JAK2/STAT3 pathway regulates microglia polarization involved in hippocampal inflammatory damage due to acute paraquat exposure

The maize SUMO conjugating enzyme ZmSCE1b protects plants from paraquat toxicity

(2021) Huanyan Wang et al.   ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY

Taurine improves neuron injuries and cognitive impairment in a mouse Parkinson’s disease model through inhibition of microglial activation

(2021) Ke Wang et al.   NEUROTOXICOLOGY

Activation of alpha7 nicotinic acetylcholine receptor protects bovine endometrial tissue against LPS-induced inflammatory injury via JAK2/STAT3 pathway and COX-2 derived prostaglandin E2

(2021) He Peng-Fei et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

MiR-135-5p Alleviates Bone Cancer Pain by Regulating Astrocyte-Mediated Neuroinflammation in Spinal Cord through JAK2/STAT3 Signaling Pathway

(2021) Ming Liu et al.   MOLECULAR NEUROBIOLOGY

Paraquat promotes acute lung injury in rats by regulating alveolar macrophage polarization through glycolysis

(2021) Yan Zhang et al.   ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY

Melatonin Reduces Neuroinflammation and Improves Axonal Hypomyelination by Modulating M1/M2 Microglia Polarization via JAK2-STAT3-Telomerase Pathway in Postnatal Rats Exposed to Lipopolysaccharide

(2021) Qiuping Zhou et al.   MOLECULAR NEUROBIOLOGY

Redox toxicology of environmental chemicals causing oxidative stress

(2020) Fuli Zheng et al.   Redox Biology

Estrogen receptor α phosphorylated at Ser216 confers inflammatory function to mouse microglia

(2020) Sawako Shindo et al.   Cell Communication and Signaling

Luteoloside Exerts Analgesic Effect in a Complete Freund’s Adjuvant-Induced Inflammatory Model via Inhibiting Interleukin-1β Expression and Macrophage/Microglia Activation

(2020) Chun-Yan Shi et al.   Frontiers in Pharmacology

Erythropoietin protects the inner blood–retinal barrier by inhibiting microglia phagocytosis via Src/Akt/cofilin signalling in experimental diabetic retinopathy

(2020) Hai Xie et al.   DIABETOLOGIA

Lipopolysaccharide mediates time-dependent macrophage M1/M2 polarization through the Tim-3/Galectin-9 signalling pathway

(2019) Wang Zhang et al.   EXPERIMENTAL CELL RESEARCH

Paraquat modulates microglia M1/M2 polarization via activation of TLR4-mediated NF-κB signaling pathway

(2019) Min Huang et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Primary hippocampal estrogenic dysfunction induces synaptic proteins alteration and neuronal cell death after single and repeated paraquat exposure

(2019) Paula Moyano et al.   FOOD AND CHEMICAL TOXICOLOGY

Taurine protects noradrenergic locus coeruleus neurons in a mouse Parkinson’s disease model by inhibiting microglial M1 polarization

(2018) Liyan Hou et al.   AMINO ACIDS

Paraquat and Maneb Exposure Alters Rat Neural Stem Cell Proliferation by Inducing Oxidative Stress: New Insights on Pesticide-Induced Neurodevelopmental Toxicity

(2018) Dirleise Colle et al.   NEUROTOXICITY RESEARCH

Manganese exposure facilitates microglial JAK2-STAT3 signaling and consequent secretion of TNF-a and IL-1β to promote neuronal death

(2018) Lifeng Yin et al.   NEUROTOXICOLOGY

Salvianolic acids enhance cerebral angiogenesis and neurological recovery by activating JAK2/STAT3 signaling pathway after ischemic stroke in mice

(2017) Yaoru Li et al.   JOURNAL OF NEUROCHEMISTRY

Paraquat and maneb co-exposure induces noradrenergic locus coeruleus neurodegeneration through NADPH oxidase-mediated microglial activation

(2017) Liyan Hou et al.   TOXICOLOGY

Primary hippocampal neuronal cell death induction after acute and repeated paraquat exposures mediated by AChE variants alteration and cholinergic and glutamatergic transmission disruption

(2017) Javier Del Pino et al.   TOXICOLOGY

A novel synthetic compound MCAP suppresses LPS-induced murine microglial activation in vitro via inhibiting NF-kB and p38 MAPK pathways

(2016) Byung-Wook Kim et al.   ACTA PHARMACOLOGICA SINICA

Functional polarization of neuroglia: Implications in neuroinflammation and neurological disorders

(2016) Mithilesh Kumar Jha et al.   BIOCHEMICAL PHARMACOLOGY

Neuronal Soluble Fas Ligand Drives M1-Microglia Polarization after Cerebral Ischemia

(2016) Hai-Lan Meng et al.   CNS Neuroscience & Therapeutics

Inflammatory Process in Alzheimer's and Parkinson's Diseases: Central Role of Cytokines

(2016) Qamre Alam et al.   CURRENT PHARMACEUTICAL DESIGN

β1-integrin restricts astrocytic differentiation of adult hippocampal neural stem cells

(2016) Sarah M. Brooker et al.   GLIA

Inhibition of the JAK/STAT Pathway Protects Against α-Synuclein-Induced Neuroinflammation and Dopaminergic Neurodegeneration

(2016) Hongwei Qin et al.   JOURNAL OF NEUROSCIENCE

Does age matter? Comparison of neurobehavioral effects of paraquat exposure on postnatal and adult C57BL/6 mice

(2016) Dan Lou et al.   TOXICOLOGY MECHANISMS AND METHODS

Does age matter? Comparison of neurobehavioral effects of paraquat exposure on postnatal and adult C57BL/6 mice

(2016) Dan Lou et al.   TOXICOLOGY MECHANISMS AND METHODS

Differential Roles of M1 and M2 Microglia in Neurodegenerative Diseases

(2015) Yu Tang et al.   MOLECULAR NEUROBIOLOGY

NLRP3 inflammasome activation by mitochondrial reactive oxygen species plays a key role in long-term cognitive impairment induced by paraquat exposure

(2015) Liuji Chen et al.   NEUROBIOLOGY OF AGING

Role of fractalkine–CX3CR1 pathway in seizure-induced microglial activation, neurodegeneration, and neuroblast production in the adult rat brain

(2015) Idrish Ali et al.   NEUROBIOLOGY OF DISEASE

Interleukin-6: a villain in the drama of pancreatic cancer development and progression

(2014) Reinhild Holmer et al.   Hepatobiliary & Pancreatic Diseases International

Microglia and brain macrophages in the molecular age: from origin to neuropsychiatric disease

(2014) Marco Prinz et al.   NATURE REVIEWS NEUROSCIENCE

Characterization of phenotype markers and neuronotoxic potential of polarised primary microglia in vitro

(2013) Vibol Chhor et al.   BRAIN BEHAVIOR AND IMMUNITY

Paraquat inhibits cell viability via enhanced oxidative stress and apoptosis in human neural progenitor cells

(2013) Xiuli Chang et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Central nervous system damage due to acute paraquat poisoning: A neuroimaging study with 3.0T MRI

(2012) Bailin Wu et al.   NEUROTOXICOLOGY

Central nervous system damage due to acute paraquat poisoning: An experimental study with rat model

(2012) Bailin Wu et al.   NEUROTOXICOLOGY

Microglia/Macrophage Polarization Dynamics Reveal Novel Mechanism of Injury Expansion After Focal Cerebral Ischemia

(2012) Xiaoming Hu et al.   STROKE

Dose-Dependent Nonlinear Effect of L-DOPA on Paired Associative Stimulation-Induced Neuroplasticity in Humans

(2011) N. Thirugnanasambandam et al.   JOURNAL OF NEUROSCIENCE