Cysteine oxidation of copper transporter CTR1 drives VEGFR2 signalling and angiogenesis

Glycolysis links reciprocal activation of myeloid cells and endothelial cells in the retinal angiogenic niche

(2020) Zhiping Liu et al.   Science Translational Medicine

Endothelium-specific deletion of Nox4 delays retinal vascular development and mitigates pathological angiogenesis

(2020) Xixiang Tang et al.   ANGIOGENESIS

ATP7A delivers copper to the lysyl oxidase family of enzymes and promotes tumorigenesis and metastasis

(2019) Vinit Shanbhag et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

CRISPResso2 provides accurate and rapid genome editing sequence analysis

(2019) Kendell Clement et al.   NATURE BIOTECHNOLOGY

Endophilin-A2 dependent VEGFR2 endocytosis promotes sprouting angiogenesis

(2019) Gael Genet et al.   Nature Communications

Copper Transporters and Copper Chaperones: Roles in Cardiovascular Physiology and Disease.

(2018) Tohru Fukai et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Redox Regulation of Mitochondrial Fission Protein Drp1 by Protein Disulfide Isomerase Limits Endothelial Senescence

(2018) Young-Mee Kim et al.   Cell Reports

Knock out of the NADPH oxidase Nox4 has no impact on life span in mice

(2017) Flavia Rezende et al.   Redox Biology

How Mammalian Cells Acquire Copper: An Essential but Potentially Toxic Metal

(2016) Jack H. Kaplan et al.   BIOPHYSICAL JOURNAL

Mechanisms and regulation of endothelial VEGF receptor signalling

(2016) Michael Simons et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Regulation of Vascular Endothelial Growth Factor Receptor Function in Angiogenesis by Numb and Numb-LikeSignficance

(2015) Max van Lessen et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Molecular modulation of the copper and cisplatin transport function of CTR1 and its interaction with IRS-4

(2014) Cheng-Yu Tsai et al.   BIOCHEMICAL PHARMACOLOGY

Copper is required for oncogenic BRAF signalling and tumorigenesis

(2014) Donita C. Brady et al.   NATURE

The Neuropilin 1 Cytoplasmic Domain Is Required for VEGF-A-Dependent Arteriogenesis

(2013) Anthony Lanahan et al.   DEVELOPMENTAL CELL

Rate and Regulation of Copper Transport by Human Copper Transporter 1 (hCTR1)

(2013) Edward B. Maryon et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Receptor Tyrosine Kinase Ubiquitylation Involves the Dynamic Regulation of Cbl-Spry2 by Intersectin 1 and the Shp2 Tyrosine Phosphatase

(2013) M. N. Okur et al.   MOLECULAR AND CELLULAR BIOLOGY

Genome engineering using the CRISPR-Cas9 system

(2013) F Ann Ran et al.   Nature Protocols

Critical Role of Endothelial Hydrogen Peroxide in Post-Ischemic Neovascularization

(2013) Norifumi Urao et al.   PLoS One

CTR1 Silencing Inhibits Angiogenesis by Limiting Copper Entry into Endothelial Cells

(2013) Gomathy Narayanan et al.   PLoS One

Copper influx transporter 1 is required for FGF, PDGF and EGF-induced MAPK signaling

(2012) Cheng-Yu Tsai et al.   BIOCHEMICAL PHARMACOLOGY

Lysyl Oxidase Plays a Critical Role in Endothelial Cell Stimulation to Drive Tumor Angiogenesis

(2012) A.-M. Baker et al.   CANCER RESEARCH

Nox4 Is a Protective Reactive Oxygen Species Generating Vascular NADPH Oxidase

(2012) Katrin Schröder et al.   CIRCULATION RESEARCH

VEGF signaling inside vascular endothelial cells and beyond

(2012) Anne Eichmann et al.   CURRENT OPINION IN CELL BIOLOGY

Nox4- and Nox2-dependent oxidant production is required for VEGF-induced SERCA cysteine-674 S-glutathiolation and endothelial cell migration

(2012) Alicia M. Evangelista et al.   FREE RADICAL BIOLOGY AND MEDICINE

Endothelial epsin deficiency decreases tumor growth by enhancing VEGF signaling

(2012) Satish Pasula et al.   JOURNAL OF CLINICAL INVESTIGATION

A Novel Role for Copper in Ras/Mitogen-Activated Protein Kinase Signaling

(2012) M. L. Turski et al.   MOLECULAR AND CELLULAR BIOLOGY

An Inside View: VEGF Receptor Trafficking and Signaling

(2012) Michael Simons   PHYSIOLOGY

Novel role of p66Shc in ROS-dependent VEGF signaling and angiogenesis in endothelial cells

(2011) Jin Oshikawa et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

NADPH Oxidase 4 Promotes Endothelial Angiogenesis Through Endothelial Nitric Oxide Synthase Activation

(2011) Siobhan M. Craige et al.   CIRCULATION

Peroxiredoxin II Is an Essential Antioxidant Enzyme that Prevents the Oxidative Inactivation of VEGF Receptor-2 in Vascular Endothelial Cells

(2011) Dong Hoon Kang et al.   MOLECULAR CELL

Direct Sensing of Endothelial Oxidants by Vascular Endothelial Growth Factor Receptor-2 and c-Src

(2011) Monica Lee et al.   PLoS One

Unexpected Role of the Copper Transporter ATP7A in PDGF-Induced Vascular Smooth Muscle Cell Migration

(2010) Takashi Ashino et al.   CIRCULATION RESEARCH

Ephrin-B2 regulates VEGFR2 function in developmental and tumour angiogenesis

(2010) Suphansa Sawamiphak et al.   NATURE

Ephrin-B2 controls VEGF-induced angiogenesis and lymphangiogenesis

(2010) Yingdi Wang et al.   NATURE

Inducible gene targeting in the neonatal vasculature and analysis of retinal angiogenesis in mice

(2010) Mara E Pitulescu et al.   Nature Protocols

Extracellular SOD-Derived H2O2 Promotes VEGF Signaling in Caveolae/Lipid Rafts and Post-Ischemic Angiogenesis in Mice

(2010) Jin Oshikawa et al.   PLoS One

Novel Role of NADPH Oxidase in Angiogenesis and Stem/Progenitor Cell Function

(2009) Masuko Ushio-Fukai et al.   ANTIOXIDANTS & REDOX SIGNALING

Copper-dependent Recycling of hCTR1, the Human High Affinity Copper Transporter

(2009) Shannon A. Molloy et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Discovering mechanisms of signaling-mediated cysteine oxidation

(2008) Leslie B Poole et al.   CURRENT OPINION IN CHEMICAL BIOLOGY