Microglia Mediated Neuroinflammation in Parkinson’s Disease

Microglia Polarization From M1 to M2 in Neurodegenerative Diseases

(2022) Shenrui Guo et al.   Frontiers in Aging Neuroscience

JAK2/STAT3 pathway regulates microglia polarization involved in hippocampal inflammatory damage due to acute paraquat exposure

(2022) Zhuo Fan et al.   ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY

Neurodegeneration and Neuroinflammation in Parkinson’s Disease: a Self-Sustained Loop

(2022) G. Arena et al.   Current Neurology and Neuroscience Reports

Subthalamic nucleus exclusively evokes dopamine release in the tail of the striatum

(2022) Kathryn L. Todd et al.   JOURNAL OF NEUROCHEMISTRY

Brain microglia activation and peripheral adaptive immunity in Parkinson’s disease: a multimodal PET study

(2022) Shu-Ying Liu et al.   Journal of Neuroinflammation

Periphery and brain, innate and adaptive immunity in Parkinson’s disease

(2021) Ashley S. Harms et al.   ACTA NEUROPATHOLOGICA

Single-Cell Transcriptomics and In Situ Morphological Analyses Reveal Microglia Heterogeneity Across the Nigrostriatal Pathway

(2021) Oihane Uriarte Huarte et al.   Frontiers in Immunology

AMPK: restoring metabolic homeostasis over space and time

(2021) Elijah Trefts et al.   MOLECULAR CELL

DJ-1 inhibits microglial activation and protects dopaminergic neurons in vitro and in vivo through interacting with microglial p65

(2021) Zixuan Lin et al.   Cell Death & Disease

Selective targeting of the TLR2/MyD88/NF-κB pathway reduces α-synuclein spreading in vitro and in vivo

(2021) Debashis Dutta et al.   Nature Communications

Single-cell sequencing of human midbrain reveals glial activation and a Parkinson-specific neuronal state

(2021) Semra Smajić et al.   BRAIN

Regulatory Effects of Quercetin on M1/M2 Macrophage Polarization and Oxidative/Antioxidative Balance

(2021) Cheng-Fang Tsai et al.   Nutrients

Targeting Microglial α-Synuclein/TLRs/NF-kappaB/NLRP3 Inflammasome Axis in Parkinson’s Disease

(2021) Yunna Li et al.   Frontiers in Immunology

The role of JAK/STAT signaling pathway and its inhibitors in diseases

(2020) Ping Xin et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Enhanced Akt/GSK‐3β/CREB signaling mediates the anti‐inflammatory actions of mGluR5 positive allosteric modulators in microglia and following traumatic brain injury in male mice

(2020) Shahnawaz A. Bhat et al.   JOURNAL OF NEUROCHEMISTRY

Immune cell regulation of glia during CNS injury and disease

(2020) Andrew D. Greenhalgh et al.   NATURE REVIEWS NEUROSCIENCE

Microglia Mediated Neuroinflammation: Focus on PI3K Modulation

(2020) Antonia Cianciulli et al.   Biomolecules

Oxidative Stress and Neuroinflammation Potentiate Each Other to Promote Progression of Dopamine Neurodegeneration

(2020) Jingyi He et al.   Oxidative Medicine and Cellular Longevity

Mitochondrial damage-associated inflammation highlights biomarkers in PRKN/PINK1 parkinsonism

(2020) Max Borsche et al.   BRAIN

Astrocytes are necessary for blood–brain barrier maintenance in the adult mouse brain

(2020) Benjamin P. Heithoff et al.   GLIA

Targeting Notch in oncology: the path forward

(2020) Samarpan Majumder et al.   NATURE REVIEWS DRUG DISCOVERY

Increased microglial activation in patients with Parkinson disease using [18F]-DPA714 TSPO PET imaging

(2020) Sonia Lavisse et al.   PARKINSONISM & RELATED DISORDERS

Neuron-Astrocyte Interactions in Parkinson’s Disease

(2020) Ikuko Miyazaki et al.   Cells

Targeting MAPK Pathways by Naringenin Modulates Microglia M1/M2 Polarization in Lipopolysaccharide-Stimulated Cultures

(2019) Bei Zhang et al.   Frontiers in Cellular Neuroscience

The Role of PI3K/Akt and ERK in Neurodegenerative Disorders

(2019) Sachchida Nand Rai et al.   NEUROTOXICITY RESEARCH

Enhancing the Astrocytic Clearance of Extracellular α-Synuclein Aggregates by Ginkgolides Attenuates Neural Cell Injury

(2019) Jun Hua et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Akt Signaling in Macrophage Polarization, Survival, and Atherosclerosis

(2019) MacRae F. Linton et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Autophagy in Synucleinopathy: The Overwhelmed and Defective Machinery

(2019) Marie-Laure Arotcarena et al.   Cells

Parkinson Disease Epidemiology, Pathology, Genetics, and Pathophysiology

(2019) David K. Simon et al.   CLINICS IN GERIATRIC MEDICINE

Microglia affect α-synuclein cell-to-cell transfer in a mouse model of Parkinson’s disease

(2019) Sonia George et al.   Molecular Neurodegeneration

Liraglutide Lowers Body Weight Set Point in DIO Rats and its Relationship with Hypothalamic Microglia Activation

(2019) Ting Liao et al.   Obesity

Innate immune responses to paraquat exposure in a Drosophila model of Parkinson’s disease

(2019) Urmila Maitra et al.   Scientific Reports

Cross-Species Single-Cell Analysis Reveals Divergence of the Primate Microglia Program

(2019) Laufey Geirsdottir et al.   CELL

Inflammasome and α-synuclein in Parkinson's disease: A cross-sectional study

(2019) Koustav Chatterjee et al.   JOURNAL OF NEUROIMMUNOLOGY

Identification of novel risk loci, causal insights, and heritable risk for Parkinson's disease: a meta-analysis of genome-wide association studies

(2019) Mike A Nalls et al.   LANCET NEUROLOGY

A Dual AMPK/Nrf2 Activator Reduces Brain Inflammation After Stroke by Enhancing Microglia M2 Polarization

(2018) Yunjie Wang et al.   ANTIOXIDANTS & REDOX SIGNALING

JAK/STAT Signal Transduction: Promising Attractive Targets for Immune, Inflammatory and Hematopoietic Diseases

(2018) Qianwen Gao et al.   CURRENT DRUG TARGETS

Cx3cr1-deficiency exacerbates alpha-synuclein-A53T induced neuroinflammation and neurodegeneration in a mouse model of Parkinson's disease

(2018) Sara Castro-Sánchez et al.   GLIA

Simvastatin alters M1/M2 polarization of murine BV2 microglia via Notch signaling

(2018) Fei Wu et al.   JOURNAL OF NEUROIMMUNOLOGY

Genomic DNA levels of mutant alpha-synuclein correlate with non-motor symptoms in an A53T Parkinson's disease mouse model

(2018) Weiwei Wang et al.   NEUROCHEMISTRY INTERNATIONAL

Predicting alpha-synuclein pathology by REM sleep behavior disorder diagnosis

(2018) David R. Shprecher et al.   PARKINSONISM & RELATED DISORDERS

Microglial Activation After Systemic Stimulation With Lipopolysaccharide and Escherichia coli

(2018) Inge C. M. Hoogland et al.   Frontiers in Cellular Neuroscience

Lack of PINK1 alters glia innate immune responses and enhances inflammation-induced, nitric oxide-mediated neuron death

(2018) Liuke Sun et al.   Scientific Reports

Partial Depletion of Peripheral M1 Macrophages Reverses Motor Deficits in MPTP-Treated Mouse by Suppressing Neuroinflammation and Dopaminergic Neurodegeneration

(2018) Aijuan Yan et al.   Frontiers in Aging Neuroscience

Silencing Alpha Synuclein in Mature Nigral Neurons Results in Rapid Neuroinflammation and Subsequent Toxicity

(2018) Matthew J. Benskey et al.   Frontiers in Molecular Neuroscience

Microglia in neurodegeneration

(2018) Suzanne Hickman et al.   NATURE NEUROSCIENCE

Microglial signatures and their role in health and disease

(2018) Oleg Butovsky et al.   NATURE REVIEWS NEUROSCIENCE

Neuroinflammation in the central nervous system: Symphony of glial cells

(2018) Qiao‐qiao Yang et al.   GLIA

Advances in Parkinson’s Disease: 200 Years Later

(2018) Natalia López-González Del Rey et al.   Frontiers in Neuroanatomy

Translocator Protein-18 kDa (TSPO) Positron Emission Tomography (PET) Imaging and Its Clinical Impact in Neurodegenerative Diseases

(2017) Anne-Claire Dupont et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

CNS inflammation and neurodegeneration

(2017) Tanuja Chitnis et al.   JOURNAL OF CLINICAL INVESTIGATION

DJ-1 deficiency impairs autophagy and reduces alpha-synuclein phagocytosis by microglia

(2017) Yuval Nash et al.   JOURNAL OF NEUROCHEMISTRY

Inhibition of AGEs/RAGE/Rho/ROCK pathway suppresses non-specific neuroinflammation by regulating BV2 microglial M1/M2 polarization through the NF-κB pathway

(2017) Jingkao Chen et al.   JOURNAL OF NEUROIMMUNOLOGY

Homologous HSV1 and alpha-synuclein peptides stimulate a T cell response in Parkinson's disease

(2017) E. Caggiu et al.   JOURNAL OF NEUROIMMUNOLOGY

Neurotoxic reactive astrocytes are induced by activated microglia

(2017) Shane A. Liddelow et al.   NATURE

Microglial phenotypes in Parkinson’s disease and animal models of the disease

(2017) Valerie Joers et al.   PROGRESS IN NEUROBIOLOGY

Modulation of Microglial Activity by Rho-Kinase (ROCK) Inhibition as Therapeutic Strategy in Parkinson’s Disease and Amyotrophic Lateral Sclerosis

(2017) Anna-Elisa Roser et al.   Frontiers in Aging Neuroscience

Targeting Microglial Activation States as a Therapeutic Avenue in Parkinson’s Disease

(2017) Sudhakar R. Subramaniam et al.   Frontiers in Aging Neuroscience

Role of Atypical Chemokine Receptors in Microglial Activation and Polarization

(2017) Valentina Salvi et al.   Frontiers in Aging Neuroscience

The Polarization States of Microglia in TBI: A New Paradigm for Pharmacological Intervention

(2017) Hangzhe Xu et al.   NEURAL PLASTICITY

Parkinson disease

(2017) Werner Poewe et al.   Nature Reviews Disease Primers

Alpha-synuclein activates BV2 microglia dependent on its aggregation state

(2016) Alana Hoffmann et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Leucine-rich repeat kinase 2 (LRRK2) regulates α-synuclein clearance in microglia

(2016) Tatsunori Maekawa et al.   BMC NEUROSCIENCE

TLR4 signaling mediates AP-1 activation in an MPTP-induced mouse model of Parkinson's disease

(2016) Xu-Dong Zhao et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Inflammatory profile in LRRK2-associated prodromal and clinical PD

(2016) Kathrin Brockmann et al.   Journal of Neuroinflammation

Serum immune markers and disease progression in an incident Parkinson's disease cohort (ICICLE-PD)

(2016) Caroline H. Williams-Gray et al.   MOVEMENT DISORDERS

A polarizing question: do M1 and M2 microglia exist?

(2016) Richard M Ransohoff   NATURE NEUROSCIENCE

The Ca 2+ /Calmodulin/CaMKK2 Axis: Nature's Metabolic CaMshaft

(2016) Kathrina L. Marcelo et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Compromised MAPK signaling in human diseases: an update

(2015) Eun Kyung Kim et al.   ARCHIVES OF TOXICOLOGY

Roles of microglia in brain development, tissue maintenance and repair

(2015) Mackenzie A. Michell-Robinson et al.   BRAIN

Microglial M1/M2 polarization and metabolic states

(2015) Ruben Orihuela et al.   BRITISH JOURNAL OF PHARMACOLOGY

Inhibition of Rho-kinase by Fasudil protects dopamine neurons and attenuates inflammatory response in an intranasal lipopolysaccharide-mediated Parkinson's model

(2015) Qing He et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

AMPK-mediated regulation of neuronal metabolism and function in brain diseases

(2015) Yu-Ju Liu et al.   JOURNAL OF NEUROGENETICS

Parkinson's disease

(2015) Lorraine V Kalia et al.   LANCET

Differential Roles of M1 and M2 Microglia in Neurodegenerative Diseases

(2015) Yu Tang et al.   MOLECULAR NEUROBIOLOGY

P2X7 receptor is critical in α-synuclein–mediated microglial NADPH oxidase activation

(2015) Tianfang Jiang et al.   NEUROBIOLOGY OF AGING

FcγRIIB mediates the inhibitory effect of aggregated α-synuclein on microglial phagocytosis

(2015) Yu Ree Choi et al.   NEUROBIOLOGY OF DISEASE

Characterization of the lipopolysaccharide induced model of Parkinson's disease: Role of oxidative stress and neuroinflammation

(2015) Neha Sharma et al.   NEUROCHEMISTRY INTERNATIONAL

Parkinson disease and incidental Lewy body disease

(2015) Diego Iacono et al.   NEUROLOGY

Diversity and plasticity of microglial cells in psychiatric and neurological disorders

(2015) Yutaka Nakagawa et al.   PHARMACOLOGY & THERAPEUTICS

Alternatively activated microglia and macrophages in the central nervous system

(2015) Rafael Franco et al.   PROGRESS IN NEUROBIOLOGY

Microglia in Health and Disease

(2015) Richard M. Ransohoff et al.   Cold Spring Harbor Perspectives in Biology

Inhibition of the Rho/Rho kinase pathway prevents lipopolysaccharide-induced hyperalgesia and the release of TNF-α and IL-1β in the mouse spinal cord

(2015) Cunjin Wang et al.   Scientific Reports

Neuroinflammation in Parkinson’s disease and its potential as therapeutic target

(2015) Qinqin Wang et al.   Translational Neurodegeneration

Induction of Microglia Activation after Infection with the Non-Neurotropic A/CA/04/2009 H1N1 Influenza Virus

(2015) Shankar Sadasivan et al.   PLoS One

Glimepiride reduces CD14 expression and cytokine secretion from macrophages

(2014) Victoria Ingham et al.   Journal of Neuroinflammation

Inhibition of Neuroinflammation and Mitochondrial Dysfunctions by Carbenoxolone in the Rotenone Model of Parkinson’s Disease

(2014) Poonam Thakur et al.   MOLECULAR NEUROBIOLOGY

Large-scale meta-analysis of genome-wide association data identifies six new risk loci for Parkinson's disease

(2014) Mike A Nalls et al.   NATURE GENETICS

Abrogation of  -synuclein-mediated dopaminergic neurodegeneration in LRRK2-deficient rats

(2014) J. P. L. Daher et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The gut microbiota influences blood-brain barrier permeability in mice

(2014) V. Braniste et al.   Science Translational Medicine

Parkin and PINK1: much more than mitophagy

(2014) Leslie A. Scarffe et al.   TRENDS IN NEUROSCIENCES

Rho family GTPases: key players in neuronal development, neuronal survival, and neurodegeneration

(2014) Trisha R. Stankiewicz et al.   Frontiers in Cellular Neuroscience

DJ-1 deficiency triggers microglia sensitivity to dopamine toward a pro-inflammatory phenotype that is attenuated by rasagiline

(2013) Dorit Trudler et al.   JOURNAL OF NEUROCHEMISTRY

Microglia express distinct M1 and M2 phenotypic markers in the postnatal and adult central nervous system in male and female mice

(2013) Jessica M. Crain et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Hypothalamic programming of systemic ageing involving IKK-β, NF-κB and GnRH

(2013) Guo Zhang et al.   NATURE

Identification of a unique TGF-β–dependent molecular and functional signature in microglia

(2013) Oleg Butovsky et al.   NATURE NEUROSCIENCE

Triggering of Inflammasome by Aggregated α–Synuclein, an Inflammatory Response in Synucleinopathies

(2013) Gaia Codolo et al.   PLoS One

Genomic insights into WNT/β-catenin signaling

(2013) Joseph Rosenbluh et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Janus-faced microglia: beneficial and detrimental consequences of microglial phagocytosis

(2013) Amanda Sierra et al.   Frontiers in Cellular Neuroscience

Neuron-released oligomeric α-synuclein is an endogenous agonist of TLR2 for paracrine activation of microglia

(2013) Changyoun Kim et al.   Nature Communications

Genetics of Parkinson's Disease

(2013) C. Klein et al.   Cold Spring Harbor Perspectives in Medicine

Clinical and Biochemical Differences in Patients Having Parkinson Disease With vs WithoutGBAMutations

(2013) Lama M. Chahine et al.   JAMA Neurology

Differential roles of astrocyte and microglia in supporting oligodendrocyte development and myelination in vitro

(2013) Yi Pang et al.   Brain and Behavior

PINK1 Deficiency Enhances Inflammatory Cytokine Release from Acutely Prepared Brain Slices

(2013) Jun Kim et al.   Experimental Neurobiology

Regionally-specific microglial activation in young mice over-expressing human wildtype alpha-synuclein

(2012) Melanie B. Watson et al.   EXPERIMENTAL NEUROLOGY

Mao-B elevation decreases parkin's ability to efficiently clear damaged mitochondria: protective effects of rapamycin

(2012) Almas Siddiqui et al.   FREE RADICAL RESEARCH

Regulation of microglia development and homeostasis

(2012) Melanie Greter et al.   GLIA

JAK and STAT Signaling Molecules in Immunoregulation and Immune-Mediated Disease

(2012) John J. O'Shea et al.   IMMUNITY

Macrophage plasticity and polarization: in vivo veritas

(2012) Antonio Sica et al.   JOURNAL OF CLINICAL INVESTIGATION

Elevated Levels of α-Synuclein Oligomer in the Cerebrospinal Fluid of Drug-Naïve Patients with Parkinson's Disease

(2012) Min Jeong Park et al.   Journal of Clinical Neurology

Defining GM-CSF- and Macrophage-CSF-Dependent Macrophage Responses by In Vitro Models

(2012) D. C. Lacey et al.   JOURNAL OF IMMUNOLOGY

Defective Autophagy in Parkinson’s Disease: Role of Oxidative Stress

(2012) Elzbieta Janda et al.   MOLECULAR NEUROBIOLOGY

A Progressive Mouse Model of Parkinson’s Disease: The Thy1-aSyn (“Line 61”) Mice

(2012) Marie-Francoise Chesselet et al.   Neurotherapeutics

Impaired Inflammatory Responses in Murine Lrrk2-Knockdown Brain Microglia

(2012) Beomsue Kim et al.   PLoS One

PI3K-PKB/Akt Pathway

(2012) B. A. Hemmings et al.   Cold Spring Harbor Perspectives in Biology

Neuropathology underlying clinical variability in patients with synucleinopathies

(2011) Glenda M. Halliday et al.   ACTA NEUROPATHOLOGICA

Toll-Like Receptor 4 Promotes α-Synuclein Clearance and Survival of Nigral Dopaminergic Neurons

(2011) Nadia Stefanova et al.   AMERICAN JOURNAL OF PATHOLOGY

E46K Human α-Synuclein Transgenic Mice Develop Lewy-like and Tau Pathology Associated with Age-dependent, Detrimental Motor Impairment

(2011) Kristel L. Emmer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The acute inflammatory response to intranigral α-synuclein differs significantly from intranigral lipopolysaccharide and is exacerbated by peripheral inflammation

(2011) Yvonne Couch et al.   Journal of Neuroinflammation

Microglial p38α MAPK is critical for LPS-induced neuron degeneration, through a mechanism involving TNFα

(2011) Bin Xing et al.   Molecular Neurodegeneration

Physiology of Microglia

(2011) Helmut Kettenmann et al.   PHYSIOLOGICAL REVIEWS

α-Synuclein Reactive Antibodies as Diagnostic Biomarkers in Blood Sera of Parkinson's Disease Patients

(2011) Kiran Yanamandra et al.   PLoS One

Lipopolysaccharide and Tumor Necrosis Factor Regulate Parkin Expression via Nuclear Factor-Kappa B

(2011) Thi A. Tran et al.   PLoS One

Increased Intestinal Permeability Correlates with Sigmoid Mucosa alpha-Synuclein Staining and Endotoxin Exposure Markers in Early Parkinson's Disease

(2011) Christopher B. Forsyth et al.   PLoS One

Synaptic Pruning by Microglia Is Necessary for Normal Brain Development

(2011) R. C. Paolicelli et al.   SCIENCE

The MAPK cascades: Signaling components, nuclear roles and mechanisms of nuclear translocation

(2010) Alexander Plotnikov et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Rho-kinase/ROCK: A key regulator of the cytoskeleton and cell polarity

(2010) Mutsuki Amano et al.   Cytoskeleton

Ulcerative colitis exacerbates lipopolysaccharide-induced damage to the nigral dopaminergic system: potential risk factor in Parkinson`s disease

(2010) Ruth F. Villarán et al.   JOURNAL OF NEUROCHEMISTRY

Pathogenic Lysosomal Depletion in Parkinson's Disease

(2010) B. Dehay et al.   JOURNAL OF NEUROSCIENCE

Oxidant stress evoked by pacemaking in dopaminergic neurons is attenuated by DJ-1

(2010) Jaime N. Guzman et al.   NATURE

MPTP-Induced Neuroinflammation Increases the Expression of Pro-Inflammatory Cytokines and Their Receptors in Mouse Brain

(2010) Dario Domenico Lofrumento et al.   NEUROIMMUNOMODULATION

Role of microglia in neurotrauma

(2010) David J. Loane et al.   Neurotherapeutics

Fate Mapping Analysis Reveals That Adult Microglia Derive from Primitive Macrophages

(2010) F. Ginhoux et al.   SCIENCE

Activity-dependent Extrinsic Regulation of Adult Olfactory Bulb and Hippocampal Neurogenesis

(2009) Dengke K. Ma et al.   Annals of the New York Academy of Sciences

Cross-regulation of Signaling Pathways by Interferon-γ: Implications for Immune Responses and Autoimmune Diseases

(2009) Xiaoyu Hu et al.   IMMUNITY

Relationship between microglial activation and dopaminergic neuronal loss in the substantia nigra: a time course study in a 6-hydroxydopamine model of Parkinson’s disease

(2009) Lilia Marinova-Mutafchieva et al.   JOURNAL OF NEUROCHEMISTRY

Heterogeneity of Microglial Activation in the Innate Immune Response in the Brain

(2009) Carol A. Colton   Journal of Neuroimmune Pharmacology

Beclin 1 Gene Transfer Activates Autophagy and Ameliorates the Neurodegenerative Pathology in  -Synuclein Models of Parkinson's and Lewy Body Diseases

(2009) B. Spencer et al.   JOURNAL OF NEUROSCIENCE

Resting Microglia Directly Monitor the Functional State of Synapses In Vivo and Determine the Fate of Ischemic Terminals

(2009) H. Wake et al.   JOURNAL OF NEUROSCIENCE

Neuropathological assessment of Parkinson's disease: refining the diagnostic criteria

(2009) Dennis W Dickson et al.   LANCET NEUROLOGY

Clearance and deposition of extracellular α-synuclein aggregates in microglia

(2008) He-Jin Lee et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Nicotinamide Adenine Dinucleotide Phosphate (NADPH) Oxidase-Dependent Activation of Phosphoinositide 3-Kinase and p38 Mitogen-Activated Protein Kinase Signal Pathways Is Required for Lipopolysaccharide-Induced Microglial Phagocytosis

(2008) Hu-Nan Sun et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Microglial phagocytosis is enhanced by monomeric α-synuclein, not aggregated α-synuclein: Implications for Parkinson's disease

(2008) Ji-Young Park et al.   GLIA

Mitochondrial Import and Accumulation of α-Synuclein Impair Complex I in Human Dopaminergic Neuronal Cultures and Parkinson Disease Brain

(2008) Latha Devi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Targeted Overexpression of Human α-Synuclein Triggers Microglial Activation and an Adaptive Immune Response in a Mouse Model of Parkinson Disease

(2008) Shaji Theodore et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Glial Dysfunction in Parkin Null Mice: Effects of Aging

(2008) R. M. Solano et al.   JOURNAL OF NEUROSCIENCE

Parkin Deficiency Increases Vulnerability to Inflammation-Related Nigral Degeneration

(2008) T. C. Frank-Cannon et al.   JOURNAL OF NEUROSCIENCE

Serum interleukin (IL-2, IL-10, IL-6, IL-4), TNFα, and INFγ concentrations are elevated in patients with atypical and idiopathic parkinsonism

(2008) Bogdan Brodacki et al.   NEUROSCIENCE LETTERS

More complicated than it looks: assembly of Notch pathway transcription complexes

(2008) R A Kovall   ONCOGENE

Synuclein activates microglia in a model of Parkinson's disease

(2007) Xiaomin Su et al.   NEUROBIOLOGY OF AGING