Selective targeting of the TLR2/MyD88/NF-κB pathway reduces α-synuclein spreading in vitro and in vivo

ACE-2-interacting Domain of SARS-CoV-2 (AIDS) Peptide Suppresses Inflammation to Reduce Fever and Protect Lungs and Heart in Mice: Implications for COVID-19 Therapy

(2021) Ramesh K. Paidi et al.   Journal of Neuroimmune Pharmacology

TNF-α and α-synuclein fibrils differently regulate human astrocyte immune reactivity and impair mitochondrial respiration

(2021) Kaspar Russ et al.   Cell Reports

alpha-Synuclein: a Modulator During Inflammatory CNS Demyelination

(2020) Kristina Kuhbandner et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Glial activation precedes alpha-synuclein pathology in a mouse model of Parkinson’s disease

(2020) Maria Izco et al.   NEUROSCIENCE RESEARCH

How is alpha‐synuclein cleared from the cell?

(2019) Leonidas Stefanis et al.   JOURNAL OF NEUROCHEMISTRY

Activation of Peroxisome Proliferator-Activated Receptor-α Increases the Expression of Nuclear Receptor Related 1 Protein (Nurr1) in Dopaminergic Neurons

(2019) Carl G. Gottschalk et al.   MOLECULAR NEUROBIOLOGY

Block of A1 astrocyte conversion by microglia is neuroprotective in models of Parkinson’s disease

(2018) Seung Pil Yun et al.   NATURE MEDICINE

Aspirin binds to PPARα to stimulate hippocampal plasticity and protect memory

(2018) Dhruv Patel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Selective disruption of TLR2-MyD88 interaction inhibits inflammation and attenuates Alzheimer’s pathology

(2018) Suresh B. Rangasamy et al.   JOURNAL OF CLINICAL INVESTIGATION

Low-Dose Aspirin Upregulates Tyrosine Hydroxylase and Increases Dopamine Production in Dopaminergic Neurons: Implications for Parkinson’s Disease

(2018) Suresh B. Rangasamy et al.   Journal of Neuroimmune Pharmacology

Immunotherapy targeting toll-like receptor 2 alleviates neurodegeneration in models of synucleinopathy by modulating α-synuclein transmission and neuroinflammation

(2018) Changyoun Kim et al.   Molecular Neurodegeneration

Secretion and Uptake of α-Synuclein Via Extracellular Vesicles in Cultured Cells

(2018) Gabriel Gustafsson et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Inflammasome inhibition prevents α-synuclein pathology and dopaminergic neurodegeneration in mice

(2018) Richard Gordon et al.   Science Translational Medicine

Induction of Adaptive Immunity Leads to Nigrostriatal Disease Progression in MPTP Mouse Model of Parkinson’s Disease

(2017) Goutam Chandra et al.   JOURNAL OF IMMUNOLOGY

Increase in Mitochondrial Biogenesis in Neuronal Cells by RNS60, a Physically-Modified Saline, via Phosphatidylinositol 3-Kinase-Mediated Upregulation of PGC1α

(2017) Goutam Chandra et al.   Journal of Neuroimmune Pharmacology

Human Astrocytes Transfer Aggregated Alpha-Synuclein via Tunneling Nanotubes

(2017) Jinar Rostami et al.   JOURNAL OF NEUROSCIENCE

Low Levels of Prohibitin in Substantia Nigra Makes Dopaminergic Neurons Vulnerable in Parkinson’s Disease

(2017) Debashis Dutta et al.   MOLECULAR NEUROBIOLOGY

Intrastriatal injection of α-synuclein can lead to widespread synucleinopathy independent of neuroanatomic connectivity

(2017) Zachary A. Sorrentino et al.   Molecular Neurodegeneration

Phosphorylated exogenous alpha-synuclein fibrils exacerbate pathology and induce neuronal dysfunction in mice

(2017) Mantia Karampetsou et al.   Scientific Reports

Toll-like receptor 2 is increased in neurons in Parkinson’s disease brain and may contribute to alpha-synuclein pathology

(2016) Nicolas Dzamko et al.   ACTA NEUROPATHOLOGICA

Exocytosis and Spreading of Normal and Aberrant α-Synuclein

(2016) Evangelia Emmanouilidou et al.   BRAIN PATHOLOGY

Noncanonical IFN Signaling: Mechanistic Linkage of Genetic and Epigenetic Events

(2016) Howard M. Johnson et al.   MEDIATORS OF INFLAMMATION

Identification and characterization of PPARα ligands in the hippocampus

(2016) Avik Roy et al.   Nature Chemical Biology

Non-cell-autonomous Neurotoxicity of α-synuclein Through Microglial Toll-like Receptor 2

(2016) Changyoun Kim et al.   Experimental Neurobiology

Activation of Peroxisome Proliferator-activated Receptor α Induces Lysosomal Biogenesis in Brain Cells

(2015) Arunava Ghosh et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Brain region-dependent differential expression of alpha-synuclein

(2015) Katsutoshi Taguchi et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Antagonizing Neuronal Toll-like Receptor 2 Prevents Synucleinopathy by Activating Autophagy

(2015) Changyoun Kim et al.   Cell Reports

Fibrillar Amyloid-  Peptides Activate Microglia via TLR2: Implications for Alzheimer's Disease

(2014) M. Jana et al.   JOURNAL OF IMMUNOLOGY

Extracellular α-synuclein—a novel and crucial factor in Lewy body diseases

(2014) He-Jin Lee et al.   Nature Reviews Neurology

Glucocerebrosidase depletion enhances cell-to-cell transmission of α-synuclein

(2014) Eun-Jin Bae et al.   Nature Communications

Neuron-released oligomeric α-synuclein is an endogenous agonist of TLR2 for paracrine activation of microglia

(2013) Changyoun Kim et al.   Nature Communications

Alpha-synuclein aggregation involves a bafilomycin A1-sensitive autophagy pathway

(2012) Jochen Klucken et al.   Autophagy

Suppression of Nuclear Factor-κB Activation and Inflammation in Microglia by Physically Modified Saline

(2012) Saurabh Khasnavis et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Potential role of α-synuclein in neurodegeneration: studies in a rat animal model

(2012) George Stoica et al.   JOURNAL OF NEUROCHEMISTRY

Testing NF-κB-based Therapy in Hemiparkinsonian Monkeys

(2012) Susanta Mondal et al.   Journal of Neuroimmune Pharmacology

Long-term polarization of microglia upon α-synuclein overexpression in nonhuman primates

(2012) P. Barkholt et al.   NEUROSCIENCE

Pathological  -Synuclein Transmission Initiates Parkinson-like Neurodegeneration in Nontransgenic Mice

(2012) K. C. Luk et al.   SCIENCE

Direct Transfer of α-Synuclein from Neuron to Astroglia Causes Inflammatory Responses in Synucleinopathies

(2010) He-Jin Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

 -Synuclein Activates Microglia by Inducing the Expressions of Matrix Metalloproteinases and the Subsequent Activation of Protease-Activated Receptor-1

(2010) E.-J. Lee et al.   JOURNAL OF IMMUNOLOGY

Alpha-Synuclein Stimulation of Astrocytes: Potential Role for Neuroinflammation and Neuroprotection

(2010) He-Jin Lee et al.   Oxidative Medicine and Cellular Longevity

Simvastatin Inhibits the Activation of p21ras and Prevents the Loss of Dopaminergic Neurons in a Mouse Model of Parkinson's Disease

(2009) A. Ghosh et al.   JOURNAL OF NEUROSCIENCE

Increased frequency of α-synuclein in the substantia nigra in human immunodeficiency virus infection

(2009) Negar Khanlou et al.   JOURNAL OF NEUROVIROLOGY

Inclusion formation and neuronal cell death through neuron-to-neuron transmission of  -synuclein

(2009) P. Desplats et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA