Oridonin is a covalent NLRP3 inhibitor with strong anti-inflammasome activity
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Title
Oridonin is a covalent NLRP3 inhibitor with strong anti-inflammasome activity
Authors
Keywords
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Journal
Nature Communications
Volume 9, Issue 1, Pages -
Publisher
Springer Nature
Online
2018-06-25
DOI
10.1038/s41467-018-04947-6
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- The Inflammasomes and Autoinflammatory Syndromes
- (2015) Lori Broderick et al. Annual Review of Pathology-Mechanisms of Disease
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- (2015) Rebecca C Coll et al. NATURE MEDICINE
- Unified Polymerization Mechanism for the Assembly of ASC-Dependent Inflammasomes
- (2014) Alvin Lu et al. CELL
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- Inflammasomes and Their Roles in Health and Disease
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- The Inflammasome NLRs in Immunity, Inflammation, and Associated Diseases
- (2011) Beckley K. Davis et al. Annual Review of Immunology
- DYNLL/LC8 Protein Controls Signal Transduction through the Nek9/Nek6 Signaling Module by Regulating Nek6 Binding to Nek9
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- (2011) Haitao Wen et al. NATURE IMMUNOLOGY
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- (2011) Juswinder Singh et al. NATURE REVIEWS DRUG DISCOVERY
- The Inflammasome-Mediated Caspase-1 Activation Controls Adipocyte Differentiation and Insulin Sensitivity
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