The NLRP3 inflammasome drives inflammation in ischemia/reperfusion injury after transient middle cerebral artery occlusion in mice

Overexpression of MicroRNA-9a-5p Ameliorates NLRP1 Inflammasome-mediated Ischemic Injury in Rats Following Ischemic Stroke

(2020) Cao Yuze et al.   NEUROSCIENCE

AIM2 inflammasome contributes to brain injury and chronic post-stroke cognitive impairment in mice

(2020) Hyunha Kim et al.   BRAIN BEHAVIOR AND IMMUNITY

Targeting Platelet GPVI Plus rt-PA Administration but Not α2β1-Mediated Collagen Binding Protects against Ischemic Brain Damage in Mice

(2019) Michael K. Schuhmann et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

NLRP3 inflammasome in ischemic stroke: As possible therapeutic target

(2019) Masoumeh Alishahi et al.   International Journal of Stroke

Thrombo-inflammation in acute ischaemic stroke — implications for treatment

(2019) Guido Stoll et al.   Nature Reviews Neurology

Validity and Reliability of Neurological Scores in Mice Exposed to Middle Cerebral Artery Occlusion

(2019) Michael Bieber et al.   STROKE

Corylin inhibits LPS-induced inflammatory response and attenuates the activation of NLRP3 inflammasome in microglia

(2018) Ming-Yii Huang et al.   BMC Complementary and Alternative Medicine

Brain-released alarmins and stress response synergize in accelerating atherosclerosis progression after stroke

(2018) Stefan Roth et al.   Science Translational Medicine

Inhibition of the NLRP3-inflammasome as a potential approach for neuroprotection after stroke

(2018) Saifudeen Ismael et al.   Scientific Reports

Evidence that NLRC4 Inflammasome Mediates Apoptotic and Pyroptotic Microglial Death Following Ischemic Stroke

(2018) Luting Poh et al.   BRAIN BEHAVIOR AND IMMUNITY

Interleukin-1 mediates ischaemic brain injury via distinct actions on endothelial cells and cholinergic neurons

(2018) Raymond Wong et al.   BRAIN BEHAVIOR AND IMMUNITY

Description of a Novel Phosphodiesterase (PDE)-3 Inhibitor Protecting Mice From Ischemic Stroke Independent From Platelet Function

(2018) Michael Bieber et al.   STROKE

Gasdermin Family: a Promising Therapeutic Target for Stroke

(2018) Sheng Chen et al.   Translational Stroke Research

Sulforaphane improves outcomes and slows cerebral ischemic/reperfusion injury via inhibition of NLRP3 inflammasome activation in rats

(2017) Chang Yu et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Human NACHT, LRR, and PYD domain–containing protein 3 (NLRP3) inflammasome activity is regulated by and potentially targetable through Bruton tyrosine kinase

(2017) Xiao Liu et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

The role of the inflammasome in patients with autoinflammatory diseases

(2016) Hal M. Hoffman et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Genipin suppresses NLRP3 inflammasome activation through uncoupling protein-2

(2015) Venugopal Rajanbabu et al.   CELLULAR IMMUNOLOGY

Sulforaphane inhibits multiple inflammasomes through an Nrf2-independent mechanism

(2015) Allison J. Greaney et al.   JOURNAL OF LEUKOCYTE BIOLOGY

A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases

(2015) Rebecca C Coll et al.   NATURE MEDICINE

Bruton’s tyrosine kinase is essential for NLRP3 inflammasome activation and contributes to ischaemic brain injury

(2015) Minako Ito et al.   Nature Communications

Unified Polymerization Mechanism for the Assembly of ASC-Dependent Inflammasomes

(2014) Alvin Lu et al.   CELL

CD28 Superagonist-Mediated Boost of Regulatory T Cells Increases Thrombo-Inflammation and Ischemic Neurodegeneration during the Acute Phase of Experimental Stroke

(2014) Michael K Schuhmann et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

NLRP3 Deficiency Ameliorates Neurovascular Damage in Experimental Ischemic Stroke

(2014) Fan Yang et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

The NLRP3 inflammasome is released as a particulate danger signal that amplifies the inflammatory response

(2014) Alberto Baroja-Mazo et al.   NATURE IMMUNOLOGY

MFGE8 inhibits inflammasome-induced IL-1β production and limits postischemic cerebral injury

(2013) Nicolas Deroide et al.   JOURNAL OF CLINICAL INVESTIGATION

Intravenous immunoglobulin suppresses NLRP1 and NLRP3 inflammasome-mediated neuronal death in ischemic stroke

(2013) D Yang-Wei Fann et al.   Cell Death & Disease

The immunology of acute stroke

(2012) Ángel Chamorro et al.   Nature Reviews Neurology

Animal Research: Reporting in vivo Experiments—The ARRIVE Guidelines

(2011) Carol Kilkenny et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Inhibition of the Inflammasome Complex Reduces the Inflammatory Response after Thromboembolic Stroke in Mice

(2008) Denise P Abulafia et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM