Leucine-rich repeat kinase 2 (LRRK2) regulates α-synuclein clearance in microglia
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Title
Leucine-rich repeat kinase 2 (LRRK2) regulates α-synuclein clearance in microglia
Authors
Keywords
Microglia, LRRK2, α-Synuclein
Journal
BMC NEUROSCIENCE
Volume 17, Issue 1, Pages -
Publisher
Springer Nature
Online
2016-11-30
DOI
10.1186/s12868-016-0315-2
References
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Related references
Note: Only part of the references are listed.- An early endosome regulator, Rab5b, is an LRRK2 kinase substrate
- (2015) Hye Jin Yun et al. JOURNAL OF BIOCHEMISTRY
- Leucine-rich repeat kinase 2 positively regulates inflammation and down-regulates NF-κB p50 signaling in cultured microglia cells
- (2015) Isabella Russo et al. Journal of Neuroinflammation
- LRRK2, a puzzling protein: Insights into Parkinson's disease pathogenesis
- (2014) A. Raquel Esteves et al. EXPERIMENTAL NEUROLOGY
- LRRK2 pathobiology in Parkinson's disease
- (2014) Ian Martin et al. JOURNAL OF NEUROCHEMISTRY
- Neuroimmune regulation of microglial activity involved in neuroinflammation and neurodegenerative diseases
- (2014) Hugo González et al. JOURNAL OF NEUROIMMUNOLOGY
- Synucleins Regulate the Kinetics of Synaptic Vesicle Endocytosis
- (2014) K. J. Vargas et al. JOURNAL OF NEUROSCIENCE
- Slowing of neurodegeneration in Parkinson's disease and Huntington's disease: future therapeutic perspectives
- (2014) Anthony H V Schapira et al. LANCET
- Large-scale meta-analysis of genome-wide association data identifies six new risk loci for Parkinson's disease
- (2014) Mike A Nalls et al. NATURE GENETICS
- Abrogation of -synuclein-mediated dopaminergic neurodegeneration in LRRK2-deficient rats
- (2014) J. P. L. Daher et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Disease Penetrance of Late-Onset Parkinsonism
- (2014) Joanne Trinh et al. JAMA Neurology
- Alpha-Synuclein Function and Dysfunction on Cellular Membranes
- (2014) David Snead et al. Experimental Neurobiology
- The Role of -Synuclein in Neurodegenerative Diseases: >From Molecular Pathways in Disease to Therapeutic Approaches
- (2013) Karima Al-Mansoori et al. Current Alzheimer Research
- Functional interaction of Parkinson's disease-associated LRRK2 with members of the dynamin GTPase superfamily
- (2013) Klodjan Stafa et al. HUMAN MOLECULAR GENETICS
- α-Synuclein and Mitochondrial Dysfunction in Parkinson’s Disease
- (2013) Stephen Mullin et al. MOLECULAR NEUROBIOLOGY
- Parkinson's Disease and Alpha Synuclein: Is Parkinson's Disease a Prion-Like Disorder?
- (2013) C. Warren Olanow et al. MOVEMENT DISORDERS
- The Function of α-Synuclein
- (2013) Jacob T. Bendor et al. NEURON
- Neuroinflammation: The role and consequences
- (2013) Monty Lyman et al. NEUROSCIENCE RESEARCH
- Neuron-released oligomeric α-synuclein is an endogenous agonist of TLR2 for paracrine activation of microglia
- (2013) Changyoun Kim et al. Nature Communications
- Microglia and neurodegeneration: The role of systemic inflammation
- (2012) Colm Cunningham GLIA
- Toll-like receptor 4 is required for α-synuclein dependent activation of microglia and astroglia
- (2012) Lisa Fellner et al. GLIA
- LRRK2 Inhibition Attenuates Microglial Inflammatory Responses
- (2012) M. S. Moehle et al. JOURNAL OF NEUROSCIENCE
- Antibody-Aided Clearance of Extracellular -Synuclein Prevents Cell-to-Cell Aggregate Transmission
- (2012) E.-J. Bae et al. JOURNAL OF NEUROSCIENCE
- The Central Theme of Parkinson’s Disease: α-Synuclein
- (2012) Mehmet Ozansoy et al. MOLECULAR NEUROBIOLOGY
- LRRK2 knockout mice have an intact dopaminergic system but display alterations in exploratory and motor co-ordination behaviors
- (2012) Kelly M Hinkle et al. Molecular Neurodegeneration
- 100 years of Lewy pathology
- (2012) Michel Goedert et al. Nature Reviews Neurology
- Parkinson's disease-linked leucine-rich repeat kinase 2(R1441G) mutation increases proinflammatory cytokine release from activated primary microglial cells and resultant neurotoxicity
- (2012) F. Gillardon et al. NEUROSCIENCE
- Impaired Inflammatory Responses in Murine Lrrk2-Knockdown Brain Microglia
- (2012) Beomsue Kim et al. PLoS One
- An extracellular mechanism that can explain the neurotoxic effects of α-synuclein aggregates in the brain
- (2012) C. Pacheco et al. Frontiers in Physiology
- Toll-Like Receptor 4 Promotes α-Synuclein Clearance and Survival of Nigral Dopaminergic Neurons
- (2011) Nadia Stefanova et al. AMERICAN JOURNAL OF PATHOLOGY
- Parkinson’s disease-linked LRRK2 is expressed in circulating and tissue immune cells and upregulated following recognition of microbial structures
- (2011) Mansoureh Hakimi et al. JOURNAL OF NEURAL TRANSMISSION
- Microglial phagocytosis induced by fibrillar β-amyloid is attenuated by oligomeric β-amyloid: implications for Alzheimer's disease
- (2011) Xiao-dong Pan et al. Molecular Neurodegeneration
- The kinase LRRK2 is a regulator of the transcription factor NFAT that modulates the severity of inflammatory bowel disease
- (2011) Zhihua Liu et al. NATURE IMMUNOLOGY
- Coordinate Regulation of Neurite Outgrowth by LRRK2 and Its Interactor, Rab5
- (2011) Hye Young Heo et al. Experimental Neurobiology
- LRRK2 Is Involved in the IFN- Response and Host Response to Pathogens
- (2010) A. Gardet et al. JOURNAL OF IMMUNOLOGY
- LRRK2 is expressed in B-2 but not in B-1 B cells, and downregulated by cellular activation
- (2010) Makoto Kubo et al. JOURNAL OF NEUROIMMUNOLOGY
- Characterization of the microglial phenotype under specific pro-inflammatory and anti-inflammatory conditions: Effects of oligomeric and fibrillar amyloid-β
- (2009) Alessandro Michelucci et al. JOURNAL OF NEUROIMMUNOLOGY
- Microglia Mediate the Clearance of Soluble A through Fluid Phase Macropinocytosis
- (2009) S. Mandrekar et al. JOURNAL OF NEUROSCIENCE
- Leucine-Rich Repeat Kinase 2 Regulates the Progression of Neuropathology Induced by Parkinson's-Disease-Related Mutant α-synuclein
- (2009) Xian Lin et al. NEURON
- Clearance and deposition of extracellular α-synuclein aggregates in microglia
- (2008) He-Jin Lee et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- LRRK2 regulates synaptic vesicle endocytosis
- (2008) Narae Shin et al. EXPERIMENTAL CELL RESEARCH
- Assembly-dependent endocytosis and clearance of extracellular a-synuclein
- (2008) He-Jin Lee et al. INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
- Lewy bodies in grafted neurons in subjects with Parkinson's disease suggest host-to-graft disease propagation
- (2008) Jia-Yi Li et al. NATURE MEDICINE
- Lewy body–like pathology in long-term embryonic nigral transplants in Parkinson's disease
- (2008) Jeffrey H Kordower et al. NATURE MEDICINE
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