Inhibitors of the NLRP3 inflammasome pathway as promising therapeutic candidates for inflammatory diseases (Review)
Published 2023 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Inhibitors of the NLRP3 inflammasome pathway as promising therapeutic candidates for inflammatory diseases (Review)
Authors
Keywords
-
Journal
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
Volume 51, Issue 4, Pages -
Publisher
Spandidos Publications
Online
2023-03-21
DOI
10.3892/ijmm.2023.5238
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Spop ameliorates diabetic nephropathy through restraining NLRP3 inflammasome
- (2022) Bin Wang et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- NLRP3 Inhibitor Tranilast Attenuates Gestational Diabetes Mellitus in a Genetic Mouse Model
- (2022) Jing Cao et al. DRUGS IN R&D
- Inhibition of Gasdermin D-Mediated Pyroptosis Attenuates the Severity of Seizures and Astroglial Damage in Kainic Acid-Induced Epileptic Mice
- (2022) Lu Xia et al. Frontiers in Pharmacology
- Application of Disulfiram and its Metabolites in Treatment of Inflammatory Disorders
- (2022) Wenyi Guo et al. Frontiers in Pharmacology
- Didymin Suppresses Microglia Pyroptosis and Neuroinflammation Through the Asc/Caspase-1/GSDMD Pathway Following Experimental Intracerebral Hemorrhage
- (2022) Lingui Gu et al. Frontiers in Immunology
- Silica nanoparticles induce pyroptosis and cardiac hypertrophy via ROS/NLRP3/Caspase-1 pathway
- (2022) Fenghong Wang et al. FREE RADICAL BIOLOGY AND MEDICINE
- Disulfiram Suppressed Peritendinous Fibrosis Through Inhibiting Macrophage Accumulation and Its Pro-inflammatory Properties in Tendon Bone Healing
- (2022) Qi Zhou et al. Frontiers in Bioengineering and Biotechnology
- Astrocyte-Derived TNF-α-Activated Platelets Promote Cerebral Ischemia/Reperfusion Injury by Regulating the RIP1/RIP3/AKT Signaling Pathway
- (2022) Wei Li et al. MOLECULAR NEUROBIOLOGY
- Diabetes Mellitus Promotes the Development of Atherosclerosis: The Role of NLRP3
- (2022) Jingxue Ye et al. Frontiers in Immunology
- Munronoid I Ameliorates DSS-Induced Mouse Colitis by Inhibiting NLRP3 Inflammasome Activation and Pyroptosis Via Modulation of NLRP3
- (2022) Xingyu Ma et al. Frontiers in Immunology
- CHRFAM7A Overexpression Attenuates Cerebral Ischemia-Reperfusion Injury via Inhibiting Microglia Pyroptosis Mediated by the NLRP3/Caspase-1 pathway
- (2021) Xiangyuan Cao et al. INFLAMMATION
- Inhibition of Caspase-1 Ameliorates Ischemia-Associated Blood-Brain Barrier Dysfunction and Integrity by Suppressing Pyroptosis Activation
- (2021) Yubin Liang et al. Frontiers in Cellular Neuroscience
- Effects of quercetin on diabetic retinopathy and its association with NLRP3 inflammasome and autophagy
- (2021) Rong Li et al. International Journal of Ophthalmology
- Specific NLRP3 inflammasome inhibitors: promising therapeutic agents for inflammatory diseases
- (2021) Chi Teng Vong et al. DRUG DISCOVERY TODAY
- NLRP3 inflammasome inhibitor INF39 attenuated NLRP3 assembly in macrophages
- (2021) Yuhua Shi et al. INTERNATIONAL IMMUNOPHARMACOLOGY
- Reactive Oxygen Species Scavenger in Acute Intracerebral Hemorrhage Patients
- (2021) Moinay Kim et al. STROKE
- Neurodegenerative Disease and the NLRP3 Inflammasome
- (2021) Jonathan A. Holbrook et al. Frontiers in Pharmacology
- Melatonin attenuates smoking-induced atherosclerosis by activating the Nrf2 pathway via NLRP3 inflammasomes in endothelial cells
- (2021) Zhewei Zhao et al. Aging-US
- An update on the regulatory mechanisms of NLRP3 inflammasome activation
- (2021) Seungwha Paik et al. Cellular & Molecular Immunology
- Salvianolic Acids for Injection alleviates cerebral ischemia/reperfusion injury by switching M1/M2 phenotypes and inhibiting NLRP3 inflammasome/pyroptosis axis in microglia in vivo and in vitro
- (2021) Dai-Chao Ma et al. JOURNAL OF ETHNOPHARMACOLOGY
- Emodin Alleviates Severe Acute Pancreatitis-Associated Acute Lung Injury by Inhibiting the Cold-Inducible RNA-Binding Protein (CIRP)-Mediated Activation of the NLRP3/IL-1β/CXCL1 Signaling
- (2021) Qiushi Xu et al. Frontiers in Pharmacology
- Targeting the NLRP3 Inflammasome in Diabetic Nephropathy
- (2021) Ming Yang et al. CURRENT MEDICINAL CHEMISTRY
- NLRP3 Inflammasome Inhibitor OLT1177 Suppresses Onset of Inflammation in Mice with Dextran Sulfate Sodium-Induced Colitis
- (2021) Tomofumi Oizumi et al. DIGESTIVE DISEASES AND SCIENCES
- N-acetylserotonin alleviated the expression of interleukin-1β in retinal ischemia–reperfusion rats via the TLR4/NF-κB/NLRP3 pathway
- (2021) Jianxiao Liu et al. EXPERIMENTAL EYE RESEARCH
- Fisetin attenuates periodontitis through FGFR1/TLR4/NLRP3 inflammasome pathway
- (2021) Xin Huang et al. INTERNATIONAL IMMUNOPHARMACOLOGY
- The P2X7 Receptor: A Promising Pharmacological Target in Diabetic Retinopathy
- (2021) Matteo Tassetto et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- A Novel Inhibitor Targeting NLRP3 Inflammasome Reduces Neuropathology and Improves Cognitive Function in Alzheimer’s Disease Transgenic Mice
- (2021) Ram Kuwar et al. JOURNAL OF ALZHEIMERS DISEASE
- Kakonein restores diabetes‐induced endothelial junction dysfunction via promoting autophagy‐mediated NLRP 3 inflammasome degradation
- (2021) Dawei Lian et al. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
- ER stress associated TXNIP-NLRP3 inflammasome activation in hippocampus of human Alzheimer's disease
- (2021) Saifudeen Ismael et al. NEUROCHEMISTRY INTERNATIONAL
- Protective effects of oridonin against cerebral ischemia/reperfusion injury by inhibiting the NLRP3 inflammasome activation
- (2021) Yujie Jia et al. TISSUE & CELL
- NLRP3 Inflammasome: A Potential Target in Isoflurane Pretreatment Alleviates Stroke-Induced Retinal Injury in Diabetes
- (2021) Hong-Bin Lin et al. Frontiers in Cellular Neuroscience
- SARS-CoV-2 N protein promotes NLRP3 inflammasome activation to induce hyperinflammation
- (2021) Pan Pan et al. Nature Communications
- Cerebral venous sinus thrombosis in patients with inflammatory bowel disease: a retrospective study
- (2021) Wang Shujun et al. Scientific Reports
- Restorative effects of Rg3-enriched Korean red ginseng and Persicaria tinctoria extract on oxazolone-induced ulcerative colitis in mice
- (2021) H.M. Arif Ullah et al. Journal of Ginseng Research
- Inhibition of IP3R/Ca2+ Dysregulation Protects Mice From Ventilator-Induced Lung Injury via Endoplasmic Reticulum and Mitochondrial Pathways
- (2021) Liu Ye et al. Frontiers in Immunology
- The Role and Mechanism of Pyroptosis and Potential Therapeutic Targets in Sepsis: A Review
- (2021) Xiangtao Zheng et al. Frontiers in Immunology
- The N-Formyl Peptide Receptor 2 (FPR2) Agonist MR-39 Exhibits Anti-Inflammatory Activity in LPS-Stimulated Organotypic Hippocampal Cultures
- (2021) Ewa Trojan et al. Cells
- The Role of Melatonin on NLRP3 Inflammasome Activation in Diseases
- (2021) Burak Ibrahim Arioz et al. Antioxidants
- Deficiency of tenascin-C attenuated cardiac injury by inactivating TLR4/NLRP3/caspase-1 pathway after myocardial infarction
- (2021) Mingyue Xu et al. CELLULAR SIGNALLING
- Licochalcone B specifically inhibits the NLRP3 inflammasome by disrupting NEK7‐NLRP3 interaction
- (2021) Qiang Li et al. EMBO REPORTS
- Disulfiram inhibits IL-1β secretion and inflammatory cells recruitment in Aspergillus fumigatus keratitis
- (2021) Haijing Yan et al. INTERNATIONAL IMMUNOPHARMACOLOGY
- Protective effect of mirtazapine against acetic acid-induced ulcerative colitis in rats: Role of NLRP3 inflammasome pathway
- (2021) Heba M. Hafez et al. INTERNATIONAL IMMUNOPHARMACOLOGY
- Estrogen receptor β alleviates inflammatory lesions in a rat model of inflammatory bowel disease via down-regulating P2X7R expression in macrophages
- (2021) Qian Jiang et al. INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
- Immunoproteasome modulates NLRP3 inflammasome‐mediated neuroinflammation under cerebral ischaemia and reperfusion conditions
- (2021) Xingyong Chen et al. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
- Blockade of the NLRP3/caspase-1 axis attenuates ketamine-induced hippocampus pyroptosis and cognitive impairment in neonatal rats
- (2021) Zhiheng Zhang et al. Journal of Neuroinflammation
- Tetramethylpyrazine alleviates diabetes-induced high platelet response and endothelial adhesion via inhibiting NLRP3 inflammasome activation
- (2021) Haowen Zhang et al. PHYTOMEDICINE
- NLPR3 inflammasome inhibition alleviates hypoxic endothelial cell death in vitro and protects blood–brain barrier integrity in murine stroke
- (2021) Maximilian Bellut et al. Cell Death & Disease
- The selective NLRP3 inhibitor MCC950 hinders atherosclerosis development by attenuating inflammation and pyroptosis in macrophages
- (2021) Wenyun Zeng et al. Scientific Reports
- Investigating Markers of the NLRP3 Inflammasome Pathway in Alzheimer’s Disease: A Human Post-Mortem Study
- (2021) Hao Tang et al. Genes
- Treatment of Severe Acute Pancreatitis and Related Lung Injury by Targeting Gasdermin D-Mediated Pyroptosis
- (2021) Jinxiang Wu et al. Frontiers in Cell and Developmental Biology
- VX-765 attenuates atherosclerosis in ApoE deficient mice by modulating VSMCs pyroptosis
- (2020) Yiyi Li et al. EXPERIMENTAL CELL RESEARCH
- NLRP10 ablation protects against ischemia/reperfusion-associated brain injury by suppression of neuroinflammation
- (2020) Zhi-Guo Li et al. EXPERIMENTAL CELL RESEARCH
- Salvianolic Acid A Ameliorates Early-Stage Atherosclerosis Development by Inhibiting NLRP3 Inflammasome Activation in Zucker Diabetic Fatty Rats
- (2020) Quanxin Ma et al. MOLECULES
- High-Fat Diet Aggravates Acute Pancreatitis via TLR4-Mediated Necroptosis and Inflammation in Rats
- (2020) Yu-pu Hong et al. Oxidative Medicine and Cellular Longevity
- Design and Catalyzed Activation of Tak-242 Prodrugs for Localized Inhibition of TLR4-Induced Inflammation
- (2020) Michael A. Plunk et al. ACS Medicinal Chemistry Letters
- Neuroprotective Effects of Qingnao Dripping Pills Against Cerebral Ischemia via Inhibiting NLRP3 Inflammasome Signaling Pathway: In Vivo and In Vitro
- (2020) Chen Fu et al. Frontiers in Pharmacology
- NLRP3 Inflammasome—A Key Player in Antiviral Responses
- (2020) Chunyuan Zhao et al. Frontiers in Immunology
- Polyphyllin VI Induces Caspase-1-Mediated Pyroptosis via the Induction of ROS/NF-κB/NLRP3/GSDMD Signal Axis in Non-Small Cell Lung Cancer
- (2020) Jin-Feng Teng et al. Cancers
- MicroRNAs as master regulators of atherosclerosis: from pathogenesis to novel therapeutic options
- (2020) Mohammed Rabiul Hosen et al. ANTIOXIDANTS & REDOX SIGNALING
- Sestrin1 inhibits oxidized low‐density lipoprotein‐induced activation of NLRP3 inflammasome in macrophages in a murine atherosclerosis model
- (2020) Yang Keping et al. EUROPEAN JOURNAL OF IMMUNOLOGY
- Targeting TLR4-dependent inflammation in post-hemorrhagic brain injury
- (2020) Jason K. Karimy et al. EXPERT OPINION ON THERAPEUTIC TARGETS
- FDA-approved disulfiram inhibits pyroptosis by blocking gasdermin D pore formation
- (2020) Jun Jacob Hu et al. NATURE IMMUNOLOGY
- T cell subsets and functions in atherosclerosis
- (2020) Ryosuke Saigusa et al. Nature Reviews Cardiology
- Role of CARD Region of MDA5 Gene in Canine Influenza Virus Infection
- (2020) Cheng Fu et al. Viruses-Basel
- SGLT2 inhibition modulates NLRP3 inflammasome activity via ketones and insulin in diabetes with cardiovascular disease
- (2020) So Ra Kim et al. Nature Communications
- Brain Metabolism Alterations in Type 2 Diabetes: What Did We Learn From Diet-Induced Diabetes Models?
- (2020) Alba M. Garcia-Serrano et al. Frontiers in Neuroscience
- Inhibition of TLR4 Induces M2 Microglial Polarization and Provides Neuroprotection via the NLRP3 Inflammasome in Alzheimer’s Disease
- (2020) Weigang Cui et al. Frontiers in Neuroscience
- TLR4 Cross-Talk With NLRP3 Inflammasome and Complement Signaling Pathways in Alzheimer's Disease
- (2020) Junling Yang et al. Frontiers in Immunology
- Cepharanthine attenuates cerebral ischemia/reperfusion injury by reducing NLRP3 inflammasome-induced inflammation and oxidative stress via inhibiting 12/15-LOX signaling
- (2020) Jie Zhao et al. BIOMEDICINE & PHARMACOTHERAPY
- Exposure of cigarette smoke condensate activates NLRP3 inflammasome in THP-1 cells in a stage-specific manner: An underlying role of innate immunity in atherosclerosis.
- (2020) Sakshi Mehta et al. CELLULAR SIGNALLING
- Alzheimer’s disease: new concepts on the role of autoimmunity and of NLRP3 inflammasome in the pathogenesis of the disease
- (2020) Cinzia Severini et al. Current Neuropharmacology
- Adiponectin peptide alleviates oxidative stress and NLRP3 inflammasome activation after cerebral ischemia-reperfusion injury by regulating AMPK/GSK-3β
- (2020) Haixiao Liu et al. EXPERIMENTAL NEUROLOGY
- Exposure of cigarette smoke condensate activates NLRP3 inflammasome in vitro and in vivo: A connotation of innate immunity and atherosclerosis
- (2020) Sakshi Mehta et al. INTERNATIONAL IMMUNOPHARMACOLOGY
- New mechanism of nerve injury in Alzheimer’s disease: β‐amyloid‐induced neuronal pyroptosis
- (2020) Chenyang Han et al. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
- ADP/P2Y1 aggravates inflammatory bowel disease through ERK5-mediated NLRP3 inflammasome activation
- (2020) Chengfei Zhang et al. Mucosal Immunology
- Inhibition of NLRP3 Inflammasome: A Prospective Target for the Treatment of Ischemic Stroke
- (2020) Ya-Shuo Feng et al. Frontiers in Cellular Neuroscience
- Macrophage–NLRP3 Inflammasome Activation Exacerbates Cardiac Dysfunction after Ischemic Stroke in a Mouse Model of Diabetes
- (2020) Hong-Bin Lin et al. Neuroscience Bulletin
- Novel Role for Tranilast in Regulating NLRP3 Ubiquitination, Vascular Inflammation, and Atherosclerosis
- (2020) Suwen Chen et al. Journal of the American Heart Association
- NEK7 Coordinates Rapid Neuroinflammation After Subarachnoid Hemorrhage in Mice
- (2020) Gen Li et al. Frontiers in Neurology
- Inflammasome activation and regulation: toward a better understanding of complex mechanisms
- (2020) Danping Zheng et al. Cell Discovery
- Molecular Mechanism of a Specific NLRP3 Inhibitor to Alleviate Seizure Severity Induced by Pentylenetetrazole
- (2020) Kai Shen et al. Current Molecular Pharmacology
- Kv1.3 channel blockade alleviates cerebral ischemia/reperfusion injury by reshaping M1/M2 phenotypes and compromising the activation of NLRP3 inflammasome in microglia
- (2020) Dai-Chao Ma et al. EXPERIMENTAL NEUROLOGY
- Excessive deubiquitination of NLRP3-R779C variant contributes to very-early-onset inflammatory bowel disease development
- (2020) Lingli Zhou et al. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
- Dimethyl fumarate ameliorates diabetes-associated vascular complications through ROS-TXNIP-NLRP3 inflammasome pathway
- (2020) Fatma M. Amin et al. LIFE SCIENCES
- Antidepressant Effect of Paeoniflorin Is Through Inhibiting Pyroptosis CASP-11/GSDMD Pathway
- (2020) Dan-Dan Tian et al. MOLECULAR NEUROBIOLOGY
- Beta-amyloid activates NLRP3 inflammasome via TLR4 in mouse microglia
- (2020) Yang Liu et al. NEUROSCIENCE LETTERS
- Succination inactivates gasdermin D and blocks pyroptosis
- (2020) Fiachra Humphries et al. SCIENCE
- NLRP3-dependent microglial training impaired the clearance of amyloid-beta and aggravated the cognitive decline in Alzheimer’s disease
- (2020) Xiao-fei He et al. Cell Death & Disease
- Effect of N-acetylcysteine on remission maintenance in patients with ulcerative colitis: A randomized, double-blind controlled clinical trial
- (2020) Kourosh Masnadi Shirazi et al. Clinics and Research in Hepatology and Gastroenterology
- Direct and indirect therapeutic effect of traditional Chinese medicine as an add-on for non-proliferative diabetic retinopathy: a systematic review and meta-analysis
- (2020) Xuedong An et al. Chinese Medicine
- The Human-Specific STING Agonist G10 Activates Type I Interferon and the NLRP3 Inflammasome in Porcine Cells
- (2020) Sheng-Li Ming et al. Frontiers in Immunology
- Approaching Inflammation Paradoxes—Proinflammatory Cytokine Blockages Induce Inflammatory Regulators
- (2020) Ming Liu et al. Frontiers in Immunology
- Mushroom Bulgaria inquinans Modulates Host Immunological Response and Gut Microbiota in Mice
- (2020) Hongzhen Sang et al. Frontiers in Nutrition
- The NLRP3 inflammasome drives inflammation in ischemia/reperfusion injury after transient middle cerebral artery occlusion in mice
- (2020) Maximilian Franke et al. BRAIN BEHAVIOR AND IMMUNITY
- Specific NLRP3 Inhibition Protects Against Diabetes-Associated Atherosclerosis
- (2020) Arpeeta Sharma et al. DIABETES
- GABA-mediated activated microglia induce neuroinflammation in the hippocampus of mice following cold exposure through the NLRP3 inflammasome and NF-κB signaling pathways
- (2020) Limin Lang et al. INTERNATIONAL IMMUNOPHARMACOLOGY
- The covalent NLRP3-inflammasome inhibitor Oridonin relieves myocardial infarction induced myocardial fibrosis and cardiac remodeling in mice
- (2020) Ri-Feng Gao et al. INTERNATIONAL IMMUNOPHARMACOLOGY
- Dimethyl Fumarate Attenuates Lung Inflammation and Oxidative Stress Induced by Chronic Exposure to Diesel Exhaust Particles in Mice
- (2020) Isabella Cattani-Cavalieri et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Chalcones Display Anti-NLRP3 Inflammasome Activity in Macrophages through Inhibition of Both Priming and Activation Steps—Structure-Activity-Relationship and Mechanism Studies
- (2020) Wohn-Jenn Leu et al. MOLECULES
- The NLRP3 inflammasome inhibitor OLT1177 rescues cognitive impairment in a mouse model of Alzheimer’s disease
- (2020) Niklas Lonnemann et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Oridonin ameliorates insulin resistance partially through inhibition of inflammatory response in rats subjected to chronic unpredictable mild stress
- (2020) Liang Liang et al. INTERNATIONAL IMMUNOPHARMACOLOGY
- Lipopolysaccharide (LPS) Aggravates High Glucose- and Hypoxia/Reoxygenation-Induced Injury through Activating ROS-Dependent NLRP3 Inflammasome-Mediated Pyroptosis in H9C2 Cardiomyocytes
- (2019) Zhen Qiu et al. Journal of Diabetes Research
- The NLRP3 Inflammasome Inhibitor, OLT1177 (Dapansutrile), Reduces Infarct Size and Preserves Contractile Function After Ischemia Reperfusion Injury in the Mouse
- (2019) Stefano Toldo et al. JOURNAL OF CARDIOVASCULAR PHARMACOLOGY
- Thioredoxin-Interacting Protein (TXNIP) Associated NLRP3 Inflammasome Activation in Human Alzheimer’s Disease Brain
- (2019) Lexiao Li et al. JOURNAL OF ALZHEIMERS DISEASE
- IMM-H004 protects against oxygen-glucose deprivation/reperfusion injury to BV2 microglia partly by modulating CKLF1 involved in microglia polarization
- (2019) Chen Chen et al. INTERNATIONAL IMMUNOPHARMACOLOGY
- A novel small molecular NLRP3 inflammasome inhibitor alleviates neuroinflammatory response following traumatic brain injury
- (2019) Ram Kuwar et al. Journal of Neuroinflammation
- NLRP3 inflammasome inhibition with MCC950 improves diabetes-mediated cognitive impairment and vasoneuronal remodeling after ischemia
- (2019) Rebecca Ward et al. PHARMACOLOGICAL RESEARCH
- Macrophage Death as a Pharmacological Target in Atherosclerosis
- (2019) Wim Martinet et al. Frontiers in Pharmacology
- Murine macrophage autophagy protects against alcohol-induced liver injury by degrading interferon regulatory factor 1 (IRF1) and removing damaged mitochondria
- (2019) Shuang Liang et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Inflammasome inhibitors: promising therapeutic approaches against cancer
- (2019) Shengchao Xu et al. Journal of Hematology & Oncology
- Flavonoid VI-16 protects against DSS-induced colitis by inhibiting Txnip-dependent NLRP3 inflammasome activation in macrophages via reducing oxidative stress
- (2019) Yue Zhao et al. Mucosal Immunology
- Microglial Pro-Inflammatory and Anti-Inflammatory Phenotypes Are Modulated by Translocator Protein Activation
- (2019) Pozzo et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- A small molecule inhibitor MCC950 ameliorates kidney injury in diabetic nephropathy by inhibiting NLRP3 inflammasome activation
- (2019) CongXiao Zhang et al. Diabetes Metabolic Syndrome and Obesity-Targets and Therapy
- Target of MCC950 in Inhibition of NLRP3 Inflammasome Activation: a Literature Review
- (2019) Danbin Wu et al. INFLAMMATION
- Ac-YVAD-cmk improves neurological function by inhibiting caspase-1-mediated inflammatory response in the intracerebral hemorrhage of rats
- (2019) Hongsheng Liang et al. INTERNATIONAL IMMUNOPHARMACOLOGY
- Vascular Macrophages in Atherosclerosis
- (2019) Hailin Xu et al. Journal of Immunology Research
- OLT1177 (Dapansutrile), a Selective NLRP3 Inflammasome Inhibitor, Ameliorates Experimental Autoimmune Encephalomyelitis Pathogenesis
- (2019) Alba Sánchez-Fernández et al. Frontiers in Immunology
- A new research hot spot: The role of NLRP3 inflammasome activation, a key step in pyroptosis, in diabetes and diabetic complications
- (2019) Zi-Wei Yu et al. LIFE SCIENCES
- NEK7 interacts with NLRP3 to modulate the pyroptosis in inflammatory bowel disease via NF-κB signaling
- (2019) Xueliang Chen et al. Cell Death & Disease
- Antidiabetic Properties of Curcumin II: Evidence from In Vivo Studies
- (2019) Danja J. Den Hartogh et al. Nutrients
- NLRP3 Inflammasome and Mineralocorticoid Receptors Are Associated with Vascular Dysfunction in Type 2 Diabetes Mellitus
- (2019) Nathanne Santos Ferreira et al. Cells
- Tranilast directly targets NLRP3 to treat inflammasome‐driven diseases
- (2018) Yi Huang et al. EMBO Molecular Medicine
- Osteomeles schwerinae Extract Prevents Diabetes-Induced Renal Injury in Spontaneously Diabetic Torii Rats
- (2018) Eunjin Sohn et al. Evidence-based Complementary and Alternative Medicine
- Structural Insights of Benzenesulfonamide Analogues as NLRP3 Inflammasome Inhibitors: Design, Synthesis, and Biological Characterization
- (2018) Jacob Fulp et al. JOURNAL OF MEDICINAL CHEMISTRY
- Inhibiting the NLRP3 Inflammasome Activation with MCC950 Ameliorates Diabetic Encephalopathy in db/db Mice
- (2018) Yadong Zhai et al. MOLECULES
- OLT1177, a β-sulfonyl nitrile compound, safe in humans, inhibits the NLRP3 inflammasome and reverses the metabolic cost of inflammation
- (2018) Carlo Marchetti et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Nicotine promotes atherosclerosis via ROS-NLRP3-mediated endothelial cell pyroptosis
- (2018) Xianxian Wu et al. Cell Death & Disease
- Oridonin is a covalent NLRP3 inhibitor with strong anti-inflammasome activity
- (2018) Hongbin He et al. Nature Communications
- MCC950, a specific small molecule inhibitor of NLRP3 inflammasome attenuates colonic inflammation in spontaneous colitis mice
- (2018) Agampodi Promoda Perera et al. Scientific Reports
- Identification of disulfiram as a secretase-modulating compound with beneficial effects on Alzheimer’s disease hallmarks
- (2018) Sven Reinhardt et al. Scientific Reports
- Pancreatic deletion of the interleukin-1 receptor disrupts whole body glucose homeostasis and promotes islet β-cell de-differentiation
- (2018) Susan J. Burke et al. Molecular Metabolism
- Alcohol accumulation promotes esophagitis via pyroptosis activation
- (2018) Fengjiao Wang et al. International Journal of Biological Sciences
- Targeting Peroxiredoxin 1 by a Curcumin Analogue, AI-44, Inhibits NLRP3 Inflammasome Activation and Attenuates Lipopolysaccharide-Induced Sepsis in Mice
- (2018) Wen Liu et al. JOURNAL OF IMMUNOLOGY
- Distinct contributions of hyperglycemia and high-fat feeding in metabolic syndrome-induced neuroinflammation
- (2018) Brooke J. Wanrooy et al. Journal of Neuroinflammation
- Association of Psoriasis With Inflammatory Bowel Disease
- (2018) Yun Fu et al. JAMA Dermatology
- A Comparative Study on the Efficacy of NLRP3 Inflammasome Signaling Inhibitors in a Pre-clinical Model of Bowel Inflammation
- (2018) Carolina Pellegrini et al. Frontiers in Pharmacology
- The Role of ADAM10 in Alzheimer’s Disease
- (2017) Xiang-Zhen Yuan et al. JOURNAL OF ALZHEIMERS DISEASE
- Identification of a selective and direct NLRP3 inhibitor to treat inflammatory disorders
- (2017) Hua Jiang et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Development of an Acrylate Derivative Targeting the NLRP3 Inflammasome for the Treatment of Inflammatory Bowel Disease
- (2017) Mattia Cocco et al. JOURNAL OF MEDICINAL CHEMISTRY
- Melatonin alleviates inflammasome-induced pyroptosis through inhibiting NF-κB/GSDMD signal in mice adipose tissue
- (2017) Zhenjiang Liu et al. JOURNAL OF PINEAL RESEARCH
- NLRP3 Inflammasome Inhibitor Ameliorates Amyloid Pathology in a Mouse Model of Alzheimer’s Disease
- (2017) Jun Yin et al. MOLECULAR NEUROBIOLOGY
- Amyloid β peptide promotes lysosomal degradation of clusterin via sortilin in hippocampal primary neurons
- (2017) Yunling Wang et al. NEUROBIOLOGY OF DISEASE
- Inverted battery design as ion generator for interfacing with biosystems
- (2017) Chengwei Wang et al. Nature Communications
- CLICs-dependent chloride efflux is an essential and proximal upstream event for NLRP3 inflammasome activation
- (2017) Tiantian Tang et al. Nature Communications
- Oroxylin A inhibits colitis by inactivating NLRP3 inflammasome
- (2017) Wei Zhou et al. Oncotarget
- Diabetic Nephropathy: Novel Molecular Mechanisms and Therapeutic Avenues
- (2017) Sebastian Oltean et al. Biomed Research International
- Estradiol Regulates Txnip and Prevents Intermittent Hypoxia-Induced Vascular Injury
- (2017) Xiao Fei Lan et al. Scientific Reports
- BOT-4-one attenuates NLRP3 inflammasome activation: NLRP3 alkylation leading to the regulation of its ATPase activity and ubiquitination
- (2017) Do-Wan Shim et al. Scientific Reports
- Neuroprotective Effects of Resatorvid Against Traumatic Brain Injury in Rat: Involvement of Neuronal Autophagy and TLR4 Signaling Pathway
- (2016) Yan Feng et al. CELLULAR AND MOLECULAR NEUROBIOLOGY
- GSDMD membrane pore formation constitutes the mechanism of pyroptotic cell death
- (2016) Lorenzo Sborgi et al. EMBO JOURNAL
- K + Efflux-Independent NLRP3 Inflammasome Activation by Small Molecules Targeting Mitochondria
- (2016) Christina J. Groß et al. IMMUNITY
- Microglia-Induced Activation of Noncanonical Wnt Signaling Aggravates Neurodegeneration in Demyelinating Disorders
- (2016) Takeshi Shimizu et al. MOLECULAR AND CELLULAR BIOLOGY
- NEK7 is an essential mediator of NLRP3 activation downstream of potassium efflux
- (2016) Yuan He et al. NATURE
- ASC filament formation serves as a signal amplification mechanism for inflammasomes
- (2016) Mathias S. Dick et al. Nature Communications
- Redox Regulation of NLRP3 Inflammasomes: ROS as Trigger or Effector?
- (2015) Justine M. Abais et al. ANTIOXIDANTS & REDOX SIGNALING
- Molecular mechanisms regulating NLRP3 inflammasome activation
- (2015) Eun-Kyeong Jo et al. Cellular & Molecular Immunology
- Pharmacologic Inhibition of the NLRP3 Inflammasome Preserves Cardiac Function After Ischemic and Nonischemic Injury in the Mouse
- (2015) Carlo Marchetti et al. JOURNAL OF CARDIOVASCULAR PHARMACOLOGY
- Evasion of inflammasome activation by microbial pathogens
- (2015) Tyler K. Ulland et al. JOURNAL OF CLINICAL INVESTIGATION
- Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death
- (2015) Jianjin Shi et al. NATURE
- A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases
- (2015) Rebecca C Coll et al. NATURE MEDICINE
- AIM2 and NLRC4 inflammasomes contribute with ASC to acute brain injury independently of NLRP3
- (2015) Adam Denes et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Members of the Chloride Intracellular Ion Channel Protein Family Demonstrate Glutaredoxin-Like Enzymatic Activity
- (2015) Heba Al Khamici et al. PLoS One
- Intracellular Glutathione Depletion by Oridonin Leads to Apoptosis in Hepatic Stellate Cells
- (2014) Liang-Mou Kuo et al. MOLECULES
- Immunological Effects of Environmental Factors: Focus on the Fibrous and Particulated Materials
- (2014) Takemi Otsuki et al. Journal of Immunology Research
- A novel benzo[d]imidazole derivate prevents the development of dextran sulfate sodium-induced murine experimental colitis via inhibition of NLRP3 inflammasome
- (2013) Wen Liu et al. BIOCHEMICAL PHARMACOLOGY
- Autophagy sequesters damaged lysosomes to control lysosomal biogenesis and kidney injury
- (2013) Ikuko Maejima et al. EMBO JOURNAL
- K+ Efflux Is the Common Trigger of NLRP3 Inflammasome Activation by Bacterial Toxins and Particulate Matter
- (2013) Raúl Muñoz-Planillo et al. IMMUNITY
- 3,4-Methylenedioxy-β-nitrostyrene Inhibits NLRP3 Inflammasome Activation by Blocking Assembly of the Inflammasome
- (2013) Yuan He et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Cutting Edge: TLR Signaling Licenses IRAK1 for Rapid Activation of the NLRP3 Inflammasome
- (2013) T. Fernandes-Alnemri et al. JOURNAL OF IMMUNOLOGY
- TRPM2 links oxidative stress to NLRP3 inflammasome activation
- (2013) Zhenyu Zhong et al. Nature Communications
- Functions of NOD-Like Receptors in Human Diseases
- (2013) Yifei Zhong et al. Frontiers in Immunology
- Mixed Lineage Kinase Domain-like Protein Mediates Necrosis Signaling Downstream of RIP3 Kinase
- (2012) Liming Sun et al. CELL
- Biochemical regulation of the inflammasome
- (2012) Jennifer K. Dowling et al. CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY
- NLRP3 is activated in Alzheimer’s disease and contributes to pathology in APP/PS1 mice
- (2012) Michael T. Heneka et al. NATURE
- The calcium-sensing receptor regulates the NLRP3 inflammasome through Ca2+ and cAMP
- (2012) Geun-Shik Lee et al. NATURE
- Treating inflammation by blocking interleukin-1 in a broad spectrum of diseases
- (2012) Charles A. Dinarello et al. NATURE REVIEWS DRUG DISCOVERY
- The Inflammasome NLRs in Immunity, Inflammation, and Associated Diseases
- (2011) Beckley K. Davis et al. Annual Review of Immunology
- Differential Expression of NLRP3 among Hematopoietic Cells
- (2011) G. Guarda et al. JOURNAL OF IMMUNOLOGY
- Cutting Edge: Reactive Oxygen Species Inhibitors Block Priming, but Not Activation, of the NLRP3 Inflammasome
- (2011) F. Bauernfeind et al. JOURNAL OF IMMUNOLOGY
- Inflammation and Alzheimer’s disease
- (2010) Young-Jung Lee et al. ARCHIVES OF PHARMACAL RESEARCH
- Anti-inflammatory Compounds Parthenolide and Bay 11-7082 Are Direct Inhibitors of the Inflammasome
- (2010) Christine Juliana et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- TAK-242 (Resatorvid), a Small-Molecule Inhibitor of Toll-Like Receptor (TLR) 4 Signaling, Binds Selectively to TLR4 and Interferes with Interactions between TLR4 and Its Adaptor Molecules
- (2010) N. Matsunaga et al. MOLECULAR PHARMACOLOGY
- Cutting Edge: NF- B Activating Pattern Recognition and Cytokine Receptors License NLRP3 Inflammasome Activation by Regulating NLRP3 Expression
- (2009) F. G. Bauernfeind et al. JOURNAL OF IMMUNOLOGY
Find the ideal target journal for your manuscript
Explore over 38,000 international journals covering a vast array of academic fields.
SearchCreate your own webinar
Interested in hosting your own webinar? Check the schedule and propose your idea to the Peeref Content Team.
Create Now