FDA-approved disulfiram inhibits pyroptosis by blocking gasdermin D pore formation
Published 2020 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
FDA-approved disulfiram inhibits pyroptosis by blocking gasdermin D pore formation
Authors
Keywords
-
Journal
NATURE IMMUNOLOGY
Volume -, Issue -, Pages -
Publisher
Springer Science and Business Media LLC
Online
2020-05-05
DOI
10.1038/s41590-020-0669-6
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Cryo-EM structure of the gasdermin A3 membrane pore
- (2018) Jianbin Ruan et al. NATURE
- Alcohol-abuse drug disulfiram targets cancer via p97 segregase adaptor NPL4
- (2017) Zdenek Skrott et al. NATURE
- Assembly of phospholipid nanodiscs of controlled size for structural studies of membrane proteins by NMR
- (2017) Franz Hagn et al. Nature Protocols
- Disulfiram as a novel inactivator of Giardia lamblia triosephosphate isomerase with antigiardial potential
- (2017) Adriana Castillo-Villanueva et al. International Journal for Parasitology-Drugs and Drug Resistance
- Pyroptosis is driven by non-selective gasdermin-D pore and its morphology is different from MLKL channel-mediated necroptosis
- (2016) Xin Chen et al. CELL RESEARCH
- GSDMD membrane pore formation constitutes the mechanism of pyroptotic cell death
- (2016) Lorenzo Sborgi et al. EMBO JOURNAL
- Active Caspase-1 Induces Plasma Membrane Pores That Precede Pyroptotic Lysis and Are Blocked by Lanthanides
- (2016) Hana M. Russo et al. JOURNAL OF IMMUNOLOGY
- Pore-forming activity and structural autoinhibition of the gasdermin family
- (2016) Jingjin Ding et al. NATURE
- Inflammasome-activated gasdermin D causes pyroptosis by forming membrane pores
- (2016) Xing Liu et al. NATURE
- Covalently circularized nanodiscs for studying membrane proteins and viral entry
- (2016) Mahmoud L Nasr et al. NATURE METHODS
- GsdmD p30 elicited by caspase-11 during pyroptosis forms pores in membranes
- (2016) Robin A. Aglietti et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Gasdermin D is an executor of pyroptosis and required for interleukin-1β secretion
- (2015) Wan-ting He et al. CELL RESEARCH
- Molecular mechanisms regulating NLRP3 inflammasome activation
- (2015) Eun-Kyeong Jo et al. Cellular & Molecular Immunology
- Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling
- (2015) Nobuhiko Kayagaki et al. NATURE
- Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death
- (2015) Jianjin Shi et al. NATURE
- Structure and assembly of the mouse ASC inflammasome by combined NMR spectroscopy and cryo-electron microscopy
- (2015) Lorenzo Sborgi et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Surviving Sepsis Campaign: International Guidelines for Management of Severe Sepsis and Septic Shock, 2012
- (2013) R. P. Dellinger et al. INTENSIVE CARE MEDICINE
- Inflammasomes and Their Roles in Health and Disease
- (2012) Mohamed Lamkanfi et al. Annual Review of Cell and Developmental Biology
- Mixed Lineage Kinase Domain-like Protein Mediates Necrosis Signaling Downstream of RIP3 Kinase
- (2012) Liming Sun et al. CELL
- Regulation of inflammasome signaling
- (2012) Vijay A K Rathinam et al. NATURE IMMUNOLOGY
- Nonprofit drugs as the salvation of the world's healthcare systems: the case of Antabuse (disulfiram)
- (2011) Boris Cvek DRUG DISCOVERY TODAY
- Non-canonical inflammasome activation targets caspase-11
- (2011) Nobuhiko Kayagaki et al. NATURE
- Anti-inflammatory Compounds Parthenolide and Bay 11-7082 Are Direct Inhibitors of the Inflammasome
- (2010) Christine Juliana et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Identification of RIP1 kinase as a specific cellular target of necrostatins
- (2008) Alexei Degterev et al. Nature Chemical Biology
- Prediction of reversibly oxidized protein cysteine thiols using protein structure properties
- (2008) Ricardo Sanchez et al. PROTEIN SCIENCE
Publish scientific posters with Peeref
Peeref publishes scientific posters from all research disciplines. Our Diamond Open Access policy means free access to content and no publication fees for authors.
Learn MoreBecome a Peeref-certified reviewer
The Peeref Institute provides free reviewer training that teaches the core competencies of the academic peer review process.
Get Started