The Role of ADAM10 in Alzheimer’s Disease

Effect of a Dominant-Negative Form of ADAM10 in a Mouse Model of Alzheimer's Disease

(2017) Anja Schroeder et al.   JOURNAL OF ALZHEIMERS DISEASE

Statins and the Squalene Synthase Inhibitor Zaragozic Acid Stimulate the Non-Amyloidogenic Pathway of Amyloid-β Protein Precursor Processing by Suppression of Cholesterol Synthesis

(2017) Elzbieta Kojro et al.   JOURNAL OF ALZHEIMERS DISEASE

Regulation of the α-secretase ADAM10 at transcriptional, translational and post-translational levels

(2016) Bruno Vincent   BRAIN RESEARCH BULLETIN

Increase of α-Secretase ADAM10 in Platelets Along Cognitively Healthy Aging

(2016) Florian Schuck et al.   JOURNAL OF ALZHEIMERS DISEASE

Novel osmotin inhibits SREBP2 via the AdipoR1/AMPK/SIRT1 pathway to improve Alzheimer’s disease neuropathological deficits

(2016) S A Shah et al.   MOLECULAR PSYCHIATRY

Sox2 functionally interacts with βAPP, the βAPP intracellular domain and ADAM10 at a transcriptional level in human cells

(2016) G. Sarlak et al.   NEUROSCIENCE

Systematic substrate identification indicates a central role for the metalloprotease ADAM10 in axon targeting and synapse function

(2016) Peer-Hendrik Kuhn et al.   eLife

Tau: The Center of a Signaling Nexus in Alzheimer's Disease

(2016) Shahzad S. Khan et al.   Frontiers in Neuroscience

Amyloid β oligomers in Alzheimer’s disease pathogenesis, treatment, and diagnosis

(2015) Kirsten L. Viola et al.   ACTA NEUROPATHOLOGICA

2015 Alzheimer's disease facts and figures

(2015)   Alzheimers & Dementia

ADAM10 gene expression in the blood cells of Alzheimer's disease patients and mild cognitive impairment subjects

(2015) Patricia Regina Manzine et al.   BIOMARKERS

TspanC8 tetraspanins differentially regulate the cleavage of ADAM10 substrates, Notch activation and ADAM10 membrane compartmentalization

(2015) Stéphanie Jouannet et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Molecular mechanisms linking amyloid β toxicity and Tau hyperphosphorylation in Alzheimer׳s disease

(2015) A. Lloret et al.   FREE RADICAL BIOLOGY AND MEDICINE

Effects of ADAM10 deletion on Notch-1 signaling pathway and neuronal maintenance in adult mouse brain

(2015) Jianlong Zhuang et al.   GENE

Serotoninergic antidepressants positively affect platelet ADAM10 expression in patients with Alzheimer's disease

(2015) Otávio Augusto Fernandes Marques Bianco et al.   INTERNATIONAL PSYCHOGERIATRICS

The Cytoplasmic Domain of A Disintegrin and Metalloproteinase 10 (ADAM10) Regulates Its Constitutive Activity but Is Dispensable for Stimulated ADAM10-dependent Shedding

(2015) Thorsten Maretzky et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TspanC8 Tetraspanins and A Disintegrin and Metalloprotease 10 (ADAM10) Interact via Their Extracellular Regions

(2015) Peter J. Noy et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Functional Maturation of A Disintegrin and Metalloproteinase (ADAM) 9, 10, and 17 Requires Processing at a Newly Identified Proprotein Convertase (PC) Cleavage Site

(2015) Eitan Wong et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Discovery of Small Molecules for Up-Regulating the Translation of Antiamyloidogenic Secretase, a Disintegrin and Metalloproteinase 10 (ADAM10), by Binding to the G-Quadruplex-Forming Sequence in the 5′ Untranslated Region (UTR) of Its mRNA

(2015) Jie Dai et al.   JOURNAL OF MEDICINAL CHEMISTRY

C6 Glioma-Secreted NGF and FGF2 Regulate Neuronal APP Processing Through Up-Regulation of ADAM10 and Down-Regulation of BACE1, Respectively

(2015) Huiping Xie et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Soluble amyloid precursor protein alpha inhibits tau phosphorylation through modulation of GSK3β signaling pathway

(2015) Juan Deng et al.   JOURNAL OF NEUROCHEMISTRY

Melatonin regulates the transcription of βAPP-cleaving secretases mediated through melatonin receptors in human neuroblastoma SH-SY5Y cells

(2015) Jiraporn Panmanee et al.   JOURNAL OF PINEAL RESEARCH

The Essential Role of Soluble Aβ Oligomers in Alzheimer’s Disease

(2015) Zi-Xuan Wang et al.   MOLECULAR NEUROBIOLOGY

The Role of Cdk5 in Alzheimer’s Disease

(2015) Shu-Lei Liu et al.   MOLECULAR NEUROBIOLOGY

η-Secretase processing of APP inhibits neuronal activity in the hippocampus

(2015) Michael Willem et al.   NATURE

Systemic administration of fibroblast growth factor-2 (FGF2) reduces BACE1 expression and amyloid pathology in APP23 mice

(2015) Loukia Katsouri et al.   NEUROBIOLOGY OF AGING

Dysregulated ADAM10-Mediated Processing of APP during a Critical Time Window Leads to Synaptic Deficits in Fragile X Syndrome

(2015) Emanuela Pasciuto et al.   NEURON

Amyloid cascade hypothesis: Pathogenesis and therapeutic strategies in Alzheimer's disease

(2015) Sagar H. Barage et al.   NEUROPEPTIDES

Genetic Association Between APP, ADAM10 Gene Polymorphism, and Sporadic Alzheimer’s Disease in the Chinese Population

(2015) Fan Zeng et al.   NEUROTOXICITY RESEARCH

Activation of peroxisome proliferator-activated receptor α stimulates ADAM10-mediated proteolysis of APP

(2015) Grant T. Corbett et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The alpha secretase ADAM10: A metalloprotease with multiple functions in the brain

(2015) Paul Saftig et al.   PROGRESS IN NEUROBIOLOGY

Amyloid β-protein oligomers upregulate the β-secretase, BACE1, through a post-translational mechanism involving its altered subcellular distribution in neurons

(2015) Naomi Mamada et al.   Molecular Brain

Apolipoprotein E in Alzheimer's Disease: An Update

(2014) Jin-Tai Yu et al.   Annual Review of Neuroscience

Retraction Notice to: SIRT1 Suppresses β-Amyloid Production by Activating the α-Secretase Gene ADAM10

(2014) Gizem Donmez et al.   CELL

Tetraspanins Regulate ADAM10-Mediated Cleavage of TNF-  and Epidermal Growth Factor

(2014) C. Arduise et al.   JOURNAL OF IMMUNOLOGY

N-Cadherin Promotes Recruitment and Migration of Neural Progenitor Cells from the SVZ Neural Stem Cell Niche into Demyelinated Lesions

(2014) M. Klingener et al.   JOURNAL OF NEUROSCIENCE

Cilostazol suppresses β-amyloid production by activating a disintegrin and metalloproteinase 10 via the upregulation of SIRT1-coupled retinoic acid receptor-β

(2014) Hye Rin Lee et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Melatonin stimulates the nonamyloidogenic processing ofβAPP through the positive transcriptional regulation of ADAM10 and ADAM17

(2014) Mayuri Shukla et al.   JOURNAL OF PINEAL RESEARCH

Oligomeric Aβ-induced synaptic dysfunction in Alzheimer’s disease

(2014) Shichun Tu et al.   Molecular Neurodegeneration

Increased CSF APPs-  levels in patients with Alzheimer disease treated with acitretin

(2014) K. Endres et al.   NEUROLOGY

Enhancement of the nonamyloidogenic pathway by exogenous NGF in an Alzheimer transgenic mouse model

(2014) Chang Yang et al.   NEUROPEPTIDES

Identification of SH3 Domain Proteins Interacting with the Cytoplasmic Tail of the A Disintegrin and Metalloprotease 10 (ADAM10)

(2014) Henriette Ebsen et al.   PLoS One

SAP97-mediated ADAM10 trafficking from Golgi outposts depends on PKC phosphorylation

(2014) C Saraceno et al.   Cell Death & Disease

Activated protein C inhibits amyloid β production via promoting expression of ADAM-10

(2013) Bing Li et al.   BRAIN RESEARCH

ADAM10 as a Biomarker for Alzheimer’s Disease: A Study with Brazilian Elderly

(2013) Patricia Regina Manzine et al.   DEMENTIA AND GERIATRIC COGNITIVE DISORDERS

Trafficking in neurons: Searching for new targets for Alzheimer's disease future therapies

(2013) Stefano Musardo et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Unfolded protein response signaling by transcription factor XBP-1 regulates ADAM10 and is affected in Alzheimer's disease

(2013) Sven Reinhardt et al.   FASEB JOURNAL

Platelet a disintegrin and metallopeptidase 10 expression correlates with clock drawing test scores in Alzheimer's disease

(2013) Patrícia Regina Manzine et al.   INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY

MicroRNA-144 Is Regulated by Activator Protein-1 (AP-1) and Decreases Expression of Alzheimer Disease-related A Disintegrin and Metalloprotease 10 (ADAM10)

(2013) Cong Cheng et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Endocytosis of synaptic ADAM10 in neuronal plasticity and Alzheimer’s disease

(2013) Elena Marcello et al.   JOURNAL OF CLINICAL INVESTIGATION

EphrinA/EphA-induced ectodomain shedding of neural cell adhesion molecule regulates growth cone repulsion through ADAM10 metalloprotease

(2013) Leann H. Brennaman et al.   JOURNAL OF NEUROCHEMISTRY

Postnatal Disruption of the Disintegrin/Metalloproteinase ADAM10 in Brain Causes Epileptic Seizures, Learning Deficits, Altered Spine Morphology, and Defective Synaptic Functions

(2013) J. Prox et al.   JOURNAL OF NEUROSCIENCE

ADAM10 in Synaptic Physiology and Pathology

(2013) Stefano Musardo et al.   Neurodegenerative Diseases

ADAM10 Prodomain Mutations Cause Late-Onset Alzheimer’s Disease: Not Just the Latest FAD

(2013) Robert Vassar   NEURON

ADAM10 Missense Mutations Potentiate β-Amyloid Accumulation by Impairing Prodomain Chaperone Function

(2013) Jaehong Suh et al.   NEURON

The Genetics of Alzheimer Disease

(2013) R. E. Tanzi   Cold Spring Harbor Perspectives in Medicine

5-HT4 Receptors Constitutively Promote the Non-Amyloidogenic Pathway of APP Cleavage and Interact with ADAM10

(2012) Maud Cochet et al.   ACS Chemical Neuroscience

Computational identification and experimental validation of microRNAs binding to the Alzheimer-related gene ADAM10

(2012) Regina Augustin et al.   BMC Medical Genetics

Sirtuins in cognitive ageing and Alzheimerʼs disease

(2012) Nady Braidy et al.   CURRENT OPINION IN PSYCHIATRY

Ectodomain shedding and ADAMs in development

(2012) S. Weber et al.   DEVELOPMENT

The TspanC8 Subgroup of Tetraspanins Interacts with A Disintegrin and Metalloprotease 10 (ADAM10) and Regulates Its Maturation and Cell Surface Expression

(2012) Elizabeth J. Haining et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TspanC8 tetraspanins regulate ADAM10/Kuzbanian trafficking and promote Notch activation in flies and mammals

(2012) Emmanuel Dornier et al.   JOURNAL OF CELL BIOLOGY

The neuropeptide PACAP38 induces dendritic spine remodeling through ADAM10-N-cadherin signaling pathway

(2012) F. Gardoni et al.   JOURNAL OF CELL SCIENCE

ADAM10 mediatesN-cadherin ectodomain shedding during retinal ganglion cell differentiation in primary cultured retinal cells from the developing chick retina

(2012) Sharada Paudel et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

sAPPα rescues deficits in amyloid precursor protein knockout mice following focal traumatic brain injury

(2012) Frances Corrigan et al.   JOURNAL OF NEUROCHEMISTRY

Soluble A  Promotes Wild-Type Tau Pathology In Vivo

(2012) M. A. Chabrier et al.   JOURNAL OF NEUROSCIENCE

Activation of NMDA Receptors Upregulates A Disintegrin and Metalloproteinase 10 via a Wnt/MAPK Signaling Pathway

(2012) X.-Z. Wan et al.   JOURNAL OF NEUROSCIENCE

ADAM10 expression and promoter haplotype in Alzheimer's disease

(2012) Lynn M. Bekris et al.   NEUROBIOLOGY OF AGING

Constitutive α- and β-secretase cleavages of the amyloid precursor protein are partially coupled in neurons, but not in frequently used cell lines

(2012) Alessio Colombo et al.   NEUROBIOLOGY OF DISEASE

Beneficial Effect of Antibodies against β- Secretase Cleavage Site of App on Alzheimer’s-Like Pathology in Triple-Transgenic Mice

(2012) Inna Rabinovich-Nikitin et al.   PLoS One

Soluble amyloid precursor protein-α modulates β-secretase activity and amyloid-β generation

(2012) Demian Obregon et al.   Nature Communications

Loss of Prohibitin Membrane Scaffolds Impairs Mitochondrial Architecture and Leads to Tau Hyperphosphorylation and Neurodegeneration

(2012) Carsten Merkwirth et al.   PLoS Genetics

Amyloid Precursor Protein Processing and Alzheimer's Disease

(2011) Richard J. O'Brien et al.   Annual Review of Neuroscience

Genetic association between ADAM10 gene polymorphism and Alzheimer's disease in a Northern Han Chinese population

(2011) Jing-Hui Song et al.   BRAIN RESEARCH

Identification and biology of α-secretase

(2011) Valérie Vingtdeux et al.   JOURNAL OF NEUROCHEMISTRY

The sirtuin pathway in ageing and Alzheimer disease: mechanistic and therapeutic considerations

(2011) David J Bonda et al.   LANCET NEUROLOGY

Adult hippocampal neurogenesis and its role in Alzheimer's disease

(2011) Yangling Mu et al.   Molecular Neurodegeneration

SFRPs act as negative modulators of ADAM10 to regulate retinal neurogenesis

(2011) Pilar Esteve et al.   NATURE NEUROSCIENCE

Amyloid precursor protein (APP) processing genes and cerebrospinal fluid APP cleavage product levels in Alzheimer's disease

(2011) L.M. Bekris et al.   NEUROBIOLOGY OF AGING

Soluble amyloid precursor protein: a novel proliferation factor of adult progenitor cells of ectodermal and mesodermal origin

(2011) Michael P Demars et al.   Stem Cell Research & Therapy

Aging and disease: connections to sirtuins

(2010) Gizem Donmez et al.   AGING CELL

Blocking ADAM10 synaptic trafficking generates a model of sporadic Alzheimer’s disease

(2010) Roberta Epis et al.   BRAIN

RETRACTED: SIRT1 Suppresses β-Amyloid Production by Activating the α-Secretase Gene ADAM10

(2010) Gizem Donmez et al.   CELL

ADAM10 is the physiologically relevant, constitutive α-secretase of the amyloid precursor protein in primary neurons

(2010) Peer-Hendrik Kuhn et al.   EMBO JOURNAL

Expression of the Anti-amyloidogenic Secretase ADAM10 Is Suppressed by Its 5′-Untranslated Region

(2010) Sven Lammich et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Alpha-secretase in Alzheimer’s disease: molecular identity, regulation and therapeutic potential

(2010) Stefan F. Lichtenthaler   JOURNAL OF NEUROCHEMISTRY

Synaptic Localization and Activity of ADAM10 Regulate Excitatory Synapses through N-Cadherin Cleavage

(2010) M. Malinverno et al.   JOURNAL OF NEUROSCIENCE

Deletion of M1 Muscarinic Acetylcholine Receptors Increases Amyloid Pathology In Vitro and In Vivo

(2010) A. A. Davis et al.   JOURNAL OF NEUROSCIENCE

Neuroligin-1 Deletion Results in Impaired Spatial Memory and Increased Repetitive Behavior

(2010) J. Blundell et al.   JOURNAL OF NEUROSCIENCE

The Disintegrin/Metalloproteinase ADAM10 Is Essential for the Establishment of the Brain Cortex

(2010) E. Jorissen et al.   JOURNAL OF NEUROSCIENCE

A  Oligomers Cause Localized Ca2+ Elevation, Missorting of Endogenous Tau into Dendrites, Tau Phosphorylation, and Destruction of Microtubules and Spines

(2010) H. Zempel et al.   JOURNAL OF NEUROSCIENCE

SAP97-mediated local trafficking is altered in Alzheimer disease patients' hippocampus

(2010) Elena Marcello et al.   NEUROBIOLOGY OF AGING

Evidence against a role for rare ADAM10 mutations in sporadic Alzheimer Disease

(2010) Guiqing Cai et al.   NEUROBIOLOGY OF AGING

Differential gene expression in ADAM10 and mutant ADAM10 transgenic mice

(2009) Claudia Prinzen et al.   BMC GENOMICS

The Canonical Notch Signaling Pathway: Unfolding the Activation Mechanism

(2009) Raphael Kopan et al.   CELL

Tetraspanin12 regulates ADAM10-dependent cleavage of amyloid precursor protein

(2009) Daosong Xu et al.   FASEB JOURNAL

Up-regulation of the α-secretase ADAM10 by retinoic acid receptors and acitretin

(2009) Frank Tippmann et al.   FASEB JOURNAL

Potential late-onset Alzheimer's disease-associated mutations in the ADAM10 gene attenuate α-secretase activity

(2009) Minji Kim et al.   HUMAN MOLECULAR GENETICS

Neuroprotective Secreted Amyloid Precursor Protein Acts by Disrupting Amyloid Precursor Protein Dimers

(2009) Matthias Gralle et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

ADAM10, the Rate-limiting Protease of Regulated Intramembrane Proteolysis of Notch and Other Proteins, Is Processed by ADAMS-9, ADAMS-15, and the γ-Secretase

(2009) Thomas Tousseyn et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A disintegrin and metalloproteinase (ADAM)-mediated ectodomain shedding of ADAM10

(2009) Edward Parkin et al.   JOURNAL OF NEUROCHEMISTRY

Lack of evidence to support the association of polymorphisms within the alpha- and beta-secretase genes (ADAM10/BACE1) with Alzheimer's disease

(2009) S.M. Laws et al.   NEUROBIOLOGY OF AGING

Genome-wide Association Analysis Reveals Putative Alzheimer's Disease Susceptibility Loci in Addition to APOE

(2008) Lars Bertram et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Understanding Synapses: Past, Present, and Future

(2008) Thomas C. Südhof et al.   NEURON

ADAM-10 over-expression increases cortical synaptogenesis

(2006) Karen F.S. Bell et al.   NEUROBIOLOGY OF AGING