4-Octyl itaconate inhibits aerobic glycolysis by targeting GAPDH to promote cuproptosis in colorectal cancer

Itaconate inhibits ferroptosis of macrophage via Nrf2 pathways against sepsis-induced acute lung injury

(2022) Ruyuan He et al.   Cell Death Discovery

Immune-responsive gene 1 protects against liver injury caused by concanavalin A via the activation Nrf2/HO-1 pathway and inhibition of ROS activation pathways

(2022) Wenchang Yang et al.   FREE RADICAL BIOLOGY AND MEDICINE

Cuproptosis: Cellular and molecular mechanisms underlying copper-induced cell death

(2022) Paul A. Cobine et al.   MOLECULAR CELL

Copper induces cell death by targeting lipoylated TCA cycle proteins

(2022) Peter Tsvetkov et al.   SCIENCE

Four-Octyl itaconate ameliorates periodontal destruction via Nrf2-dependent antioxidant system

(2022) Liangjing Xin et al.   International Journal of Oral Science

Whole-genome CRISPR screening identifies N-glycosylation as a genetic and therapeutic vulnerability in CALR-mutant MPN

(2022) Jonas Samuel Jutzi et al.   BLOOD

An Enzyme‐Engineered Nonporous Copper(I) Coordination Polymer Nanoplatform for Cuproptosis‐Based Synergistic Cancer Therapy

(2022) Yuzhi Xu et al.   ADVANCED MATERIALS

Aerobic glycolysis promotes tumor immune evasion by hexokinase2-mediated phosphorylation of IκBα

(2022) Dong Guo et al.   Cell Metabolism

Identification of cuproptosis-related subtypes, cuproptosis-related gene prognostic index in hepatocellular carcinoma

(2022) Lei Ding et al.   Frontiers in Immunology

Targeting cell death pathways for cancer therapy: recent developments in necroptosis, pyroptosis, ferroptosis, and cuproptosis research

(2022) Xuhui Tong et al.   Journal of Hematology & Oncology

Oxygen sensing, mitochondrial biology and experimental therapeutics for pulmonary hypertension and cancer

(2021) Danchen Wu et al.   FREE RADICAL BIOLOGY AND MEDICINE

Anti-Warburg effect by targeting HRD1-PFKP pathway may inhibit breast cancer progression

(2021) Ya Fan et al.   Cell Communication and Signaling

Ferroptosis and its potential as a therapeutic target

(2021) Hanshu Yuan et al.   BIOCHEMICAL PHARMACOLOGY

The therapeutic implications of immunosuppressive tumor aerobic glycolysis

(2021) Bradley I. Reinfeld et al.   Cellular & Molecular Immunology

Elesclomol-induced increase of mitochondrial reactive oxygen species impairs glioblastoma stem-like cell survival and tumor growth

(2021) Mariachiara Buccarelli et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Melatonin inhibits lung cancer development by reversing the Warburg effect via stimulating the SIRT3/PDH axis

(2021) Xiangyun Chen et al.   JOURNAL OF PINEAL RESEARCH

Maresin 1 protects against lipopolysaccharide/d-galactosamine-induced acute liver injury by inhibiting macrophage pyroptosis and inflammatory response

(2021) Wenchang Yang et al.   BIOCHEMICAL PHARMACOLOGY

Targeting MUS81 promotes the anticancer effect of WEE1 inhibitor and immune checkpoint blocking combination therapy via activating cGAS/STING signaling in gastric cancer cells

(2021) Chengguo Li et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Rising incidence of early-onset colorectal cancer — a call to action

(2020) Naohiko Akimoto et al.   Nature Reviews Clinical Oncology

Biomarker concordance between primary colorectal cancer and its metastases

(2019) D.S. Bhullar et al.   EBioMedicine

The Warburg Effect, Lactate, and Nearly a Century of Trying to Cure Cancer

(2019) Netanya Y. Spencer et al.   SEMINARS IN NEPHROLOGY

4-Octyl itaconate inhibits aerobic glycolysis by targeting GAPDH to exert anti-inflammatory effects

(2019) Shan-Ting Liao et al.   Nature Communications

Aerobic Glycolysis Controls Myeloid-Derived Suppressor Cells and Tumor Immunity via a Specific CEBPB Isoform in Triple-Negative Breast Cancer

(2018) Wei Li et al.   Cell Metabolism

Dimethyl fumarate targets GAPDH and aerobic glycolysis to modulate immunity

(2018) Michael D. Kornberg et al.   SCIENCE

Itaconic acid mediates crosstalk between macrophage metabolism and peritoneal tumors

(2018) Jonathan M. Weiss et al.   JOURNAL OF CLINICAL INVESTIGATION

Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1

(2018) Evanna L. Mills et al.   NATURE

Nrf2 inhibition reverses resistance to GPX4 inhibitor-induced ferroptosis in head and neck cancer

(2018) Daiha Shin et al.   FREE RADICAL BIOLOGY AND MEDICINE

Curcumin suppresses gastric tumor cell growth via ROS-mediated DNA polymerase γ depletion disrupting cellular bioenergetics

(2017) Lihua Wang et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

PKM2 methylation by CARM1 activates aerobic glycolysis to promote tumorigenesis

(2017) Fabao Liu et al.   NATURE CELL BIOLOGY

The Warburg effect and drug resistance

(2016) Bhaskar Bhattacharya et al.   BRITISH JOURNAL OF PHARMACOLOGY

Itaconate Links Inhibition of Succinate Dehydrogenase with Macrophage Metabolic Remodeling and Regulation of Inflammation

(2016) Vicky Lampropoulou et al.   Cell Metabolism

Colorectal cancer

(2013) Hermann Brenner et al.   LANCET

Adrenodoxin-A versatile ferredoxin

(2012) Kerstin Maria Ewen et al.   IUBMB LIFE

Both human ferredoxins 1 and 2 and ferredoxin reductase are important for iron-sulfur cluster biogenesis

(2011) Yanbo Shi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Functional Characterization of Fdx1: Evidence for an Evolutionary Relationship between P450-Type and ISC-Type Ferredoxins

(2011) Kerstin Maria Ewen et al.   JOURNAL OF MOLECULAR BIOLOGY

Adrenodoxin: The archetype of vertebrate-type [2Fe–2S] cluster ferredoxins

(2010) Kerstin Maria Ewen et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Chemistry and Biology of Deoxynyboquinone, a Potent Inducer of Cancer Cell Death

(2010) Joseph S. Bair et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Humans possess two mitochondrial ferredoxins, Fdx1 and Fdx2, with distinct roles in steroidogenesis, heme, and Fe/S cluster biosynthesis

(2010) A. D. Sheftel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA