TLR4 Cross-Talk With NLRP3 Inflammasome and Complement Signaling Pathways in Alzheimer's Disease

Classical complement cascade initiating C1q protein within neurons in the aged rhesus macaque dorsolateral prefrontal cortex

(2020) Dibyadeep Datta et al.   Journal of Neuroinflammation

Inflammatory markers in Alzheimer’s disease and mild cognitive impairment: a meta-analysis and systematic review of 170 studies

(2019) Xue-Ning Shen et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

ApoE attenuates unresolvable inflammation by complex formation with activated C1q

(2019) Changjun Yin et al.   NATURE MEDICINE

Inflammatory biomarkers in Alzheimer's disease plasma

(2019) Angharad R. Morgan et al.   Alzheimers & Dementia

Lipopolysaccharide-Induced Neuroinflammation as a Bridge to Understand Neurodegeneration

(2019) Carla Ribeiro Alvares Batista et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Priming Microglia for Innate Immune Memory in the Brain

(2019) Jonas J. Neher et al.   TRENDS IN IMMUNOLOGY

Predictable chronic mild stress promotes recovery from LPS-induced depression

(2019) Ruili Dang et al.   Molecular Brain

Association of TLR4 with Alzheimer's disease risk and presymptomatic biomarkers of inflammation

(2019) Justin Miron et al.   Alzheimers & Dementia

Systemic inflammation impairs microglial Aβ clearance through NLRP 3 inflammasome

(2019) Dario Tejera et al.   EMBO JOURNAL

Involvement of the microglial NLRP3 inflammasome in the anti-inflammatory effect of the antidepressant clomipramine

(2019) Wenqing Gong et al.   JOURNAL OF AFFECTIVE DISORDERS

Complement Receptor Type 1 (CR1, CD35), the Inhibitor of BCR-Mediated Human B Cell Activation, Differentially Regulates TLR7, and TLR9 Induced Responses

(2019) Bernadett Mácsik-Valent et al.   Frontiers in Immunology

Modeling Alzheimer’s disease with iPSC-derived brain cells

(2019) Jay Penney et al.   MOLECULAR PSYCHIATRY

The MS4A gene cluster is a key modulator of soluble TREM2 and Alzheimer’s disease risk

(2019) Yuetiva Deming et al.   Science Translational Medicine

Complement C3 Is Activated in Human AD Brain and Is Required for Neurodegeneration in Mouse Models of Amyloidosis and Tauopathy

(2019) Tiffany Wu et al.   Cell Reports

Activated microglia desialylate their surface, stimulating complement receptor 3‐mediated phagocytosis of neurons

(2019) David H. Allendorf et al.   GLIA

NLRP3 inflammasome activation drives tau pathology

(2019) Christina Ising et al.   NATURE

Complement dysregulation in the central nervous system during development and disease

(2019) John D. Lee et al.   SEMINARS IN IMMUNOLOGY

The Immune System Drives Synapse Loss During Lipopolysaccharide-Induced Learning and Memory Impairment in Mice

(2019) Yi-Rong Xin et al.   Frontiers in Aging Neuroscience

Inflammasome-mediated innate immunity in Alzheimer’s disease

(2019) Carmen Venegas et al.   FASEB JOURNAL

NLRP3 Inflammasome and the IL-1 Pathway in Atherosclerosis

(2018) Alena Grebe et al.   CIRCULATION RESEARCH

Cellular senescence in brain aging and neurodegenerative diseases: evidence and perspectives

(2018) Darren J. Baker et al.   JOURNAL OF CLINICAL INVESTIGATION

Re-evaluating microglia expression profiles using RiboTag and cell isolation strategies

(2018) Zhana Haimon et al.   NATURE IMMUNOLOGY

Activation of EphA4 induced by EphrinA1 exacerbates disruption of the blood‑brain barrier following cerebral ischemia‑reperfusion via the Rho/ROCK signaling pathway

(2018) Fangbin Chen et al.   Experimental and Therapeutic Medicine

A20 critically controls microglia activation and inhibits inflammasome-dependent neuroinflammation

(2018) Sofie Voet et al.   Nature Communications

Triggering Receptors Expressed on Myeloid Cells 2 Promotes Corneal Resistance Against Pseudomonas aeruginosa by Inhibiting Caspase-1-Dependent Pyroptosis

(2018) Wenting Qu et al.   Frontiers in Immunology

Ageing, Cellular Senescence and Neurodegenerative Disease

(2018) Marios Kritsilis et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Bacterial Infection and Alzheimer's Disease: A Meta-Analysis

(2018) Priya Maheshwari et al.   JOURNAL OF ALZHEIMERS DISEASE

Innate immune memory in the brain shapes neurological disease hallmarks

(2018) Ann-Christin Wendeln et al.   NATURE

Inflammasome signalling in brain function and neurodegenerative disease

(2018) Michael T. Heneka et al.   NATURE REVIEWS NEUROSCIENCE

Can an Infection Hypothesis Explain the Beta Amyloid Hypothesis of Alzheimer’s Disease?

(2018) Tamas Fulop et al.   Frontiers in Aging Neuroscience

Role of Microbes in the Development of Alzheimer’s Disease: State of the Art – An International Symposium Presented at the 2017 IAGG Congress in San Francisco

(2018) Tamàs Fülöp et al.   Frontiers in Genetics

An updated Alzheimer hypothesis: Complement C3 and risk of Alzheimer's disease—A cohort study of 95,442 individuals

(2018) Katrine Laura Rasmussen et al.   Alzheimers & Dementia

TREM2 triggers microglial density and age‐related neuronal loss

(2018) Bettina Linnartz‐Gerlach et al.   GLIA

Changes in the Synaptic Proteome in Tauopathy and Rescue of Tau-Induced Synapse Loss by C1q Antibodies

(2018) Borislav Dejanovic et al.   NEURON

Complement C3aR Inactivation Attenuates Tau Pathology and Reverses an Immune Network Deregulated in Tauopathy Models and Alzheimer’s Disease

(2018) Alexandra Litvinchuk et al.   NEURON

The integration of inflammaging in age-related diseases

(2018) Tamas Fulop et al.   SEMINARS IN IMMUNOLOGY

Novel insights into the expression pattern of anaphylatoxin receptors in mice and men

(2017) Yves Laumonnier et al.   MOLECULAR IMMUNOLOGY

TREM2 in Neurodegenerative Diseases

(2017) Taylor R. Jay et al.   Molecular Neurodegeneration

Microglia-derived ASC specks cross-seed amyloid-β in Alzheimer’s disease

(2017) Carmen Venegas et al.   NATURE

Neurotoxic reactive astrocytes are induced by activated microglia

(2017) Shane A. Liddelow et al.   NATURE

Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease

(2017) Rebecca Sims et al.   NATURE GENETICS

NLRP3 inflammasome activation contributes to long-term behavioral alterations in mice injected with lipopolysaccharide

(2017) Wei Zhu et al.   NEUROSCIENCE

Complement C3 deficiency protects against neurodegeneration in aged plaque-rich APP/PS1 mice

(2017) Qiaoqiao Shi et al.   Science Translational Medicine

Inflammasome Priming in Sterile Inflammatory Disease

(2017) Meghana N. Patel et al.   TRENDS IN MOLECULAR MEDICINE

Evidence for C1q-mediated crosslinking of CD33/LAIR-1 inhibitory immunoreceptors and biological control of CD33/LAIR-1 expression

(2017) Myoungsun Son et al.   Scientific Reports

Complementing the inflammasome

(2016) Martha Triantafilou et al.   IMMUNOLOGY

Complement Biomarkers as Predictors of Disease Progression in Alzheimer’s Disease

(2016) Svetlana Hakobyan et al.   JOURNAL OF ALZHEIMERS DISEASE

Suppression of LPS-induced tau hyperphosphorylation by serum amyloid A

(2016) Jin Liu et al.   Journal of Neuroinflammation

Innate Immunity Stimulation via Toll-Like Receptor 9 Ameliorates Vascular Amyloid Pathology in Tg-SwDI Mice with Associated Cognitive Benefits

(2016) Henrieta Scholtzova et al.   JOURNAL OF NEUROSCIENCE

Complement in disease: a defence system turning offensive

(2016) Daniel Ricklin et al.   Nature Reviews Nephrology

Complement and microglia mediate early synapse loss in Alzheimer mouse models

(2016) S. Hong et al.   SCIENCE

Mechanism and Regulation of NLRP3 Inflammasome Activation

(2016) Yuan He et al.   TRENDS IN BIOCHEMICAL SCIENCES

CSF complement 3 and factor H are staging biomarkers in Alzheimer’s disease

(2016) William T. Hu et al.   Acta Neuropathologica Communications

Unraveling the Pathogenesis of MDS: The NLRP3 Inflammasome and Pyroptosis Drive the MDS Phenotype

(2016) David A. Sallman et al.   Frontiers in Oncology

Anti-Inflamm-Aging Effects of Long-Term Caloric Restriction via Overexpression of SIGIRR to Inhibit NF-κB Signaling Pathway

(2015) Xiao-meng Xu et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Complement C3-Deficient Mice Fail to Display Age-Related Hippocampal Decline

(2015) Q. Shi et al.   JOURNAL OF NEUROSCIENCE

Inflammasomes: mechanism of action, role in disease and therapeutics

(2015) Haitao Guo et al.   NATURE MEDICINE

RiboTag: Not Lost in Translation

(2015) Adam J Lesiak et al.   NEUROPSYCHOPHARMACOLOGY

Activation of MyD88-dependent TLR1/2 signaling by misfolded α-synuclein, a protein linked to neurodegenerative disorders

(2015) Stefano G. Daniele et al.   Science Signaling

The age factor in Alzheimer’s disease

(2015) Rita Guerreiro et al.   Genome Medicine

Activation of MyD88-dependent TLR1/2 signaling by misfolded α-synuclein, a protein linked to neurodegenerative disorders

(2015) Stefano G. Daniele et al.   Science Signaling

Complement and Its Receptors: New Insights into Human Disease

(2014) V. Michael Holers   Annual Review of Immunology

Geroscience: Linking Aging to Chronic Disease

(2014) Brian K. Kennedy et al.   CELL

A study on the association between infectious burden and Alzheimer's disease

(2014) X.-L. Bu et al.   EUROPEAN JOURNAL OF NEUROLOGY

Pattern recognition receptors and central nervous system repair

(2014) Kristina A. Kigerl et al.   EXPERIMENTAL NEUROLOGY

Target risk factors for dementia prevention: a systematic review and Delphi consensus study on the evidence from observational studies

(2014) Kay Deckers et al.   INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY

Negative Regulation of Toll-like Receptor-4 Signaling through the Binding of Glycosylphosphatidylinositol-anchored Glycoprotein, CD14, with the Sialic Acid-binding Lectin, CD33

(2014) Akiko Ishida et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Neurodegeneration by Activation of the Microglial Complement-Phagosome Pathway

(2014) L.-G. Bodea et al.   JOURNAL OF NEUROSCIENCE

Chronic Inflammation (Inflammaging) and Its Potential Contribution to Age-Associated Diseases

(2014) C. Franceschi et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Stress, Inflammation, and Defense of Homeostasis

(2014) Raj Chovatiya et al.   MOLECULAR CELL

CR1 in Alzheimer's Disease

(2014) Xi-Chen Zhu et al.   MOLECULAR NEUROBIOLOGY

Microglial priming in neurodegenerative disease

(2014) V. Hugh Perry et al.   Nature Reviews Neurology

Interleukin-6 and C-reactive protein as predictors of cognitive decline in late midlife

(2014) A. Singh-Manoux et al.   NEUROLOGY

Individual differences in the peripheral immune system promote resilience versus susceptibility to social stress

(2014) Georgia E. Hodes et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Systemic inflammation, blood-brain barrier vulnerability and cognitive/non-cognitive symptoms in Alzheimer disease: relevance to pathogenesis and therapy

(2014) Shuko Takeda et al.   Frontiers in Aging Neuroscience

The Triggering Receptor Expressed on Myeloid Cells 2 Inhibits Complement Component 1q Effector Mechanisms and Exerts Detrimental Effects during Pneumococcal Pneumonia

(2014) Omar Sharif et al.   PLoS Pathogens

Toll-Like Receptor Signaling Pathways

(2014) Takumi Kawasaki et al.   Frontiers in Immunology

Amyloid ß and Tau Alzheimer¿s disease related pathology is reduced by toll-like receptor 9 stimulation

(2014) Henrieta Scholtzova et al.   Acta Neuropathologica Communications

MicroRNA-containing microvesicles regulating inflammation in association with atherosclerotic disease

(2013) Maarten Hulsmans et al.   CARDIOVASCULAR RESEARCH

Canonical Nlrp3 Inflammasome Links Systemic Low-Grade Inflammation to Functional Decline in Aging

(2013) Yun-Hee Youm et al.   Cell Metabolism

Immune System, Cell Senescence, Aging and Longevity - Inflamm-Aging Reappraised

(2013) Stefano Salvioli et al.   CURRENT PHARMACEUTICAL DESIGN

The complement membrane attack complex triggers intracellular Ca2+ fluxes leading to NLRP3 inflammasome activation

(2013) K. Triantafilou et al.   JOURNAL OF CELL SCIENCE

Inflammatory Responses Induced by Lipopolysaccharide Are Amplified in Primary Human Monocytes but Suppressed in Macrophages by Complement Protein C5a

(2013) V. Seow et al.   JOURNAL OF IMMUNOLOGY

Cutting Edge: TLR Signaling Licenses IRAK1 for Rapid Activation of the NLRP3 Inflammasome

(2013) T. Fernandes-Alnemri et al.   JOURNAL OF IMMUNOLOGY

A Dramatic Increase of C1q Protein in the CNS during Normal Aging

(2013) A. H. Stephan et al.   JOURNAL OF NEUROSCIENCE

Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease

(2013) Jean-Charles Lambert et al.   NATURE GENETICS

Differential pathways for interleukin-1β production activated by chromogranin A and amyloid β in microglia

(2013) Zhou Wu et al.   NEUROBIOLOGY OF AGING

Respiratory infection promotes T cell infiltration and amyloid-β deposition in APP/PS1 mice

(2013) Róisín M. McManus et al.   NEUROBIOLOGY OF AGING

Alzheimer disease in the United States (2010-2050) estimated using the 2010 census

(2013) L. E. Hebert et al.   NEUROLOGY

Neuroprotective Sirtuin ratio reversed by ApoE4

(2013) V. Theendakara et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Toll-like receptor 4 stimulation with the detoxified ligand monophosphoryl lipid A improves Alzheimer's disease-related pathology

(2013) J.-P. Michaud et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Oligomeric amyloid β induces IL-1β processing via production of ROS: implication in Alzheimer’s disease

(2013) B Parajuli et al.   Cell Death & Disease

Neuron-released oligomeric α-synuclein is an endogenous agonist of TLR2 for paracrine activation of microglia

(2013) Changyoun Kim et al.   Nature Communications

The Complement System: An Unexpected Role in Synaptic Pruning During Development and Disease

(2012) Alexander H. Stephan et al.   Annual Review of Neuroscience

Prolonged elevation in hippocampal Aβ and cognitive deficits following repeated endotoxin exposure in the mouse

(2012) Marielle S. Kahn et al.   BEHAVIOURAL BRAIN RESEARCH

Metabolic syndrome, mild cognitive impairment and Alzheimer's disease—The emerging role of systemic low-grade inflammation and adiposity

(2012) Blazej Misiak et al.   BRAIN RESEARCH BULLETIN

Common Variants in Toll-Like Receptor 4 Confer Susceptibility to Alzheimer's Disease in a Han Chinese Population

(2012) Jin-Tai Yu et al.   Current Alzheimer Research

C1q-induced LRP1B and GPR6 Proteins Expressed Early in Alzheimer Disease Mouse Models, Are Essential for the C1q-mediated Protection against Amyloid-β Neurotoxicity

(2012) Marie E. Benoit et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Asp299Gly Polymorphism Alters TLR4 Signaling by Interfering with Recruitment of MyD88 and TRIF

(2012) L. Figueroa et al.   JOURNAL OF IMMUNOLOGY

Systemic immune challenges trigger and drive Alzheimer-like neuropathology in mice

(2012) Dimitrije Krstic et al.   Journal of Neuroinflammation

NLRP3 is activated in Alzheimer’s disease and contributes to pathology in APP/PS1 mice

(2012) Michael T. Heneka et al.   NATURE

The cellular and signaling networks linking the immune system and metabolism in disease

(2012) Olivia Osborn et al.   NATURE MEDICINE

Review: Systemic inflammation and Alzheimer's disease

(2012) C. Holmes   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Sequence Variants of Toll Like Receptor 4 and Late-Onset Alzheimer's Disease

(2012) Yen-Ching Chen et al.   PLoS One

Elevated C-Reactive Protein Levels, Psychological Distress, and Depression in 73 131 Individuals

(2012) Marie Kim Wium-Andersen et al.   JAMA Psychiatry

MyD88 Deficiency Ameliorates β-Amyloidosis in an Animal Model of Alzheimer's Disease

(2011) Jeong-Eun Lim et al.   AMERICAN JOURNAL OF PATHOLOGY

The effects of MyD88 deficiency on exploratory activity, anxiety, motor coordination, and spatial learning in C57BL/6 and APPswe/PS1dE9 mice

(2011) Jeong-Eun Lim et al.   BEHAVIOURAL BRAIN RESEARCH

Genetic association of TLR4/11367 polymorphism with late-onset Alzheimer's disease in a Han Chinese population

(2011) Li-Zhu Wang et al.   BRAIN RESEARCH

TREM-2, triggering receptor expressed on myeloid cell-2, negatively regulates TLR responses in dendritic cells

(2011) Hiroaki Ito et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Lipopolysaccharide-induced tau phosphorylation and kinase activity - modulation, but not mediation, by corticotropin-releasing factor receptors

(2011) Allyson D. Roe et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Toll-like Receptors and Their Crosstalk with Other Innate Receptors in Infection and Immunity

(2011) Taro Kawai et al.   IMMUNITY

TLR4 mutation reduces microglial activation, increases Aβ deposits and exacerbates cognitive deficits in a mouse model of Alzheimer's disease

(2011) Min Song et al.   Journal of Neuroinflammation

LPS-mediated production of pro/anti-inflammatory cytokines and eicosanoids in whole blood samples: Biological effects of +896A/G TLR4 polymorphism in a Sicilian population of healthy subjects

(2011) Carmela Rita Balistreri et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Cross-Talk between Apolipoprotein E and Cytokines

(2011) Hongliang Zhang et al.   MEDIATORS OF INFLAMMATION

Complement in the brain

(2011) Robert Veerhuis et al.   MOLECULAR IMMUNOLOGY

Progress and challenges in translating the biology of atherosclerosis

(2011) Peter Libby et al.   NATURE

Apolipoprotein E inhibits Toll-like receptor (TLR)-3- and TLR-4-mediated macrophage activation through distinct mechanisms

(2010) Yanjuan Zhu et al.   BIOCHEMICAL JOURNAL

Myeloid differentiation factor 88-deficient bone marrow cells improve Alzheimer’s disease-related symptoms and pathology

(2010) Wenlin Hao et al.   BRAIN

Pattern Recognition Receptors and Inflammation

(2010) Osamu Takeuchi et al.   CELL

Intracellular Toll-like Receptors

(2010) Amanda L. Blasius et al.   IMMUNITY

Activation of Murine Macrophages via TLR2 and TLR4 Is Negatively Regulated by a Lyn/PI3K Module and Promoted by SHIP1

(2010) S. Keck et al.   JOURNAL OF IMMUNOLOGY

Deletion of CD14 Attenuates Alzheimer's Disease Pathology by Influencing the Brain's Inflammatory Milieu

(2010) E. G. Reed-Geaghan et al.   JOURNAL OF NEUROSCIENCE

Complement regulates TLR4-mediated inflammatory responses during intestinal ischemia reperfusion

(2010) Michael R. Pope et al.   MOLECULAR IMMUNOLOGY

Diabetes-accelerated memory dysfunction via cerebrovascular inflammation and A  deposition in an Alzheimer mouse model with diabetes

(2010) S. Takeda et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TREM2- and DAP12-Dependent Activation of PI3K Requires DAP10 and Is Inhibited by SHIP1

(2010) Q. Peng et al.   Science Signaling

TLR4 and Insulin Resistance

(2010) Jane J. Kim et al.   Gastroenterology Research and Practice

Microglia Activated with the Toll-Like Receptor 9 Ligand CpG Attenuate Oligomeric Amyloid β Neurotoxicity in in Vitro and in Vivo Models of Alzheimer’s Disease

(2009) Yukiko Doi et al.   AMERICAN JOURNAL OF PATHOLOGY

TLR4 Polymorphisms and Ageing: Implications for the Pathophysiology of Age-Related Diseases

(2009) Carmela Rita Balistreri et al.   JOURNAL OF CLINICAL IMMUNOLOGY

Treatment with a C5aR Antagonist Decreases Pathology and Enhances Behavioral Performance in Murine Models of Alzheimer's Disease

(2009) M. I. Fonseca et al.   JOURNAL OF IMMUNOLOGY

Cutting Edge: NF- B Activating Pattern Recognition and Cytokine Receptors License NLRP3 Inflammasome Activation by Regulating NLRP3 Expression

(2009) F. G. Bauernfeind et al.   JOURNAL OF IMMUNOLOGY

TNF-α and antibodies to periodontal bacteria discriminate between Alzheimer's disease patients and normal subjects

(2009) Angela R. Kamer et al.   JOURNAL OF NEUROIMMUNOLOGY

Synergy of TRIF-dependent TLR3 and MyD88-dependent TLR7 in up-regulating expression of mouse FPR2, a promiscuous G-protein-coupled receptor, in microglial cells

(2009) Keqiang Chen et al.   JOURNAL OF NEUROIMMUNOLOGY

CD14 and Toll-Like Receptors 2 and 4 Are Required for Fibrillar A -Stimulated Microglial Activation

(2009) E. G. Reed-Geaghan et al.   JOURNAL OF NEUROSCIENCE

Induction of Toll-Like Receptor 9 Signaling as a Method for Ameliorating Alzheimer's Disease-Related Pathology

(2009) H. Scholtzova et al.   JOURNAL OF NEUROSCIENCE

Finding the missing heritability of complex diseases

(2009) Teri A. Manolio et al.   NATURE

Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer's disease

(2009) Jean-Charles Lambert et al.   NATURE GENETICS

CD36 ligands promote sterile inflammation through assembly of a Toll-like receptor 4 and 6 heterodimer

(2009) Cameron R Stewart et al.   NATURE IMMUNOLOGY

Inhibition of soluble TNF signaling in a mouse model of Alzheimer's disease prevents pre-plaque amyloid-associated neuropathology

(2009) Fiona E. McAlpine et al.   NEUROBIOLOGY OF DISEASE

Endogenous signals initiating inflammation in the injured nervous system

(2008) Isabelle Pineau et al.   GLIA

Toll-like receptors, wound healing, and carcinogenesis

(2008) Johannes Kluwe et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Toll-like receptor 4-dependent upregulation of cytokines in a transgenic mouse model of Alzheimer's disease

(2008) Jing-Ji Jin et al.   Journal of Neuroinflammation

Inflammaging as a prodrome to Alzheimer's disease

(2008) Brian Giunta et al.   Journal of Neuroinflammation

The role of interleukin-1 in neuroinflammation and Alzheimer disease: an evolving perspective

(2008) Solomon S Shaftel et al.   Journal of Neuroinflammation

Neuro-inflammation induced by lipopolysaccharide causes cognitive impairment through enhancement of beta-amyloid generation

(2008) Jae Lee et al.   Journal of Neuroinflammation

Complement C3 Deficiency Leads to Accelerated Amyloid   Plaque Deposition and Neurodegeneration and Modulation of the Microglia/Macrophage Phenotype in Amyloid Precursor Protein Transgenic Mice

(2008) M. Maier et al.   JOURNAL OF NEUROSCIENCE

Toll-Like Receptor 2 Acts as a Natural Innate Immune Receptor to Clear Amyloid  1-42 and Delay the Cognitive Decline in a Mouse Model of Alzheimer's Disease

(2008) K. L. Richard et al.   JOURNAL OF NEUROSCIENCE

TRAM couples endocytosis of Toll-like receptor 4 to the induction of interferon-β

(2008) Jonathan C Kagan et al.   NATURE IMMUNOLOGY

The NALP3 inflammasome is involved in the innate immune response to amyloid-β

(2008) Annett Halle et al.   NATURE IMMUNOLOGY

Midlife C-reactive protein and risk of cognitive decline: A 31-year follow-up

(2008) Danielle Laurin et al.   NEUROBIOLOGY OF AGING

High-fat diet aggravates amyloid-beta and tau pathologies in the 3xTg-AD mouse model

(2008) Carl Julien et al.   NEUROBIOLOGY OF AGING

The immune system and cardiac repair

(2008) N FRANGOGIANNIS   PHARMACOLOGICAL RESEARCH