Elesclomol elevates cellular and mitochondrial iron levels by delivering copper to the iron import machinery

Human glutaredoxin-1 can transfer copper to isolated metal binding domains of the P1B-type ATPase, ATP7B

(2020) Shadi Maghool et al.   Scientific Reports

Elesclomol alleviates Menkes pathology and mortality by escorting Cu to cuproenzymes in mice

(2020) Liam M. Guthrie et al.   SCIENCE

Repurposing elesclomol, an investigational drug for the treatment of copper metabolism disorders

(2020) Vishal M. Gohil   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Elesclomol restores mitochondrial function in genetic models of copper deficiency

(2018) Shivatheja Soma et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Chelating principles in Menkes and Wilson diseases

(2018) Nina Horn et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Potassium and the K+/H+Exchanger Kha1p Promote Binding of Copper to ApoFet3p Multi-copper Ferroxidase

(2016) Xiaobin Wu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mutations inCOA6cause CytochromecOxidase Deficiency and Neonatal Hypertrophic Cardiomyopathy

(2014) Fabian Baertling et al.   HUMAN MUTATION

Neurodevelopment and brain growth in classic Menkes disease is influenced by age and symptomatology at initiation of copper treatment

(2014) Stephen G. Kaler   JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY

Syntheses and antitumor activities of N′1,N′3-dialkyl-N′1,N′3-di-(alkylcarbonothioyl) malonohydrazide: The discovery of elesclomol

(2013) Shoujun Chen et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Final Results of Phase III SYMMETRY Study: Randomized, Double-Blind Trial of Elesclomol Plus Paclitaxel Versus Paclitaxel Alone As Treatment for Chemotherapy-Naive Patients With Advanced Melanoma

(2013) Steven J. O'Day et al.   JOURNAL OF CLINICAL ONCOLOGY

Molecular mechanisms of the biological activity of the anticancer drug elesclomol and its complexes with Cu(II), Ni(II) and Pt(II)

(2013) Arun A. Yadav et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Multi-Copper Oxidases and Human Iron Metabolism

(2013) Ganna Vashchenko et al.   Nutrients

Charting the travels of copper in eukaryotes from yeast to mammals

(2012) Tracy Nevitt et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Inherited Copper Transport Disorders: Biochemical Mechanisms, Diagnosis, and Treatment

(2012) Hiroko Kodama et al.   CURRENT DRUG METABOLISM

The oncology drug elesclomol selectively transports copper to the mitochondria to induce oxidative stress in cancer cells

(2012) Masazumi Nagai et al.   FREE RADICAL BIOLOGY AND MEDICINE

Mitochondrial Electron Transport Is the Cellular Target of the Oncology Drug Elesclomol

(2012) Ronald K. Blackman et al.   PLoS One

Copper: An essential metal in biology

(2011) Richard A. Festa et al.   CURRENT BIOLOGY

Knocking out multigene redundancies via cycles of sexual assortment and fluorescence selection

(2011) Yo Suzuki et al.   NATURE METHODS

ATP7A-related copper transport diseases—emerging concepts and future trends

(2011) Stephen G. Kaler   Nature Reviews Neurology

LC–MS/MS and density functional theory study of copper(II) and nickel(II) chelating complexes of elesclomol (a novel anticancer agent)

(2010) Lianming Wu et al.   JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

Menkes disease

(2009) Zeynep Tümer et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Human copper transporters: mechanism, role in human diseases and therapeutic potential

(2009) Arnab Gupta et al.   Future Medicinal Chemistry

Phase II, Randomized, Controlled, Double-Blinded Trial of Weekly Elesclomol Plus Paclitaxel Versus Paclitaxel Alone for Stage IV Metastatic Melanoma

(2009) Steven O'Day et al.   JOURNAL OF CLINICAL ONCOLOGY

Elesclomol induces cancer cell apoptosis through oxidative stress

(2008) J. R. Kirshner et al.   MOLECULAR CANCER THERAPEUTICS

Cell-specific ATP7A transport sustains copper-dependent tyrosinase activity in melanosomes

(2008) Subba Rao Gangi Setty et al.   NATURE

Mechanisms for copper acquisition, distribution and regulation

(2008) Byung-Eun Kim et al.   Nature Chemical Biology