Defective Autophagy in Parkinson’s Disease: Role of Oxidative Stress

Paraquat-and Rotenone-Induced Models of Parkinson's Disease

(2017) R. Nisticò et al.   INTERNATIONAL JOURNAL OF IMMUNOPATHOLOGY AND PHARMACOLOGY

Oxidative stress and autophagy

(2012) Ryan J.H. West et al.   Autophagy

The antidote effect of quinone oxidoreductase 2 inhibitor against paraquat-induced toxicityin vitroandin vivo

(2012) Elzbieta Janda et al.   BRITISH JOURNAL OF PHARMACOLOGY

Curcumin: A Potential Neuroprotective Agent in Parkinson's Disease

(2012) R. B. Mythri et al.   CURRENT PHARMACEUTICAL DESIGN

Paraquat, but Not Maneb, Induces Synucleinopathy and Tauopathy in Striata of Mice through Inhibition of Proteasomal and Autophagic Pathways

(2012) Jonathan Wills et al.   PLoS One

Monitoring of transglutaminase2 under different oxidative stress conditions

(2011) Daniela Caccamo et al.   AMINO ACIDS

High Mobility Group Box 1 (HMGB1) Activates an Autophagic Response to Oxidative Stress

(2011) Daolin Tang et al.   ANTIOXIDANTS & REDOX SIGNALING

FIP200, an essential component of mammalian autophagy is indispensible for fetal hematopoiesis

(2011) Fei Liu et al.   Autophagy

DJ-1 regulation of mitochondrial function and autophagy through oxidative stress

(2011) Melissa K. McCoy et al.   Autophagy

Quercetin induces protective autophagy in gastric cancer cells: Involvement of Akt-mTOR- and hypoxia-induced factor 1α-mediated signaling

(2011) Kui Wang et al.   Autophagy

Microautophagy in mammalian cells: Revisiting a 40-year-old conundrum

(2011) Dalibor Mijaljica et al.   Autophagy

Rapamycin treatment augments motor neuron degeneration in SOD1G93Amouse model of amyotrophic lateral sclerosis

(2011) Xiaojie Zhang et al.   Autophagy

EGCG stimulates autophagy and reduces cytoplasmic HMGB1 levels in endotoxin-stimulated macrophages

(2011) Wei Li et al.   BIOCHEMICAL PHARMACOLOGY

Molecular machinery of macroautophagy and its deregulation in diseases

(2011) Alan S.L. Wong et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Autophagy Dysregulation in Amyotrophic Lateral Sclerosis

(2011) Sheng Chen et al.   BRAIN PATHOLOGY

Animal models of Parkinson's disease: a source of novel treatments and clues to the cause of the disease

(2011) Susan Duty et al.   BRITISH JOURNAL OF PHARMACOLOGY

Autophagy as a therapeutic target in cancer

(2011) Ning Chen et al.   CANCER BIOLOGY & THERAPY

PKD is a kinase of Vps34 that mediates ROS-induced autophagy downstream of DAPk

(2011) A Eisenberg-Lerner et al.   CELL DEATH AND DIFFERENTIATION

High-Mobility Group Box 1 Is Essential for Mitochondrial Quality Control

(2011) Daolin Tang et al.   Cell Metabolism

Autophagic activity in cortical neurons under acute oxidative stress directly contributes to cell death

(2011) Gavin C. Higgins et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Dopamine-derived biological reactive intermediates and protein modifications: Implications for Parkinson's disease

(2011) Yunden Jinsmaa et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Parkinson’s disease risk from ambient exposure to pesticides

(2011) Anthony Wang et al.   EUROPEAN JOURNAL OF EPIDEMIOLOGY

Parkin mediates beclin-dependent autophagic clearance of defective mitochondria and ubiquitinated A  in AD models

(2011) P. J. Khandelwal et al.   HUMAN MOLECULAR GENETICS

The Biochemical and Cellular Basis for Nutraceutical Strategies to Attenuate Neurodegeneration in Parkinson’s Disease

(2011) Elizabeth A. Mazzio et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Rac1 Protein Rescues Neurite Retraction Caused by G2019S Leucine-rich Repeat Kinase 2 (LRRK2)

(2011) Diane Chan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Autophagy deregulation in neurodegenerative diseases - recent advances and future perspectives

(2011) Zelda H. Cheung et al.   JOURNAL OF NEUROCHEMISTRY

HMGB1 Acts on Microglia Mac1 to Mediate Chronic Neuroinflammation That Drives Progressive Neurodegeneration

(2011) H.-M. Gao et al.   JOURNAL OF NEUROSCIENCE

Protection Against Dopaminergic Neurodegeneration in Parkinson’s Disease–Model Animals by a Modulator of the Oxidized Form of DJ-1, a Wild-type of Familial Parkinson’s Disease–Linked PARK7

(2011) Masatoshi Inden et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Complex Inhibitory Effects of Nitric Oxide on Autophagy

(2011) Sovan Sarkar et al.   MOLECULAR CELL

Synaptic Protein Alterations in Parkinson’s Disease

(2011) Ilse S. Pienaar et al.   MOLECULAR NEUROBIOLOGY

Modulation of Nrf2/ARE Pathway by Food Polyphenols: A Nutritional Neuroprotective Strategy for Cognitive and Neurodegenerative Disorders

(2011) Giovanni Scapagnini et al.   MOLECULAR NEUROBIOLOGY

Oxidation of the cysteine-rich regions of parkin perturbs its E3 ligase activity and contributes to protein aggregation

(2011) Fanjun Meng et al.   Molecular Neurodegeneration

α-Synuclein occurs physiologically as a helically folded tetramer that resists aggregation

(2011) Tim Bartels et al.   NATURE

Autophagy in immunity and inflammation

(2011) Beth Levine et al.   NATURE

Cdk5-mediated phosphorylation of endophilin B1 is required for induced autophagy in models of Parkinson's disease

(2011) Alan S. L. Wong et al.   NATURE CELL BIOLOGY

Control of autophagy as a therapy for neurodegenerative disease

(2011) Harry Harris et al.   Nature Reviews Neurology

Fighting neurodegeneration with rapamycin: mechanistic insights

(2011) Jordi Bové et al.   NATURE REVIEWS NEUROSCIENCE

In vitro drug treatments reduce the deleterious effects of aggregates containing polyAla expanded PHOX2B proteins

(2011) Eleonora Di Zanni et al.   NEUROBIOLOGY OF DISEASE

In vivo 6-OHDA-induced neurodegeneration and nigral autophagic markers expression

(2011) C. Marin et al.   NEUROCHEMISTRY INTERNATIONAL

Potential autophagy enhancers attenuate rotenone-induced toxicity in SH-SY5Y

(2011) N. Xiong et al.   NEUROSCIENCE

Resveratrol-Activated AMPK/SIRT1/Autophagy in Cellular Models of Parkinson’s Disease

(2011) Yuncheng Wu et al.   NEUROSIGNALS

2-Deoxy-D-Glucose Treatment of Endothelial Cells Induces Autophagy by Reactive Oxygen Species-Mediated Activation of the AMP-Activated Protein Kinase

(2011) Qilong Wang et al.   PLoS One

Oxidative stress induces overgrowth of the Drosophila neuromuscular junction

(2011) V. J. Milton et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

l-DOPA: A scapegoat for accelerated neurodegeneration in Parkinson's disease?

(2011) Janusz Lipski et al.   PROGRESS IN NEUROBIOLOGY

Autophagy Protects Against Aminochrome-Induced Cell Death in Substantia Nigra-Derived Cell Line

(2011) Irmgard Paris et al.   TOXICOLOGICAL SCIENCES

Chelation of Lysosomal Iron Protects Dopaminergic SH-SY5Y Neuroblastoma Cells from Hydrogen Peroxide Toxicity by Precluding Autophagy and Akt Dephosphorylation

(2011) Roberta Castino et al.   TOXICOLOGICAL SCIENCES

Regulation of lipid droplets by autophagy

(2011) Hanqing Dong et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

The Origins of Oxidant Stress in Parkinson's Disease and Therapeutic Strategies

(2010) Dalton James Surmeier et al.   ANTIOXIDANTS & REDOX SIGNALING

The Extending Network of FOXO Transcriptional Target Genes

(2010) Kristan E. van der Vos et al.   ANTIOXIDANTS & REDOX SIGNALING

p62/SQSTM1 is required for Parkin-induced mitochondrial clustering but not mitophagy; VDAC1 is dispensable for both

(2010) Derek Narendra et al.   Autophagy

Cystic fibrosis: A disorder with defective autophagy

(2010) Alessandro Luciani et al.   Autophagy

Binding preference of p62 towards LC3-ll during dopaminergic neurotoxin-induced impairment of autophagic flux

(2010) Junghyun Lim et al.   Autophagy

Neuroprotective properties of resveratrol in different neurodegenerative disorders

(2010) Diego Albani et al.   BIOFACTORS

Effects of cysteamine on MPTP-induced dopaminergic neurodegeneration in mice

(2010) Linjuan Sun et al.   BRAIN RESEARCH

The protective effect of tianeptine on Gp120-induced apoptosis in astroglial cells: role of GS and NOS, and NF-κB suppression

(2010) Elzbieta Janda et al.   BRITISH JOURNAL OF PHARMACOLOGY

Defective autophagy control by the p53 rheostat in cancer

(2010) Lorenzo Galluzzi et al.   CELL CYCLE

The Parkinson-associated protein PINK1 interacts with Beclin1 and promotes autophagy

(2010) S Michiorri et al.   CELL DEATH AND DIFFERENTIATION

Paraquat and Parkinson's disease

(2010) C Berry et al.   CELL DEATH AND DIFFERENTIATION

Apoptosis in Parkinson's disease: Is p53 the missing link between genetic and sporadic Parkinsonism?

(2010) Cristine Alves da Costa et al.   CELLULAR SIGNALLING

Chaperone-mediated autophagy in protein quality control

(2010) Esperanza Arias et al.   CURRENT OPINION IN CELL BIOLOGY

Reactive oxygen species, cellular redox systems, and apoptosis

(2010) Magdalena L. Circu et al.   FREE RADICAL BIOLOGY AND MEDICINE

Astrocyte-derived metallothionein protects dopaminergic neurons from dopamine quinone toxicity

(2010) Ikuko Miyazaki et al.   GLIA

Mitofusin 1 and mitofusin 2 are ubiquitinated in a PINK1/parkin-dependent manner upon induction of mitophagy

(2010) Matthew E. Gegg et al.   HUMAN MOLECULAR GENETICS

Loss of the Parkinson's disease-linked gene DJ-1 perturbs mitochondrial dynamics

(2010) I. Irrcher et al.   HUMAN MOLECULAR GENETICS

Antioxidants can inhibit basal autophagy and enhance neurodegeneration in models of polyglutamine disease

(2010) B. R. Underwood et al.   HUMAN MOLECULAR GENETICS

Genetic etiology of Parkinson disease associated with mutations in the SNCA, PARK2, PINK1, PARK7, and LRRK2 genes: a mutation update

(2010) Karen Nuytemans et al.   HUMAN MUTATION

Lysosomal Degradation of α-Synucleinin Vivo

(2010) Sally K. Mak et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

α-Synuclein impairs macroautophagy: implications for Parkinson’s disease

(2010) Ashley R. Winslow et al.   JOURNAL OF CELL BIOLOGY

PINK1 stabilized by mitochondrial depolarization recruits Parkin to damaged mitochondria and activates latent Parkin for mitophagy

(2010) Noriyuki Matsuda et al.   JOURNAL OF CELL BIOLOGY

Endogenous HMGB1 regulates autophagy

(2010) Daolin Tang et al.   JOURNAL OF CELL BIOLOGY

Pathogenic Lysosomal Depletion in Parkinson's Disease

(2010) B. Dehay et al.   JOURNAL OF NEUROSCIENCE

Oxidant stress evoked by pacemaking in dopaminergic neurons is attenuated by DJ-1

(2010) Jaime N. Guzman et al.   NATURE

Defective CFTR induces aggresome formation and lung inflammation in cystic fibrosis through ROS-mediated autophagy inhibition

(2010) Alessandro Luciani et al.   NATURE CELL BIOLOGY

PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1

(2010) Sven Geisler et al.   NATURE CELL BIOLOGY

Neuroprotection of kaempferol by autophagy in models of rotenone-mediated acute toxicity: possible implications for Parkinson's disease

(2010) Giuseppe Filomeni et al.   NEUROBIOLOGY OF AGING

Chaperone-mediated autophagy dysfunction in the pathogenesis of neurodegeneration

(2010) Hiroshi Koga et al.   NEUROBIOLOGY OF DISEASE

Synaptic dysfunction in genetic models of Parkinson's disease: A role for autophagy?

(2010) Edward D. Plowey et al.   NEUROBIOLOGY OF DISEASE

Neuroprotection of deferoxamine on rotenone-induced injury via accumulation of HIF-1α and induction of autophagy in SH-SY5Y cells

(2010) Yuncheng Wu et al.   NEUROCHEMISTRY INTERNATIONAL

Genetic Analysis of Pathways to Parkinson Disease

(2010) John Hardy   NEURON

Autophagy protects the rotenone-induced cell death in α-synuclein overexpressing SH-SY5Y cells

(2010) Shorafidinkhuja Dadakhujaev et al.   NEUROSCIENCE LETTERS

Reduced Basal Autophagy and Impaired Mitochondrial Dynamics Due to Loss of Parkinson's Disease-Associated Protein DJ-1

(2010) Guido Krebiehl et al.   PLoS One

The Mitochondrial Fusion-Promoting Factor Mitofusin Is a Substrate of the PINK1/Parkin Pathway

(2010) Angela C. Poole et al.   PLoS One

Oral N-Acetyl-Cysteine Attenuates Loss of Dopaminergic Terminals in α-Synuclein Overexpressing Mice

(2010) Joanne Clark et al.   PLoS One

Drosophila Parkin requires PINK1 for mitochondrial translocation and ubiquitinates Mitofusin

(2010) E. Ziviani et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Phosphorylation of ULK1 (hATG1) by AMP-Activated Protein Kinase Connects Energy Sensing to Mitophagy

(2010) D. F. Egan et al.   SCIENCE

Role of Astrocytes in Brain Function and Disease

(2010) Marta Sidoryk-Wegrzynowicz et al.   TOXICOLOGIC PATHOLOGY

Inhibition of PI3k Class III–Dependent Autophagy Prevents Apoptosis and Necrosis by Oxidative Stress in Dopaminergic Neuroblastoma Cells

(2010) Roberta Castino et al.   TOXICOLOGICAL SCIENCES

ASK1 Overexpression Accelerates Paraquat-Induced Autophagy via Endoplasmic Reticulum Stress

(2010) Mireia Niso-Santano et al.   TOXICOLOGICAL SCIENCES

Astrocytic expression of Parkinson's disease-related A53T α-synuclein causes neurodegeneration in mice

(2010) Xing-Long Gu et al.   Molecular Brain

PINK1 Is Selectively Stabilized on Impaired Mitochondria to Activate Parkin

(2010) Derek P. Narendra et al.   PLOS BIOLOGY

Metabolic Activity Determines Efficacy of Macroautophagic Clearance of Pathological Oligomeric α-Synuclein

(2009) Wai Haung Yu et al.   AMERICAN JOURNAL OF PATHOLOGY

Regulation Mechanisms and Signaling Pathways of Autophagy

(2009) Congcong He et al.   Annual Review of Genetics

Olomoucine inhibits cathepsin L nuclear translocation, activates autophagy and attenuates toxicity of 6-hydroxydopamine

(2009) Xi-Feng Fei et al.   BRAIN RESEARCH

Autophagy Suppresses Tumorigenesis through Elimination of p62

(2009) Robin Mathew et al.   CELL

Superoxide is the major reactive oxygen species regulating autophagy

(2009) Y Chen et al.   CELL DEATH AND DIFFERENTIATION

Mammalian autophagy: core molecular machinery and signaling regulation

(2009) Zhifen Yang et al.   CURRENT OPINION IN CELL BIOLOGY

Modulation of intracellular ROS levels by TIGAR controls autophagy

(2009) Karim Bensaad et al.   EMBO JOURNAL

The transcription factor Nrf2 as a new therapeutic target in Parkinson's disease

(2009) Antonio Cuadrado et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

DJ-1 and prevention of oxidative stress in Parkinson's disease and other age-related disorders

(2009) Philipp J. Kahle et al.   FREE RADICAL BIOLOGY AND MEDICINE

LRRK2 regulates autophagic activity and localizes to specific membrane microdomains in a novel human genomic reporter cellular model

(2009) Javier Alegre-Abarrategui et al.   HUMAN MOLECULAR GENETICS

The role of dopamine oxidation in mitochondrial dysfunction: implications for Parkinson’s disease

(2009) Teresa G. Hastings   JOURNAL OF BIOENERGETICS AND BIOMEMBRANES

Autophagy promotes synapse development inDrosophila

(2009) Wei Shen et al.   JOURNAL OF CELL BIOLOGY

Silencing DJ-1 reveals its contribution in paraquat-induced autophagy

(2009) Rosa A. González-Polo et al.   JOURNAL OF NEUROCHEMISTRY

A novel mTOR activating protein protects dopamine neurons against oxidative stress by repressing autophagy related cell death

(2009) Kyou-Chan Choi et al.   JOURNAL OF NEUROCHEMISTRY

Parkinson's disease

(2009) Andrew J Lees et al.   LANCET

Oxidative modifications, mitochondrial dysfunction, and impaired protein degradation in Parkinson's disease: how neurons are lost in the Bermuda triangle

(2009) Kristen A Malkus et al.   Molecular Neurodegeneration

Autophagy regulates lipid metabolism

(2009) Rajat Singh et al.   NATURE

A subdomain of the endoplasmic reticulum forms a cradle for autophagosome formation

(2009) Mitsuko Hayashi-Nishino et al.   NATURE CELL BIOLOGY

Two Beclin 1-binding proteins, Atg14L and Rubicon, reciprocally regulate autophagy at different stages

(2009) Kohichi Matsunaga et al.   NATURE CELL BIOLOGY

Rapamycin activation of 4E-BP prevents parkinsonian dopaminergic neuron loss

(2009) Luke S Tain et al.   NATURE NEUROSCIENCE

Neuroinflammation in Parkinson's disease: Its role in neuronal death and implications for therapeutic intervention

(2009) Malú G. Tansey et al.   NEUROBIOLOGY OF DISEASE

MPP+ impairs autophagic clearance of alpha-synuclein by impairing the activity of dynein

(2009) Zeng-Lin Cai et al.   NEUROREPORT

Rapamycin protects against rotenone-induced apoptosis through autophagy induction

(2009) T. Pan et al.   NEUROSCIENCE

Abberant α-Synuclein Confers Toxicity to Neurons in Part through Inhibition of Chaperone-Mediated Autophagy

(2009) Maria Xilouri et al.   PLoS One

Dopamine-Induced Conformational Changes in Alpha-Synuclein

(2009) Tiago F. Outeiro et al.   PLoS One

Postmortem Analyses Unveil the Poor Efficacy of Decontamination, Anti-Inflammatory and Immunosuppressive Therapies in Paraquat Human Intoxications

(2009) Ricardo Jorge Dinis-Oliveira et al.   PLoS One

PINK1-dependent recruitment of Parkin to mitochondria in mitophagy

(2009) C. Vives-Bauza et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Differential Contribution of the Mitochondrial Respiratory Chain Complexes to Reactive Oxygen Species Production by Redox Cycling Agents Implicated in Parkinsonism

(2009) Derek A. Drechsel et al.   TOXICOLOGICAL SCIENCES

Environmental toxins and Parkinson's disease: what have we learned from pesticide-induced animal models?

(2009) Francesca Cicchetti et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Unsaturated lipid peroxidation-derived aldehydes activate autophagy in vascular smooth-muscle cells

(2008) Bradford G. Hill et al.   BIOCHEMICAL JOURNAL

Role of non-canonical Beclin 1-independent autophagy in cell death induced by resveratrol in human breast cancer cells

(2008) F Scarlatti et al.   CELL DEATH AND DIFFERENTIATION

Synergistic antiglioma action of hyperthermia and nitric oxide

(2008) Kristina Janjetovic et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Oxidative and nitrative protein modifications in Parkinson's disease

(2008) Steven R. Danielson et al.   FREE RADICAL BIOLOGY AND MEDICINE

Role of reactive oxygen species in the neurotoxicity of environmental agents implicated in Parkinson's disease

(2008) Derek A. Drechsel et al.   FREE RADICAL BIOLOGY AND MEDICINE

Aberrant molecular properties shared by familial Parkinson’s disease-associated mutant UCH-L1 and carbonyl-modified UCH-L1

(2008) Tomohiro Kabuta et al.   HUMAN MOLECULAR GENETICS

Quinone Reductase 2 Is a Catechol Quinone Reductase

(2008) Yue Fu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Aberrant Interaction between Parkinson Disease-associated Mutant UCH-L1 and the Lysosomal Receptor for Chaperone-mediated Autophagy

(2008) Tomohiro Kabuta et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Identification of Nitric Oxide as an Endogenous Activator of the AMP-activated Protein Kinase in Vascular Endothelial Cells

(2008) Junhua Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Parkin is recruited selectively to impaired mitochondria and promotes their autophagy

(2008) Derek Narendra et al.   JOURNAL OF CELL BIOLOGY

Suppression of autophagy precipitates neuronal cell death following low doses of methamphetamine

(2008) Roberta Castino et al.   JOURNAL OF NEUROCHEMISTRY

Identification of Genes Associated with Paraquat-Induced Toxicity in SH-SY5Y Cells by PCR Array Focused on Apoptotic Pathways

(2008) José M. Morán et al.   JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES

JNK1-Mediated Phosphorylation of Bcl-2 Regulates Starvation-Induced Autophagy

(2008) Yongjie Wei et al.   MOLECULAR CELL

Botanical Phenolics and Brain Health

(2008) Albert Y. Sun et al.   NEUROMOLECULAR MEDICINE

Protection against Parkinson’s disease progression: Clinical experience

(2008) Peter A. LeWitt et al.   Neurotherapeutics

Chloroquine-induced nitric oxide increase and cell death is dependent on cellular GSH depletion in A172 human glioblastoma cells

(2008) Byung Chul Park et al.   TOXICOLOGY LETTERS

Parkinson's disease and pesticides: a toxicological perspective

(2008) J HATCHER et al.   TRENDS IN PHARMACOLOGICAL SCIENCES