(2020) Cheng Cheng et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Elesclomol alleviates Menkes pathology and mortality by escorting Cu to cuproenzymes in mice

(2020) Liam M. Guthrie et al.   SCIENCE

MIF as a biomarker and therapeutic target for overcoming resistance to proteasome inhibitors in human myeloma

(2020) Qiang Wang et al.   BLOOD

Copper metabolism as a unique vulnerability in cancer

(2020) Vinit C. Shanbhag et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Intratumoral Copper Modulates PD-L1 Expression and Influences Tumor Immune Evasion

(2020) Florida Voli et al.   CANCER RESEARCH

Manganese is critical for antitumor immune responses via cGAS-STING and improves the efficacy of clinical immunotherapy

(2020) Mengze Lv et al.   CELL RESEARCH

LOXL4 Fosters an Immunosuppressive Microenvironment During Hepatocarcinogenesis

(2020) Hor‐Yue Tan et al.   HEPATOLOGY

Comprehensive elaboration of the cGAS-STING signaling axis in cancer development and immunotherapy

(2020) Juyan Zheng et al.   Molecular Cancer

Remodeling tumor immune microenvironment (TIME) for glioma therapy using multi-targeting liposomal codelivery

(2020) Zening Zheng et al.   Journal for ImmunoTherapy of Cancer

Quantitative proteomics revealed energy metabolism pathway alterations in human epithelial ovarian carcinoma and their regulation by the antiparasite drug ivermectin: data interpretation in the context of 3P medicine

(2020) Na Li et al.   EPMA Journal

Regulation of murine copper homeostasis by members of the COMMD protein family

(2020) Amika Singla et al.   Disease Models & Mechanisms

Downregulation of dihydrolipoyl dehydrogenase by UVA suppresses melanoma progression via triggering oxidative stress and altering energy metabolism

(2020) Silvia Yumnam et al.   FREE RADICAL BIOLOGY AND MEDICINE

Mitochondrial metabolism promotes adaptation to proteotoxic stress

(2019) Peter Tsvetkov et al.   Nature Chemical Biology

Determination of Pyruvate Metabolic Fates Modulates Head and Neck Tumorigenesis

(2019) Tsai-Ying Chen et al.   NEOPLASIA

The classic metal-sensing transcription factor MTF1 promotes myogenesis in response to copper

(2019) Cristina Tavera-Montañez et al.   FASEB JOURNAL

Compartmentalized activities of the pyruvate dehydrogenase complex sustain lipogenesis in prostate cancer

(2018) Jingjing Chen et al.   NATURE GENETICS

Overexpression of Pyruvate dehydrogenase E1a subunit Inhibits Warburg effect and Induces Cell Apoptosis through Mitochondria-mediated Pathway in Hepatocellular Carcinoma

(2018) Jihong Sun et al.   ONCOLOGY RESEARCH

Curcumin enhances cisplatin sensitivity of human NSCLC cell lines through influencing Cu-Sp1-CTR1 regulatory loop

(2018) Wei Zhang et al.   PHYTOMEDICINE

PGC1α promotes cholangiocarcinoma metastasis by upregulating PDHA1 and MPC1 expression to reverse the Warburg effect

(2018) Dan Li et al.   Cell Death & Disease

Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1

(2018) Evanna L. Mills et al.   NATURE

Carnosine modulates the Sp1-Slc31a1/Ctr1 copper sensing system and influences copper homeostasis in murine CNS-derived cells

(2018) Amilcare Barca et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

The yeast copper chaperone for copper-zinc superoxide dismutase (CCS1) is a multifunctional chaperone promoting all levels of SOD1 maturation

(2018) Stefanie D. Boyd et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cryo-EM structures of human STEAP4 reveal mechanism of iron(III) reduction

(2018) Wout Oosterheert et al.   Nature Communications

Identification of a novel mitochondrial interacting protein of C1QBP using subcellular fractionation coupled with CoIP-MS

(2016) Ruibing Chen et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Mitochondrial Protein Lipoylation and the 2-Oxoglutarate Dehydrogenase Complex Controls HIF1α Stability in Aerobic Conditions

(2016) Stephen P. Burr et al.   Cell Metabolism

Downregulation of COMMD1 by miR-205 promotes a positive feedback loop for amplifying inflammatory- and stemness-associated properties of cancer cells

(2015) D-W Yeh et al.   CELL DEATH AND DIFFERENTIATION

The copper transporter 1 (CTR1) is required to maintain the stability of copper transporter 2 (CTR2)

(2015) Cheng-Yu Tsai et al.   Metallomics

COMMD1 is linked to the WASH complex and regulates endosomal trafficking of the copper transporter ATP7A

(2015) Christine A. Phillips-Krawczak et al.   MOLECULAR BIOLOGY OF THE CELL

Wilson Disease Protein ATP7B Utilizes Lysosomal Exocytosis to Maintain Copper Homeostasis

(2014) Elena V. Polishchuk et al.   DEVELOPMENTAL CELL

SIRT3 deacetylates and increases pyruvate dehydrogenase activity in cancer cells

(2014) Ozkan Ozden et al.   FREE RADICAL BIOLOGY AND MEDICINE

Tyr-94 Phosphorylation Inhibits Pyruvate Dehydrogenase Phosphatase 1 and Promotes Tumor Growth

(2014) Changliang Shan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Roles of Atox1 and p53 in the trafficking of copper-64 to tumor cell nuclei: implications for cancer therapy

(2014) Wissam Beaino et al.   JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY

Tyr Phosphorylation of PDP1 Toggles Recruitment between ACAT1 and SIRT3 to Regulate the Pyruvate Dehydrogenase Complex

(2014) Jun Fan et al.   MOLECULAR CELL

Copper is required for oncogenic BRAF signalling and tumorigenesis

(2014) Donita C. Brady et al.   NATURE

Spectrum of diverse genomic alterations define non–clear cell renal carcinoma subtypes

(2014) Steffen Durinck et al.   NATURE GENETICS

Copper chaperone for superoxide dismutase-1 transfers copper to mitochondria but does not affect cytochrome c oxidase activity

(2013) Biao Wang et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Ctr2 regulates biogenesis of a cleaved form of mammalian Ctr1 metal transporter lacking the copper- and cisplatin-binding ecto-domain

(2013) H. Ohrvik et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Human copper chaperone for superoxide dismutase 1 mediates its own oxidation-dependent import into mitochondria

(2013) Yutaka Suzuki et al.   Nature Communications

Safety, Activity, and Immune Correlates of Anti–PD-1 Antibody in Cancer

(2012) Suzanne L. Topalian et al.   NEW ENGLAND JOURNAL OF MEDICINE

Single nucleotide in the MTF-1 binding site can determine metal-specific transcription activation

(2012) H. I. Sims et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Impact of Copper Limitation on Expression and Function of Multicopper Oxidases (Ferroxidases)

(2012) Joseph R. Prohaska   Advances in Nutrition

Prognostic value of the copper transporters, CTR1 and CTR2, in patients with ovarian carcinoma receiving platinum-based chemotherapy

(2011) Yoo-Young Lee et al.   GYNECOLOGIC ONCOLOGY

Clusterin and COMMD1 Independently Regulate Degradation of the Mammalian Copper ATPases ATP7A and ATP7B

(2011) Stephanie Materia et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cisplatin binds human copper chaperone Atox1 and promotes unfolding in vitro

(2011) M. E. Palm et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Role of Glutaredoxin1 and Glutathione in Regulating the Activity of the Copper-transporting P-type ATPases, ATP7A and ATP7B

(2010) William C. J. Singleton et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Combined Proteomics and Metabolomics Profiling of Gastric Cardia Cancer Reveals Characteristic Dysregulations in Glucose Metabolism

(2010) Zhen Cai et al.   MOLECULAR & CELLULAR PROTEOMICS

Conformational Dynamics of Metal-Binding Domains in Wilson Disease Protein: Molecular Insights into Selective Copper Transfer†

(2009) Agustina Rodriguez-Granillo et al.   BIOCHEMISTRY

Residues of rotenone, azadirachtin, pyrethrins and copper used to controlBactrocera oleae(Gmel.) in organic olives and oil

(2009) V. Simeone et al.   Food Additives and Contaminants Part A-Chemistry Analysis Control Exposure & Risk Assessment

Elevated copper and oxidative stress in cancer cells as a target for cancer treatment

(2008) Anshul Gupte et al.   CANCER TREATMENT REVIEWS

Transcription Factor Sp1 Plays an Important Role in the Regulation of Copper Homeostasis in Mammalian Cells

(2008) I.-S. Song et al.   MOLECULAR PHARMACOLOGY

Mitochondrial copper(I) transfer from Cox17 to Sco1 is coupled to electron transfer

(2008) L. Banci et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA