Silica nanoparticles induce pyroptosis and cardiac hypertrophy via ROS/NLRP3/Caspase-1 pathway

NLRP3 inflammasome is a key driver of obesity-induced atrial arrhythmias

(2021) Larry Scott Jr et al.   CARDIOVASCULAR RESEARCH

NLRP3-mediated pyroptosis aggravates pressure overload-induced cardiac hypertrophy, fibrosis, and dysfunction in mice: cardioprotective role of irisin

(2021) Rongchuan Yue et al.   Cell Death Discovery

GSDMD-Mediated Cardiomyocyte Pyroptosis Promotes Myocardial I/R Injury

(2021) Huairui Shi et al.   CIRCULATION RESEARCH

Thrombin receptor PAR4 drives canonical NLRP3 inflammasome signaling in the heart

(2020) Anke C. Fender et al.   BASIC RESEARCH IN CARDIOLOGY

S-Nitrosylation of Muscle LIM Protein Facilitates Myocardial Hypertrophy Through Toll-Like Receptor 3-Mediated Receptor-Interacting ProteinKinase 3 and NLRP3 Inflammasome Activation

(2020) Xin Tang et al.   CIRCULATION

Diabetes aggravates myocardial ischaemia reperfusion injury via activating Nox2‐related programmed cell death in an AMPK‐dependent manner

(2020) Chunyan Wang et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Amorphous SiO2 nanoparticles promote cardiac dysfunction via the opening of the mitochondrial permeability transition pore in rat heart and human cardiomyocytes

(2020) Omar Lozano et al.   Particle and Fibre Toxicology

A closer look into NADPH oxidase inhibitors: Validation and insight into their mechanism of action

(2020) Joana Reis et al.   Redox Biology

Molecular Basis of Atrial Fibrillation Pathophysiology and Therapy

(2020) Stanley Nattel et al.   CIRCULATION RESEARCH

Atrial Myocyte NLRP3/CaMKII Nexus Forms a Substrate for Post-Operative Atrial Fibrillation

(2020) Jordi Heijman et al.   CIRCULATION RESEARCH

Silica nanoparticles induce JNK-mediated inflammation and myocardial contractile dysfunction

(2020) Lin Feng et al.   JOURNAL OF HAZARDOUS MATERIALS

Amorphous silica nanoparticles accelerated atherosclerotic lesion progression in ApoE−/− mice through endoplasmic reticulum stress-mediated CD36 up-regulation in macrophage

(2020) Ru Ma et al.   Particle and Fibre Toxicology

NLRP3 inflammasome in endothelial dysfunction

(2020) Baochen Bai et al.   Cell Death & Disease

Adverse effects of amorphous silica nanoparticles: Focus on human cardiovascular health

(2020) Caixia Guo et al.   JOURNAL OF HAZARDOUS MATERIALS

The fate and oxidative stress of different sized SiO2 nanoparticles in zebrafish (Danio rerio) larvae

(2019) Biran Zhu et al.   CHEMOSPHERE

Subchronic toxicity of silica nanoparticles as a function of size and porosity

(2019) Raziye Mohammadpour et al.   JOURNAL OF CONTROLLED RELEASE

Propofol directly induces caspase-1-dependent macrophage pyroptosis through the NLRP3-ASC inflammasome

(2019) Lingbin Sun et al.   Cell Death & Disease

Circular RNA circRNA_000203 aggravates cardiac hypertrophy via suppressing miR-26b-5p and miR-140-3p binding to Gata4

(2019) Hui Li et al.   CARDIOVASCULAR RESEARCH

NADPH oxidases and oxidase crosstalk in cardiovascular diseases: novel therapeutic targets

(2019) Yixuan Zhang et al.   Nature Reviews Cardiology

BRD4 blockage alleviates pathological cardiac hypertrophy through the suppression of fibrosis and inflammation via reducing ROS generation

(2019) Wen Zhu et al.   BIOMEDICINE & PHARMACOTHERAPY

Chemometric modeling to predict air half-life of persistent organic pollutants (POPs)

(2019) Pathan Mohsin Khan et al.   JOURNAL OF HAZARDOUS MATERIALS

VAS2870 and VAS3947 attenuate platelet activation and thrombus formation via a NOX-independent pathway downstream of PKC

(2019) Wan Jung Lu et al.   Scientific Reports

Caspase-1 inhibition by VX-765 administered at reperfusion in P2Y12 receptor antagonist-treated rats provides long-term reduction in myocardial infarct size and preservation of ventricular function

(2018) Jonathon P. Audia et al.   BASIC RESEARCH IN CARDIOLOGY

Enhanced Cardiomyocyte NLRP3 Inflammasome Signaling Promotes Atrial Fibrillation

(2018) Chunxia Yao et al.   CIRCULATION

CXCL1–CXCR2 axis mediates angiotensin II-induced cardiac hypertrophy and remodelling through regulation of monocyte infiltration

(2018) Lei Wang et al.   EUROPEAN HEART JOURNAL

Mechanisms of physiological and pathological cardiac hypertrophy

(2018) Michinari Nakamura et al.   Nature Reviews Cardiology

Toxicological status of nanoparticles: What we know and what we don't know

(2018) Wided N. Missaoui et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Mesoporous silica nanoparticles induced hepatotoxicity via NLRP3 inflammasome activation and caspase-1-dependent pyroptosis

(2018) Xuyao Zhang et al.   Nanoscale

Cardiac and pulmonary toxicity of mesoporous silica nanoparticles is associated with excessive ROS production and redox imbalance in Wistar rats

(2018) Walaa G. Hozayen et al.   BIOMEDICINE & PHARMACOTHERAPY

NLRP3 inflammasome: Its regulation and involvement in atherosclerosis

(2017) Zahra Hoseini et al.   JOURNAL OF CELLULAR PHYSIOLOGY

NLRP3 Inflammasome Activation-Mediated Pyroptosis Aggravates Myocardial Ischemia/Reperfusion Injury in Diabetic Rats

(2017) Zhen Qiu et al.   Oxidative Medicine and Cellular Longevity

Scutellarin protects cardiomyocyte ischemia–reperfusion injury by reducing apoptosis and oxidative stress

(2016) Zhou Wang et al.   LIFE SCIENCES

Pathophysiology of cardiac hypertrophy and heart failure: signaling pathways and novel therapeutic targets

(2015) Yow Keat Tham et al.   ARCHIVES OF TOXICOLOGY

Sphingosylphosphorylcholine potentiates vasoreactivity and voltage-gated Ca2+ entry via NOX1 and reactive oxygen species

(2015) Yasin Shaifta et al.   CARDIOVASCULAR RESEARCH

Characterization of materials released into water from paint containing nano-SiO 2

(2015) Ahmed Al-Kattan et al.   CHEMOSPHERE

TXNIP mediates NLRP3 inflammasome activation in cardiac microvascular endothelial cells as a novel mechanism in myocardial ischemia/reperfusion injury

(2014) Yi Liu et al.   BASIC RESEARCH IN CARDIOLOGY