A Novel Inhibitor Targeting NLRP3 Inflammasome Reduces Neuropathology and Improves Cognitive Function in Alzheimer’s Disease Transgenic Mice

Adult hippocampal neurogenesis is abundant in neurologically healthy subjects and drops sharply in patients with Alzheimer’s disease

(2019) Elena P. Moreno-Jiménez et al.   NATURE MEDICINE

A novel small molecular NLRP3 inflammasome inhibitor alleviates neuroinflammatory response following traumatic brain injury

(2019) Ram Kuwar et al.   Journal of Neuroinflammation

MCC950 directly targets the NLRP3 ATP-hydrolysis motif for inflammasome inhibition

(2019) Rebecca C. Coll et al.   Nature Chemical Biology

The NLRP3 Inflammasome: An Overview of Mechanisms of Activation and Regulation

(2019) Nathan Kelley et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

NLRP3 inflammasome activation drives tau pathology

(2019) Christina Ising et al.   NATURE

Dihydromyricetin inhibits microglial activation and neuroinflammation by suppressing NLRP3 inflammasome activation in APP/PS1 transgenic mice

(2018) Jie Feng et al.   CNS Neuroscience & Therapeutics

Structural Insights of Benzenesulfonamide Analogues as NLRP3 Inflammasome Inhibitors: Design, Synthesis, and Biological Characterization

(2018) Jacob Fulp et al.   JOURNAL OF MEDICINAL CHEMISTRY

NLRP3-dependent synaptic plasticity deficit in an Alzheimer's disease amyloidosis model in vivo

(2018) Yingjie Qi et al.   NEUROBIOLOGY OF DISEASE

Impaired Hippocampal Neurogenesis and its Enhancement with Ghrelin in 5XFAD Mice

(2018) Minho Moon et al.   JOURNAL OF ALZHEIMERS DISEASE

NLRP3 Inflammasome Inhibitor Ameliorates Amyloid Pathology in a Mouse Model of Alzheimer’s Disease

(2017) Jun Yin et al.   MOLECULAR NEUROBIOLOGY

NLRP3 Inflammasome in Neurological Diseases, from Functions to Therapies

(2017) Limin Song et al.   Frontiers in Cellular Neuroscience

Studies on Colony Stimulating Factor Receptor-1 and Ligands Colony Stimulating Factor-1 and Interleukin-34 in Alzheimer's Disease Brains and Human Microglia

(2017) Douglas G. Walker et al.   Frontiers in Aging Neuroscience

Strategies targeting endogenous neurogenic cell response to improve recovery following traumatic brain injury

(2016) Kaushal Patel et al.   BRAIN RESEARCH

Activation of p53 in Down Syndrome and in the Ts65Dn Mouse Brain is Associated with a Pro-Apoptotic Phenotype

(2016) Antonella Tramutola et al.   JOURNAL OF ALZHEIMERS DISEASE

Activation of phagocytic activity in astrocytes by reduced expression of the inflammasome component ASC and its implication in a mouse model of Alzheimer disease

(2016) Julien Couturier et al.   Journal of Neuroinflammation

The NLRP3 and NLRP1 inflammasomes are activated in Alzheimer’s disease

(2016) Marina Saresella et al.   Molecular Neurodegeneration

Fenamate NSAIDs inhibit the NLRP3 inflammasome and protect against Alzheimer’s disease in rodent models

(2016) Michael J. D. Daniels et al.   Nature Communications

Curcumin/Melatonin Hybrid 5-(4-Hydroxy-phenyl)-3-oxo-pentanoic Acid [2-(5-Methoxy-1H-indol-3-yl)-ethyl]-amide Ameliorates AD-Like Pathology in the APP/PS1 Mouse Model

(2015) Gorka Gerenu et al.   ACS Chemical Neuroscience

Initiation and perpetuation of NLRP3 inflammasome activation and assembly

(2015) Eric I. Elliott et al.   IMMUNOLOGICAL REVIEWS

Pharmacologic Inhibition of the NLRP3 Inflammasome Preserves Cardiac Function After Ischemic and Nonischemic Injury in the Mouse

(2015) Carlo Marchetti et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

Neuroinflammation in Alzheimer's disease

(2015) Michael T Heneka et al.   LANCET NEUROLOGY

NLRP3 inflammasome: From a danger signal sensor to a regulatory node of oxidative stress and inflammatory diseases

(2015) Amna Abderrazak et al.   Redox Biology

Link Between Chronic Bacterial Inflammation and Alzheimer Disease

(2014) Fehmida Bibi et al.   CNS & Neurological Disorders-Drug Targets

Neuroinflammation in Alzheimer’s Disease: from Pathogenesis to a Therapeutic Target

(2014) Sanjay W. Pimplikar   JOURNAL OF CLINICAL IMMUNOLOGY

A small molecule binding HMGB1 and HMGB2 inhibits microglia-mediated neuroinflammation

(2014) Sanghee Lee et al.   Nature Chemical Biology

The potential of endogenous neurogenesis for brain repair and regeneration following traumatic brain injury

(2014) Dong Sun   Neural Regeneration Research

Systemic inflammation, blood-brain barrier vulnerability and cognitive/non-cognitive symptoms in Alzheimer disease: relevance to pathogenesis and therapy

(2014) Shuko Takeda et al.   Frontiers in Aging Neuroscience

A Novel Pharmacologic Inhibitor of the NLRP3 Inflammasome Limits Myocardial Injury After Ischemia–Reperfusion in the Mouse

(2013) Carlo Marchetti et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

Sustained Interleukin-1  Overexpression Exacerbates Tau Pathology Despite Reduced Amyloid Burden in an Alzheimer's Mouse Model

(2013) S. Ghosh et al.   JOURNAL OF NEUROSCIENCE

NLRP3 is activated in Alzheimer’s disease and contributes to pathology in APP/PS1 mice

(2012) Michael T. Heneka et al.   NATURE

Deciphering the mechanism underlying late-onset Alzheimer disease

(2012) Dimitrije Krstic et al.   Nature Reviews Neurology

Neuroinflammatory phenotype in early Alzheimer's disease

(2012) Tiffany L. Sudduth et al.   NEUROBIOLOGY OF AGING

A Review: Inflammatory Process in Alzheimer's Disease, Role of Cytokines

(2012) Jose Miguel Rubio-Perez et al.   TheScientificWorldJOURNAL

Selective Cell Death of Hyperploid Neurons in Alzheimer’s Disease

(2010) Thomas Arendt et al.   AMERICAN JOURNAL OF PATHOLOGY

Immune modulation of learning, memory, neural plasticity and neurogenesis

(2010) Raz Yirmiya et al.   BRAIN BEHAVIOR AND IMMUNITY

NLRP3 Plays a Critical Role in the Development of Experimental Autoimmune Encephalomyelitis by Mediating Th1 and Th17 Responses

(2010) D. Gris et al.   JOURNAL OF IMMUNOLOGY

The Effect of Epidermal Growth Factor in the Injured Brain after Trauma in Rats

(2010) Dong Sun et al.   JOURNAL OF NEUROTRAUMA

HMGB1 release and redox regulates autophagy and apoptosis in cancer cells

(2010) D Tang et al.   ONCOGENE

The NALP3 inflammasome is involved in the innate immune response to amyloid-β

(2008) Annett Halle et al.   NATURE IMMUNOLOGY

Protective effects of NSAIDs on the development of Alzheimer disease

(2008) Steven C. Vlad et al.   NEUROLOGY

Neuroinflammation: Implications for the Pathogenesis and Molecular Diagnosis of Alzheimer's Disease

(2007) Leonel E. Rojo et al.   ARCHIVES OF MEDICAL RESEARCH