Compromised MAPK signaling in human diseases: an update

The role of TDP-43 in the pathogenesis of ALS and FTLD: Figure 1

(2015) Marco Baralle et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Clearance of misfolded and aggregated proteins by aggrephagy and implications for aggregation diseases

(2014) Juha M.T. Hyttinen et al.   AGEING RESEARCH REVIEWS

Functions of FUS/TLS From DNA Repair to Stress Response: Implications for ALS

(2014) Reddy Ranjith Kumar Sama et al.   ASN Neuro

Decoding RAS isoform and codon-specific signalling

(2014) Anna U. Newlaczyl et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Intrinsic and acquired resistance to MEK1/2 inhibitors in cancer

(2014) Matthew J. Sale et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Role of mitochondria in mutant SOD1 linked amyotrophic lateral sclerosis

(2014) Wenzhi Tan et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Naturally Occurring Neomorphic PIK3R1 Mutations Activate the MAPK Pathway, Dictating Therapeutic Response to MAPK Pathway Inhibitors

(2014) Lydia W.T. Cheung et al.   CANCER CELL

Repeat associated non-ATG (RAN) translation: new starts in microsatellite expansion disorders

(2014) John Douglas Cleary et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

C9orf72 amyotrophic lateral sclerosis and frontotemporal dementia

(2014) Sarah Mizielinska et al.   CURRENT OPINION IN NEUROLOGY

MicroRNA-125b induces tau hyperphosphorylation and cognitive deficits in Alzheimer's disease

(2014) J. Banzhaf-Strathmann et al.   EMBO JOURNAL

ERK-mediated phosphorylation of TFAM downregulates mitochondrial transcription: Implications for Parkinson's disease

(2014) Kent Z.Q. Wang et al.   MITOCHONDRION

eIF4F is a nexus of resistance to anti-BRAF and anti-MEK cancer therapies

(2014) Lise Boussemart et al.   NATURE

A unique inhibitor binding site in ERK1/2 is associated with slow binding kinetics

(2014) Apirat Chaikuad et al.   Nature Chemical Biology

In vivo RNAi screening identifies a mechanism of sorafenib resistance in liver cancer

(2014) Ramona Rudalska et al.   NATURE MEDICINE

The phenotypic variability of amyotrophic lateral sclerosis

(2014) Bart Swinnen et al.   Nature Reviews Neurology

Discovery of a Biomarker and Lead Small Molecules to Target r(GGGGCC)-Associated Defects in c9FTD/ALS

(2014) Zhaoming Su et al.   NEURON

Axonal Transport of TDP-43 mRNA Granules Is Impaired by ALS-Causing Mutations

(2014) Nael H. Alami et al.   NEURON

BRAFV600E Mutation and Its Association with Clinicopathological Features of Colorectal Cancer: A Systematic Review and Meta-Analysis

(2014) Dong Chen et al.   PLoS One

Activated Scavenger Receptor A Promotes Glial Internalization of Aβ

(2014) He Zhang et al.   PLoS One

Loss of p53 induces cell proliferation via Ras-independent activation of the Raf/Mek/Erk signaling pathway

(2014) Matthias Drosten et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

C9orf72 repeat expansions cause neurodegeneration in Drosophila through arginine-rich proteins

(2014) S. Mizielinska et al.   SCIENCE

TNF and MAP kinase signalling pathways

(2014) Guadalupe Sabio et al.   SEMINARS IN IMMUNOLOGY

Parkin and PINK1: much more than mitophagy

(2014) Leslie A. Scarffe et al.   TRENDS IN NEUROSCIENCES

p38α MAPK pathway: A key factor in colorectal cancer therapy and chemoresistance

(2014) Valentina Grossi   WORLD JOURNAL OF GASTROENTEROLOGY

The ER mitochondria calcium cycle and ER stress response as therapeutic targets in amyotrophic lateral sclerosis

(2014) Vedrana Tadic et al.   Frontiers in Cellular Neuroscience

c-Jun N-terminal kinase has a key role in Alzheimer disease synaptic dysfunction in vivo

(2014) A Sclip et al.   Cell Death & Disease

Parkinson’s disease-implicated kinases in the brain; insights into disease pathogenesis

(2014) Nicolas Dzamko et al.   Frontiers in Molecular Neuroscience

Aβ and tau toxicities in Alzheimer’s are linked via oxidative stress-induced p38 activation: Protective role of vitamin E

(2014) E. Giraldo et al.   Redox Biology

A Small Molecule Bidentate-Binding Dual Inhibitor Probe of the LRRK2 and JNK Kinases

(2013) Yangbo Feng et al.   ACS Chemical Biology

The RASopathies

(2013) Katherine A. Rauen   Annual Review of Genomics and Human Genetics

Toward the Treatment and Prevention of Alzheimer's Disease: Rational Strategies and Recent Progress

(2013) Sam Gandy et al.   Annual Review of Medicine

Inhibition of ERK-DLP1 signaling and mitochondrial division alleviates mitochondrial dysfunction in Alzheimer's disease cybrid cell

(2013) Xueqi Gan et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Hierarchical scaffolding of an ERK1/2 activation pathway

(2013) Susanne Vetterkind et al.   Cell Communication and Signaling

Genetic Correction of a LRRK2 Mutation in Human iPSCs Links Parkinsonian Neurodegeneration to ERK-Dependent Changes in Gene Expression

(2013) Peter Reinhardt et al.   Cell Stem Cell

Molecular Pathways: Response and Resistance to BRAF and MEK Inhibitors in BRAFV600ETumors

(2013) Meghna Das Thakur et al.   CLINICAL CANCER RESEARCH

NOSH-aspirin (NBS-1120), a novel nitric oxide and hydrogen sulfide releasing hybrid, attenuates neuroinflammation induced by microglial and astrocytic activation: A new candidate for treatment of neurodegenerative disorders

(2013) Moonhee Lee et al.   GLIA

Pink1 deficiency attenuates astrocyte proliferation through mitochondrial dysfunction, reduced akt and increased p38 mapk activation, and downregulation of egfr

(2013) Insup Choi et al.   GLIA

Accumulation of the parkin substrate, FAF1, plays a key role in the dopaminergic neurodegeneration

(2013) Jee-Won Sul et al.   HUMAN MOLECULAR GENETICS

β2Adrenergic Receptor, Protein Kinase A (PKA) and c-Jun N-terminal Kinase (JNK) Signaling Pathways Mediate Tau Pathology in Alzheimer Disease Models

(2013) Dayong Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Selective mitochondrial Ca2+uptake deficit in disease endstage vulnerable motoneurons of the SOD1G93Amouse model of amyotrophic lateral sclerosis

(2013) Andrea Fuchs et al.   JOURNAL OF PHYSIOLOGY-LONDON

Noonan syndrome

(2013) Amy E Roberts et al.   LANCET

Modelling vemurafenib resistance in melanoma reveals a strategy to forestall drug resistance

(2013) Meghna Das Thakur et al.   NATURE

The role of autophagy in neurodegenerative disease

(2013) Ralph A Nixon   NATURE MEDICINE

DJ-1 facilitates the interaction between STAT1 and its phosphatase, SHP-1, in brain microglia and astrocytes: A novel anti-inflammatory function of DJ-1

(2013) Jong-hyeon Kim et al.   NEUROBIOLOGY OF DISEASE

Autophagy activation and neuroprotection by progesterone in the G93A-SOD1 transgenic mouse model of amyotrophic lateral sclerosis

(2013) Jean Kim et al.   NEUROBIOLOGY OF DISEASE

Neuroprotective effects of the Sigma-1 receptor (S1R) agonist PRE-084, in a mouse model of motor neuron disease not linked to SOD1 mutation

(2013) Marco Peviani et al.   NEUROBIOLOGY OF DISEASE

Parkin Plays a Role in Sporadic Parkinson's Disease

(2013) Ted M. Dawson et al.   Neurodegenerative Diseases

SA4503, a sigma-1 receptor agonist, suppresses motor neuron damage in in vitro and in vivo amyotrophic lateral sclerosis models

(2013) Yoko Ono et al.   NEUROSCIENCE LETTERS

MEK in cancer and cancer therapy

(2013) Cindy Neuzillet et al.   PHARMACOLOGY & THERAPEUTICS

Mild Oxidative Stress Induces Redistribution of BACE1 in Non-Apoptotic Conditions and Promotes the Amyloidogenic Processing of Alzheimer’s Disease Amyloid Precursor Protein

(2013) Jiang-Li Tan et al.   PLoS One

Inhibition of Fast Axonal Transport by Pathogenic SOD1 Involves Activation of p38 MAP Kinase

(2013) Gerardo A. Morfini et al.   PLoS One

Rotenone Directly Induces BV2 Cell Activation via the p38 MAPK Pathway

(2013) Feng Gao et al.   PLoS One

Molecular chaperone Hsp110 rescues a vesicle transport defect produced by an ALS-associated mutant SOD1 protein in squid axoplasm

(2013) Y. Song et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MST1 functions as a key modulator of neurodegeneration in a mouse model of ALS

(2013) J. K. Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Impaired autophagy and APP processing in Alzheimer's disease: The potential role of Beclin 1 interactome

(2013) Antero Salminen et al.   PROGRESS IN NEUROBIOLOGY

Autophagy and apoptosis dysfunction in neurodegenerative disorders

(2013) Saeid Ghavami et al.   PROGRESS IN NEUROBIOLOGY

Molecular basis of MAP kinase regulation

(2013) Wolfgang Peti et al.   PROTEIN SCIENCE

Mitochondrial dysfunctions in Parkinson's disease

(2013) C.A. Gautier et al.   REVUE NEUROLOGIQUE

Promiscuous Alzheimer's Amyloid: Yet Another Partner

(2013) I. Benilova et al.   SCIENCE

PLC-  and PI3K Link Cytokines to ERK Activation in Hematopoietic Cells with Normal and Oncogenic Kras

(2013) E. Diaz-Flores et al.   Science Signaling

Drosophila DJ-1 Decreases Neural Sensitivity to Stress by Negatively Regulating Daxx-Like Protein through dFOXO

(2013) Soojin Hwang et al.   PLoS Genetics

Characterization of early pathogenesis in the SOD1G93Amouse model of ALS: part I, background and methods

(2013) Sharon Vinsant et al.   Brain and Behavior

Maturation of autophagosomes and endosomes: A key role for Rab7

(2012) Juha M.T. Hyttinen et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

TWIST1 Is an ERK1/2 Effector That Promotes Invasion and Regulates MMP-1 Expression in Human Melanoma Cells

(2012) M. B. Weiss et al.   CANCER RESEARCH

MED12 Controls the Response to Multiple Cancer Drugs through Regulation of TGF-β Receptor Signaling

(2012) Sidong Huang et al.   CELL

(G2019S) LRRK2 activates MKK4-JNK pathway and causes degeneration of SN dopaminergic neurons in a transgenic mouse model of PD

(2012) C-Y Chen et al.   CELL DEATH AND DIFFERENTIATION

ERK5: Structure, regulation and function

(2012) Gopika N. Nithianandarajah-Jones et al.   CELLULAR SIGNALLING

Modularity and functional plasticity of scaffold proteins as p(l)acemakers in cell signaling

(2012) Catherine Qiurong Pan et al.   CELLULAR SIGNALLING

Nuclear translocation of DJ-1 during oxidative stress-induced neuronal cell death

(2012) Su-Jeong Kim et al.   FREE RADICAL BIOLOGY AND MEDICINE

Increase of oxidative stress by a novel PINK1 mutation, P209A

(2012) Wei-Lin Chien et al.   FREE RADICAL BIOLOGY AND MEDICINE

A Liver Full of JNK: Signaling in Regulation of Cell Function and Disease Pathogenesis, and Clinical Approaches

(2012) Ekihiro Seki et al.   GASTROENTEROLOGY

MEK inhibition exhibits efficacy in human and mouse neurofibromatosis tumors

(2012) Walter J. Jessen et al.   JOURNAL OF CLINICAL INVESTIGATION

Loss of Interleukin Receptor-Associated Kinase 4 Signaling Suppresses Amyloid Pathology and Alters Microglial Phenotype in a Mouse Model of Alzheimer's Disease

(2012) B. Cameron et al.   JOURNAL OF NEUROSCIENCE

The toxic Aβ oligomer and Alzheimer's disease: an emperor in need of clothes

(2012) Iryna Benilova et al.   NATURE NEUROSCIENCE

Parkinson's Disease DJ-1 L166P Alters rRNA Biogenesis by Exclusion of TTRAP from the Nucleolus and Sequestration into Cytoplasmic Aggregates via TRAF6

(2012) Sandra Vilotti et al.   PLoS One

Autophagy activators rescue and alleviate pathogenesis of a mouse model with proteinopathies of the TAR DNA-binding protein 43

(2012) I.-F. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

RETRACTED: 6-OHDA-induced apoptosis and mitochondrial dysfunction are mediated by early modulation of intracellular signals and interaction of Nrf2 and NF-κB factors

(2012) Julio C. Tobón-Velasco et al.   TOXICOLOGY

The cBio Cancer Genomics Portal: An Open Platform for Exploring Multidimensional Cancer Genomics Data: Figure 1.

(2012) Ethan Cerami et al.   Cancer Discovery

MyD88 Deficiency Ameliorates β-Amyloidosis in an Animal Model of Alzheimer's Disease

(2011) Jeong-Eun Lim et al.   AMERICAN JOURNAL OF PATHOLOGY

A mutation in sigma-1 receptor causes juvenile amyotrophic lateral sclerosis

(2011) Amr Al-Saif et al.   ANNALS OF NEUROLOGY

Synaptic Mitochondrial Pathology in Alzheimer's Disease

(2011) Heng Du et al.   ANTIOXIDANTS & REDOX SIGNALING

Region-specific tauopathy and synucleinopathy in brain of the alpha-synuclein overexpressing mouse model of Parkinson's disease

(2011) Tiffany Kaul et al.   BMC NEUROSCIENCE

Phosphorylation of HtrA2 by cyclin-dependent kinase-5 is important for mitochondrial function

(2011) J C Fitzgerald et al.   CELL DEATH AND DIFFERENTIATION

The increased density of p38 mitogen-activated protein kinase-immunoreactive microglia in the sensorimotor cortex of aged TgCRND8 mice is associated predominantly with smaller dense-core amyloid plaques

(2011) J. Chlan-Fourney et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Ghrelin protects spinal cord motoneurons against chronic glutamate-induced excitotoxicity via ERK1/2 and phosphatidylinositol-3-kinase/Akt/glycogen synthase kinase-3β pathways

(2011) Eunjin Lim et al.   EXPERIMENTAL NEUROLOGY

TDP-43 and FUS/TLS: cellular functions and implications for neurodegeneration

(2011) Fabienne C. Fiesel et al.   FEBS Journal

Blocking IL-1 Signaling Rescues Cognition, Attenuates Tau Pathology, and Restores Neuronal  -Catenin Pathway Function in an Alzheimer's Disease Model

(2011) M. Kitazawa et al.   JOURNAL OF IMMUNOLOGY

Dopamine and α-synuclein dysfunction in Smad3 null mice

(2011) Silvia Tapia-González et al.   Molecular Neurodegeneration

A Raf-induced allosteric transition of KSR stimulates phosphorylation of MEK

(2011) Damian F. Brennan et al.   NATURE

Exome sequencing identifies recurrent somatic MAP2K1 and MAP2K2 mutations in melanoma

(2011) Sergey I Nikolaev et al.   NATURE GENETICS

An overlooked neurotoxic species in Alzheimer's disease

(2011) Iryna Benilova et al.   NATURE NEUROSCIENCE

Potent amyloidogenicity and pathogenicity of Aβ43

(2011) Takashi Saito et al.   NATURE NEUROSCIENCE

The biological and therapeutic relevance of mRNA translation in cancer

(2011) Sarah P. Blagden et al.   Nature Reviews Clinical Oncology

Autophagy failure in Alzheimer's disease—locating the primary defect

(2011) Ralph A. Nixon et al.   NEUROBIOLOGY OF DISEASE

Increased Mitochondrial Calcium Sensitivity and Abnormal Expression of Innate Immunity Genes Precede Dopaminergic Defects in Pink1-Deficient Mice

(2011) Ravi S. Akundi et al.   PLoS One

High Frequency of PIK3R1 and PIK3R2 Mutations in Endometrial Cancer Elucidates a Novel Mechanism for Regulation of PTEN Protein Stability

(2011) Lydia W.T. Cheung et al.   Cancer Discovery

Apoptosis Signaling Kinases: From Stress Response to Health Outcomes

(2010) Kohsuke Takeda et al.   ANTIOXIDANTS & REDOX SIGNALING

Pathological roles of MAPK signaling pathways in human diseases

(2010) Eun Kyung Kim et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Anti-inflammatory Agents: Present and Future

(2010) Charles A. Dinarello   CELL

Mechanisms Underlying Inflammation in Neurodegeneration

(2010) Christopher K. Glass et al.   CELL

The Beclin 1 interactome

(2010) Congcong He et al.   CURRENT OPINION IN CELL BIOLOGY

Neurotoxicity of Alzheimer's disease Aβ peptides is induced by small changes in the Aβ42 to Aβ40 ratio

(2010) Inna Kuperstein et al.   EMBO JOURNAL

The small heat shock protein B8 (HspB8) promotes autophagic removal of misfolded proteins involved in amyotrophic lateral sclerosis (ALS)

(2010) Valeria Crippa et al.   HUMAN MOLECULAR GENETICS

Amyloid-β Protein Oligomer at Low Nanomolar Concentrations Activates Microglia and Induces Microglial Neurotoxicity

(2010) Izumi Maezawa et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

VEGF protects spinal motor neurons against chronic excitotoxic degeneration in vivo by activation of PI3-K pathway and inhibition of p38MAPK

(2010) Luis B. Tovar-y-Romo et al.   JOURNAL OF NEUROCHEMISTRY

Tumour necrosis factor alpha induces rapid reduction in AMPA receptor-mediated calcium entry in motor neurones by increasing cell surface expression of the GluR2 subunit: relevance to neurodegeneration

(2010) Stephanie R Rainey-Smith et al.   JOURNAL OF NEUROCHEMISTRY

JNK3 Mediates Paraquat- and Rotenone-Induced Dopaminergic Neuron Death

(2010) Won-Seok Choi et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Parkin Suppresses c-Jun N-terminal kinase-induced cell death via transriptional regulation in Drosophila

(2010) Soojin Hwang et al.   MOLECULES AND CELLS

Regulation of Amyloid Precursor Protein Processing by the Beclin 1 Complex

(2010) Philipp A. Jaeger et al.   PLoS One

Glial Innate Immunity Generated by Non-Aggregated Alpha-Synuclein in Mouse: Differences between Wild-type and Parkinson's Disease-Linked Mutants

(2010) Cintia Roodveldt et al.   PLoS One

Alzheimer's Disease: From Pathology to Therapeutic Approaches

(2009) Roland Jakob-Roetne et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A Nurr1/CoREST Pathway in Microglia and Astrocytes Protects Dopaminergic Neurons from Inflammation-Induced Death

(2009) Kaoru Saijo et al.   CELL

Drosophila HtrA2 is dispensable for apoptosis but acts downstream of PINK1 independently from Parkin

(2009) L S Tain et al.   CELL DEATH AND DIFFERENTIATION

A Switch in Retrograde Signaling from Survival to Stress in Rapid-Onset Neurodegeneration

(2009) E. Perlson et al.   JOURNAL OF NEUROSCIENCE

CD14 and Toll-Like Receptors 2 and 4 Are Required for Fibrillar A -Stimulated Microglial Activation

(2009) E. G. Reed-Geaghan et al.   JOURNAL OF NEUROSCIENCE

KSR2 Is a Calcineurin Substrate that Promotes ERK Cascade Activation in Response to Calcium Signals

(2009) Michele K. Dougherty et al.   MOLECULAR CELL

Inflammation, microglia, and alzheimer's disease

(2009) Brent Cameron et al.   NEUROBIOLOGY OF DISEASE

ALS motor phenotype heterogeneity, focality, and spread: Deconstructing motor neuron degeneration

(2009) J. M. Ravits et al.   NEUROLOGY

Induction of EMT by Twist Proteins as a Collateral Effect of Tumor-Promoting Inactivation of Premature Senescence

(2008) Stéphane Ansieau et al.   CANCER CELL

Genetic variability in the mitochondrial serine proteaseHTRA2contributes to risk for Parkinson disease

(2008) Veerle Bogaerts et al.   HUMAN MUTATION

Small molecule enhancers of autophagy for neurodegenerative diseases

(2008) Sovan Sarkar et al.   Molecular BioSystems

Cyclophilin D deficiency attenuates mitochondrial and neuronal perturbation and ameliorates learning and memory in Alzheimer's disease

(2008) Heng Du et al.   NATURE MEDICINE

Amyloid-β protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory

(2008) Ganesh M Shankar et al.   NATURE MEDICINE

Oxidative stress hypothesis in Alzheimer’s disease: a reappraisal

(2008) Domenico Praticò   TRENDS IN PHARMACOLOGICAL SCIENCES