Akt Signaling in Macrophage Polarization, Survival, and Atherosclerosis

PTEN-opathies: from biological insights to evidence-based precision medicine

(2019) Lamis Yehia et al.   JOURNAL OF CLINICAL INVESTIGATION

Loss of Rictor in Monocyte/Macrophages Suppresses Their Proliferation and Viability Reducing Atherosclerosis in LDLR Null Mice

(2018) Vladimir R. Babaev et al.   Frontiers in Immunology

Loss of 2 Akt (Protein Kinase B) Isoforms in Hematopoietic Cells Diminished Monocyte and Macrophage Survival and Reduces Atherosclerosis in Ldl Receptor-Null Mice

(2018) Vladimir R. Babaev et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Critical roles of mTORC1 signaling and metabolic reprogramming for M-CSF–mediated myelopoiesis

(2017) Peer W.F. Karmaus et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Targeting Metabolism as a Novel Therapeutic Approach to Autoimmunity, Inflammation, and Transplantation

(2017) Ian A. Bettencourt et al.   JOURNAL OF IMMUNOLOGY

Akt Signaling Pathway in Macrophage Activation and M1/M2 Polarization

(2017) Eleni Vergadi et al.   JOURNAL OF IMMUNOLOGY

Twenty-five years of mTOR: Uncovering the link from nutrients to growth

(2017) David M. Sabatini   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Anti-inflammatory effect of IL-10 mediated by metabolic reprogramming of macrophages

(2017) W. K. Eddie Ip et al.   SCIENCE

Macrophage Metabolism As Therapeutic Target for Cancer, Atherosclerosis, and Obesity

(2017) Xenia Geeraerts et al.   Frontiers in Immunology

Jnk1Deficiency in Hematopoietic Cells Suppresses Macrophage Apoptosis and Increases Atherosclerosis in Low-Density Lipoprotein Receptor Null MiceHighlights

(2016) Vladimir R. Babaev et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Macrophage IKKα Deficiency Suppresses Akt Phosphorylation, Reduces Cell Survival, and Decreases Early AtherosclerosisSignificance

(2016) Vladimir R. Babaev et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Spontaneous Hepatocellular Carcinoma after the Combined Deletion of Akt Isoforms

(2016) Qi Wang et al.   CANCER CELL

Macrophage Phenotype and Function in Different Stages of Atherosclerosis

(2016) Ira Tabas et al.   CIRCULATION RESEARCH

Cardiovascular Toxic Effects of Targeted Cancer Therapies

(2016) Javid J. Moslehi   NEW ENGLAND JOURNAL OF MEDICINE

PI3K inhibitors as new cancer therapeutics: implications for clinical trial design

(2016) Cristian Massacesi et al.   OncoTargets and Therapy

PI3K/Akt promotes feedforward mTORC2 activation through IKKα

(2016) Han C. Dan et al.   Oncotarget

Akt-mTORC1 signaling regulates Acly to integrate metabolic input to control of macrophage activation

(2016) Anthony J Covarrubias et al.   eLife

Autocrine IL-10 functions as a rheostat for M1 macrophage glycolytic commitment by tuning nitric oxide production

(2016) Walter A. Baseler et al.   Redox Biology

Regression of Atherosclerosis

(2015) Edward A. Fisher   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Hematopoietic Akt2 deficiency attenuates the progression of atherosclerosis

(2015) Noemi Rotllan et al.   FASEB JOURNAL

Recent insights into the cellular biology of atherosclerosis

(2015) Ira Tabas et al.   JOURNAL OF CELL BIOLOGY

Immunometabolism governs dendritic cell and macrophage function

(2015) Luke A.J. O’Neill et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Vascular and Metabolic Implications of Novel Targeted Cancer Therapies

(2015) Weijuan Li et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Regulation of mTORC1 by PI3K signaling

(2015) Christian C. Dibble et al.   TRENDS IN CELL BIOLOGY

Disruption of Mammalian Target of Rapamycin Complex 1 in Macrophages Decreases Chemokine Gene Expression and Atherosclerosis

(2014) Ding Ai et al.   CIRCULATION RESEARCH

Interleukin-10 Receptor Signaling in Innate Immune Cells Regulates Mucosal Immune Tolerance and Anti-Inflammatory Macrophage Function

(2014) Dror S. Shouval et al.   IMMUNITY

Genetic Analysis of the Role of the PI3K-Akt Pathway in Lipopolysaccharide-Induced Cytokine and Tissue Factor Gene Expression in Monocytes/Macrophages

(2014) J. P. Luyendyk et al.   JOURNAL OF IMMUNOLOGY

Myeloid PTEN Deficiency Protects Livers from Ischemia Reperfusion Injury by Facilitating M2 Macrophage Differentiation

(2014) S. Yue et al.   JOURNAL OF IMMUNOLOGY

Macrophage PTEN Regulates Expression and Secretion of Arginase I Modulating Innate and Adaptive Immune Responses

(2014) Emine Sahin et al.   JOURNAL OF IMMUNOLOGY

Macrophage deficiency of Akt2 reduces atherosclerosis inLdlrnull mice

(2014) Vladimir R. Babaev et al.   JOURNAL OF LIPID RESEARCH

Picking the Point of Inhibition: A Comparative Review of PI3K/AKT/mTOR Pathway Inhibitors

(2014) R. Dienstmann et al.   MOLECULAR CANCER THERAPEUTICS

PI3K and cancer: lessons, challenges and opportunities

(2014) David A. Fruman et al.   NATURE REVIEWS DRUG DISCOVERY

Bone Marrow-Specific Knock-In of a Non-Activatable Ikkα Kinase Mutant Influences Haematopoiesis but Not Atherosclerosis in Apoe-Deficient Mice

(2014) Pathricia V. Tilstam et al.   PLoS One

Myeloid-Specific Rictor Deletion Induces M1 Macrophage Polarization and Potentiates In Vivo Pro-Inflammatory Response to Lipopolysaccharide

(2014) William T. Festuccia et al.   PLoS One

mTOR inhibition improves immune function in the elderly

(2014) J. B. Mannick et al.   Science Translational Medicine

Akt2/LDLr double knockout mice display impaired glucose tolerance and develop more complex atherosclerotic plaques than LDLr knockout mice

(2013) Katrijn L. Rensing et al.   CARDIOVASCULAR RESEARCH

Akt1 is the principal Akt isoform regulating apoptosis in limiting cytokine concentrations

(2013) B D Green et al.   CELL DEATH AND DIFFERENTIATION

IKK interacts with rictor and regulates mTORC2

(2013) Yuanfei Xu et al.   CELLULAR SIGNALLING

The TSC-mTOR pathway regulates macrophage polarization

(2013) Vanessa Byles et al.   Nature Communications

Inflammation in Atherosclerosis

(2012) Peter Libby   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

mTOR Signaling in Growth Control and Disease

(2012) Mathieu Laplante et al.   CELL

Toll-like receptors, signaling adapters and regulation of the pro-inflammatory response by PI3K

(2012) Ty Dale Troutman et al.   CELL CYCLE

Akt3 Deficiency in Macrophages Promotes Foam Cell Formation and Atherosclerosis in Mice

(2012) Liang Ding et al.   Cell Metabolism

NF- B, the first quarter-century: remarkable progress and outstanding questions

(2012) M. S. Hayden et al.   GENES & DEVELOPMENT

Macrophage Differentiation and Function in Atherosclerosis: Opportunities for Therapeutic Intervention?

(2012) Howell J. Williams et al.   Journal of Innate Immunity

Akt1 and Akt2 protein kinases differentially contribute to macrophage polarization

(2012) A. Arranz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulation and Functions of the IL-10 Family of Cytokines in Inflammation and Disease

(2011) Wenjun Ouyang et al.   Annual Review of Immunology

Mechanisms of ER Stress-Induced Apoptosis in Atherosclerosis

(2011) Christopher M. Scull et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Alternative activation of macrophages by IL-4 requires SHIP degradation

(2011) Shelley B. Weisser et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Integrating the mechanisms of apoptosis induced by endoplasmic reticulum stress

(2011) Ira Tabas et al.   NATURE CELL BIOLOGY

Akt isoform-specific signaling in breast cancer

(2011) Y. Rebecca Chin et al.   Cell Adhesion & Migration

AKT1 and AKT2 maintain hematopoietic stem cell function by regulating reactive oxygen species

(2010) M. M. Juntilla et al.   BLOOD

Non-canonical NF-κB signaling pathway

(2010) Shao-Cong Sun   CELL RESEARCH

Alternative Activation of Macrophages: Mechanism and Functions

(2010) Siamon Gordon et al.   IMMUNITY

Tumor-Induced Tolerance and Immune Suppression Depend on the C/EBPβ Transcription Factor

(2010) Ilaria Marigo et al.   IMMUNITY

Akt isoforms and glucose homeostasis – the leptin connection

(2010) Nissim Hay   TRENDS IN ENDOCRINOLOGY AND METABOLISM

The Discovery of Cellular Immunity in the Atherosclerotic Plaque

(2009) Göran K. Hansson et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Macrophage Diversity and Polarization in Atherosclerosis

(2009) Alberto Mantovani et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Akt1 and Akt2 promote peripheral B-cell maturation and survival

(2009) M. Calamito et al.   BLOOD

Akt1 and Akt2 Play Distinct Roles in the Initiation and Metastatic Phases of Mammary Tumor Progression

(2009) R. L. Dillon et al.   CANCER RESEARCH

Reduced Apoptosis and Plaque Necrosis in Advanced Atherosclerotic Lesions of Apoe−/− and Ldlr−/− Mice Lacking CHOP

(2009) Edward Thorp et al.   Cell Metabolism

Macrophage Apoptosis Exerts Divergent Effects on Atherogenesis as a Function of Lesion Stage

(2009) Emmanuel L. Gautier et al.   CIRCULATION

SHIP Represses the Generation of IL-3-Induced M2 Macrophages by Inhibiting IL-4 Production from Basophils

(2009) E. Kuroda et al.   JOURNAL OF IMMUNOLOGY

Reducing endoplasmic reticulum stress through a macrophage lipid chaperone alleviates atherosclerosis

(2009) Ebru Erbay et al.   NATURE MEDICINE

The life of a cell: apoptosis regulation by the PI3K/PKB pathway

(2008) Vincent Duronio   BIOCHEMICAL JOURNAL

How IRE1 Reacts to ER Stress

(2008) David Ron et al.   CELL

Macrophage EP4 Deficiency Increases Apoptosis and Suppresses Early Atherosclerosis

(2008) Vladimir R. Babaev et al.   Cell Metabolism

Mechanisms of Cardiac Dysfunction Associated With Tyrosine Kinase Inhibitor Cancer Therapeutics

(2008) Ming Hui Chen et al.   CIRCULATION

Mechanisms and consequences of macrophage apoptosis in atherosclerosis

(2008) Tracie Seimon et al.   JOURNAL OF LIPID RESEARCH

Brain Cancer Stem Cells Display Preferential Sensitivity to Akt Inhibition

(2008) Christine E. Eyler et al.   STEM CELLS