Targeting Microglial α-Synuclein/TLRs/NF-kappaB/NLRP3 Inflammasome Axis in Parkinson’s Disease

α‐Synuclein evokes NLRP3 inflammasome‐mediated IL ‐1β secretion from primary human microglia

(2021) Adrianne F. Pike et al.   GLIA

Soluble α-synuclein–antibody complexes activate the NLRP3 inflammasome in hiPSC-derived microglia

(2021) Dorit Trudler et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Systemic activation of NLRP3 inflammasome and plasma α-synuclein levels are correlated with motor severity and progression in Parkinson’s disease

(2020) Zheng Fan et al.   Journal of Neuroinflammation

Alpha-synuclein-induced mitochondrial dysfunction is mediated via a sirtuin 3-dependent pathway

(2020) Jae-Hyeon Park et al.   Molecular Neurodegeneration

Targeting α-synuclein for PD Therapeutics: A Pursuit on All Fronts

(2020) Margaux Teil et al.   Biomolecules

Microglial exosomes facilitate α-synuclein transmission in Parkinson’s disease

(2020) Min Guo et al.   BRAIN

[18F]-DPA-714 PET as a specific in vivo marker of early microglial activation in a rat model of progressive dopaminergic degeneration

(2020) Tatiana Rodríguez-Chinchilla et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

Microglia clear neuron-released α-synuclein via selective autophagy and prevent neurodegeneration

(2020) Insup Choi et al.   Nature Communications

IL‐1β/IL‐1R1 signaling induced by intranasal lipopolysaccharide infusion regulates alpha‐synuclein pathology in the olfactory bulb, substantia nigra and striatum

(2020) Haichen Niu et al.   BRAIN PATHOLOGY

Safety and immunogenicity of the α-synuclein active immunotherapeutic PD01A in patients with Parkinson's disease: a randomised, single-blinded, phase 1 trial

(2020) Dieter Volc et al.   LANCET NEUROLOGY

Fasudil Promotes α-Synuclein Clearance in an AAV-Mediated α-Synuclein Rat Model of Parkinson’s Disease by Autophagy Activation

(2020) Yu-Jie Yang et al.   Journal of Parkinsons Disease

Inflammation in Parkinson’s Disease: Mechanisms and Therapeutic Implications

(2020) Marta Pajares et al.   Cells

Andrographolide suppresses NLRP3 inflammasome activation in microglia through induction of parkin-mediated mitophagy in in-vitro and in-vivo models of Parkinson disease

(2020) Sahabuddin Ahmed et al.   BRAIN BEHAVIOR AND IMMUNITY

Naphthoquinone‐Dopamine hybrids inhibit α‐synuclein aggregation, disrupt preformed fibrils and attenuate aggregate‐induced toxicity

(2020) Ashim Paul et al.   CHEMISTRY-A EUROPEAN JOURNAL

CLR01 protects dopaminergic neurons in vitro and in mouse models of Parkinson’s disease

(2020) Nora Bengoa-Vergniory et al.   Nature Communications

Targeting α-synuclein by PD03 AFFITOPE® and Anle138b rescues neurodegenerative pathology in a model of multiple system atrophy: clinical relevance

(2020) Miguel Lemos et al.   Translational Neurodegeneration

Targeting microglial autophagic degradation in NLRP3 inflammasome-mediated neurodegenerative diseases

(2020) An-Guo Wu et al.   AGEING RESEARCH REVIEWS

CMT-3 targets different α-synuclein aggregates mitigating their toxic and inflammogenic effects

(2020) Florencia González-Lizárraga et al.   Scientific Reports

Neuroinflammation in neurodegenerative disorders: the roles of microglia and astrocytes

(2020) Hyuk Sung Kwon et al.   Translational Neurodegeneration

PET imaging reveals early and progressive dopaminergic deficits after intra-striatal injection of preformed alpha-synuclein fibrils in rats

(2020) Majken B. Thomsen et al.   NEUROBIOLOGY OF DISEASE

The molecular tweezer CLR01 inhibits aberrant superoxide dismutase 1 (SOD1) self-assembly in vitro and in the G93A-SOD1 mouse model of ALS

(2019) Ravinder Malik et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Long-term RNAi knockdown of α-synuclein in the adult rat substantia nigra without neurodegeneration

(2019) Alevtina Zharikov et al.   NEUROBIOLOGY OF DISEASE

Plant Extracts and Phytochemicals Targeting α-Synuclein Aggregation in Parkinson's Disease Models

(2019) Hayate Javed et al.   Frontiers in Pharmacology

Multikinase Abl/DDR/Src Inhibition Produces Optimal Effects for Tyrosine Kinase Inhibition in Neurodegeneration

(2019) Alan J. Fowler et al.   Drugs in research & development

Microglia as modulators of exosomal alpha-synuclein transmission

(2019) Yun Xia et al.   Cell Death & Disease

Farrerol attenuates MPP+ -induced inflammatory response by TLR4 signaling in a microglia cell line

(2019) Bei Cui et al.   PHYTOTHERAPY RESEARCH

Kaempferol Attenuates LPS-Induced Striatum Injury in Mice Involving Anti-Neuroinflammation, Maintaining BBB Integrity, and Down-Regulating the HMGB1/TLR4 Pathway

(2019) Ying-Lin Yang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Naturally occurring antibodies isolated from PD patients inhibit synuclein seeding in vitro and recognize Lewy pathology

(2019) Xinyi Li et al.   ACTA NEUROPATHOLOGICA

Small molecule-driven NLRP3 inflammation inhibition via interplay between ubiquitination and autophagy: implications for Parkinson disease

(2019) Xiaojuan Han et al.   Autophagy

Temporal evolution of microglia and α-synuclein accumulation following foetal grafting in Parkinson’s disease

(2019) C Warren Olanow et al.   BRAIN

Targeting α-Synuclein in Parkinson’s Disease: Progress Towards the Development of Disease-Modifying Therapeutics

(2019) Daniel Savitt et al.   DRUGS

Fyn kinase regulates misfolded α-synuclein uptake and NLRP3 inflammasome activation in microglia

(2019) Nikhil Panicker et al.   JOURNAL OF EXPERIMENTAL MEDICINE

FTY720 Inhibits MPP+-Induced Microglial Activation by Affecting NLRP3 Inflammasome Activation

(2019) Shu Yao et al.   Journal of Neuroimmune Pharmacology

Triptolide Inhibits Preformed Fibril-Induced Microglial Activation by Targeting the MicroRNA155-5p/SHIP1 Pathway

(2019) Yang Feng et al.   Oxidative Medicine and Cellular Longevity

Microglia-mediated neuroinflammation in neurodegenerative diseases

(2019) Charannya Sozheesvari Subhramanyam et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Inhibition of NADPH oxidase by apocynin prevents learning and memory deficits in a mouse Parkinson's disease model

(2019) Liyan Hou et al.   Redox Biology

Increased immune activation by pathologic alpha‐synuclein in Parkinson's Disease

(2019) Veselin Grozdanov et al.   ANNALS OF NEUROLOGY

The molecular tweezer CLR01 reduces aggregated, pathologic, and seeding-competent α-synuclein in experimental multiple system atrophy

(2019) Marcos Herrera-Vaquero et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Progress of immunotherapy of anti-α-synuclein in Parkinson’s disease

(2019) Zhipeng Wang et al.   BIOMEDICINE & PHARMACOTHERAPY

Toll-like receptors and their therapeutic potential in Parkinson’s disease and α-synucleinopathies

(2019) Antonina Kouli et al.   BRAIN BEHAVIOR AND IMMUNITY

Exosomes from patients with Parkinson’s disease are pathological in mice

(2019) Chao Han et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Randomized phase I clinical trial of anti–α‐synuclein antibody BIIB054

(2019) Miroslaw Brys et al.   MOVEMENT DISORDERS

Targeting the microglial NLRP3 inflammasome and its role in Parkinson's disease

(2019) Md. Ezazul Haque et al.   MOVEMENT DISORDERS

Mitochondrial damage by α-synuclein causes cell death in human dopaminergic neurons

(2019) Goutham K. Ganjam et al.   Cell Death & Disease

Inflammasome and α-synuclein in Parkinson's disease: A cross-sectional study

(2019) Koustav Chatterjee et al.   JOURNAL OF NEUROIMMUNOLOGY

Preclinical development of a high affinity α-synuclein antibody, MEDI1341, that can enter the brain, sequester extracellular α-synuclein and attenuate α-synuclein spreading in vivo

(2019) Darren J. Schofield et al.   NEUROBIOLOGY OF DISEASE

Characterization of novel conformation-selective α-synuclein antibodies as potential immunotherapeutic agents for Parkinson's disease

(2019) Michael X. Henderson et al.   NEUROBIOLOGY OF DISEASE

Targeting alpha synuclein and amyloid beta by a multifunctional, brain-penetrant dopamine D2/D3 agonist D-520: Potential therapeutic application in Parkinson’s disease with dementia

(2019) Deepthi Yedlapudi et al.   Scientific Reports

Small molecule modulator of aggrephagy regulates neuroinflammation to curb pathogenesis of neurodegeneration

(2019) Suresh SN et al.   EBioMedicine

Hydroxytyrosol Decreases LPS- and α-Synuclein-Induced Microglial Activation In Vitro

(2019) Marta Gallardo-Fernández et al.   Antioxidants

Juglanin ameliorates LPS-induced neuroinflammation in animal models of Parkinson’s disease and cell culture via inactivating TLR4/NF-κB pathway

(2018) Fang-Xue Zhang et al.   BIOMEDICINE & PHARMACOTHERAPY

Triptolide up-regulates metabotropic glutamate receptor 5 to inhibit microglia activation in the lipopolysaccharide-induced model of Parkinson’s disease

(2018) Yi-Ying Huang et al.   BRAIN BEHAVIOR AND IMMUNITY

Release and uptake of pathologic alpha-synuclein

(2018) Veselin Grozdanov et al.   CELL AND TISSUE RESEARCH

MPTP-driven NLRP3 inflammasome activation in microglia plays a central role in dopaminergic neurodegeneration

(2018) Eunju Lee et al.   CELL DEATH AND DIFFERENTIATION

C-Abl Inhibition; A Novel Therapeutic Target for Parkinson's Disease

(2018) Abdelrahman Ibrahim Abushouk et al.   CNS & Neurological Disorders-Drug Targets

Peripheral monocyte entry is required for alpha-Synuclein induced inflammation and Neurodegeneration in a model of Parkinson disease

(2018) Ashley S. Harms et al.   EXPERIMENTAL NEUROLOGY

Parkin deficiency modulates NLRP3 inflammasome activation by attenuating an A20-dependent negative feedback loop

(2018) François Mouton-Liger et al.   GLIA

Diosgenin Attenuates Lipopolysaccharide-Induced Parkinson’s Disease by Inhibiting the TLR/NF-κB Pathway

(2018) Bingyu Li et al.   JOURNAL OF ALZHEIMERS DISEASE

Triptolide inhibits the inflammatory activities of neutrophils to ameliorate chronic arthritis

(2018) Guangrui Huang et al.   MOLECULAR IMMUNOLOGY

Taurine protects dopaminergic neurons in a mouse Parkinson’s disease model through inhibition of microglial M1 polarization

(2018) Yuning Che et al.   Cell Death & Disease

Safety and Tolerability of Multiple Ascending Doses of PRX002/RG7935, an Anti–α-Synuclein Monoclonal Antibody, in Patients With Parkinson Disease

(2018) Joseph Jankovic et al.   JAMA Neurology

Integrin CD11b mediates α-synuclein-induced activation of NADPH oxidase through a Rho-dependent pathway

(2018) Liyan Hou et al.   Redox Biology

Picomolar concentrations of oligomeric alpha-synuclein sensitizes TLR4 to play an initiating role in Parkinson’s disease pathogenesis

(2018) Craig D. Hughes et al.   ACTA NEUROPATHOLOGICA

Immunotherapy targeting toll-like receptor 2 alleviates neurodegeneration in models of synucleinopathy by modulating α-synuclein transmission and neuroinflammation

(2018) Changyoun Kim et al.   Molecular Neurodegeneration

New mitochondrial DNA synthesis enables NLRP3 inflammasome activation

(2018) Zhenyu Zhong et al.   NATURE

Microglia in neurodegeneration

(2018) Suzanne Hickman et al.   NATURE NEUROSCIENCE

Inflammasome signalling in brain function and neurodegenerative disease

(2018) Michael T. Heneka et al.   NATURE REVIEWS NEUROSCIENCE

miR-146a Attenuates Sepsis-Induced Myocardial Dysfunction by Suppressing IRAK1 and TRAF6 via Targeting ErbB4 Expression

(2018) Rui An et al.   Oxidative Medicine and Cellular Longevity

The small molecule alpha-synuclein misfolding inhibitor, NPT200-11, produces multiple benefits in an animal model of Parkinson’s disease

(2018) Diana L. Price et al.   Scientific Reports

TLR4 absence reduces neuroinflammation and inflammasome activation in Parkinson’s diseases in vivo model

(2018) Michela Campolo et al.   BRAIN BEHAVIOR AND IMMUNITY

Peripheral Immunity, Immunoaging and Neuroinflammation in Parkinson`s Disease

(2018) Kustrimovic Natasa et al.   CURRENT MEDICINAL CHEMISTRY

Calycosin attenuates MPTP-induced Parkinson's disease by suppressing the activation of TLR/NF-κB and MAPK pathways

(2018) Jing Yang et al.   PHYTOTHERAPY RESEARCH

Inflammasome inhibition prevents α-synuclein pathology and dopaminergic neurodegeneration in mice

(2018) Richard Gordon et al.   Science Translational Medicine

The mechanisms of NLRP3 inflammasome/pyroptosis activation and their role in Parkinson's disease

(2018) Shuo Wang et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Development of an aggregate-selective, human-derived α-synuclein antibody BIIB054 that ameliorates disease phenotypes in Parkinson's disease models

(2018) Andreas Weihofen et al.   NEUROBIOLOGY OF DISEASE

Molecular mechanisms and functions of pyroptosis, inflammatory caspases and inflammasomes in infectious diseases

(2017) Si Ming Man et al.   IMMUNOLOGICAL REVIEWS

Chaperone-mediated autophagy and endosomal microautophagy: Jointed by a chaperone

(2017) Kumsal Tekirdag et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Molecular Tweezer CLR01 Stabilizes a Disordered Protein–Protein Interface

(2017) David Bier et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Inhibition of Huntingtin Exon-1 Aggregation by the Molecular Tweezer CLR01

(2017) Tobias Vöpel et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A Molecular Tweezer Ameliorates Motor Deficits in Mice Overexpressing α-Synuclein

(2017) Franziska Richter et al.   Neurotherapeutics

Paraquat and maneb co-exposure induces noradrenergic locus coeruleus neurodegeneration through NADPH oxidase-mediated microglial activation

(2017) Liyan Hou et al.   TOXICOLOGY

MicroRNA-30e regulates neuroinflammation in MPTP model of Parkinson’s disease by targeting Nlrp3

(2017) Dongsheng Li et al.   Human Cell

c-Abl and Parkinson’s Disease: Mechanisms and Therapeutic Potential

(2017) Saurav Brahmachari et al.   Journal of Parkinsons Disease

Parkinson disease

(2017) Werner Poewe et al.   Nature Reviews Disease Primers

α-Synuclein fibrils recruit peripheral immune cells in the rat brain prior to neurodegeneration

(2017) Ashley S. Harms et al.   Acta Neuropathologica Communications

Isobavachalcone Attenuates MPTP-Induced Parkinson's Disease in Mice by Inhibition of Microglial Activation through NF-κB Pathway

(2017) Haoran Jing et al.   PLoS One

Toll-like receptor 2 is increased in neurons in Parkinson’s disease brain and may contribute to alpha-synuclein pathology

(2016) Nicolas Dzamko et al.   ACTA NEUROPATHOLOGICA

Alpha-synuclein activates BV2 microglia dependent on its aggregation state

(2016) Alana Hoffmann et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Ade novocompound targeting α-synuclein improves deficits in models of Parkinson’s disease

(2016) Wolfgang Wrasidlo et al.   BRAIN

NF-κB Restricts Inflammasome Activation via Elimination of Damaged Mitochondria

(2016) Zhenyu Zhong et al.   CELL

α-Mangostin Inhibits α-Synuclein-Induced Microglial Neuroinflammation and Neurotoxicity

(2016) Zhaoyang Hu et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Pyroptosis

(2016) Lieselotte Vande Walle et al.   CURRENT BIOLOGY

Human Monocytes Engage an Alternative Inflammasome Pathway

(2016) Moritz M. Gaidt et al.   IMMUNITY

Triptolide Promotes the Clearance of α-Synuclein by Enhancing Autophagy in Neuronal Cells

(2016) Guanzheng Hu et al.   MOLECULAR NEUROBIOLOGY

FLZ Attenuates α-Synuclein-Induced Neurotoxicity by Activating Heat Shock Protein 70

(2016) Xiu-Qi Bao et al.   MOLECULAR NEUROBIOLOGY

MicroRNA-7 targets Nod-like receptor protein 3 inflammasome to modulate neuroinflammation in the pathogenesis of Parkinson’s disease

(2016) Yan Zhou et al.   Molecular Neurodegeneration

Autophagy and Alpha-Synuclein: Relevance to Parkinson's Disease and Related Synucleopathies

(2016) Maria Xilouri et al.   MOVEMENT DISORDERS

First-in-human assessment of PRX002, an anti-α-synuclein monoclonal antibody, in healthy volunteers

(2016) Dale B. Schenk et al.   MOVEMENT DISORDERS

α-Synuclein binds to TOM20 and inhibits mitochondrial protein import in Parkinson’s disease

(2016) Roberto Di Maio et al.   Science Translational Medicine

Fasudil attenuates aggregation of α-synuclein in models of Parkinson’s disease

(2016) Lars Tatenhorst et al.   Acta Neuropathologica Communications

Non-cell-autonomous Neurotoxicity of α-synuclein Through Microglial Toll-like Receptor 2

(2016) Changyoun Kim et al.   Experimental Neurobiology

Salusin-β induces foam cell formation and monocyte adhesion in human vascular smooth muscle cells via miR155/NOX2/NFκB pathway

(2016) Hai-Jian Sun et al.   Scientific Reports

Amyloid fibrils are the molecular trigger of inflammation in Parkinson's disease

(2015) A. Gustot et al.   BIOCHEMICAL JOURNAL

Exogenous α-synuclein induces toll-like receptor 4 dependent inflammatory responses in astrocytes

(2015) Emmy H. Rannikko et al.   BMC NEUROSCIENCE

Post-treatment with an ultra-low dose of NADPH oxidase inhibitor diphenyleneiodonium attenuates disease progression in multiple Parkinson’s disease models

(2015) Qingshan Wang et al.   BRAIN

Fibril growth and seeding capacity play key roles in α-synuclein-mediated apoptotic cell death

(2015) A-L Mahul-Mellier et al.   CELL DEATH AND DIFFERENTIATION

Reduced plasma taurine level in Parkinson's disease: association with motor severity and levodopa treatment

(2015) Li Zhang et al.   INTERNATIONAL JOURNAL OF NEUROSCIENCE

Lenalidomide reduces microglial activation and behavioral deficits in a transgenic model of Parkinson’s disease

(2015) Elvira Valera et al.   Journal of Neuroinflammation

Hypoestoxide reduces neuroinflammation and α-synuclein accumulation in a mouse model of Parkinson’s disease

(2015) Changyoun Kim et al.   Journal of Neuroinflammation

Targeting α-synuclein for treatment of Parkinson's disease: mechanistic and therapeutic considerations

(2015) Benjamin Dehay et al.   LANCET NEUROLOGY

Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling

(2015) Nobuhiko Kayagaki et al.   NATURE

Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death

(2015) Jianjin Shi et al.   NATURE

Structural characterization of toxic oligomers that are kinetically trapped during α-synuclein fibril formation

(2015) Serene W. Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Activation of MyD88-dependent TLR1/2 signaling by misfolded α-synuclein, a protein linked to neurodegenerative disorders

(2015) Stefano G. Daniele et al.   Science Signaling

Antagonizing Neuronal Toll-like Receptor 2 Prevents Synucleinopathy by Activating Autophagy

(2015) Changyoun Kim et al.   Cell Reports

Activation of MyD88-dependent TLR1/2 signaling by misfolded α-synuclein, a protein linked to neurodegenerative disorders

(2015) Stefano G. Daniele et al.   Science Signaling

Subpicomolar diphenyleneiodonium inhibits microglial NADPH oxidase with high specificity and shows great potential as a therapeutic agent for neurodegenerative diseases

(2014) Qingshan Wang et al.   GLIA

2-Cyclopropylimino-3-Methyl-1,3-Thiazoline Hydrochloride Inhibits Microglial Activation by Suppression of Nuclear Factor-Kappa B and Mitogen-Activated Protein Kinase Signaling

(2014) Eun-A Kim et al.   Journal of Neuroimmune Pharmacology

Inflammatory caspases are innate immune receptors for intracellular LPS

(2014) Jianjin Shi et al.   NATURE

The NLRP3 inflammasome is released as a particulate danger signal that amplifies the inflammatory response

(2014) Alberto Baroja-Mazo et al.   NATURE IMMUNOLOGY

Inflammasomes in the CNS

(2014) John G. Walsh et al.   NATURE REVIEWS NEUROSCIENCE

A novel α-synuclein mutation A53E associated with atypical multiple system atrophy and Parkinson's disease-type pathology

(2014) Petra Pasanen et al.   NEUROBIOLOGY OF AGING

G51D α-synuclein mutation causes a novel Parkinsonian-pyramidal syndrome

(2013) Suzanne Lesage et al.   ANNALS OF NEUROLOGY

Neuroinflammation and α-synuclein accumulation in response to glucocerebrosidase deficiency are accompanied by synaptic dysfunction

(2013) Edward I. Ginns et al.   MOLECULAR GENETICS AND METABOLISM

Alpha-synuclein p.H50Q, a novel pathogenic mutation for Parkinson's disease

(2013) Silke Appel-Cresswell et al.   MOVEMENT DISORDERS

A novel  -synuclein missense mutation in Parkinson disease

(2013) C. Proukakis et al.   NEUROLOGY

Microglia, Amyloid and Glucose Metabolism in Parkinson’s Disease with and without Dementia

(2013) Paul Edison et al.   NEUROPSYCHOPHARMACOLOGY

Triggering of Inflammasome by Aggregated α–Synuclein, an Inflammatory Response in Synucleinopathies

(2013) Gaia Codolo et al.   PLoS One

Cytoplasmic LPS Activates Caspase-11: Implications in TLR4-Independent Endotoxic Shock

(2013) J. A. Hagar et al.   SCIENCE

Neuron-released oligomeric α-synuclein is an endogenous agonist of TLR2 for paracrine activation of microglia

(2013) Changyoun Kim et al.   Nature Communications

Taurine and inflammatory diseases

(2012) Janusz Marcinkiewicz et al.   AMINO ACIDS

Taurine and central nervous system disorders

(2012) Janet Menzie et al.   AMINO ACIDS

Inflammasomes and Their Roles in Health and Disease

(2012) Mohamed Lamkanfi et al.   Annual Review of Cell and Developmental Biology

Fibrillar α-Synuclein and Huntingtin Exon 1 Assemblies Are Toxic to the Cells

(2012) Laura Pieri et al.   BIOPHYSICAL JOURNAL

Protection of primary neurons and mouse brain from Alzheimer's pathology by molecular tweezers

(2012) A. Attar et al.   BRAIN

Schisandrin B exerts anti-neuroinflammatory activity by inhibiting the Toll-like receptor 4-dependent MyD88/IKK/NF-κB signaling pathway in lipopolysaccharide-induced microglia

(2012) Ke-Wu Zeng et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Regionally-specific microglial activation in young mice over-expressing human wildtype alpha-synuclein

(2012) Melanie B. Watson et al.   EXPERIMENTAL NEUROLOGY

Regulation of the MIR155 host gene in physiological and pathological processes

(2012) Terry S. Elton et al.   GENE

Alpha-synuclein impairs normal dynamics of mitochondria in cell and animal models of Parkinson’s disease

(2012) Weilin Xie et al.   JOURNAL OF NEUROCHEMISTRY

Inflammasomes in health and disease

(2012) Till Strowig et al.   NATURE

The many faces of α-synuclein: from structure and toxicity to therapeutic target

(2012) Hilal A. Lashuel et al.   NATURE REVIEWS NEUROSCIENCE

A Novel “Molecular Tweezer” Inhibitor of α-Synuclein Neurotoxicity in Vitro and in Vivo

(2012) Shubhangi Prabhudesai et al.   Neurotherapeutics

NADPH oxidases: novel therapeutic targets for neurodegenerative diseases

(2012) Hui-Ming Gao et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Toll-Like Receptor 4 Promotes α-Synuclein Clearance and Survival of Nigral Dopaminergic Neurons

(2011) Nadia Stefanova et al.   AMERICAN JOURNAL OF PATHOLOGY

Glia: Initiators and progressors of pathology in Parkinson's disease

(2011) Glenda M. Halliday et al.   MOVEMENT DISORDERS

Triptolide Down-regulates COX-2 Expression and PGE2 Release by Suppressing the Activity of NF-κB and MAP kinases in Lipopolysaccharide-treated PC12 Cells

(2011) Yu Geng et al.   PHYTOTHERAPY RESEARCH

Anti-inflammatory drugs and risk of Parkinson disease: A meta-analysis

(2010) J. J. Gagne et al.   NEUROLOGY

Cutting Edge: TNF-  Mediates Sensitization to ATP and Silica via the NLRP3 Inflammasome in the Absence of Microbial Stimulation

(2009) L. Franchi et al.   JOURNAL OF IMMUNOLOGY

Cutting Edge: NF- B Activating Pattern Recognition and Cytokine Receptors License NLRP3 Inflammasome Activation by Regulating NLRP3 Expression

(2009) F. G. Bauernfeind et al.   JOURNAL OF IMMUNOLOGY

Exogenous  -synuclein fibrils seed the formation of Lewy body-like intracellular inclusions in cultured cells

(2009) K. C. Luk et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Classical Inhibitors of NOX NAD(P)H Oxidases Are Not Specific

(2008) Elisabetta Aldieri et al.   CURRENT DRUG METABOLISM

Assembly-dependent endocytosis and clearance of extracellular a-synuclein

(2008) He-Jin Lee et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Anthrax lethal toxin and Salmonella elicit the common cell death pathway of caspase-1-dependent pyroptosis via distinct mechanisms

(2008) S. L. Fink et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA