A new thinking: deciphering the aberrance and clinical implication of copper-death signatures in clear cell renal cell carcinoma

Cancer statistics, 2022

(2022) Rebecca L. Siegel et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Establishment of a Prognostic Prediction and Drug Selection Model for Patients with Clear Cell Renal Cell Carcinoma by Multiomics Data Analysis

(2022) Aimin Jiang et al.   Oxidative Medicine and Cellular Longevity

Blocking CD47 promotes antitumour immunity through CD103+ dendritic cell–NK cell axis in murine hepatocellular carcinoma model

(2022) Shuai Wang et al.   JOURNAL OF HEPATOLOGY

CCNA2 as an Immunological Biomarker Encompassing Tumor Microenvironment and Therapeutic Response in Multiple Cancer Types

(2022) Aimin Jiang et al.   Oxidative Medicine and Cellular Longevity

Copper induces cell death by targeting lipoylated TCA cycle proteins

(2022) Peter Tsvetkov et al.   SCIENCE

Ferredoxin 1 is a cuproptosis-key gene responsible for tumor immunity and drug sensitivity: A pan-cancer analysis

(2022) Longfei Yang et al.   Frontiers in Pharmacology

Cuproptosis status affects treatment options about immunotherapy and targeted therapy for patients with kidney renal clear cell carcinoma

(2022) Ganghua Zhang et al.   Frontiers in Immunology

Somatic Copy Number Alterations and Associated Genes in Clear-Cell Renal-Cell Carcinoma in Brazilian Patients

(2021) Flávia Gonçalves Fernandes et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Copper‐Based Nanoscale Coordination Polymers Augmented Tumor Radioimmunotherapy for Immunogenic Cell Death Induction and T‐Cell Infiltration

(2021) Yuxiang Wang et al.   Small

The inhibitory receptor TIM-3 limits activation of the cGAS-STING pathway in intra-tumoral dendritic cells by suppressing extracellular DNA uptake

(2021) Álvaro de Mingo Pulido et al.   IMMUNITY

Genomic analysis uncovers prognostic and immunogenic characteristics of ferroptosis for clear cell renal cell carcinoma

(2021) Dan Bai et al.   Molecular Therapy-Nucleic Acids

The thermogenic activity of adjacent adipocytes fuels the progression of ccRCC and compromises anti-tumor therapeutic efficacy

(2021) Gang Wei et al.   Cell Metabolism

Endothelial surface translocation of mitochondrial PDCE2 involves the non-canonical secretory autophagy pathway: Putative molecular target for radiation-guided drug delivery

(2021) F. Faqihi et al.   EXPERIMENTAL CELL RESEARCH

Establishment of a prognosis Prediction Model Based on Pyroptosis-Related Signatures Associated With the Immune Microenvironment and Molecular Heterogeneity in Clear Cell Renal Cell Carcinoma

(2021) Aimin Jiang et al.   Frontiers in Oncology

Inhibition of BCL2 family members increases the efficacy of copper chelation in BRAFV600E-driven melanoma

(2020) Ye-Jin Kim et al.   CANCER RESEARCH

Checkpoint inhibitor immunotherapy in kidney cancer

(2020) Wenxin Xu et al.   Nature Reviews Urology

Gut Bacteria Composition Drives Primary Resistance to Cancer Immunotherapy in Renal Cell Carcinoma Patients

(2020) Lisa Derosa et al.   EUROPEAN UROLOGY

Immunogenic Cell Death of Breast Cancer Stem Cells by an Endoplasmic Reticulum‐Targeting Copper(II) Complex

(2020) Pooja Kaur et al.   CHEMBIOCHEM

Manganese is critical for antitumor immune responses via cGAS-STING and improves the efficacy of clinical immunotherapy

(2020) Mengze Lv et al.   CELL RESEARCH

FGFR4 regulates tumor subtype differentiation in luminal breast cancer and metastatic disease

(2020) Susana Garcia-Recio et al.   JOURNAL OF CLINICAL INVESTIGATION

Discovery of a Copper-Based Mcl-1 Inhibitor as an Effective Antitumor Agent

(2020) Xing Lu et al.   JOURNAL OF MEDICINAL CHEMISTRY

Mutual regulation between OGT and XIAP to control colon cancer cell growth and invasion

(2020) Hyeon Gyu Seo et al.   Cell Death & Disease

Remodeling tumor immune microenvironment (TIME) for glioma therapy using multi-targeting liposomal codelivery

(2020) Zening Zheng et al.   Journal for ImmunoTherapy of Cancer

EGFR-AS1 Promotes Bladder Cancer Progression by Upregulating EGFR

(2020) Anbang Wang et al.   Biomed Research International

Long noncoding RNA EGFR-AS1 promotes cell growth and metastasis via affecting HuR mediated mRNA stability of EGFR in renal cancer

(2019) Anbang Wang et al.   Cell Death & Disease

Mitochondrial metabolism promotes adaptation to proteotoxic stress

(2019) Peter Tsvetkov et al.   Nature Chemical Biology

PTPRB promotes metastasis of colorectal carcinoma via inducing epithelial-mesenchymal transition

(2019) Xingyue Weng et al.   Cell Death & Disease

MTF1 binds to metal‐responsive element e within the ATP7B promoter and is a strong candidate in regulating the ATP7B expression

(2019) Amelie Stalke et al.   ANNALS OF HUMAN GENETICS

Genetic variants of DNAH 11 and LRFN 2 genes and their association with ovarian and breast cancer

(2019) Sonali Verma et al.   INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS

The classic metal-sensing transcription factor MTF1 promotes myogenesis in response to copper

(2019) Cristina Tavera-Montañez et al.   FASEB JOURNAL

Transcriptional responses and mechanisms of copper nanoparticle toxicology on zebrafish embryos

(2018) YanJun Zhang et al.   JOURNAL OF HAZARDOUS MATERIALS

Signatures of T cell dysfunction and exclusion predict cancer immunotherapy response

(2018) Peng Jiang et al.   NATURE MEDICINE

Somatic mutations in renal cell carcinomas from Chinese patients revealed by whole exome sequencing

(2018) Jie Wang et al.   Cancer Cell International

Maftools: efficient and comprehensive analysis of somatic variants in cancer

(2018) Anand Mayakonda et al.   GENOME RESEARCH

A Role for The ATP7A Copper Transporter in Tumorigenesis and Cisplatin Resistance

(2017) Sha Zhu et al.   Journal of Cancer

MEXPRESS: visualizing expression, DNA methylation and clinical TCGA data

(2015) Alexander Koch et al.   BMC GENOMICS

Molecular Subtypes of Clear Cell Renal Cell Carcinoma Are Associated with Sunitinib Response in the Metastatic Setting

(2015) B. Beuselinck et al.   CLINICAL CANCER RESEARCH

STING-Dependent Cytosolic DNA Sensing Mediates Innate Immune Recognition of Immunogenic Tumors

(2014) Seng-Ryong Woo et al.   IMMUNITY

The promise of copper lowering therapy with tetrathiomolybdate in the cure of cancer and in the treatment of inflammatory disease

(2014) George J. Brewer   JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY

Comprehensive molecular characterization of gastric adenocarcinoma

(2014) Adam J. Bass et al.   NATURE

Copper is required for oncogenic BRAF signalling and tumorigenesis

(2014) Donita C. Brady et al.   NATURE

pRRophetic: An R Package for Prediction of Clinical Chemotherapeutic Response from Tumor Gene Expression Levels

(2014) Paul Geeleher et al.   PLoS One

GSVA: gene set variation analysis for microarray and RNA-Seq data

(2013) Sonja Hänzelmann et al.   BMC BIOINFORMATICS

Identification of Rtl1, a Retrotransposon-Derived Imprinted Gene, as a Novel Driver of Hepatocarcinogenesis

(2013) Jesse D. Riordan et al.   PLoS Genetics

CellMiner: A Web-Based Suite of Genomic and Pharmacologic Tools to Explore Transcript and Drug Patterns in the NCI-60 Cell Line Set

(2012) W. C. Reinhold et al.   CANCER RESEARCH

The oncology drug elesclomol selectively transports copper to the mitochondria to induce oxidative stress in cancer cells

(2012) Masazumi Nagai et al.   FREE RADICAL BIOLOGY AND MEDICINE

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity

(2012) Jordi Barretina et al.   NATURE

clusterProfiler: an R Package for Comparing Biological Themes Among Gene Clusters

(2012) Guangchuang Yu et al.   OMICS-A JOURNAL OF INTEGRATIVE BIOLOGY

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(2011) A. Liberzon et al.   BIOINFORMATICS

Disulfiram modulated ROS–MAPK and NFκB pathways and targeted breast cancer cells with cancer stem cell-like properties

(2011) N C Yip et al.   BRITISH JOURNAL OF CANCER

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(2011) Börje Ljungberg et al.   EUROPEAN UROLOGY

GISTIC2.0 facilitates sensitive and confident localization of the targets of focal somatic copy-number alteration in human cancers

(2011) Craig H Mermel et al.   GENOME BIOLOGY

ConsensusClusterPlus: a class discovery tool with confidence assessments and item tracking

(2010) Matthew D. Wilkerson et al.   BIOINFORMATICS

Age-Adjusted Incidence, Mortality, and Survival Rates of Stage-Specific Renal Cell Carcinoma in North America: A Trend Analysis

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ConsensusPathDB—a database for integrating human functional interaction networks

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