Melatonin alleviates inflammasome-induced pyroptosis through inhibiting NF-κB/GSDMD signal in mice adipose tissue

Melatonin alleviates cadmium-induced liver injury by inhibiting the TXNIP-NLRP3 inflammasome

(2017) Zhengwang Cao et al.   JOURNAL OF PINEAL RESEARCH

Melatonin administration to wild-type mice and nontreated NLRP3 mutant mice share similar inhibition of the inflammatory response during sepsis

(2017) Ibtissem Rahim et al.   JOURNAL OF PINEAL RESEARCH

Melatonin promotes circadian rhythm-induced proliferation through Clock/histone deacetylase 3/c-Myc interaction in mouse adipose tissue

(2017) Zhenjiang Liu et al.   JOURNAL OF PINEAL RESEARCH

Melatonin signaling in T cells: Functions and applications

(2017) Wenkai Ren et al.   JOURNAL OF PINEAL RESEARCH

Pyroptosis: Gasdermin-Mediated Programmed Necrotic Cell Death

(2017) Jianjin Shi et al.   TRENDS IN BIOCHEMICAL SCIENCES

NF-κB Restricts Inflammasome Activation via Elimination of Damaged Mitochondria

(2016) Zhenyu Zhong et al.   CELL

IL-18 Production from the NLRP1 Inflammasome Prevents Obesity and Metabolic Syndrome

(2016) Andrew J. Murphy et al.   Cell Metabolism

Pyroptosis

(2016) Lieselotte Vande Walle et al.   CURRENT BIOLOGY

GSDMD membrane pore formation constitutes the mechanism of pyroptotic cell death

(2016) Lorenzo Sborgi et al.   EMBO JOURNAL

Protein phosphatase 1 abrogates IRF7-mediated type I IFN response in antiviral immunity

(2016) Ling Wang et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

PKA Has the Gall to Oppose NLRP3

(2016) Christina J. Groß et al.   IMMUNITY

Melatonin inhibits MMP-9 transactivation and renal cell carcinoma metastasis by suppressing Akt-MAPKs pathway and NF-κB DNA-binding activity

(2016) Yung-Wei Lin et al.   JOURNAL OF PINEAL RESEARCH

Melatonin attenuated early brain injury induced by subarachnoid hemorrhage via regulating NLRP3 inflammasome and apoptosis signaling

(2016) Yushu Dong et al.   JOURNAL OF PINEAL RESEARCH

Same molecule but different expression: aging and sepsis trigger NLRP3 inflammasome activation, a target of melatonin

(2016) Huayqui Volt et al.   JOURNAL OF PINEAL RESEARCH

The RelA/cRel nuclear factor-κB (NF-κB) dimer, crucial for inflammation resolution, mediates the transcription of the key enzyme in melatonin synthesis in RAW 264.7 macrophages

(2016) Sandra Marcia Muxel et al.   JOURNAL OF PINEAL RESEARCH

Melatonin synergizes the chemotherapeutic effect of 5-fluorouracil in colon cancer by suppressing PI3K/AKT and NF-κB/iNOS signaling pathways

(2016) Yue Gao et al.   JOURNAL OF PINEAL RESEARCH

Melatonin alleviates acute lung injury through inhibiting the NLRP3 inflammasome

(2016) Yong Zhang et al.   JOURNAL OF PINEAL RESEARCH

Pore-forming activity and structural autoinhibition of the gasdermin family

(2016) Jingjin Ding et al.   NATURE

GsdmD p30 elicited by caspase-11 during pyroptosis forms pores in membranes

(2016) Robin A. Aglietti et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Adiponectin reduces ER stress-induced apoptosis through PPARα transcriptional regulation of ATF2 in mouse adipose

(2016) Zhenjiang Liu et al.   Cell Death & Disease

Disruption of the NF-κB/NLRP3 connection by melatonin requires retinoid-related orphan receptor-α and blocks the septic response in mice

(2015) José A. García et al.   FASEB JOURNAL

Pyroptotic cell death defends against intracellular pathogens

(2015) Ine Jorgensen et al.   IMMUNOLOGICAL REVIEWS

Melatonin set out to ER stress signaling thwarts epithelial mesenchymal transition and peritoneal dissemination via calpain-mediated C/EBPβand NFκB cleavage

(2015) Sheng-Mao Wu et al.   JOURNAL OF PINEAL RESEARCH

Melatonin attenuates neurogenic pulmonary edema via the regulation of inflammation and apoptosis after subarachnoid hemorrhage in rats

(2015) Jingyin Chen et al.   JOURNAL OF PINEAL RESEARCH

Melatonin alleviates brain injury in mice subjected to cecal ligation and puncture via attenuating inflammation, apoptosis, and oxidative stress: the role of SIRT1 signaling

(2015) Lei Zhao et al.   JOURNAL OF PINEAL RESEARCH

Pinealectomy interferes with the circadian clock genes expression in white adipose tissue

(2015) Talita da Silva Mendes de Farias et al.   JOURNAL OF PINEAL RESEARCH

Inter-relationships of the chronobiotic, melatonin, with leptin and adiponectin: implications for obesity

(2015) Karolina Szewczyk-Golec et al.   JOURNAL OF PINEAL RESEARCH

Melatonin: an ancient molecule that makes oxygen metabolically tolerable

(2015) Lucien C. Manchester et al.   JOURNAL OF PINEAL RESEARCH

Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling

(2015) Nobuhiko Kayagaki et al.   NATURE

Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death

(2015) Jianjin Shi et al.   NATURE

Dermal adipocytes protect against invasive Staphylococcus aureus skin infection

(2015) L.-j. Zhang et al.   SCIENCE

Mitochondria: diversity in the regulation of the NLRP3 inflammasome

(2015) Prajwal Gurung et al.   TRENDS IN MOLECULAR MEDICINE

FABP4 reversed the regulation of leptin on mitochondrial fatty acid oxidation in mice adipocytes

(2015) Lu Gan et al.   Scientific Reports

Melatonin normalizes clinical and biochemical parameters of mild inflammation in diet-induced metabolic syndrome in rats

(2014) Pilar Cano Barquilla et al.   JOURNAL OF PINEAL RESEARCH

Melatonin and its metabolites as copper chelating agents and their role in inhibiting oxidative stress: a physicochemical analysis

(2014) Annia Galano et al.   JOURNAL OF PINEAL RESEARCH

Melatonin blunts the mitochondrial/NLRP3 connection and protects against radiation-induced oral mucositis

(2014) Francisco Ortiz et al.   JOURNAL OF PINEAL RESEARCH

Inflammasomes and Metabolic Disease

(2013) Jorge Henao-Mejia et al.   Annual Review of Physiology

Lipopolysaccharide-induced inhibition of transcription of tlr4 in vitro is reversed by dexamethasone and correlates with presence of conserved NFκB binding sites

(2013) Camila P. Bonin et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Obese adipocytes show ultrastructural features of stressed cells and die of pyroptosis

(2013) Antonio Giordano et al.   JOURNAL OF LIPID RESEARCH

The inhibition of TNF-α-induced leucocyte apoptosis by melatonin involves membrane receptor MT1/MT2 interaction

(2013) Javier Espino et al.   JOURNAL OF PINEAL RESEARCH

Inflammasomes and Their Roles in Health and Disease

(2012) Mohamed Lamkanfi et al.   Annual Review of Cell and Developmental Biology

TLR-induced NF-κB activation regulates NLRP3 expression in murine macrophages

(2012) Yu Qiao et al.   FEBS LETTERS

Melatonin MT1 receptor-induced transcriptional up-regulation of p27Kip1 in prostate cancer antiproliferation is mediated via inhibition of constitutively active nuclear factor kappa B (NF-κB): potential implications on prostate cancer chemoprevention and

(2012) Stephen Y. W. Shiu et al.   JOURNAL OF PINEAL RESEARCH

Melatonin ameliorates low-grade inflammation and oxidative stress in young Zucker diabetic fatty rats

(2012) Ahmad Agil et al.   JOURNAL OF PINEAL RESEARCH

A review of the molecular aspects of melatonin’s anti-inflammatory actions: recent insights and new perspectives

(2012) José L. Mauriz et al.   JOURNAL OF PINEAL RESEARCH

Inflammasomes in health and disease

(2012) Till Strowig et al.   NATURE

The Inflammasome NLRs in Immunity, Inflammation, and Associated Diseases

(2011) Beckley K. Davis et al.   Annual Review of Immunology

Inflammatory links between obesity and metabolic disease

(2011) Carey N. Lumeng et al.   JOURNAL OF CLINICAL INVESTIGATION

Melatonin as a natural ally against oxidative stress: a physicochemical examination

(2011) Annia Galano et al.   JOURNAL OF PINEAL RESEARCH

Melatonin, the circadian multioscillator system and health: the need for detailed analyses of peripheral melatonin signaling

(2011) Rüdiger Hardeland et al.   JOURNAL OF PINEAL RESEARCH

Linking the inflammasome to obesity-related disease

(2011) Tiffany Horng et al.   NATURE MEDICINE

The Inflammasomes

(2010) Kate Schroder et al.   CELL

The inhibition of apoptosis by melatonin in VSC4.1 motoneurons exposed to oxidative stress, glutamate excitotoxicity, or TNF-α toxicity involves membrane melatonin receptors

(2010) Arabinda Das et al.   JOURNAL OF PINEAL RESEARCH

Caspase-1-induced pyroptosis is an innate immune effector mechanism against intracellular bacteria

(2010) Edward A Miao et al.   NATURE IMMUNOLOGY

Melatonin improves oxidative stress parameters measured in the blood of elderly type 2 diabetic patients

(2009) Kornelia Kędziora-Kornatowska et al.   JOURNAL OF PINEAL RESEARCH

Adipocyte differentiation is inhibited by melatonin through the regulation of C/EBPβ transcriptional activity

(2009) Maria Isabel Cardoso Alonso-Vale et al.   JOURNAL OF PINEAL RESEARCH

Pyroptosis: host cell death and inflammation

(2009) Tessa Bergsbaken et al.   NATURE REVIEWS MICROBIOLOGY

Stimulation of Toll-like receptor 3 and 4 induces interleukin-1β maturation by caspase-8

(2008) Jonathan Maelfait et al.   JOURNAL OF EXPERIMENTAL MEDICINE