Enhancing the Astrocytic Clearance of Extracellular α-Synuclein Aggregates by Ginkgolides Attenuates Neural Cell Injury

Overexpression of α-synuclein in an astrocyte cell line promotes autophagy inhibition and apoptosis

(2017) Adolfo Garcia Erustes et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Past, present, and future of Parkinson's disease: A special essay on the 200th Anniversary of the Shaking Palsy

(2017) J.A. Obeso et al.   MOVEMENT DISORDERS

Novel animal model defines genetic contributions for neuron-to-neuron transfer of α-synuclein

(2017) Trevor Tyson et al.   Scientific Reports

Proteolysis of α-synuclein fibrils in the lysosomal pathway limits induction of inclusion pathology

(2016) Amanda N. Sacino et al.   JOURNAL OF NEUROCHEMISTRY

Pathological  -synuclein transmission initiated by binding lymphocyte-activation gene 3

(2016) X. Mao et al.   SCIENCE

A strategy for screening antioxidants in Ginkgo biloba extract by comprehensive two-dimensional ultra high performance liquid chromatography

(2015) Ru-Zhou Guo et al.   JOURNAL OF CHROMATOGRAPHY A

Parkinson's disease

(2015) Lorraine V Kalia et al.   LANCET

Ginkgo bilobaExtract Improves Insulin Signaling and Attenuates Inflammation in Retroperitoneal Adipose Tissue Depot of Obese Rats

(2015) Bruna Kelly Sousa Hirata et al.   MEDIATORS OF INFLAMMATION

Antagonizing Neuronal Toll-like Receptor 2 Prevents Synucleinopathy by Activating Autophagy

(2015) Changyoun Kim et al.   Cell Reports

Extracellular α-synuclein—a novel and crucial factor in Lewy body diseases

(2014) He-Jin Lee et al.   Nature Reviews Neurology

Prognostic impact of Beclin 1, p62/sequestosome 1 and LC3 protein expression in colon carcinomas from patients receiving 5-fluorouracil as adjuvant chemotherapy

(2013) Jae Myung Park et al.   CANCER BIOLOGY & THERAPY

The nuclear accumulation of alpha-synuclein is mediated by importin alpha and promotes neurotoxicity by accelerating the cell cycle

(2013) Kai-Li Ma et al.   NEUROPHARMACOLOGY

Polo-like kinase 2 regulates selective autophagic  -synuclein clearance and suppresses its toxicity in vivo

(2013) A. Oueslati et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Neuron-released oligomeric α-synuclein is an endogenous agonist of TLR2 for paracrine activation of microglia

(2013) Changyoun Kim et al.   Nature Communications

Protein degradation pathways in Parkinson’s disease: curse or blessing

(2012) Darius Ebrahimi-Fakhari et al.   ACTA NEUROPATHOLOGICA

Neuronal Autophagy,  -Synuclein Clearance, and LRRK2 Regulation: A Lost Equilibrium in Parkinsonian Brain

(2012) N. Plotegher et al.   JOURNAL OF NEUROSCIENCE

Hepatocellular Carcinomas in B6C3F1 Mice Treated with Ginkgo biloba Extract for Two Years Differ from Spontaneous Liver Tumors in Cancer Gene Mutations and Genomic Pathways

(2012) Mark J. Hoenerhoff et al.   TOXICOLOGIC PATHOLOGY

Autophagy: Renovation of Cells and Tissues

(2011) Noboru Mizushima et al.   CELL

Neuroinflammation and α-Synuclein Dysfunction Potentiate Each Other, Driving Chronic Progression of Neurodegeneration in a Mouse Model of Parkinson’s Disease

(2011) Hui-Ming Gao et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Phosphorylated α-synuclein can be detected in blood plasma and is potentially a useful biomarker for Parkinson's disease

(2011) Penelope G. Foulds et al.   FASEB JOURNAL

Pathological roles of α-synuclein in neurological disorders

(2011) Kostas Vekrellis et al.   LANCET NEUROLOGY

The accumulation of neurotoxic proteins, induced by proteasome inhibition, is reverted by trehalose, an enhancer of autophagy, in human neuroblastoma cells

(2011) M.J. Casarejos et al.   NEUROCHEMISTRY INTERNATIONAL

Exogenous α-Synuclein Fibrils Induce Lewy Body Pathology Leading to Synaptic Dysfunction and Neuron Death

(2011) Laura A. Volpicelli-Daley et al.   NEURON

Bilobalide prevents apoptosis through activation of the PI3K/Akt pathway in SH-SY5Y cells

(2010) Chun Shi et al.   APOPTOSIS

The Ginkgo biloba extract EGb 761® and its main constituent flavonoids and ginkgolides increase extracellular dopamine levels in the rat prefrontal cortex

(2010) T Yoshitake et al.   BRITISH JOURNAL OF PHARMACOLOGY

Ginkgolide B protects hippocampal neurons from apoptosis induced by beta-amyloid 25–35 partly via up-regulation of brain-derived neurotrophic factor

(2010) Qian Xiao et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Lysosomal Degradation of α-Synucleinin Vivo

(2010) Sally K. Mak et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inclusion formation and neuronal cell death through neuron-to-neuron transmission of  -synuclein

(2009) P. Desplats et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Clearance and deposition of extracellular α-synuclein aggregates in microglia

(2008) He-Jin Lee et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Assembly-dependent endocytosis and clearance of extracellular a-synuclein

(2008) He-Jin Lee et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Controlling the mass action of α-synuclein in Parkinson’s disease

(2008) Changyoun Kim et al.   JOURNAL OF NEUROCHEMISTRY

A Transcriptome Database for Astrocytes, Neurons, and Oligodendrocytes: A New Resource for Understanding Brain Development and Function

(2008) J. D. Cahoy et al.   JOURNAL OF NEUROSCIENCE

Effects of ginkgolide B on neuronal discharges in paraventricular nucleus of rat hypothalamic slices

(2008) Yue Lin et al.   Neuroscience Bulletin