Neurodegeneration and Neuroinflammation in Parkinson’s Disease: a Self-Sustained Loop

Single-dose L-dopa increases upper brainstem GABA in Parkinson's disease: A preliminary study

(2021) Yulu Song et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Impaired meningeal lymphatic drainage in patients with idiopathic Parkinson’s disease

(2021) Xue-Bing Ding et al.   NATURE MEDICINE

Periphery and brain, innate and adaptive immunity in Parkinson’s disease

(2021) Ashley S. Harms et al.   ACTA NEUROPATHOLOGICA

α‐Synuclein evokes NLRP3 inflammasome‐mediated IL ‐1β secretion from primary human microglia

(2021) Adrianne F. Pike et al.   GLIA

Cytokines and Gaucher Biomarkers in Glucocerebrosidase Carriers With and Without Parkinson Disease

(2021) Jasmin Galper et al.   MOVEMENT DISORDERS

A LRRK2 GTP Binding Inhibitor, 68, Reduces LPS-Induced Signaling Events and TNF-α Release in Human Lymphoblasts

(2021) Tianxia Li et al.   Cells

The DJ1-Nrf2-STING axis mediates the neuroprotective effects of Withaferin A in Parkinson’s disease

(2021) Miao Zhao et al.   CELL DEATH AND DIFFERENTIATION

P2X7 receptor/NLRP3 inflammasome complex and α‐synuclein in peripheral blood mononuclear cells: a prospective study in neo‐diagnosed, treatment‐naïve Parkinson’s disease

(2021) Anna Solini et al.   EUROPEAN JOURNAL OF NEUROLOGY

The Contribution of Microglia to Neuroinflammation in Parkinson’s Disease

(2021) Katja Badanjak et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Development of a Sensitive Diagnostic Assay for Parkinson Disease Quantifying α-Synuclein–Containing Extracellular Vesicles

(2021) Zhen Hong et al.   NEUROLOGY

Helicobacter pylori eradication improves motor fluctuations in advanced Parkinson’s disease patients: A prospective cohort study (HP-PD trial)

(2021) Praween Lolekha et al.   PLoS One

Review: The Role of Intestinal Dysbiosis in Parkinson’s Disease

(2021) Yiying Huang et al.   Frontiers in Cellular and Infection Microbiology

Inflammatory Responses to Monomeric and Aggregated α-Synuclein in Peripheral Blood of Parkinson Disease Patients

(2021) Federica Piancone et al.   Frontiers in Neuroscience

Unraveling the Link Between Mitochondrial Dynamics and Neuroinflammation

(2021) Lilian Gomes de Oliveira et al.   Frontiers in Immunology

Single-Cell Transcriptomics and In Situ Morphological Analyses Reveal Microglia Heterogeneity Across the Nigrostriatal Pathway

(2021) Oihane Uriarte Huarte et al.   Frontiers in Immunology

The subcellular arrangement of alpha-synuclein proteoforms in the Parkinson’s disease brain as revealed by multicolor STED microscopy

(2021) Tim E. Moors et al.   ACTA NEUROPATHOLOGICA

Microglia jointly degrade fibrillar alpha-synuclein cargo by distribution through tunneling nanotubes

(2021) Hannah Scheiblich et al.   CELL

Crosstalk between astrocytes and microglia results in increased degradation of α-synuclein and amyloid-β aggregates

(2021) Jinar Rostami et al.   Journal of Neuroinflammation

Clinical correlates of white matter lesions in Parkinson's disease using automated multi-modal segmentation measures

(2021) Eric Fang et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Decreased glucocerebrosidase activity and substrate accumulation of glycosphingolipids in a novel GBA1 D409V knock-in mouse model

(2021) Nicole K. Polinski et al.   PLoS One

Genome-wide screen identifies curli amyloid fibril as a bacterial component promoting host neurodegeneration

(2021) Chenyin Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

DJ-1 inhibits microglial activation and protects dopaminergic neurons in vitro and in vivo through interacting with microglial p65

(2021) Zixuan Lin et al.   Cell Death & Disease

Selective targeting of the TLR2/MyD88/NF-κB pathway reduces α-synuclein spreading in vitro and in vivo

(2021) Debashis Dutta et al.   Nature Communications

Poly (ADP-ribose) Interacts With Phosphorylated α-Synuclein in Post Mortem PD Samples

(2021) Laura N. Puentes et al.   Frontiers in Aging Neuroscience

The Genetics of Parkinson’s Disease and Implications for Clinical Practice

(2021) Jacob Oliver Day et al.   Genes

The Pathogenesis of Parkinson's Disease: A Complex Interplay Between Astrocytes, Microglia, and T Lymphocytes?

(2021) Adina N. MacMahon Copas et al.   Frontiers in Neurology

Association Between Irritable Bowel Syndrome and Risk of Parkinson's Disease: A Systematic Review and Meta-Analysis

(2021) XinYue Zhang et al.   Frontiers in Neurology

LRRK2 Targeting Strategies as Potential Treatment of Parkinson’s Disease

(2021) Dominika Natalia Wojewska et al.   Biomolecules

Interplay Between Microbiota, Toll-Like Receptors and Cytokines for the Maintenance of Epithelial Barrier Integrity

(2021) Iaroslav Semin et al.   Frontiers in Medicine

The blood–brain barrier in systemic infection and inflammation

(2021) Ian Galea   Cellular & Molecular Immunology

Pathological α-syn aggregation is mediated by glycosphingolipid chain length and the physiological state of α-syn in vivo

(2021) Kristina Fredriksen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Phase II Study to Evaluate the Safety and Efficacy of Prasinezumab in Early Parkinson's Disease (PASADENA): Rationale, Design, and Baseline Data

(2021) Gennaro Pagano et al.   Frontiers in Neurology

Global ubiquitylation analysis of mitochondria in primary neurons identifies endogenous Parkin targets following activation of PINK1

(2021) Odetta Antico et al.   Science Advances

Molecular Mechanisms of mtDNA-Mediated Inflammation

(2021) Anna De Gaetano et al.   Cells

Systemic activation of NLRP3 inflammasome and plasma α-synuclein levels are correlated with motor severity and progression in Parkinson’s disease

(2020) Zheng Fan et al.   Journal of Neuroinflammation

The progress of gut microbiome research related to brain disorders

(2020) Sibo Zhu et al.   Journal of Neuroinflammation

Immune cell regulation of glia during CNS injury and disease

(2020) Andrew D. Greenhalgh et al.   NATURE REVIEWS NEUROSCIENCE

The STING pathway does not contribute to behavioural or mitochondrial phenotypes in Drosophila Pink1/parkin or mtDNA mutator models

(2020) Juliette J. Lee et al.   Scientific Reports

The Role of Short-Chain Fatty Acids From Gut Microbiota in Gut-Brain Communication

(2020) Ygor Parladore Silva et al.   Frontiers in Endocrinology

Mitochondrial Signatures in Circulating Extracellular Vesicles of Older Adults with Parkinson’s Disease: Results from the EXosomes in PArkiNson’s Disease (EXPAND) Study

(2020) Anna Picca et al.   Journal of Clinical Medicine

Plasma Cytokines Profile in Patients with Parkinson’s Disease Associated with Mutations in GBA Gene

(2020) I. V. Miliukhina et al.   BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE

A longitudinal study on α‐synuclein in plasma neuronal exosomes as a biomarker for Parkinson’s disease development and progression

(2020) M. Niu et al.   EUROPEAN JOURNAL OF NEUROLOGY

Serum neuronal exosomes predict and differentiate Parkinson’s disease from atypical parkinsonism

(2020) Cheng Jiang et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

The association between TLR3 rs3775290 polymorphism and sporadic Parkinson’s disease in Chinese Han population

(2020) Jing Wang et al.   NEUROSCIENCE LETTERS

The Role of Mitochondria in Inflammation: From Cancer to Neurodegenerative Disorders

(2020) Sonia Missiroli et al.   Journal of Clinical Medicine

Parkinson’s disease-associated alterations of the gut microbiome predict disease-relevant changes in metabolic functions

(2020) Federico Baldini et al.   BMC BIOLOGY

Nonsteroidal Anti‐Inflammatory Use and LRRK2 Parkinson's Disease Penetrance

(2020) Marta San Luciano et al.   MOVEMENT DISORDERS

Penetrance of Glucocerebrosidase ( GBA ) Mutations in Parkinson’s Disease: a Kin Cohort Study

(2020) Roberta Balestrino et al.   MOVEMENT DISORDERS

Characterizing dysbiosis of gut microbiome in PD: evidence for overabundance of opportunistic pathogens

(2020) Zachary D. Wallen et al.   npj Parkinsons Disease

Genetic predispositions of Parkinson’s disease revealed in patient-derived brain cells

(2020) Jenne Tran et al.   npj Parkinsons Disease

Mitochondrial damage-associated inflammation highlights biomarkers in PRKN/PINK1 parkinsonism

(2020) Max Borsche et al.   BRAIN

T cell infiltration and upregulation of MHCII in microglia leads to accelerated neuronal loss in an α-synuclein rat model of Parkinson’s disease

(2020) Meena S. Subbarayan et al.   Journal of Neuroinflammation

Microglia and astrocyte dysfunction in parkinson's disease

(2020) Tae-In Kam et al.   NEUROBIOLOGY OF DISEASE

Modulation of the Microbiome in Parkinson’s Disease: Diet, Drug, Stool Transplant, and Beyond

(2020) Ethan G. Brown et al.   Neurotherapeutics

DJ-1 (Park7) affects the gut microbiome, metabolites and the development of innate lymphoid cells (ILCs)

(2020) Yogesh Singh et al.   Scientific Reports

Brain Microglial Activation Increased in Glucocerebrosidase ( GBA ) Mutation Carriers without Parkinson's disease

(2020) Stephen Mullin et al.   MOVEMENT DISORDERS

Neuroinflammation in neurodegenerative disorders: the roles of microglia and astrocytes

(2020) Hyuk Sung Kwon et al.   Translational Neurodegeneration

Blocking meningeal lymphatic drainage aggravates Parkinson’s disease-like pathology in mice overexpressing mutated α-synuclein

(2019) Wenyan Zou et al.   Translational Neurodegeneration

The short-chain fatty acid pentanoate suppresses autoimmunity by modulating the metabolic-epigenetic crosstalk in lymphocytes

(2019) Maik Luu et al.   Nature Communications

Gut microbiota in neurodegenerative disorders

(2019) Suparna Roy Sarkar et al.   JOURNAL OF NEUROIMMUNOLOGY

Evidence for bidirectional and trans-synaptic parasympathetic and sympathetic propagation of alpha-synuclein in rats

(2019) Nathalie Van Den Berge et al.   ACTA NEUROPATHOLOGICA

Dysregulation in the Brain Protein Profile of Zebrafish Lacking the Parkinson’s Disease-Related Protein DJ-1

(2019) Amanda J. Edson et al.   MOLECULAR NEUROBIOLOGY

Intestinal infection triggers Parkinson’s disease-like symptoms in Pink1−/− mice

(2019) Diana Matheoud et al.   NATURE

Transneuronal Propagation of Pathologic α-Synuclein from the Gut to the Brain Models Parkinson’s Disease

(2019) Sangjune Kim et al.   NEURON

ccf-mtDNA as a Potential Link Between the Brain and Immune System in Neuro-Immunological Disorders

(2019) Stefano Gambardella et al.   Frontiers in Immunology

Mitochondrial Protein PINK1 Positively Regulates RLR Signaling

(2019) Jun Zhou et al.   Frontiers in Immunology

Inflammasome and α-synuclein in Parkinson's disease: A cross-sectional study

(2019) Koustav Chatterjee et al.   JOURNAL OF NEUROIMMUNOLOGY

Identification of novel risk loci, causal insights, and heritable risk for Parkinson's disease: a meta-analysis of genome-wide association studies

(2019) Mike A Nalls et al.   LANCET NEUROLOGY

α-synuclein promotes progression of Parkinson's disease by upregulating autophagy signaling pathway to activate NLRP3 inflammasome

(2019) Xiaohong Wang et al.   Experimental and Therapeutic Medicine

Tryptophan Metabolism by Gut Microbiome and Gut-Brain-Axis: An in silico Analysis

(2019) Harrisham Kaur et al.   Frontiers in Neuroscience

Basal Mitophagy Occurs Independently of PINK1 in Mouse Tissues of High Metabolic Demand

(2018) Thomas G. McWilliams et al.   Cell Metabolism

Basal mitophagy is widespread inDrosophilabut minimally affected by loss of Pink1 or parkin

(2018) Juliette J. Lee et al.   JOURNAL OF CELL BIOLOGY

Association between diabetes and subsequent Parkinson disease

(2018) Eduardo De Pablo-Fernandez et al.   NEUROLOGY

Functional variants in the LRRK2 gene confer shared effects on risk for Crohn’s disease and Parkinson’s disease

(2018) Ken Y. Hui et al.   Science Translational Medicine

Lack of PINK1 alters glia innate immune responses and enhances inflammation-induced, nitric oxide-mediated neuron death

(2018) Liuke Sun et al.   Scientific Reports

The Parkinson Pandemic—A Call to Action

(2018) E. Ray Dorsey et al.   JAMA Neurology

Silencing Alpha Synuclein in Mature Nigral Neurons Results in Rapid Neuroinflammation and Subsequent Toxicity

(2018) Matthew J. Benskey et al.   Frontiers in Molecular Neuroscience

Astroglial DJ-1 over-expression up-regulates proteins involved in redox regulation and is neuroprotective in vivo

(2018) Ann Kristin Frøyset et al.   Redox Biology

Parkin and PINK1 mitigate STING-induced inflammation

(2018) Danielle A. Sliter et al.   NATURE

Inflammation and neurodegeneration: chronicity matters

(2018) Keenan A. Walker   Aging-US

Single-Cell Sequencing of iPSC-Dopamine Neurons Reconstructs Disease Progression and Identifies HDAC4 as a Regulator of Parkinson Cell Phenotypes

(2018) Charmaine Lang et al.   Cell Stem Cell

Inflammasome inhibition prevents α-synuclein pathology and dopaminergic neurodegeneration in mice

(2018) Richard Gordon et al.   Science Translational Medicine

CNS inflammation and neurodegeneration

(2017) Tanuja Chitnis et al.   JOURNAL OF CLINICAL INVESTIGATION

Progression of pathology in PINK1-deficient mouse brain from splicing via ubiquitination, ER stress, and mitophagy changes to neuroinflammation

(2017) Sylvia Torres-Odio et al.   Journal of Neuroinflammation

T cells from patients with Parkinson’s disease recognize α-synuclein peptides

(2017) David Sulzer et al.   NATURE

Structural changes of gut microbiota in Parkinson’s disease and its correlation with clinical features

(2017) Wei Li et al.   Science China-Life Sciences

PINK1/Parkin-Dependent Mitochondrial Surveillance: From Pleiotropy to Parkinson's Disease

(2017) Francois Mouton-Liger et al.   Frontiers in Molecular Neuroscience

Plasma Extracellular Vesicles Enriched for Neuronal Origin: A Potential Window into Brain Pathologic Processes

(2017) Maja Mustapic et al.   Frontiers in Neuroscience

Gut Microbiota Regulate Motor Deficits and Neuroinflammation in a Model of Parkinson’s Disease

(2016) Timothy R. Sampson et al.   CELL

The Central Nervous System and the Gut Microbiome

(2016) Gil Sharon et al.   CELL

Parkinson’s Disease-Related Proteins PINK1 and Parkin Repress Mitochondrial Antigen Presentation

(2016) Diana Matheoud et al.   CELL

Inflammatory profile in LRRK2-associated prodromal and clinical PD

(2016) Kathrin Brockmann et al.   Journal of Neuroinflammation

Increased peripheral inflammation in asymptomatic leucine-rich repeat kinase 2 mutation carriers

(2016) Nicolas Dzamko et al.   MOVEMENT DISORDERS

Parkinson's Disease and Neurodegeneration: GABA-Collapse Hypothesis

(2016) Janusz W. Błaszczyk   Frontiers in Neuroscience

Alpha-Synuclein Proteins Promote Pro-Inflammatory Cascades in Microglia: Stronger Effects of the A53T Mutant

(2016) Claire Hoenen et al.   PLoS One

Amyloid fibrils are the molecular trigger of inflammation in Parkinson's disease

(2015) A. Gustot et al.   BIOCHEMICAL JOURNAL

Gastrointestinal dysfunction in Parkinson's disease

(2015) Alfonso Fasano et al.   LANCET NEUROLOGY

The ubiquitin kinase PINK1 recruits autophagy receptors to induce mitophagy

(2015) Michael Lazarou et al.   NATURE

Altered microRNA profiles in cerebrospinal fluid exosome in Parkinson disease and Alzheimer disease

(2015) YaXing Gui et al.   Oncotarget

The Synaptic Function of α-Synuclein

(2015) Jacqueline Burré   Journal of Parkinsons Disease

Immune aging, dysmetabolism, and inflammation in neurological diseases

(2015) Michela Deleidi et al.   Frontiers in Neuroscience

Biogenesis, Secretion, and Intercellular Interactions of Exosomes and Other Extracellular Vesicles

(2014) Marina Colombo et al.   Annual Review of Cell and Developmental Biology

Pink1, the first ubiquitin kinase

(2014) X. Zheng et al.   EMBO JOURNAL

PINK1 and Its Familial Parkinson's Disease-Associated Mutation Regulate Brain Vascular Endothelial Inflammation

(2014) Wang Yunfu et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Identifying the Association Between Alzheimer’s Disease and Parkinson’s Disease Using Genome-Wide Association Studies and Protein-Protein Interaction Network

(2014) Guiyou Liu et al.   MOLECULAR NEUROBIOLOGY

Gut microbiota are related to Parkinson's disease and clinical phenotype

(2014) Filip Scheperjans et al.   MOVEMENT DISORDERS

Prion-like spreading of pathological α-synuclein in brain

(2013) Masami Masuda-Suzukake et al.   BRAIN

Loss of iron triggers PINK1/Parkin-independent mitophagy

(2013) George F G Allen et al.   EMBO REPORTS

Elevated TRAF2/6 expression in Parkinson’s disease is caused by the loss of Parkin E3 ligase activity

(2013) Ji-Yun Chung et al.   LABORATORY INVESTIGATION

The ubiquitin ligase parkin mediates resistance to intracellular pathogens

(2013) Paolo S. Manzanillo et al.   NATURE

Neuroprotective Function of DJ-1 in Parkinson’s Disease

(2013) Hiroyoshi Ariga et al.   Oxidative Medicine and Cellular Longevity

Triggering of Inflammasome by Aggregated α–Synuclein, an Inflammatory Response in Synucleinopathies

(2013) Gaia Codolo et al.   PLoS One

Clinical and Biochemical Differences in Patients Having Parkinson Disease With vs WithoutGBAMutations

(2013) Lama M. Chahine et al.   JAMA Neurology

PINK1 Deficiency Enhances Inflammatory Cytokine Release from Acutely Prepared Brain Slices

(2013) Jun Kim et al.   Experimental Neurobiology

Neuron-to-neuron transmission of α-synuclein fibrils through axonal transport

(2012) Eric C. Freundt et al.   ANNALS OF NEUROLOGY

Further characterisation of the LPS model of Parkinson’s disease: A comparison of intra-nigral and intra-striatal lipopolysaccharide administration on motor function, microgliosis and nigrostriatal neurodegeneration in the rat

(2012) Deirdre B. Hoban et al.   BRAIN BEHAVIOR AND IMMUNITY

Inflammation and α-Synuclein’s Prion-like Behavior in Parkinson's Disease—Is There a Link?

(2012) Carla M. Lema Tomé et al.   MOLECULAR NEUROBIOLOGY

Parkinson's disease-linked leucine-rich repeat kinase 2(R1441G) mutation increases proinflammatory cytokine release from activated primary microglial cells and resultant neurotoxicity

(2012) F. Gillardon et al.   NEUROSCIENCE

Gaucher Disease Glucocerebrosidase and α-Synuclein Form a Bidirectional Pathogenic Loop in Synucleinopathies

(2011) Joseph R. Mazzulli et al.   CELL

Increased Mitochondrial Calcium Sensitivity and Abnormal Expression of Innate Immunity Genes Precede Dopaminergic Defects in Pink1-Deficient Mice

(2011) Ravi S. Akundi et al.   PLoS One

Regulation of LRRK2 Expression Points to a Functional Role in Human Monocyte Maturation

(2011) Jonathan Thévenet et al.   PLoS One

CNS expression of glucocerebrosidase corrects  -synuclein pathology and memory in a mouse model of Gaucher-related synucleinopathy

(2011) S. P. Sardi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Short communication Interleukin-6 levels in cerebrospinal fluid inversely correlate to severity of Parkinson's disease

(2010) T. Müller et al.   ACTA NEUROLOGICA SCANDINAVICA

DJ-1 and α-synuclein in human cerebrospinal fluid as biomarkers of Parkinson’s disease

(2010) Zhen Hong et al.   BRAIN

The Role of Glucocerebrosidase Mutations in Parkinson Disease and Lewy Body Disorders

(2010) Arash Velayati et al.   Current Neurology and Neuroscience Reports

Cell-Produced  -Synuclein Is Secreted in a Calcium-Dependent Manner by Exosomes and Impacts Neuronal Survival

(2010) E. Emmanouilidou et al.   JOURNAL OF NEUROSCIENCE

Anti-inflammatory drugs and risk of Parkinson disease: A meta-analysis

(2010) J. J. Gagne et al.   NEUROLOGY

Multicenter Analysis of Glucocerebrosidase Mutations in Parkinson's Disease

(2009) E. Sidransky et al.   NEW ENGLAND JOURNAL OF MEDICINE

Targeted Overexpression of Human α-Synuclein Triggers Microglial Activation and an Adaptive Immune Response in a Mouse Model of Parkinson Disease

(2008) Shaji Theodore et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Parkin Deficiency Increases Vulnerability to Inflammation-Related Nigral Degeneration

(2008) T. C. Frank-Cannon et al.   JOURNAL OF NEUROSCIENCE

Vascular pathology in patients with idiopathic Parkinson's disease

(2008) Ivan Rektor et al.   PARKINSONISM & RELATED DISORDERS

Synuclein activates microglia in a model of Parkinson's disease

(2007) Xiaomin Su et al.   NEUROBIOLOGY OF AGING