Silencing Alpha Synuclein in Mature Nigral Neurons Results in Rapid Neuroinflammation and Subsequent Toxicity
Published 2018 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Silencing Alpha Synuclein in Mature Nigral Neurons Results in Rapid Neuroinflammation and Subsequent Toxicity
Authors
Keywords
-
Journal
Frontiers in Molecular Neuroscience
Volume 11, Issue -, Pages -
Publisher
Frontiers Media SA
Online
2018-02-13
DOI
10.3389/fnmol.2018.00036
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Candidate inflammatory biomarkers display unique relationships with alpha-synuclein and correlate with measures of disease severity in subjects with Parkinson’s disease
- (2017) Lori N. Eidson et al. Journal of Neuroinflammation
- α-Synuclein promotes dilation of the exocytotic fusion pore
- (2017) Todd Logan et al. NATURE NEUROSCIENCE
- αSynuclein control of mitochondrial homeostasis in human-derived neurons is disrupted by mutations associated with Parkinson’s disease
- (2017) Victorio Martin Pozo Devoto et al. Scientific Reports
- α-Synuclein fibrils recruit peripheral immune cells in the rat brain prior to neurodegeneration
- (2017) Ashley S. Harms et al. Acta Neuropathologica Communications
- Suppression of Map Kinases Inhibits Microglial Activation and Attenuates Neuronal Cell Death Induced by α-Synuclein Protofibrils
- (2017) H. Wilms et al. INTERNATIONAL JOURNAL OF IMMUNOPATHOLOGY AND PHARMACOLOGY
- Microglia in dementia with Lewy bodies
- (2016) Wolfgang J. Streit et al. BRAIN BEHAVIOR AND IMMUNITY
- The contribution of alpha synuclein to neuronal survival and function - Implications for Parkinson's disease
- (2016) Matthew J. Benskey et al. JOURNAL OF NEUROCHEMISTRY
- Monomeric Alpha-Synuclein Exerts a Physiological Role on Brain ATP Synthase
- (2016) M. H. R. Ludtmann et al. JOURNAL OF NEUROSCIENCE
- Continuous Collection of Adeno-Associated Virus from Producer Cell Medium Significantly Increases Total Viral Yield
- (2016) Matthew J. Benskey et al. Human Gene Therapy Methods
- Is Alpha-Synuclein Loss-of-Function a Contributor to Parkinsonian Pathology? Evidence from Non-human Primates
- (2016) Timothy J. Collier et al. Frontiers in Neuroscience
- Impact of age and vector construct on striatal and nigral transgene expression
- (2016) Nicole K Polinski et al. Molecular Therapy-Methods & Clinical Development
- Microglia-specific targeting by novel capsid-modified AAV6 vectors
- (2016) Awilda M Rosario et al. Molecular Therapy-Methods & Clinical Development
- Non-cell-autonomous Neurotoxicity of α-synuclein Through Microglial Toll-like Receptor 2
- (2016) Changyoun Kim et al. Experimental Neurobiology
- α-Synuclein Expression in the Mouse Cerebellum Is Restricted to VGluT1 Excitatory Terminals and Is Enriched in Unipolar Brush Cells
- (2015) Sun Kyong Lee et al. CEREBELLUM
- shRNA targeting α-synuclein prevents neurodegeneration in a Parkinson’s disease model
- (2015) Alevtina D. Zharikov et al. JOURNAL OF CLINICAL INVESTIGATION
- The role of parkin in the differential susceptibility of tuberoinfundibular and nigrostriatal dopamine neurons to acute toxicant exposure
- (2015) Matthew J. Benskey et al. NEUROTOXICOLOGY
- Progressive Aggregation of Alpha-Synuclein and Selective Degeneration of Lewy Inclusion-Bearing Neurons in a Mouse Model of Parkinsonism
- (2015) Valerie R. Osterberg et al. Cell Reports
- The Newly Discovered Parkinson’s Disease Associated Finnish Mutation (A53E) Attenuates α-Synuclein Aggregation and Membrane Binding
- (2014) Dhiman Ghosh et al. BIOCHEMISTRY
- Targeting alpha-synuclein with a microRNA-embedded silencing vector in the rat substantia nigra: Positive and negative effects
- (2014) Christina E. Khodr et al. BRAIN RESEARCH
- The novel Parkinson's disease linked mutation G51D attenuates in vitro aggregation and membrane binding of -synuclein, and enhances its secretion and nuclear localization in cells
- (2014) M.-B. Fares et al. HUMAN MOLECULAR GENETICS
- Redundant dopaminergic activity may enable compensatory axonal sprouting in Parkinson disease
- (2014) D. Arkadir et al. NEUROLOGY
- Does α-synuclein have a dual and opposing effect in preclinical vs. clinical Parkinson's disease?
- (2014) Katerina Markopoulou et al. PARKINSONISM & RELATED DISORDERS
- MHC-I expression renders catecholaminergic neurons susceptible to T-cell-mediated degeneration
- (2014) Carolina Cebrián et al. Nature Communications
- Neuronal MHC-I expression and its implications in synaptic function, axonal regeneration and Parkinson’s and other brain diseases
- (2014) Carolina Cebrián et al. Frontiers in Neuroanatomy
- Neuroimmunological Processes in Parkinson's Disease and their Relation to α-Synuclein: Microglia as the Referee between Neuronal Processes and Peripheral Immunity
- (2013) Vanesa Sanchez-Guajardo et al. ASN Neuro
- Disease duration and the integrity of the nigrostriatal system in Parkinson’s disease
- (2013) Jeffrey H. Kordower et al. BRAIN
- Endogenous alpha-synuclein influences the number of dopaminergic neurons in mouse substantia nigra
- (2013) Pablo Garcia-Reitboeck et al. EXPERIMENTAL NEUROLOGY
- MHC class I immune proteins are critical for hippocampus-dependent memory and gate NMDAR-dependent hippocampal long-term depression
- (2013) P. A. Nelson et al. LEARNING & MEMORY
- Sustained resistance to acute MPTP toxicity by hypothalamic dopamine neurons following chronic neurotoxicant exposure is associated with sustained up-regulation of parkin protein
- (2013) Matthew Benskey et al. NEUROTOXICOLOGY
- Neuron-glia crosstalk in health and disease: fractalkine and CX3CR1 take centre stage
- (2013) G. K. Sheridan et al. Open Biology
- α-Synuclein mRNA and soluble α-synuclein protein levels in post-mortem brain from patients with Parkinson's disease, dementia with Lewy bodies, and Alzheimer's disease
- (2012) Joseph G. Quinn et al. BRAIN RESEARCH
- Regionally-specific microglial activation in young mice over-expressing human wildtype alpha-synuclein
- (2012) Melanie B. Watson et al. EXPERIMENTAL NEUROLOGY
- α-Synuclein Controls Mitochondrial Calcium Homeostasis by Enhancing Endoplasmic Reticulum-Mitochondria Interactions
- (2012) Tito Calì et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Long-term polarization of microglia upon α-synuclein overexpression in nonhuman primates
- (2012) P. Barkholt et al. NEUROSCIENCE
- An alpha-synuclein AAV gene silencing vector ameliorates a behavioral deficit in a rat model of Parkinson's disease, but displays toxicity in dopamine neurons
- (2011) Christina E. Khodr et al. BRAIN RESEARCH
- Lack of Alpha-Synuclein Modulates Microglial Phenotype In Vitro
- (2011) Susan A. Austin et al. NEUROCHEMICAL RESEARCH
- Exogenous α-Synuclein Fibrils Induce Lewy Body Pathology Leading to Synaptic Dysfunction and Neuron Death
- (2011) Laura A. Volpicelli-Daley et al. NEURON
- -Synuclein Activates Microglia by Inducing the Expressions of Matrix Metalloproteinases and the Subsequent Activation of Protease-Activated Receptor-1
- (2010) E.-J. Lee et al. JOURNAL OF IMMUNOLOGY
- Non-classical exocytosis of α-synuclein is sensitive to folding states and promoted under stress conditions
- (2010) Ara Jang et al. JOURNAL OF NEUROCHEMISTRY
- Neurodegeneration in a Transgenic Mouse Model of Multiple System Atrophy Is Associated with Altered Expression of Oligodendroglial-Derived Neurotrophic Factors
- (2010) K. Ubhi et al. JOURNAL OF NEUROSCIENCE
- In Vivo RNAi-Mediated α-Synuclein Silencing Induces Nigrostriatal Degeneration
- (2010) Oleg S Gorbatyuk et al. MOLECULAR THERAPY
- Microglia Acquire Distinct Activation Profiles Depending on the Degree of α-Synuclein Neuropathology in a rAAV Based Model of Parkinson's Disease
- (2010) Vanesa Sanchez-Guajardo et al. PLoS One
- In Vivo Imaging of α-Synuclein in Mouse Cortex Demonstrates Stable Expression and Differential Subcellular Compartment Mobility
- (2010) Vivek K. Unni et al. PLoS One
- Nitrated α-Synuclein Induces the Loss of Dopaminergic Neurons in the Substantia Nigra of Rats
- (2010) Zhongwang Yu et al. PLoS One
- α-Synuclein Suppression by Targeted Small Interfering RNA in the Primate Substantia Nigra
- (2010) Alison L. McCormack et al. PLoS One
- -Synuclein triple knockout mice reveal age-dependent neuronal dysfunction
- (2010) B. Greten-Harrison et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- -Synuclein Promotes SNARE-Complex Assembly in Vivo and in Vitro
- (2010) J. Burre et al. SCIENCE
- 14-3-3ζ Contributes to Tyrosine Hydroxylase Activity in MN9D Cells
- (2009) Jian Wang et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Tight Long-term Dynamic Doxycycline Responsive Nigrostriatal GDNF Using a Single rAAV Vector
- (2009) Fredric P Manfredsson et al. MOLECULAR THERAPY
- Targeted Overexpression of Human α-Synuclein Triggers Microglial Activation and an Adaptive Immune Response in a Mouse Model of Parkinson Disease
- (2008) Shaji Theodore et al. JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY
- In vivo silencing of alpha-synuclein using naked siRNA
- (2008) Jada Lewis et al. Molecular Neurodegeneration
- α-Synuclein aggregation alters tyrosine hydroxylase phosphorylation and immunoreactivity: Lessons from viral transduction of knockout mice
- (2008) Tshianda N.M. Alerte et al. NEUROSCIENCE LETTERS
- In vivo alpha-synuclein overexpression in rodents: A useful model of Parkinson's disease?
- (2007) Marie-Francoise Chesselet EXPERIMENTAL NEUROLOGY
- Synuclein activates microglia in a model of Parkinson's disease
- (2007) Xiaomin Su et al. NEUROBIOLOGY OF AGING
Publish scientific posters with Peeref
Peeref publishes scientific posters from all research disciplines. Our Diamond Open Access policy means free access to content and no publication fees for authors.
Learn MoreAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started