Microglial M1/M2 polarization and metabolic states

Inflammasome-Independent Regulation of IL-1-Family Cytokines

(2015) Mihai G. Netea et al.   Annual Review of Immunology

Differential effects of lipopolysaccharide on energy metabolism in murine microglial N9 and cholinergic SN56 neuronal cells

(2015) Joanna Klimaszewska-Łata et al.   JOURNAL OF NEUROCHEMISTRY

Differential Roles of M1 and M2 Microglia in Neurodegenerative Diseases

(2015) Yu Tang et al.   MOLECULAR NEUROBIOLOGY

M1 and M2 immune activation in Parkinson’s Disease: Foe and ally?

(2015) M.S. Moehle et al.   NEUROSCIENCE

Protective and Toxic Neuroinflammation in Amyotrophic Lateral Sclerosis

(2015) Kristopher G. Hooten et al.   Neurotherapeutics

Proinflammatory-Activated Glioma Cells Induce a Switch in Microglial Polarization and Activation Status, From a Predominant M2b Phenotype to a Mixture of M1 and M2a/B Polarized Cells

(2014) Lucia Lisi et al.   ASN Neuro

Innate immune memory: towards a better understanding of host defense mechanisms

(2014) Jessica Quintin et al.   CURRENT OPINION IN IMMUNOLOGY

NADPH oxidase- and mitochondria-derived reactive oxygen species in proinflammatory microglial activation: a bipartisan affair?

(2014) Evan A. Bordt et al.   FREE RADICAL BIOLOGY AND MEDICINE

Differential role of CCR2 in the dynamics of microglia and perivascular macrophages during prion disease

(2014) Diego Gómez-Nicola et al.   GLIA

Macrophage Activation and Polarization: Nomenclature and Experimental Guidelines

(2014) Peter J. Murray et al.   IMMUNITY

Transcriptomic analysis of mononuclear phagocyte differentiation and activation

(2014) David A. Hume et al.   IMMUNOLOGICAL REVIEWS

Activation and Regulation of Cellular Inflammasomes: Gaps in Our Knowledge for Central Nervous System Injury

(2014) Juan Pablo de Rivero Vaccari et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Differential roles of microglia and monocytes in the inflamed central nervous system

(2014) Ryo Yamasaki et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Macrophage Polarization in Bacterial Infections

(2014) M. Benoit et al.   JOURNAL OF IMMUNOLOGY

Interactions Between Microglia and T Cells in Multiple Sclerosis Pathobiology

(2014) Megan Strachan-Whaley et al.   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

Deoxyglucose prevents neurodegeneration in culture by eliminating microglia

(2014) Anna Vilalta et al.   Journal of Neuroinflammation

Neuroinflammation and M2 microglia: the good, the bad, and the inflamed

(2014) Jonathan D Cherry et al.   Journal of Neuroinflammation

TLR-driven early glycolytic reprogramming via the kinases TBK1-IKKɛ supports the anabolic demands of dendritic cell activation

(2014) Bart Everts et al.   NATURE IMMUNOLOGY

Mutant Huntingtin promotes autonomous microglia activation via myeloid lineage-determining factors

(2014) Andrea Crotti et al.   NATURE NEUROSCIENCE

The Monocyte to Macrophage Transition in the Murine Sterile Wound

(2014) Meredith J. Crane et al.   PLoS One

Transcriptomic Profiling of the Development of the Inflammatory Response in Human Monocytes In Vitro

(2014) Paola Italiani et al.   PLoS One

Rapid inflammasome activation in microglia contributes to brain disease in HIV/AIDS

(2014) John G Walsh et al.   Retrovirology

2-Deoxy-d-glucose attenuates sevoflurane-induced neuroinflammation through nuclear factor-kappa B pathway in vitro

(2014) Qingxiu Wang et al.   TOXICOLOGY IN VITRO

The interplay between iron accumulation, mitochondrial dysfunction, and inflammation during the execution step of neurodegenerative disorders

(2014) Pamela J. Urrutia et al.   Frontiers in Pharmacology

Are “Resting” Microglia More “M2”?

(2014) Jonathan D. Cherry et al.   Frontiers in Immunology

Characterization of phenotype markers and neuronotoxic potential of polarised primary microglia in vitro

(2013) Vibol Chhor et al.   BRAIN BEHAVIOR AND IMMUNITY

The Concise Guide to PHARMACOLOGY 2013/14: Catalytic Receptors

(2013) Stephen P.H. Alexander et al.   BRITISH JOURNAL OF PHARMACOLOGY

The Concise Guide to PHARMACOLOGY 2013/14: Enzymes

(2013) Stephen P.H. Alexander et al.   BRITISH JOURNAL OF PHARMACOLOGY

The Concise Guide to PHARMACOLOGY 2013/14: G Protein-Coupled Receptors

(2013) Stephen P.H. Alexander et al.   BRITISH JOURNAL OF PHARMACOLOGY

Jmjd3 is essential for the epigenetic modulation of microglia phenotypes in the immune pathogenesis of Parkinson’s disease

(2013) Y Tang et al.   CELL DEATH AND DIFFERENTIATION

The Role of the Immune System in Huntington’s Disease

(2013) Gisa Ellrichmann et al.   Clinical & Developmental Immunology

Role of Microglia in CNS Autoimmunity

(2013) Tobias Goldmann et al.   Clinical & Developmental Immunology

A quick look at biochemistry: Carbohydrate metabolism

(2013) Monireh Dashty   CLINICAL BIOCHEMISTRY

M1 and M2 Macrophages: Oracles of Health and Disease

(2013) Charles Mills   CRITICAL REVIEWS IN IMMUNOLOGY

Resolution of inflammation: an integrated view

(2013) Almudena Ortega-Gómez et al.   EMBO Molecular Medicine

Training innate immunity: the changing concept of immunological memory in innate host defence

(2013) Mihai G. Netea   EUROPEAN JOURNAL OF CLINICAL INVESTIGATION

Inflammatory response of microglial BV-2 cells includes a glycolytic shift and is modulated by mitochondrial glucose-regulated protein 75/mortalin

(2013) Ludmila A. Voloboueva et al.   FEBS LETTERS

Recruitment of Beneficial M2 Macrophages to Injured Spinal Cord Is Orchestrated by Remote Brain Choroid Plexus

(2013) Ravid Shechter et al.   IMMUNITY

Tissue-Resident Macrophages Self-Maintain Locally throughout Adult Life with Minimal Contribution from Circulating Monocytes

(2013) Daigo Hashimoto et al.   IMMUNITY

Metabolic Pathways in Immune Cell Activation and Quiescence

(2013) Erika L. Pearce et al.   IMMUNITY

Macrophage phenotypes during tissue repair

(2013) Margaret L. Novak et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Mitochondrial dynamics modulate the expression of pro-inflammatory mediators in microglial cells

(2013) Junghyung Park et al.   JOURNAL OF NEUROCHEMISTRY

Neural and Immune Mechanisms in the Pathogenesis of Parkinson’s Disease

(2013) Fabio Blandini   Journal of Neuroimmune Pharmacology

Immune-mediated Mechanisms in the Pathoprogression of Amyotrophic Lateral Sclerosis

(2013) Weihua Zhao et al.   Journal of Neuroimmune Pharmacology

Macrophages in inflammatory multiple sclerosis lesions have an intermediate activation status

(2013) Daphne YS Vogel et al.   Journal of Neuroinflammation

Characterization of peripheral hematopoietic stem cells and monocytes in Parkinson's disease

(2013) Natalja Funk et al.   MOVEMENT DISORDERS

Macrophage biology in development, homeostasis and disease

(2013) Thomas A. Wynn et al.   NATURE

Metabolism of inflammation limited by AMPK and pseudo-starvation

(2013) Luke A. J. O'Neill et al.   NATURE

The microglial sensome revealed by direct RNA sequencing

(2013) Suzanne E Hickman et al.   NATURE NEUROSCIENCE

In Vivo Molecular Markers for Pro-inflammatory Cytokine M1 Stage and Resident Microglia in Trimethyltin-Induced Hippocampal Injury

(2013) C. A. McPherson et al.   NEUROTOXICITY RESEARCH

The IUPHAR/BPS Guide to PHARMACOLOGY: an expert-driven knowledgebase of drug targets and their ligands

(2013) Adam J. Pawson et al.   NUCLEIC ACIDS RESEARCH

Integrated Expression Profiles of mRNA and miRNA in Polarized Primary Murine Microglia

(2013) Robert W. Freilich et al.   PLoS One

Cytokine Induced Phenotypic and Epigenetic Signatures Are Key to Establishing Specific Macrophage Phenotypes

(2013) Nicolai A. Kittan et al.   PLoS One

Macrophage Polarisation: an Immunohistochemical Approach for Identifying M1 and M2 Macrophages

(2013) Mário Henrique M. Barros et al.   PLoS One

Chronic exposure to exogenous glucocorticoids primes microglia to pro-inflammatory stimuli and induces NLRP3 mRNA in the hippocampus

(2013) Matthew G. Frank et al.   PSYCHONEUROENDOCRINOLOGY

Factors regulating microglia activation

(2013) Katrin Kierdorf et al.   Frontiers in Cellular Neuroscience

The Classification of Microglial Activation Phenotypes on Neurodegeneration and Regeneration in Alzheimer’s Disease Brain

(2012) Megan M. Varnum et al.   ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS

Commitment to glycolysis sustains survival of NO-producing inflammatory dendritic cells

(2012) B. Everts et al.   BLOOD

The Sedoheptulose Kinase CARKL Directs Macrophage Polarization through Control of Glucose Metabolism

(2012) Arvand Haschemi et al.   Cell Metabolism

Orchestration of Metabolism by Macrophages

(2012) Subhra K. Biswas et al.   Cell Metabolism

N9 microglial cells polarized by LPS and IL4 show differential responses to secondary environmental stimuli

(2012) Hong-Cui Liu et al.   CELLULAR IMMUNOLOGY

Assessing Activation States in Microglia

(2012) Carol A. Colton et al.   CNS & Neurological Disorders-Drug Targets

Comparison of polarization properties of human adult microglia and blood-derived macrophages

(2012) Bryce A. Durafourt et al.   GLIA

Fate Mapping Reveals Origins and Dynamics of Monocytes and Tissue Macrophages under Homeostasis

(2012) Simon Yona et al.   IMMUNITY

Macrophage plasticity and polarization: in vivo veritas

(2012) Antonio Sica et al.   JOURNAL OF CLINICAL INVESTIGATION

Innate immunity in the central nervous system

(2012) Richard M. Ransohoff et al.   JOURNAL OF CLINICAL INVESTIGATION

IL-10 Triggers Changes in Macrophage Phenotype That Promote Muscle Growth and Regeneration

(2012) B. Deng et al.   JOURNAL OF IMMUNOLOGY

The NALP3 inflammasome is involved in neurotoxic prion peptide-induced microglial activation

(2012) Fushan Shi et al.   Journal of Neuroinflammation

The effects of Foxp3 on gene expression profiles in activated microglial cells

(2012) Sung-Hwa Sohn et al.   Molecular & Cellular Toxicology

Inflammation and neurovascular changes in amyotrophic lateral sclerosis

(2012) M.C. Evans et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Gene-expression profiles and transcriptional regulatory pathways that underlie the identity and diversity of mouse tissue macrophages

(2012) Emmanuel L Gautier et al.   NATURE IMMUNOLOGY

Review: Activation patterns of microglia and their identification in the human brain

(2012) D. Boche et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Microglia in the developing brain: A potential target with lifetime effects

(2012) G. Jean Harry et al.   NEUROTOXICOLOGY

Bacille Calmette-Guerin induces NOD2-dependent nonspecific protection from reinfection via epigenetic reprogramming of monocytes

(2012) J. Kleinnijenhuis et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Disease Tolerance as a Defense Strategy

(2012) R. Medzhitov et al.   SCIENCE

CNS sterile injury: just another wound healing?

(2012) Ravid Shechter et al.   TRENDS IN MOLECULAR MEDICINE

Non-Identical Twins – Microglia and Monocyte-Derived Macrophages in Acute Injury and Autoimmune Inflammation

(2012) Steffen Jung et al.   Frontiers in Immunology

Alternative Macrophage Activation and Metabolism

(2011) Justin I. Odegaard et al.   Annual Review of Pathology-Mechanisms of Disease

Gene expression profiling reveals the defining features of the classical, intermediate, and nonclassical human monocyte subsets

(2011) K. L. Wong et al.   BLOOD

Voluntary exercise protects hippocampal neurons from trimethyltin injury: Possible role of interleukin-6 to modulate tumor necrosis factor receptor-mediated neurotoxicity

(2011) Jason A. Funk et al.   BRAIN BEHAVIOR AND IMMUNITY

Lipopolysaccharide-induced interleukin (IL)-4 receptor-α expression and corresponding sensitivity to the M2 promoting effects of IL-4 are impaired in microglia of aged mice

(2011) Ashley M. Fenn et al.   BRAIN BEHAVIOR AND IMMUNITY

Trained Immunity: A Memory for Innate Host Defense

(2011) Mihai G. Netea et al.   Cell Host & Microbe

Taming of macrophage and microglial cell activation by microRNA-124

(2011) Ashley T Conrad et al.   CELL RESEARCH

Microglia Phenotype Diversity

(2011) M. Olah et al.   CNS & Neurological Disorders-Drug Targets

Tumor-Associated Macrophages in the Cutaneous SCC Microenvironment Are Heterogeneously Activated

(2011) Julia S. Pettersen et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Distinct and Non-Redundant Roles of Microglia and Myeloid Subsets in Mouse Models of Alzheimer's Disease

(2011) A. Mildner et al.   JOURNAL OF NEUROSCIENCE

TLR signalling augments macrophage bactericidal activity through mitochondrial ROS

(2011) A. Phillip West et al.   NATURE

Physiology of Microglia

(2011) Helmut Kettenmann et al.   PHYSIOLOGICAL REVIEWS

The Mitochondrial Genome Is a “Genetic Sanctuary” during the Oncogenic Process

(2011) Marcos Seoane et al.   PLoS One

Synaptic Pruning by Microglia Is Necessary for Normal Brain Development

(2011) R. C. Paolicelli et al.   SCIENCE

Nomenclature of monocytes and dendritic cells in blood

(2010) L. Ziegler-Heitbrock et al.   BLOOD

Toll-like receptor-induced changes in glycolytic metabolism regulate dendritic cell activation

(2010) C. M. Krawczyk et al.   BLOOD

Microglia Shape Adult Hippocampal Neurogenesis through Apoptosis-Coupled Phagocytosis

(2010) Amanda Sierra et al.   Cell Stem Cell

Alternative Activation of Macrophages: Mechanism and Functions

(2010) Siamon Gordon et al.   IMMUNITY

CXC Chemokine Ligand 4 Induces a Unique Transcriptome in Monocyte-Derived Macrophages

(2010) C. A. Gleissner et al.   JOURNAL OF IMMUNOLOGY

Substrate Fate in Activated Macrophages: A Comparison between Innate, Classic, and Alternative Activation

(2010) J.-C. Rodriguez-Prados et al.   JOURNAL OF IMMUNOLOGY

Mycobacterium tuberculosis Activates Human Macrophage Peroxisome Proliferator-Activated Receptor   Linking Mannose Receptor Recognition to Regulation of Immune Responses

(2010) M. V. S. Rajaram et al.   JOURNAL OF IMMUNOLOGY

Effects of mitochondrial dysfunction on the immunological properties of microglia

(2010) Annette I Ferger et al.   Journal of Neuroinflammation

The myeloid cells of the central nervous system parenchyma

(2010) Richard M. Ransohoff et al.   NATURE

Changing Face of Microglia

(2010) M. B. Graeber   SCIENCE

Fate Mapping Analysis Reveals That Adult Microglia Derive from Primitive Macrophages

(2010) F. Ginhoux et al.   SCIENCE

Microglial Interactions with Synapses Are Modulated by Visual Experience

(2010) Marie-Ève Tremblay et al.   PLOS BIOLOGY

Microglial Physiology: Unique Stimuli, Specialized Responses

(2009) Richard M. Ransohoff et al.   Annual Review of Immunology

The Inflammasomes: Guardians of the Body

(2009) Fabio Martinon et al.   Annual Review of Immunology

Recent advances in arginine metabolism: roles and regulation of the arginases

(2009) Sidney M Morris Jr   BRITISH JOURNAL OF PHARMACOLOGY

Mitochondrial Dysfunction Leads to Nuclear Genome Instability via an Iron-Sulfur Cluster Defect

(2009) Joshua R. Veatch et al.   CELL

Role of microglial redox balance in modulation of neuroinflammation

(2009) Nadia G Innamorato et al.   CURRENT OPINION IN NEUROLOGY

CCL2 and Interleukin-6 Promote Survival of Human CD11b+Peripheral Blood Mononuclear Cells and Induce M2-type Macrophage Polarization

(2009) Hernan Roca et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SHIP Represses the Generation of IL-3-Induced M2 Macrophages by Inhibiting IL-4 Production from Basophils

(2009) E. Kuroda et al.   JOURNAL OF IMMUNOLOGY

IL-33 Amplifies the Polarization of Alternatively Activated Macrophages That Contribute to Airway Inflammation

(2009) M. Kurowska-Stolarska et al.   JOURNAL OF IMMUNOLOGY

Alternatively Activated Macrophages Elicited by Helminth Infection Can Be Reprogrammed to Enable Microbial Killing

(2009) K. J. Mylonas et al.   JOURNAL OF IMMUNOLOGY

Differential gene expression in LPS/IFNγ activated microglia and macrophages:in vitroversusin vivo

(2009) Christoph D. Schmid et al.   JOURNAL OF NEUROCHEMISTRY

Microglia in ALS: The Good, The Bad, and The Resting

(2009) Jenny S. Henkel et al.   Journal of Neuroimmune Pharmacology

Heterogeneity of Microglial Activation in the Innate Immune Response in the Brain

(2009) Carol A. Colton   Journal of Neuroimmune Pharmacology

Characterization of the microglial phenotype under specific pro-inflammatory and anti-inflammatory conditions: Effects of oligomeric and fibrillar amyloid-β

(2009) Alessandro Michelucci et al.   JOURNAL OF NEUROIMMUNOLOGY

Resting Microglia Directly Monitor the Functional State of Synapses In Vivo and Determine the Fate of Ischemic Terminals

(2009) H. Wake et al.   JOURNAL OF NEUROSCIENCE

Identification of Two Distinct Macrophage Subsets with Divergent Effects Causing either Neurotoxicity or Regeneration in the Injured Mouse Spinal Cord

(2009) K. A. Kigerl et al.   JOURNAL OF NEUROSCIENCE

Long-Term Gliosis and Molecular Changes in the Cervical Spinal Cord of the Rhesus Monkey after Traumatic Brain Injury

(2009) Kumi Nagamoto-Combs et al.   JOURNAL OF NEUROTRAUMA

Tolerance and M2 (alternative) macrophage polarization are related processes orchestrated by p50 nuclear factor  B

(2009) C. Porta et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A CREB-C/EBP  cascade induces M2 macrophage-specific gene expression and promotes muscle injury repair

(2009) D. Ruffell et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lysophosphatidic acid receptor activation affects the C13NJ microglia cell line proteome leading to alterations in glycolysis, motility, and cytoskeletal architecture

(2009) Eva Bernhart et al.   PROTEOMICS

Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation

(2009) M. G. Vander Heiden et al.   SCIENCE

Endotoxin tolerance: new mechanisms, molecules and clinical significance

(2009) Subhra K. Biswas et al.   TRENDS IN IMMUNOLOGY

Arginase-1–Expressing Macrophages Suppress Th2 Cytokine–Driven Inflammation and Fibrosis

(2009) John T. Pesce et al.   PLoS Pathogens

Alternative Activation of Macrophages: An Immunologic Functional Perspective

(2008) Fernando O. Martinez et al.   Annual Review of Immunology

Cell death in the host response to infection

(2008) K Labbé et al.   CELL DEATH AND DIFFERENTIATION

HIV-1-infected and/or immune-activated macrophage-secreted TNF-α affects human fetal cortical neural progenitor cell proliferation and differentiation

(2008) Hui Peng et al.   GLIA

Shifts in macrophage phenotypes and macrophage competition for arginine metabolism affect the severity of muscle pathology in muscular dystrophy

(2008) S. A. Villalta et al.   HUMAN MOLECULAR GENETICS

Amyloid-β oligomers set fire to inflammasomes and induce Alzheimer's pathology

(2008) Antero Salminen et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Toll-like receptor–induced arginase 1 in macrophages thwarts effective immunity against intracellular pathogens

(2008) Karim C El Kasmi et al.   NATURE IMMUNOLOGY

Persistent Coxiella burnetii Infection in Mice Overexpressing IL-10: An Efficient Model for Chronic Q Fever Pathogenesis

(2008) Soraya Meghari et al.   PLoS Pathogens

The Uptake of Apoptotic Cells Drives Coxiella burnetii Replication and Macrophage Polarization: A Model for Q Fever Endocarditis

(2008) Marie Benoit et al.   PLoS Pathogens

Macrophage activation and polarization

(2007) Fernando Oneissi Martinez   Frontiers in Bioscience-Landmark