Inhibition of TLR4 Induces M2 Microglial Polarization and Provides Neuroprotection via the NLRP3 Inflammasome in Alzheimer’s Disease

ProNGF and Neurodegeneration in Alzheimer’s Disease

(2019) Margaret Fahnestock et al.   Frontiers in Neuroscience

Imbalance of Microglial TLR4/TREM2 in LPS-Treated APP/PS1 Transgenic Mice: A Potential Link Between Alzheimer’s Disease and Systemic Inflammation

(2019) Jian Zhou et al.   NEUROCHEMICAL RESEARCH

Reno-protective effects of TAK-242 on acute kidney injury in a rat model

(2018) Bassim I. Mohammad et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Quercetin ameliorates kidney injury and fibrosis by modulating M1/M2 macrophage polarization

(2018) Hong Lu et al.   BIOCHEMICAL PHARMACOLOGY

Effects of the TLR4/Myd88/NF-κB Signaling Pathway on NLRP3 Inflammasome in Coronary Microembolization-Induced Myocardial Injury

(2018) Qiang Su et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Modulation of Inflammation as a Way of Delaying Alzheimer's Disease Progression: The Diet's Role

(2018) R. Businaro et al.   Current Alzheimer Research

Interferon regulatory factor 4/5 signaling impacts on microglial activation after ischemic stroke in mice

(2018) Abdullah Al Mamun et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Immunotherapy of Mild Cognitive Impairment by ω-3 Supplementation: Why Are Amyloid-β Antibodies and ω-3 Not Working in Clinical Trials?

(2018) Milan Fiala et al.   JOURNAL OF ALZHEIMERS DISEASE

TLR4 Gene Expression and Pro-Inflammatory Cytokines in Alzheimer’s Disease and in Response to Hippocampal Deafferentation in Rodents

(2018) Justin Miron et al.   JOURNAL OF ALZHEIMERS DISEASE

Inhibition of toll-like receptor 4 alleviates hyperalgesia induced by acute dural inflammation in experimental migraine

(2018) Min Su et al.   Molecular Pain

Inflammation as a Possible Link Between Dyslipidemia and Alzheimer’s Disease

(2018) Bruno Cabral de Lima Oliveira et al.   NEUROSCIENCE

A Complex Proinflammatory Role for Peripheral Monocytes in Alzheimer's Disease

(2018) Marina Saresella et al.   JOURNAL OF ALZHEIMERS DISEASE

Knockdown of NLRP3 alleviates high glucose or TGFB1-induced EMT in human renal tubular cells

(2018) Shan Song et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

Andrographolide Alleviates Acute Brain Injury in a Rat Model of Traumatic Brain Injury: Possible Involvement of Inflammatory Signaling

(2018) Li Tao et al.   Frontiers in Neuroscience

LncRNA XIST mediates bovine mammary epithelial cell inflammatory response via NF-κB/NLRP3 inflammasome pathway

(2018) Mengru Ma et al.   CELL PROLIFERATION

TLR4 inhibitor TAK-242 attenuates the adverse neural effects of diet-induced obesity

(2018) V. Alexandra Moser et al.   Journal of Neuroinflammation

Systemic immune-checkpoint blockade with anti-PD1 antibodies does not alter cerebral amyloid-β burden in several amyloid transgenic mouse models

(2017) Martine Latta-Mahieu et al.   GLIA

Inhibition of TLR4 alleviates the inflammation and apoptosis of retinal ganglion cells in high glucose

(2017) Lili Hu et al.   GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY

Progesterone therapy induces an M1 to M2 switch in microglia phenotype and suppresses NLRP3 inflammasome in a cuprizone-induced demyelination mouse model

(2017) Roya Aryanpour et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Toll-like receptor 4 antagonist TAK-242 inhibits autoinflammatory symptoms in DITRA

(2017) Akitaka Shibata et al.   JOURNAL OF AUTOIMMUNITY

Toll-like receptor 4–induced ryanodine receptor 2 oxidation and sarcoplasmic reticulum Ca2+leakage promote cardiac contractile dysfunction in sepsis

(2017) Jie Yang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Magnesium Lithospermate B Suppresses Lipopolysaccharide-Induced Neuroinflammation in BV2 Microglial Cells and Attenuates Neurodegeneration in Lipopolysaccharide-Injected Mice

(2017) Yaojun Tai et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Inhibition of PTEN Attenuates Endoplasmic Reticulum Stress and Apoptosis via Activation of PI3K/AKT Pathway in Alzheimer’s Disease

(2017) Weigang Cui et al.   NEUROCHEMICAL RESEARCH

Acute Hypoxia Induced an Imbalanced M1/M2 Activation of Microglia through NF-κB Signaling in Alzheimer’s Disease Mice and Wild-Type Littermates

(2017) Feng Zhang et al.   Frontiers in Aging Neuroscience

The Pathophysiological Role of Microglia in Dynamic Surveillance, Phagocytosis and Structural Remodeling of the Developing CNS

(2017) Cataldo Arcuri et al.   Frontiers in Molecular Neuroscience

Astragalus polysaccharides exerts immunomodulatory effects via TLR4-mediated MyD88-dependent signaling pathway in vitro and in vivo

(2017) Lijing Zhou et al.   Scientific Reports

Protective Effect of 2-Dodecyl-6-Methoxycyclohexa-2, 5-Diene-1, 4-Dione, Isolated from Averrhoa Carambola L., Against Palmitic Acid-Induced Inflammation and Apoptosis in Min6 Cells by Inhibiting the TLR4-MyD88-NF-κB Signaling Pathway

(2016) Qiuqiao Xie et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Characterization of a novel adult murine immortalized microglial cell line and its activation by amyloid-beta

(2016) Ryan C. McCarthy et al.   Journal of Neuroinflammation

Inhibition of TLR4 Signalling-Induced Inflammation Attenuates Secondary Injury after Diffuse Axonal Injury in Rats

(2016) Yonglin Zhao et al.   MEDIATORS OF INFLAMMATION

Obesity Takes Its Toll on Visceral Pain: High-Fat Diet Induces Toll-Like Receptor 4-Dependent Visceral Hypersensitivity

(2016) Mónica Tramullas et al.   PLoS One

TAK-242, an Antagonist for Toll-like Receptor 4, Protects against Acute Cerebral Ischemia/Reperfusion Injury in Mice

(2015) Fang Hua et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

TAK-242, a Toll-Like Receptor 4 Antagonist, Protects against Aldosterone-Induced Cardiac and Renal Injury

(2015) Yide Zhang et al.   PLoS One

MyD88 acts as an adaptor protein for inflammatory signalling induced by amyloid-β in macrophages

(2014) Sophie O’Halloran et al.   IMMUNOLOGY LETTERS

Role of the TLR4 pathway in blood-spinal cord barrier dysfunction during the bimodal stage after ischemia/reperfusion injury in rats

(2014) Xiao-Qian Li et al.   Journal of Neuroinflammation

The NLRP3 Inflammasome in Alzheimer’s Disease

(2013) Meng-Shan Tan et al.   MOLECULAR NEUROBIOLOGY

Neuregulin1beta1 Antagonizes Apoptosis Via ErbB4-Dependent Activation of PI3-Kinase/Akt in APP/PS1 Transgenic Mice

(2013) Weigang Cui et al.   NEUROCHEMICAL RESEARCH

Prion protein participates in the regulation of classical and alternative activation of BV2 microglia

(2012) Fushan Shi et al.   JOURNAL OF NEUROCHEMISTRY

Liver X receptor activation attenuates inflammatory response and protects cholinergic neurons in APP/PS1 transgenic mice

(2012) W. Cui et al.   NEUROSCIENCE

Microglia/Macrophage Polarization Dynamics Reveal Novel Mechanism of Injury Expansion After Focal Cerebral Ischemia

(2012) Xiaoming Hu et al.   STROKE

Adolescent binge alcohol exposure induces long-lasting partial activation of microglia

(2011) Justin A. McClain et al.   BRAIN BEHAVIOR AND IMMUNITY

TAK-242 (Resatorvid), a Small-Molecule Inhibitor of Toll-Like Receptor (TLR) 4 Signaling, Binds Selectively to TLR4 and Interferes with Interactions between TLR4 and Its Adaptor Molecules

(2010) N. Matsunaga et al.   MOLECULAR PHARMACOLOGY

Treatment of Neck Pain

(2009) Eugene J. Carragee et al.   JOURNAL OF MANIPULATIVE AND PHYSIOLOGICAL THERAPEUTICS