Cope with copper: From copper linked mechanisms to copper-based clinical cancer therapies

COMMD10 inhibits HIF1α/CP loop to enhance ferroptosis and radiosensitivity by disrupting Cu-Fe balance in hepatocellular carcinoma

(2022) Mi Yang et al.   JOURNAL OF HEPATOLOGY

Copper-induced tumor cell death mechanisms and antitumor theragnostic applications of copper complexes

(2022) Yicheng Jiang et al.   Nanomedicine

Autophagy in cancer cell remodeling and quality control

(2022) Grace A. Hernandez et al.   MOLECULAR CELL

Copper induces cell death by targeting lipoylated TCA cycle proteins

(2022) Peter Tsvetkov et al.   SCIENCE

Developing a Copper(II) Agent Based on His-146 and His-242 Residues of Human Serum Albumin Nanoparticles: Integration To Overcome Cisplatin Resistance and Inhibit the Metastasis of Nonsmall Cell Lung Cancer

(2022) Ming Jiang et al.   JOURNAL OF MEDICINAL CHEMISTRY

SOX15 transcriptionally increases the function of AOC1 to modulate ferroptosis and progression in prostate cancer

(2022) Yinghui Ding et al.   Cell Death & Disease

Coordination of metal center biogenesis in human cytochrome c oxidase

(2022) Eva Nývltová et al.   Nature Communications

An Enzyme‐Engineered Nonporous Copper(I) Coordination Polymer Nanoplatform for Cuproptosis‐Based Synergistic Cancer Therapy

(2022) Yuzhi Xu et al.   ADVANCED MATERIALS

Elesclomol: a copper ionophore targeting mitochondrial metabolism for cancer therapy

(2022) Peijie Zheng et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Oxidation state-specific fluorescent copper sensors reveal oncogene-driven redox changes that regulate labile copper(II) pools

(2022) Aidan T. Pezacki et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ferroptosis: mechanisms, biology and role in disease

(2021) Xuejun Jiang et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Diethyldithiocarbamate-copper complex (CuET) inhibits colorectal cancer progression via miR-16-5p and 15b-5p/ALDH1A3/PKM2 axis-mediated aerobic glycolysis pathway

(2021) Xin Huang et al.   Oncogenesis

A first-in-human phase I/Ib dose-escalation clinical trial of the autophagy inducer ABTL0812 in patients with advanced solid tumours

(2021) Laura Vidal et al.   EUROPEAN JOURNAL OF CANCER

Are trace element concentrations suitable biomarkers for the diagnosis of cancer?

(2021) Kristina Lossow et al.   Redox Biology

Copper: An intracellular Achilles heel allowing the targeting of epigenetics, kinase pathways and cell metabolism in cancer therapeutics

(2021) Filip Michniewicz et al.   ChemMedChem

Copper biology

(2021) Tiffany Tsang et al.   CURRENT BIOLOGY

APEX2‐based Proximity Labeling of Atox1 Identifies CRIP2 as a Nuclear Copper‐binding Protein that Regulates Autophagy Activation

(2021) Jing Wang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Elesclomol-induced increase of mitochondrial reactive oxygen species impairs glioblastoma stem-like cell survival and tumor growth

(2021) Mariachiara Buccarelli et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Wilson’s disease: update on pathogenesis, biomarkers and treatments

(2021) Samuel Shribman et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Liver cirrhosis

(2021) Pere Ginès et al.   LANCET

Elesclomol induces copper‐dependent ferroptosis in colorectal cancer cells via degradation of ATP7A

(2021) Wei Gao et al.   Molecular Oncology

Dysregulated copper transport in multiple sclerosis may cause demyelination via astrocytes

(2021) Emanuela Colombo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The P-type ATPase transporter ATP7A promotes angiogenesis by limiting autophagic degradation of VEGFR2

(2021) Dipankar Ash et al.   Nature Communications

Copper Promotes Tumorigenesis by Activating the PDK1‐AKT Oncogenic Pathway in a Copper Transporter 1 Dependent Manner

(2021) Jianping Guo et al.   Advanced Science

Recent Advances in Repurposing Disulfiram and Disulfiram Derivatives as Copper-Dependent Anticancer Agents

(2021) Vinodh Kannappan et al.   Frontiers in Molecular Biosciences

Leveraging disulfiram to treat cancer: Mechanisms of action, delivery strategies, and treatment regimens

(2021) Yao Lu et al.   BIOMATERIALS

The copper chaperone CCS facilitates copper binding to MEK1/2 to promote kinase activation

(2021) Michael Grasso et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Interference between copper transport systems and platinum drugs

(2021) Fabio Arnesano et al.   SEMINARS IN CANCER BIOLOGY

Copper depletion modulates mitochondrial oxidative phosphorylation to impair triple negative breast cancer metastasis

(2021) Divya Ramchandani et al.   Nature Communications

The Disulfiram/Copper Complex Induces Autophagic Cell Death in Colorectal Cancer by Targeting ULK1

(2021) Yeting Hu et al.   Frontiers in Pharmacology

Overcoming the compensatory elevation of NRF2 renders hepatocellular carcinoma cells more vulnerable to disulfiram/copper-induced ferroptosis

(2021) Xueying Ren et al.   Redox Biology

Single-cell tracking demonstrates copper chaperone Atox1 to be required for breast cancer cell migration

(2020) Stéphanie Blockhuys et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inflammation mobilizes copper metabolism to promote colon tumorigenesis via an IL-17-STEAP4-XIAP axis

(2020) Yun Liao et al.   Nature Communications

Copper–Oxygen Dynamics in the Tyrosinase Mechanism

(2020) Nobutaka Fujieda et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Disrupting Mitochondrial Copper Distribution Inhibits Leukemic Stem Cell Self-Renewal

(2020) Rashim Pal Singh et al.   Cell Stem Cell

Lysyl oxidase (LOX) family members: rationale and their potential as therapeutic targets for liver fibrosis

(2020) Wei Chen et al.   HEPATOLOGY

Copper is an essential regulator of the autophagic kinases ULK1/2 to drive lung adenocarcinoma

(2020) Tiffany Tsang et al.   NATURE CELL BIOLOGY

Sending copper where it is needed most

(2020) Svetlana Lutsenko   SCIENCE

Elesclomol alleviates Menkes pathology and mortality by escorting Cu to cuproenzymes in mice

(2020) Liam M. Guthrie et al.   SCIENCE

Copper homeostasis: Emerging target for cancer treatment

(2020) Yueqin Li   IUBMB LIFE

The histone H3-H4 tetramer is a copper reductase enzyme

(2020) Narsis Attar et al.   SCIENCE

Copper bioavailability is a KRAS-specific vulnerability in colorectal cancer

(2020) Léo Aubert et al.   Nature Communications

Copper metabolism as a unique vulnerability in cancer

(2020) Vinit C. Shanbhag et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Intratumoral Copper Modulates PD-L1 Expression and Influences Tumor Immune Evasion

(2020) Florida Voli et al.   CANCER RESEARCH

LOXL4 Fosters an Immunosuppressive Microenvironment During Hepatocarcinogenesis

(2020) Hor‐Yue Tan et al.   HEPATOLOGY

Mitochondrial copper depletion suppresses triple-negative breast cancer in mice

(2020) Liyang Cui et al.   NATURE BIOTECHNOLOGY

SOD1 suppresses pro-inflammatory immune responses by protecting against oxidative stress in colitis

(2020) Jiyoung Hwang et al.   Redox Biology

X-ray structures of the high-affinity copper transporter Ctr1

(2019) Feifei Ren et al.   Nature Communications

ATP7A delivers copper to the lysyl oxidase family of enzymes and promotes tumorigenesis and metastasis

(2019) Vinit Shanbhag et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A multicenter phase II study of temozolomide plus disulfiram and copper for recurrent temozolomide-resistant glioblastoma

(2019) Jiayi Huang et al.   JOURNAL OF NEURO-ONCOLOGY

Blockage of SLC31A1-dependent copper absorption increases pancreatic cancer cell autophagy to resist cell death

(2019) Ze Yu et al.   CELL PROLIFERATION

Copper Sulfide Facilitates Hepatobiliary Clearance of Gold Nanoparticles through the Copper-Transporting ATPase ATP7B

(2019) Xiaodong Wang et al.   ACS Nano

Mitochondrial metabolism promotes adaptation to proteotoxic stress

(2019) Peter Tsvetkov et al.   Nature Chemical Biology

Pantoprazole Affecting Docetaxel Resistance Pathways via Autophagy (PANDORA): Phase II Trial of High Dose Pantoprazole (Autophagy Inhibitor) with Docetaxel in Metastatic Castration‐Resistant Prostate Cancer (mCRPC)

(2019) Aaron R. Hansen et al.   ONCOLOGIST

Copper (II) Ions Activate Ligand-Independent Receptor Tyrosine Kinase (RTK) Signaling Pathway

(2019) Fang He et al.   Biomed Research International

Effect of Gemcitabine and nab-Paclitaxel With or Without Hydroxychloroquine on Patients With Advanced Pancreatic Cancer

(2019) Thomas B. Karasic et al.   JAMA Oncology

Copper Transport and Disease: What Can We Learn from Organoids?

(2019) Hannah Pierson et al.   Annual Review of Nutrition

The Relationship Between Serum Copper and Overweight/Obesity: a Meta-analysis

(2019) Kunfang Gu et al.   BIOLOGICAL TRACE ELEMENT RESEARCH

X-ray induced photodynamic therapy with copper-cysteamine nanoparticles in mice tumors

(2019) Samana Shrestha et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Iron-dependent histone 3 lysine 9 demethylation controls B cell proliferation and humoral immune responses

(2019) Yuhang Jiang et al.   Nature Communications

LOXL2 Upregulates Phosphorylation of Ezrin to Promote Cytoskeletal Reorganization and Tumor Cell Invasion

(2019) Xiu-Hui Zhan et al.   CANCER RESEARCH

The role of zinc and copper in insulin resistance and diabetes mellitus

(2019) Geir Bjørklund et al.   CURRENT MEDICINAL CHEMISTRY

The role of zinc, copper, manganese and iron in neurodegenerative diseases

(2019) Leda Mezzaroba et al.   NEUROTOXICOLOGY

Activity-based ratiometric FRET probe reveals oncogene-driven changes in labile copper pools induced by altered glutathione metabolism

(2019) Clive Yik-Sham Chung et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Copper trafficking in eukaryotic systems: current knowledge from experimental and computational efforts

(2019) Alessandra Magistrato et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Recent Advances in Antabuse (Disulfiram): The Importance of its Metal-binding Ability to its Anticancer Activity

(2018) Maricela Viola-Rhenals et al.   CURRENT MEDICINAL CHEMISTRY

Suppressing autophagy enhances disulfiram/copper-induced apoptosis in non-small cell lung cancer

(2018) Xi Wu et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

miR-145 Antagonizes SNAI1-Mediated Stemness and Radiation Resistance in Colorectal Cancer

(2018) Yun Zhu et al.   MOLECULAR THERAPY

Copper regulates rest-activity cycles through the locus coeruleus-norepinephrine system

(2018) Tong Xiao et al.   Nature Chemical Biology

Redox-Dependent Copper Carrier Promotes Cellular Copper Uptake and Oxidative Stress-Mediated Apoptosis of Cancer Cells

(2018) Junmin Zhang et al.   ACS Applied Materials & Interfaces

Liver as a key organ in the supply, storage, and excretion of copper

(2018) Eve A Roberts et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Deletion of hephaestin and ceruloplasmin induces a serious systemic iron deficiency and disrupts iron homeostasis

(2018) En Xu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Wilson disease

(2018) Anna Członkowska et al.   Nature Reviews Disease Primers

Activation of autophagy, observed in liver tissues from patients with Wilson disease and from Atp7b-deficient animals, protects hepatocytes from copper-induced apoptosis

(2018) Elena V. Polishchuk et al.   GASTROENTEROLOGY

Chelating principles in Menkes and Wilson diseases

(2018) Nina Horn et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Copper and Zinc Dysregulation in Alzheimer’s Disease

(2018) Stefano L. Sensi et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Disulfiram combined with copper inhibits metastasis and epithelial-mesenchymal transition in hepatocellular carcinoma through the NF-κB and TGF-β pathways

(2017) Yi Li et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Alcohol-abuse drug disulfiram targets cancer via p97 segregase adaptor NPL4

(2017) Zdenek Skrott et al.   NATURE

Detention of copper by sulfur nanoparticles inhibits the proliferation of A375 malignant melanoma and MCF-7 breast cancer cells

(2016) Hao Liu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Leukemic Stem Cells Evade Chemotherapy by Metabolic Adaptation to an Adipose Tissue Niche

(2016) Haobin Ye et al.   Cell Stem Cell

Lysyl oxidase-like 2 (LOXL2) oxidizes trimethylated lysine 4 in histone H3

(2016) Nicolás Herranz et al.   FEBS Journal

A phase I study to repurpose disulfiram in combination with temozolomide to treat newly diagnosed glioblastoma after chemoradiotherapy

(2016) Jiayi Huang et al.   JOURNAL OF NEURO-ONCOLOGY

Copper regulates cyclic-AMP-dependent lipolysis

(2016) Lakshmi Krishnamoorthy et al.   Nature Chemical Biology

PD-1–PD-L1 immune-checkpoint blockade in B-cell lymphomas

(2016) Aaron Goodman et al.   Nature Reviews Clinical Oncology

The Warburg Effect: How Does it Benefit Cancer Cells?

(2016) Maria V. Liberti et al.   TRENDS IN BIOCHEMICAL SCIENCES

Regulation of PD-L1: a novel role of pro-survival signalling in cancer

(2015) J. Chen et al.   ANNALS OF ONCOLOGY

Synthetic fluorescent probes for studying copper in biological systems

(2015) Joseph A. Cotruvo et al.   CHEMICAL SOCIETY REVIEWS

Wilson's disease and other neurological copper disorders

(2015) Oliver Bandmann et al.   LANCET NEUROLOGY

Copper uptake by DMT1: a compensatory mechanism for CTR1 deficiency in human umbilical vein endothelial cells

(2015) Chen Lin et al.   Metallomics

LOXL2 Oxidizes Methylated TAF10 and Controls TFIID-Dependent Genes during Neural Progenitor Differentiation

(2015) Ane Iturbide et al.   MOLECULAR CELL

Opening LOX to metastasis

(2015) Neta Erez   NATURE

A Phase IIb Trial Assessing the Addition of Disulfiram to Chemotherapy for the Treatment of Metastatic Non-Small Cell Lung Cancer

(2015) H. Nechushtan et al.   ONCOLOGIST

Copper activates HIF-1α/GPER/VEGF signalling in cancer cells

(2015) Damiano Cosimo Rigiracciolo et al.   Oncotarget

Copper: toxicological relevance and mechanisms

(2014) Lisa M. Gaetke et al.   ARCHIVES OF TOXICOLOGY

Copper transporter CTR1 expression and tissue platinum concentration in non-small cell lung cancer

(2014) Eric S. Kim et al.   LUNG CANCER

Copper is required for oncogenic BRAF signalling and tumorigenesis

(2014) Donita C. Brady et al.   NATURE

VCAM-1 and VAP-1 recruit myeloid cells that promote pulmonary metastasis in mice

(2013) S. Ferjancic et al.   BLOOD

Disulfiram targets cancer stem-like cells and reverses resistance and cross-resistance in acquired paclitaxel-resistant triple-negative breast cancer cells

(2013) P Liu et al.   BRITISH JOURNAL OF CANCER

Stromally Derived Lysyl Oxidase Promotes Metastasis of Transforming Growth Factor- -Deficient Mouse Mammary Carcinomas

(2013) M. W. Pickup et al.   CANCER RESEARCH

Final Results of Phase III SYMMETRY Study: Randomized, Double-Blind Trial of Elesclomol Plus Paclitaxel Versus Paclitaxel Alone As Treatment for Chemotherapy-Naive Patients With Advanced Melanoma

(2013) Steven J. O'Day et al.   JOURNAL OF CLINICAL ONCOLOGY

Regulation of Heterochromatin Transcription by Snail1/LOXL2 during Epithelial-to-Mesenchymal Transition

(2013) Alba Millanes-Romero et al.   MOLECULAR CELL

Inactivation of the HIF-1 /PDK3 Signaling Axis Drives Melanoma toward Mitochondrial Oxidative Metabolism and Potentiates the Therapeutic Activity of Pro-Oxidants

(2012) J. Kluza et al.   CANCER RESEARCH

Role of the Human High-Affinity Copper Transporter in Copper Homeostasis Regulation and Cisplatin Sensitivity in Cancer Chemotherapy

(2012) M. T. Kuo et al.   CANCER RESEARCH

The oncology drug elesclomol selectively transports copper to the mitochondria to induce oxidative stress in cancer cells

(2012) Masazumi Nagai et al.   FREE RADICAL BIOLOGY AND MEDICINE

Wilson's disease: Changes in methionine metabolism and inflammation affect global DNA methylation in early liver disease

(2012) Valentina Medici et al.   HEPATOLOGY

Structural insights into electron transfer in caa3-type cytochrome oxidase

(2012) Joseph A. Lyons et al.   NATURE

VAP-1–Mediated M2 Macrophage Infiltration Underlies IL-1β– but Not VEGF-A–Induced Lymph- and Angiogenesis

(2011) Shintaro Nakao et al.   AMERICAN JOURNAL OF PATHOLOGY

Prognostic value of the copper transporters, CTR1 and CTR2, in patients with ovarian carcinoma receiving platinum-based chemotherapy

(2011) Yoo-Young Lee et al.   GYNECOLOGIC ONCOLOGY

Affinity gradients drive copper to cellular destinations

(2010) Lucia Banci et al.   NATURE

Antiangiogenic Tetrathiomolybdate Protects against Her2/neu-Induced Breast Carcinoma by Hypoplastic Remodeling of the Mammary Gland

(2009) Q. Pan et al.   CLINICAL CANCER RESEARCH

Phase II, Randomized, Controlled, Double-Blinded Trial of Weekly Elesclomol Plus Paclitaxel Versus Paclitaxel Alone for Stage IV Metastatic Melanoma

(2009) Steven O'Day et al.   JOURNAL OF CLINICAL ONCOLOGY

Elevated copper and oxidative stress in cancer cells as a target for cancer treatment

(2008) Anshul Gupte et al.   CANCER TREATMENT REVIEWS

Mechanisms for copper acquisition, distribution and regulation

(2008) Byung-Eun Kim et al.   Nature Chemical Biology

Superoxide dismutase 1 (SOD1) is essential for H2O2-mediated oxidation and inactivation of phosphatases in growth factor signaling

(2008) J. C. Juarez et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mitochondrial copper(I) transfer from Cox17 to Sco1 is coupled to electron transfer

(2008) L. Banci et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cu2+ is required for pyrrolidine dithiocarbamate to inhibit histone acetylation and induce human leukemia cell apoptosis

(2007) Jie Chen et al.   CHEMICO-BIOLOGICAL INTERACTIONS