Enhanced Akt/GSK‐3β/CREB signaling mediates the anti‐inflammatory actions of mGluR5 positive allosteric modulators in microglia and following traumatic brain injury in male mice
Published 2020 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Enhanced Akt/GSK‐3β/CREB signaling mediates the anti‐inflammatory actions of mGluR5 positive allosteric modulators in microglia and following traumatic brain injury in male mice
Authors
Keywords
-
Journal
JOURNAL OF NEUROCHEMISTRY
Volume -, Issue -, Pages -
Publisher
Wiley
Online
2020-01-11
DOI
10.1111/jnc.14954
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Inhibition of Glycogen Synthase Kinase 3β as a Treatment for the Prevention of Cognitive Deficits after a Traumatic Brain Injury
- (2019) Susan A. Farr et al. JOURNAL OF NEUROTRAUMA
- Neuropharmacological Insight from Allosteric Modulation of mGlu Receptors
- (2019) Branden J. Stansley et al. TRENDS IN PHARMACOLOGICAL SCIENCES
- PI3K-AKT-GSK3β-CREB signaling pathway regulates anxiety-like behavior in rats following alcohol withdrawal
- (2018) Xiaomeng Qiao et al. JOURNAL OF AFFECTIVE DISORDERS
- AT2R Activation Prevents Microglia Pro-inflammatory Activation in a NOX-Dependent Manner: Inhibition of PKC Activation and p47phox Phosphorylation by PP2A
- (2018) Shahnawaz Ali Bhat et al. MOLECULAR NEUROBIOLOGY
- Inhibition of miR-155 Limits Neuroinflammation and Improves Functional Recovery After Experimental Traumatic Brain Injury in Mice
- (2018) Rebecca J. Henry et al. Neurotherapeutics
- In Vivo Non-radioactive Assessment of mGlu5 Receptor-Activated Polyphosphoinositide Hydrolysis in Response to Systemic Administration of a Positive Allosteric Modulator
- (2018) Anna R. Zuena et al. Frontiers in Pharmacology
- Akt Signaling Pathway in Macrophage Activation and M1/M2 Polarization
- (2017) Eleni Vergadi et al. JOURNAL OF IMMUNOLOGY
- DHEA inhibits acute microglia-mediated inflammation through activation of the TrkA-Akt1/2-CREB-Jmjd3 pathway
- (2017) V I Alexaki et al. MOLECULAR PSYCHIATRY
- The far-reaching scope of neuroinflammation after traumatic brain injury
- (2017) Dennis W. Simon et al. Nature Reviews Neurology
- Allosteric Modulation of GPCRs: New Insights and Potential Utility for Treatment of Schizophrenia and Other CNS Disorders
- (2017) Daniel J. Foster et al. NEURON
- Metabotropic glutamate receptors and neurodegenerative diseases
- (2017) Fabiola M. Ribeiro et al. PHARMACOLOGICAL RESEARCH
- β-Arrestin2 Couples Metabotropic Glutamate Receptor 5 to Neuronal Protein Synthesis and Is a Potential Target to Treat Fragile X
- (2017) Laura J. Stoppel et al. Cell Reports
- Anti-inflammatory Microglia/Macrophages As a Potential Therapeutic Target in Brain Metastasis
- (2017) Kleopatra E. Andreou et al. Frontiers in Oncology
- Microglia in the TBI brain: The good, the bad, and the dysregulated
- (2016) David J. Loane et al. EXPERIMENTAL NEUROLOGY
- Orchestrated activation of mGluR5 and CB1 promotes neuroprotection
- (2016) Edleusa M. L. Batista et al. Molecular Brain
- Progressive inflammation-mediated neurodegeneration after traumatic brain or spinal cord injury
- (2015) Alan I Faden et al. BRITISH JOURNAL OF PHARMACOLOGY
- Dysregulation and restoration of translational homeostasis in fragile X syndrome
- (2015) Joel D. Richter et al. NATURE REVIEWS NEUROSCIENCE
- The mGluR5 positive allosteric modulator, CDPPB, ameliorates pathology and phenotypic signs of a mouse model of Huntington's disease
- (2015) J.G. Doria et al. NEUROBIOLOGY OF DISEASE
- Glycogen synthase kinase-3 (GSK3): Regulation, actions, and diseases
- (2015) Eleonore Beurel et al. PHARMACOLOGY & THERAPEUTICS
- HDAC inhibition prevents white matter injury by modulating microglia/macrophage polarization through the GSK3β/PTEN/Akt axis
- (2015) Guohua Wang et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Positive Allosteric Modulators (PAMs) of Metabotropic Glutamate Receptor 5 (mGluR5) Attenuate Microglial Activation
- (2014) Fengtian Xue et al. CNS & Neurological Disorders-Drug Targets
- Mechanisms and Potential Therapeutic Applications of Microglial Activation after Brain Injury
- (2014) Jong-Youl Kim et al. CNS Neuroscience & Therapeutics
- Metabotropic glutamate receptor 5 as a potential therapeutic target in Huntington’s disease
- (2014) Fabiola M Ribeiro et al. EXPERT OPINION ON THERAPEUTIC TARGETS
- Downregulation of miR-23a and miR-27a following Experimental Traumatic Brain Injury Induces Neuronal Cell Death through Activation of Proapoptotic Bcl-2 Proteins
- (2014) B. Sabirzhanov et al. JOURNAL OF NEUROSCIENCE
- Novel mGluR5 Positive Allosteric Modulator Improves Functional Recovery, Attenuates Neurodegeneration, and Alters Microglial Polarization after Experimental Traumatic Brain Injury
- (2014) David J. Loane et al. Neurotherapeutics
- Chronic Neurodegeneration After Traumatic Brain Injury: Alzheimer Disease, Chronic Traumatic Encephalopathy, or Persistent Neuroinflammation?
- (2014) Alan I. Faden et al. Neurotherapeutics
- Metabotropic glutamate receptor 5 positive allosteric modulators are neuroprotective in a mouse model of Huntington's disease
- (2013) JG Doria et al. BRITISH JOURNAL OF PHARMACOLOGY
- Transcranial amelioration of inflammation and cell death after brain injury
- (2013) Theodore L. Roth et al. NATURE
- Signalling bias in new drug discovery: detection, quantification and therapeutic impact
- (2013) Terry Kenakin et al. NATURE REVIEWS DRUG DISCOVERY
- Development of allosteric modulators of GPCRs for treatment of CNS disorders
- (2013) Hilary Highfield Nickols et al. NEUROBIOLOGY OF DISEASE
- Microglia: New Roles for the Synaptic Stripper
- (2013) Helmut Kettenmann et al. NEURON
- Angiogenin in Parkinson Disease Models: Role of Akt Phosphorylation and Evaluation of AAV-Mediated Angiogenin Expression in MPTP Treated Mice
- (2013) Trent U. Steidinger et al. PLoS One
- The Pathophysiology of Fragile X (and What It Teaches Us about Synapses)
- (2012) Asha L. Bhakar et al. Annual Review of Neuroscience
- Activation of metabotropic glutamate receptor 5 reduces the secondary brain injury after traumatic brain injury in rats
- (2012) Jia-Wei Wang et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Expression and cell distribution of metabotropic glutamate receptor 5 in the rat cortex following traumatic brain injury
- (2012) Jia-Wei Wang et al. BRAIN RESEARCH
- Regulation of glycogen synthase kinase-3 beta (GSK-3β) by the Akt pathway in gliomas
- (2012) Ryan J. Atkins et al. JOURNAL OF CLINICAL NEUROSCIENCE
- Microglial neurotransmitter receptors trigger superoxide production in microglia; consequences for microglial-neuronal interactions
- (2012) Emma L. Mead et al. JOURNAL OF NEUROCHEMISTRY
- Involvement of metabotropic glutamate receptor 5, AKT/PI3K Signaling and NF-κB pathway in methamphetamine-mediated increase in IL-6 and IL-8 expression in astrocytes
- (2012) Ankit Shah et al. Journal of Neuroinflammation
- Delayed mGluR5 activation limits neuroinflammation and neurodegeneration after traumatic brain injury
- (2012) Kimberly R Byrnes et al. Journal of Neuroinflammation
- A comparative review of cell culture systems for the study of microglial biology in Alzheimer’s disease
- (2012) Branden Stansley et al. Journal of Neuroinflammation
- Activation of mGluR5 and Inhibition of NADPH Oxidase Improves Functional Recovery after Traumatic Brain Injury
- (2012) David J. Loane et al. JOURNAL OF NEUROTRAUMA
- Protective Effects of mGluR5 Positive Modulators Against Traumatic Neuronal Injury Through PKC-Dependent Activation of MEK/ERK Pathway
- (2012) Tao Chen et al. NEUROCHEMICAL RESEARCH
- The selective mGluR5 agonist CHPG protects against traumatic brain injury in vitro and in vivo via ERK and Akt pathway
- (2011) TAO CHEN et al. INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
- Positive allosteric modulation of metabotropic glutamate receptor 5 down-regulates fibrinogen-activated microglia providing neuronal protection
- (2011) Thomas M. Piers et al. NEUROSCIENCE LETTERS
- GSK-3 Inhibitors: Preclinical and Clinical Focus on CNS
- (2011) Hagit Eldar-Finkelman et al. Frontiers in Molecular Neuroscience
- Metabotropic Glutamate Receptors: Physiology, Pharmacology, and Disease
- (2010) Colleen M. Niswender et al. Annual Review of Pharmacology and Toxicology
- The Role of the Transcription Factor CREB in Immune Function
- (2010) A. Y. Wen et al. JOURNAL OF IMMUNOLOGY
- Hypersensitivity to mGluR5 and ERK1/2 Leads to Excessive Protein Synthesis in the Hippocampus of a Mouse Model of Fragile X Syndrome
- (2010) E. K. Osterweil et al. JOURNAL OF NEUROSCIENCE
- Discovery of Novel Allosteric Modulators of Metabotropic Glutamate Receptor Subtype 5 Reveals Chemical and Functional Diversity and In Vivo Activity in Rat Behavioral Models of Anxiolytic and Antipsychotic Activity
- (2010) A. L. Rodriguez et al. MOLECULAR PHARMACOLOGY
- Role of microglia in neurotrauma
- (2010) David J. Loane et al. Neurotherapeutics
- Activation of metabotropic glutamate receptor 5 improves recovery after spinal cord injury in rodents
- (2009) Kimberly R. Byrnes et al. ANNALS OF NEUROLOGY
- Activation of Metabotropic Glutamate Receptor 5 Modulates Microglial Reactivity and Neurotoxicity by Inhibiting NADPH Oxidase
- (2009) David J. Loane et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Amyloid precursor protein secretases as therapeutic targets for traumatic brain injury
- (2009) David J Loane et al. NATURE MEDICINE
- Metabotropic glutamate receptor 5 activation inhibits microglial associated inflammation and neurotoxicity
- (2008) Kimberly R. Byrnes et al. GLIA
- Metabotropic glutamate receptors as targets for multipotential treatment of neurological disorders
- (2008) Kimberly R. Byrnes et al. Neurotherapeutics
Publish scientific posters with Peeref
Peeref publishes scientific posters from all research disciplines. Our Diamond Open Access policy means free access to content and no publication fees for authors.
Learn MoreCreate your own webinar
Interested in hosting your own webinar? Check the schedule and propose your idea to the Peeref Content Team.
Create Now