DLAT as a Cuproptosis Promoter and a Molecular Target of Elesclomol in Hepatocellular Carcinoma

Copper-induced tumor cell death mechanisms and antitumor theragnostic applications of copper complexes

(2022) Yicheng Jiang et al.   Nanomedicine

Copper induces cell death by targeting lipoylated TCA cycle proteins

(2022) Peter Tsvetkov et al.   SCIENCE

Comprehensive Molecular Analyses of a Macrophage-Related Gene Signature With Regard to Prognosis, Immune Features, and Biomarkers for Immunotherapy in Hepatocellular Carcinoma Based on WGCNA and the LASSO Algorithm

(2022) Tao Wang et al.   Frontiers in Immunology

PM2.5 promotes NSCLC carcinogenesis through translationally and transcriptionally activating DLAT-mediated glycolysis reprograming

(2022) Qianqian Chen et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Comprehensive Analysis of Cuproptosis-Related Genes in Immune Infiltration and Prognosis in Melanoma

(2022) Haozhen Lv et al.   Frontiers in Pharmacology

Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

(2021) Hyuna Sung et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Advances in drug development for hepatocellular carcinoma: clinical trials and potential therapeutic targets

(2021) Xiang-Yuan Luo et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Elesclomol-induced increase of mitochondrial reactive oxygen species impairs glioblastoma stem-like cell survival and tumor growth

(2021) Mariachiara Buccarelli et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Elesclomol induces copper‐dependent ferroptosis in colorectal cancer cells via degradation of ATP7A

(2021) Wei Gao et al.   Molecular Oncology

Inflammation mobilizes copper metabolism to promote colon tumorigenesis via an IL-17-STEAP4-XIAP axis

(2020) Yun Liao et al.   Nature Communications

Intratumoral Copper Modulates PD-L1 Expression and Influences Tumor Immune Evasion

(2020) Florida Voli et al.   CANCER RESEARCH

Ovarian cancer risk according to circulating zinc and copper concentrations: A meta-analysis and Mendelian randomization study

(2020) Song Lin et al.   CLINICAL NUTRITION

Inhibition of Copper Transport Induces Apoptosis in Triple Negative Breast Cancer Cells and Suppresses Tumor Angiogenesis

(2019) Olga Karginova et al.   MOLECULAR CANCER THERAPEUTICS

GEPIA2: an enhanced web server for large-scale expression profiling and interactive analysis

(2019) Zefang Tang et al.   NUCLEIC ACIDS RESEARCH

Defining the human copper proteome and analysis of its expression variation in cancers

(2017) S. Blockhuys et al.   Metallomics

Influencing the Tumor Microenvironment: A Phase II Study of Copper Depletion Using Tetrathiomolybdate in Patients with Breast Cancer at High Risk for Recurrence and in Preclinical Models of Lung Metastases

(2016) Nancy Chan et al.   CLINICAL CANCER RESEARCH

Final Results of Phase III SYMMETRY Study: Randomized, Double-Blind Trial of Elesclomol Plus Paclitaxel Versus Paclitaxel Alone As Treatment for Chemotherapy-Naive Patients With Advanced Melanoma

(2013) Steven J. O'Day et al.   JOURNAL OF CLINICAL ONCOLOGY

Bioavailable copper modulates oxidative phosphorylation and growth of tumors

(2013) S. Ishida et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Human copper homeostasis: a network of interconnected pathways

(2010) Svetlana Lutsenko   CURRENT OPINION IN CHEMICAL BIOLOGY

N′1,N′3-Dimethyl-N′1,N′3-bis(phenylcarbonothioyl) Propanedihydrazide (Elesclomol) Selectively Kills Cisplatin Resistant Lung Cancer Cells through Reactive Oxygen Species (ROS)

(2009) Medhi Wangpaichitr et al.   Cancers

Elevated copper and oxidative stress in cancer cells as a target for cancer treatment

(2008) Anshul Gupte et al.   CANCER TREATMENT REVIEWS