SIRT5 functions as a tumor suppressor in renal cell carcinoma by reversing the Warburg effect

Mitochondrial Sirtuins in Reproduction

(2021) Giovanna Di Emidio et al.   Antioxidants

SIRT5 deficiency enhances the proliferative and therapeutic capacities of adipose‐derived mesenchymal stem cells via metabolic switching

(2020) Tiantong Ou et al.   Clinical and Translational Medicine

Transcriptomic Profiling of the Tumor Microenvironment Reveals Distinct Subgroups of Clear cell Renal Cell Cancer - Data from a Randomized Phase III Trial

(2019) A. Ari Hakimi et al.   Cancer Discovery

European Association of Urology Guidelines on Renal Cell Carcinoma: The 2019 Update

(2019) Börje Ljungberg et al.   EUROPEAN UROLOGY

Timing the Landmark Events in the Evolution of Clear Cell Renal Cell Cancer: TRACERx Renal

(2018) Thomas J. Mitchell et al.   CELL

Aminoacylation of Proteins: New Targets for the Old ARSenal

(2018) Seyed Mehdi Jafarnejad et al.   Cell Metabolism

SIRT5 Desuccinylates and Activates Pyruvate Kinase M2 to Block Macrophage IL-1β Production and to Prevent DSS-Induced Colitis in Mice

(2017) Fang Wang et al.   Cell Reports

The Emerging Hallmarks of Cancer Metabolism

(2016) Natalya N. Pavlova et al.   Cell Metabolism

Human Melanoma Cell Need SIRT5 to Survive

(2016) Jeongsoon Park et al.   FREE RADICAL BIOLOGY AND MEDICINE

NADP+-IDH Mutations Promote Hypersuccinylation that Impairs Mitochondria Respiration and Induces Apoptosis Resistance

(2015) Feng Li et al.   MOLECULAR CELL

SIRT5 Regulates both Cytosolic and Mitochondrial Protein Malonylation with Glycolysis as a Major Target

(2015) Yuya Nishida et al.   MOLECULAR CELL

A Nuclear Pyruvate Dehydrogenase Complex Is Important for the Generation of Acetyl-CoA and Histone Acetylation

(2014) Gopinath Sutendra et al.   CELL

Sirtuin 4 Is a Lipoamidase Regulating Pyruvate Dehydrogenase Complex Activity

(2014) Rommel A. Mathias et al.   CELL

Lysine Glutarylation Is a Protein Posttranslational Modification Regulated by SIRT5

(2014) Minjia Tan et al.   Cell Metabolism

Tyr Phosphorylation of PDP1 Toggles Recruitment between ACAT1 and SIRT3 to Regulate the Pyruvate Dehydrogenase Complex

(2014) Jun Fan et al.   MOLECULAR CELL

SIRT5 desuccinylates and activates SOD1 to eliminate ROS

(2013) Zhi-Feng Lin et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

SIRT5 Regulates the Mitochondrial Lysine Succinylome and Metabolic Networks

(2013) Matthew J. Rardin et al.   Cell Metabolism

Sirt3 Regulates Metabolic Flexibility of Skeletal Muscle Through Reversible Enzymatic Deacetylation

(2013) E. Jing et al.   DIABETES

SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways

(2013) Jeongsoon Park et al.   MOLECULAR CELL

SIRT5 deacetylates and activates urate oxidase in liver mitochondria of mice

(2012) Yasuhiko Nakamura et al.   FEBS LETTERS

Mammalian Sirtuins and Energy Metabolism

(2012) Xiaoling Li et al.   International Journal of Biological Sciences

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

The First Identification of Lysine Malonylation Substrates and Its Regulatory Enzyme

(2011) Chao Peng et al.   MOLECULAR & CELLULAR PROTEOMICS

Sirt5 Is a NAD-Dependent Protein Lysine Demalonylase and Desuccinylase

(2011) J. Du et al.   SCIENCE

Serine/Threonine Phosphatases: Mechanism through Structure

(2009) Yigong Shi   CELL

Structural Basis for Inactivation of the Human Pyruvate Dehydrogenase Complex by Phosphorylation: Role of Disordered Phosphorylation Loops

(2008) Masato Kato et al.   STRUCTURE