Senolytic treatment reduces cell senescence and necroptosis in Sod1 knockout mice that is associated with reduced inflammation and hepatocellular carcinoma

Role of necroptosis in chronic hepatic inflammation and fibrosis in a mouse model of increased oxidative stress

(2021) Sabira Mohammed et al.   FREE RADICAL BIOLOGY AND MEDICINE

Differential role of MLKL in alcohol-associated and non–alcohol-associated fatty liver diseases in mice and humans

(2021) Tatsunori Miyata et al.   JCI Insight

Dasatinib inhibits proliferation of liver cancer cells, but activation of Akt/mTOR compromises dasatinib as a cancer drug

(2021) Chang Liu et al.   ACTA BIOCHIMICA ET BIOPHYSICA SINICA

Necroptosis contributes to chronic inflammation and fibrosis in aging liver

(2021) Sabira Mohammed et al.   AGING CELL

Senolytic drugs: from discovery to translation

(2020) J. L. Kirkland et al.   JOURNAL OF INTERNAL MEDICINE

Dasatinib Inhibits Lung Cancer Cell Growth and Patient Derived Tumor Growth in Mice by Targeting LIMK1

(2020) Man Zhang et al.   Frontiers in Cell and Developmental Biology

Small Extracellular Vesicles Are Key Regulators of Non-cell Autonomous Intercellular Communication in Senescence via the Interferon Protein IFITM3

(2019) Michela Borghesan et al.   Cell Reports

Cellular Senescence and Inflammaging in Age-Related Diseases

(2018) Fabiola Olivieri et al.   MEDIATORS OF INFLAMMATION

Nonsteroidal anti-inflammatory drugs, especially aspirin, are linked to lower risk and better survival of hepatocellular carcinoma: a meta-analysis

(2018) Yuquan Tao et al.   Cancer Management and Research

MLKL, the Protein that Mediates Necroptosis, Also Regulates Endosomal Trafficking and Extracellular Vesicle Generation

(2017) Seongmin Yoon et al.   IMMUNITY

The effects of nonsteroidal anti-inflammatory drugs in the incident and recurrent risk of hepatocellular carcinoma: a meta-analysis

(2017) Qing Pang et al.   OncoTargets and Therapy

A new role for oxidative stress in aging: The accelerated aging phenotype in Sod1−/ − mice is correlated to increased cellular senescence

(2017) Yiqiang Zhang et al.   Redox Biology

Hepatic macrophages in homeostasis and liver diseases: from pathogenesis to novel therapeutic strategies

(2016) Cynthia Ju et al.   Cellular & Molecular Immunology

Cu,Zn-SOD deficiency induces the accumulation of hepatic collagen

(2016) Haruhiko Sakiyama et al.   FREE RADICAL RESEARCH

Liver specific expression of Cu/ZnSOD extends the lifespan of Sod1 null mice

(2016) Yiqiang Zhang et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Increased collagen cross-linking is a signature of dystrophin-deficient muscle

(2016) Lucas R. Smith et al.   MUSCLE & NERVE

The Achilles’ heel of senescent cells: from transcriptome to senolytic drugs

(2015) Yi Zhu et al.   AGING CELL

How longevity research can lead to therapies for Alzheimer's disease: The rapamycin story

(2015) Arlan Richardson et al.   EXPERIMENTAL GERONTOLOGY

Necroptosis and its role in inflammation

(2015) Manolis Pasparakis et al.   NATURE

Geroscience: Linking Aging to Chronic Disease

(2014) Brian K. Kennedy et al.   CELL

Inflammatory and metabolic biomarkers and risk of liver and biliary tract cancer

(2014) Krasimira Aleksandrova et al.   HEPATOLOGY

Chronic Inflammation (Inflammaging) and Its Potential Contribution to Age-Associated Diseases

(2014) C. Franceschi et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Evaluation of the Contribution of Multiple DAMPs and DAMP Receptors in Cell Death-Induced Sterile Inflammatory Responses

(2014) Hiroshi Kataoka et al.   PLoS One

Necroptosis Mediates TNF-Induced Toxicity of Hippocampal Neurons

(2014) Shan Liu et al.   Biomed Research International

Translocation of mixed lineage kinase domain-like protein to plasma membrane leads to necrotic cell death

(2013) Xin Chen et al.   CELL RESEARCH

Dietary restriction attenuates the accelerated aging phenotype of Sod1−/− mice

(2013) Yiqiang Zhang et al.   FREE RADICAL BIOLOGY AND MEDICINE

p53-dependent release of Alarmin HMGB1 is a central mediator of senescent phenotypes

(2013) Albert R. Davalos et al.   JOURNAL OF CELL BIOLOGY

A complex secretory program orchestrated by the inflammasome controls paracrine senescence

(2013) Juan Carlos Acosta et al.   NATURE CELL BIOLOGY

Nonsteroidal Anti-inflammatory Drug Use, Chronic Liver Disease, and Hepatocellular Carcinoma

(2012) Vikrant V. Sahasrabuddhe et al.   JNCI-Journal of the National Cancer Institute

Necrostatin-1 analogues: critical issues on the specificity, activity and in vivo use in experimental disease models

(2012) N Takahashi et al.   Cell Death & Disease

Interactions of vimentin- or desmin-expressing liver cells with N-acetylglucosamine-bearing polymers

(2011) Sun-Jung Kim et al.   BIOMATERIALS

TNF-induced necroptosis in L929 cells is tightly regulated by multiple TNFR1 complex I and II members

(2011) N Vanlangenakker et al.   Cell Death & Disease

Dietary and Genetic Obesity Promote Liver Inflammation and Tumorigenesis by Enhancing IL-6 and TNF Expression

(2010) Eek Joong Park et al.   CELL

Circulating mitochondrial DAMPs cause inflammatory responses to injury

(2010) Qin Zhang et al.   NATURE

Inflammatory networks during cellular senescence: causes and consequences

(2010) Adam Freund et al.   TRENDS IN MOLECULAR MEDICINE

Chemokine Signaling via the CXCR2 Receptor Reinforces Senescence

(2008) Juan C. Acosta et al.   CELL

Senescence-Associated Secretory Phenotypes Reveal Cell-Nonautonomous Functions of Oncogenic RAS and the p53 Tumor Suppressor

(2008) Jean-Philippe Coppé et al.   PLOS BIOLOGY