Article
Multidisciplinary Sciences
Du Zheng, Hongwei Wang, Youfa Zhou, Yeru Chen, Gang Chen
Summary: This study demonstrated that sevoflurane-induced cognitive dysfunction in elderly mice and primary hippocampus neuron involved the activation of NLRP3 inflammasome and impairment of mitophagy. Caspase-1 inhibitor Ac-YVAD-cmk mitigated the mitochondria dysfunction and revised the mitophagy impairment induced by sevoflurane.
Article
Multidisciplinary Sciences
Shiyu Xia, Zhibin Zhang, Venkat Giri Magupalli, Juan Lorenzo Pablo, Ying Dong, Setu M. Vora, Longfei Wang, Tian-Min Fu, Matthew P. Jacobson, Anna Greka, Judy Lieberman, Jianbin Ruan, Hao Wu
Summary: Inflammasomes activate caspase-1 to cleave GSDMD and generate mature cytokines like IL-1 beta and IL-18, which are released through pores formed by GSDMD. The GSDMD pore mediates IL-1 release by electrostatic filtering, favoring the passage of mature cytokines over their precursors.
Article
Neurosciences
Pengfei Wang, Baogen Pan, Jun Tian, Lei Yang, Zeshang Chen, Lijun Yang, Zhenzeng Fan
Summary: The study revealed that Ac-FLTD-CMK treatment significantly decreased the expression of caspase-1 p20, caspase-11 p20, GSDMD N-terminal, IL-1 beta, and IL-18; reduced LDH release; alleviated neuronal death; attenuated brain edema and blood-brain barrier damage; and improved neurobehavioral function, indicating that Ac-FLTD-CMK suppresses pyroptosis and provides protective effects against TBI in mice.
Article
Biochemistry & Molecular Biology
Vasantha L. Kolachala, Chrissy Lopez, Ming Shen, Dmitry Shayakhmetov, Nitika Arora Gupta
Summary: The study identified Caspase 1 as a key driver of hepatocellular injury in steatotic liver undergoing ischemia reperfusion injury (IRI), with its inhibition leading to hepatoprotection, providing a new therapeutic target for treatment.
Article
Immunology
Wei Zhu, Yuan-Yuan Li, Han-Xu Zeng, Xue-Qi Liu, Yu-Ting Sun, Ling Jiang, Ling-Ling Xia, Yong-Gui Wu
Summary: The study demonstrates the protective effects of carnosine on glomerular podocytes in diabetic nephropathy, highlighting its potential as a therapeutic agent by targeting caspase-1. The mechanism involves inhibition of podocyte pyroptosis and inflammation, with promising results in both in vivo and in vitro models. This novel role of carnosine in alleviating podocyte injury provides new insights for potential treatment of diabetic nephropathy.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Immunology
Li Wang, Xubin Dong, Shuyi Feng, Haoran Pan, Xuepei Jang, Lifei Chen, Yuan Zhao, Weizhen Chen, Zhiming Huang
Summary: In this study, the therapeutic effect of VX765 on colitis was investigated using a mouse model. The results showed that VX765 attenuated body weight loss, colonic shortening, and colonic pathological injury in mice. It was found that VX765 exerted its therapeutic effect by inhibiting pyroptosis and curbing the production of key inflammatory cytokines.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Immunology
Zhongtai Wang, Xinyu Yang, Xiangyu Wang, Fang Liang, Yiting Tang
Summary: This study found that glycyrrhizin can block cytosolic delivery of LPS mediated by HMGB1, thereby attenuating the inflammatory response, coagulopathy, organ injury, and death caused by endotoxemia and sepsis. This finding suggests that pharmacological inhibition of cytosolic delivery of LPS may be a potential therapeutic strategy for treating sepsis.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Immunology
Zhiheng Zhang, Hui Bai, Xiangying Ma, Meilun Shen, Rouqian Li, Di Qiu, Siyao Li, Li Gao
Summary: The study found that ketamine exposure led to neuronal cell damage and increased levels of pyroptosis, but targeting NLRP3 and caspase-1 with inhibitors improved this condition, reduced neuropathological damages, and alleviated cognitive dysfunction associated with ketamine-induced neurotoxicity.
JOURNAL OF NEUROINFLAMMATION
(2021)
Article
Immunology
Yueyang Song, Jiameng Song, Meng Wang, Junwei Wang, Bo Ma, Wenlong Zhang
Summary: Gasdermin family proteins, including GSDMD, have been identified as the key players in pyroptosis. While the mechanism of GSDMD-mediated pyroptosis is well understood in humans and mice, the activation and function of porcine GSDMD (pGSDMD) remain largely unknown. This study demonstrated the activation of porcine caspase-1 (pcaspase-1) and cleavage of pGSDMD in the small intestine of piglets infected with enterotoxigenic Escherichia coli. The cleavage of pGSDMD by pcaspase-1 resulted in the production of pGSDMD-NT, which exhibited the ability to induce cell membrane rupture and showed bactericidal activity. These findings suggest that pGSDMD plays a role in pyroptosis and provide insights into its activation mechanisms and functions.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Heng Cao, Junyu Liang, Jing Liu, Ye He, Yini Ke, Yiduo Sun, Song Jiang, Jin Lin
Summary: In both systemic lupus nephritis patients and mice, combination therapy effectively suppressed caspase-1/GSDMD-mediated pyroptosis and reduced disease progression. The numbers of caspase-1/PI positive cells in peripheral blood were positively correlated with the systemic lupus erythematosus disease activity index (SLEDAI).
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Medicine, General & Internal
Yuanjian Fang, Xiaoyu Wang, Jianan Lu, Hui Shi, Lei Huang, Anwen Shao, Anke Zhang, Yibo Liu, Reng Ren, Cameron Lenahan, Jiping Tang, Jianmin Zhang, John H. Zhang, Sheng Chen
Summary: This study investigates the role of caspase-1-mediated inflammasome activation on extrinsic blood coagulation in cerebrospinal fluid (CSF) after subarachnoid hemorrhage (SAH). The results demonstrate that inhibiting caspase-1 with VX-765 can attenuate neuroinflammation and blood coagulation, leading to improved neurological outcomes and memory capacity in SAH rats. These findings suggest that VX-765 may be a potential treatment for SAH-related neuroinflammatory and hemostatic disorders.
Review
Immunology
Xiangtao Zheng, Weiwei Chen, Fangchen Gong, Ying Chen, Erzhen Chen
Summary: Recent studies have found that pyroptosis, a unique form of proinflammatory programmed death, is related to sepsis. While moderate pyroptosis in sepsis can control pathogen infection, excessive pyroptosis may lead to dysregulated host immune response and organ dysfunction. This review provides insights into the mechanisms and potential therapeutic targets of pyroptosis in sepsis, suggesting future directions for sepsis treatment.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Medicine, Research & Experimental
Xiaomei Luo, Yuanyuan Li, Bingdian Wang, Sai Zhu, Xinran Liu, Xueqi Liu, Xiangming Qi, Yonggui Wu
Summary: This study investigated the protective effect of carnosine on renal tubule cells in AKI. The results showed that carnosine reduced inflammation and pyroptosis by targeting caspase-1, highlighting its potential as a therapeutic agent for AKI.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Physiology
Tian Shen, Tao Lei, Lin Chen, Bing-Bing Zhu, Bi-Lin Xu, Cui-Ping Zhang, Hong-Ping Wang
Summary: The study confirmed the therapeutic effects of gardenoside on NAFLD by reducing lipid accumulation, enhancing cell viability, decreasing oxidative stress, alleviating pyroptosis and apoptosis, and reducing the expression levels of pro-pyroptotic markers such as NLRP3 and ASC. The potential mechanisms of action involve regulation of CTCF and DPP4, with CTCF possibly being a target responsible for the therapeutic effects of gardenoside in alleviating NAFLD.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Immunology
Hongfeng Ruan, Huihao Zhang, Jing Feng, Huan Luo, Fangda Fu, Sai Yao, Chengcong Zhou, Zhiguo Zhang, Yishan Bian, Hongting Jin, Yuliang Zhang, Chengliang Wu, Peijian Tong
Summary: This study found that the levels of pyroptosis-related proteins were significantly increased in patients with osteoporosis and a mouse model, while osteogenic capacity was compromised. Bioinformatics analysis confirmed shared gene expression patterns between pyroptosis and osteoporosis pathology. In vitro experiments revealed that inhibition of Caspase-1-mediated pyroptosis promotes osteogenic differentiation.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Medicine, Research & Experimental
Jinhong Zhu, Haijiao Ao, Mingdong Liu, Kui Cao, Jianqun Ma
Summary: The study demonstrated that UBE2T upregulates autophagy in NSCLC cells by activating the p53/AMPK/mTOR signaling pathway. The clinical predicting ability of UBE2T in LUAD can be improved by considering the autophagy-regulatory role of UBE2T.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Article
Oncology
Kui Cao, Mingdong Liu, Keru Ma, Xiangyu Jiang, Jianqun Ma, Jinhong Zhu
Summary: The study developed a prognostic signature based on immune-related lncRNAs in lung adenocarcinoma, which significantly predicts patient survival rates and treatment responses.
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2022)
Article
Biochemistry & Molecular Biology
Jinfeng Zhang, Xiaodong Ling, Chengyuan Fang, Jianqun Ma
Summary: This study identified an eight-lncRNA signature that can be used for the diagnosis and treatment of esophageal squamous cell carcinoma. Further functional experiments revealed that one of the lncRNAs (LINC00470) plays a crucial role in cell proliferation and migration.
CELLULAR & MOLECULAR BIOLOGY LETTERS
(2022)
Article
Gastroenterology & Hepatology
Yang Yang, Lijie Tan, Jian Hu, Yin Li, Yousheng Mao, Ziqiang Tian, Baihua Zhang, Jianqun Ma, Hecheng Li, Chun Chen, Keneng Chen, Yongtao Han, Longqi Chen, Junfeng Liu, Bentong Yu, Zhentao Yu, Zhigang Li
Summary: This study retrospectively reviewed the data from multiple esophageal cancer centers in China and found that immune checkpoint inhibitors (ICIs) demonstrated acceptable toxicity in neoadjuvant therapy for esophageal cancer. The rates of surgical resection and pathological complete response were high, but the incidence of postoperative complications was also high.
DISEASES OF THE ESOPHAGUS
(2022)
Article
Oncology
Jianqun Ma, Kui Cao, Xiaodong Ling, Ping Zhang, Jinhong Zhu
Summary: The study found that HAR1A acts as a tumor suppressor in NSCLC by inhibiting the STAT3 signaling pathway and a gene signature derived from HAR1A-related genes shows promise in predicting prognosis and chemotherapy response.
Article
Oncology
You-Sheng Mao, Shu-Geng Gao, Yin Li, An-Lin Hao, Jun-Feng Liu, Xiao-Fei Li, Tie-Hua Rong, Jian-Hua Fu, Jian-Qun Ma, Mei-Qing Xu, Ren-Quan Zhang, Gao-Ming Xiao, Xiang-Ning Fu, Ke-Neng Chen, Wei-Min Mao, Yong-Yu Liu, Hong-Xu Liu, Zhi-Rong Zhang, Yan Fang, Dong-Hong Fu, Xu-Dong Wei, Li-Gong Yuan, Shan Muhammad, Wen-Qiang Wei, Philip Wai-Yan Chiu, Shane Lloyd, Francisco Schlottmann, Kenneth Meredith, Jose M. Pimiento, Yi-Bo Gao, Jie He
Summary: Esophagectomies via both LTA and RTA can achieve similar outcomes in middle or lower TESCC patients without suspected umLN. RTA is recommended for the surgical treatment of more advanced stage TESCC due to more complete lymphadenectomy.
ANNALS OF TRANSLATIONAL MEDICINE
(2022)
Article
Oncology
Xiaoyuan Wang, Xiaodong Ling, Changhong Wang, Jinfeng Zhang, Yingnan Yang, Hao Jiang, Yanzhong Xin, Luquan Zhang, Hao Liang, Chengyuan Fang, Dayong Zheng, Jinhong Zhu, Jianqun Ma
Summary: This study evaluated the efficacy of neoadjuvant treatment with ICIs and chemotherapy in patients with advanced ESCC and explored the tumor microenvironment immune profiles during neoadjuvant therapy. The results showed that neoadjuvant ICIs combined with chemotherapy effectively controlled ESCC and altered the immune profiles of the tumor microenvironment. This study is of significant importance for understanding the role of ICIs in the treatment of ESCC.
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2023)
Article
Biochemistry & Molecular Biology
Yuwen Bai, Kui Cao, Ping Zhang, Jianqun Ma, Jinhong Zhu
Summary: FAM72A is overexpressed in multiple types of cancer and its specific contributions to tumorigenesis are not well understood. Analysis of TCGA database showed that FAM72A is upregulated in 33 types of cancer and its high levels predict poor prognosis in half of these cancer types. FAM72A also correlates with immune scores, tumor mutation burden, immune checkpoint genes, and has been identified as an oncogene in lung adenocarcinoma.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Jinhong Zhu, Kui Cao, Ping Zhang, Jianqun Ma
Summary: Lung cancer is a serious threat to human health, and the discovery of druggable molecular targets is crucial. In this study, a dysregulated long non-coding RNA (lncRNA) called LINC00669 was identified in lung adenocarcinoma (LUAD) through database analysis. The upregulation of LINC00669 was observed in various cancer types, and it was found to be associated with the cell cycle. By establishing a risk signature based on cell cycle genes, the prognostic accuracy of LINC00669 was improved. The risk signature successfully stratified LUAD patients into low- and high-risk subgroups and predicted prognosis and therapy responses.
Article
Oncology
Keru Ma, Hao Wang, Chengyuan Fang, Xiangyu Jiang, Jianqun Ma
Summary: The subclassification of pN3 based on the number of metastatic lymph nodes has been found to improve the ability to distinguish survival differences in patients with esophageal cancer. This study provides evidence for the potential clinical utility of subclassifying pN3.
FRONTIERS IN ONCOLOGY
(2023)
Article
Oncology
Xiaodong Ling, Luquan Zhang, Chengyuan Fang, Hao Liang, Jinhong Zhu, Jianqun Ma
Summary: This study identified a gene set related to copper-induced cell death in lung adenocarcinoma and constructed a prognostic risk model consisting of 7 genes. The model can predict the survival risk of patients with lung adenocarcinoma and improve the development of personalized treatment strategies.
TRANSLATIONAL LUNG CANCER RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Jinhong Zhu, Kui Cao, Meng Zhao, Keru Ma, Xiangyu Jiang, Yuwen Bai, Xiaodong Ling, Jianqun Ma
Summary: This study aimed to investigate the mechanisms and improve the efficacy of ACK1 inhibitors in cancer treatment. RNA-seq analysis revealed the regulatory role of ACK1 in autophagy. A risk signature based on ACK1-related autophagy genes was developed and shown to predict survival and drug sensitivity in lung adenocarcinoma (LUAD). In vitro experiments demonstrated that blocking lysosomal degradation or inhibiting AMPK signaling enhanced the cytotoxic effects of the ACK1 inhibitor on lung cancer cells.
MOLECULAR MEDICINE
(2023)
Article
Cell Biology
Jinfeng Zhang, Yanzhong Xin, Xiaodong Ling, Hao Liang, Luquan Zhang, Chengyuan Fang, Jianqun Ma
Summary: This study reveals that NUP93 has pro-tumorigenic properties in esophageal squamous cell carcinoma (ESCC). It promotes cell proliferation, migration, and invasion while suppressing NK cell-mediated lysis. NUP93 also positively regulates epithelial-mesenchymal transition and AKT signaling. Additionally, HECTD1 is identified as an upstream regulator of NUP93 and acts as a tumor suppressor in ESCC.
Article
Respiratory System
Kui Cao, Xiaodong Ling, Xiangyu Jiang, Jianqun Ma, Jinhong Zhu
Summary: UBE2T is a critical oncogene that is highly expressed and serves as a prognostic risk factor in multiple cancers. The gene is positively correlated with the cell cycle and can be used to predict the prognosis of lung adenocarcinoma. Furthermore, based on cell cycle genes, different subgroups with distinct survival, molecular features, immune infiltrates, and immunotherapy responses can be identified in lung adenocarcinoma patients.
RESPIRATORY RESEARCH
(2022)
Article
Oncology
Xiaoyuan Wang, Yang Liu, Xue Leng, Kui Cao, Wentao Sun, Jinhong Zhu, Jianqun Ma
Summary: The study revealed significantly increased expression levels of UBE2T in ESCC tissues and its association with multiple signaling pathways. Prognostic signatures based on UBE2T-associated genes could stratify ESCC patients into different risk groups with significant prognostic differences. Additionally, the low-risk group showed higher sensitivity to chemotherapy.
PATHOLOGY & ONCOLOGY RESEARCH
(2021)
