Flavonoid VI-16 protects against DSS-induced colitis by inhibiting Txnip-dependent NLRP3 inflammasome activation in macrophages via reducing oxidative stress

Small molecule GL-V9 protects against colitis-associated colorectal cancer by limiting NLRP3 inflammasome through autophagy

(2017) Yue Zhao et al.   OncoImmunology

NF-κB Restricts Inflammasome Activation via Elimination of Damaged Mitochondria

(2016) Zhenyu Zhong et al.   CELL

An LGG-derived protein promotes IgA production through upregulation of APRIL expression in intestinal epithelial cells

(2016) Y Wang et al.   Mucosal Immunology

LYG-202 exerts antitumor effect on PI3K/Akt signaling pathway in human breast cancer cells

(2015) Yue Zhao et al.   APOPTOSIS

Epithelial IL-18 Equilibrium Controls Barrier Function in Colitis

(2015) Roni Nowarski et al.   CELL

Anti-Inflammatory Effect of Emodin via Attenuation of NLRP3 Inflammasome Activation

(2015) Ji-Won Han et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Posttranscriptional control of NLRP3 inflammasome activation in colonic macrophages

(2015) A A Filardy et al.   Mucosal Immunology

NLRP3 inflammasome: From a danger signal sensor to a regulatory node of oxidative stress and inflammatory diseases

(2015) Amna Abderrazak et al.   Redox Biology

Bioavailability, bioactivity and impact on health of dietary flavonoids and related compounds: an update

(2014) Ana Rodriguez-Mateos et al.   ARCHIVES OF TOXICOLOGY

Nod-like Receptor Protein 3 (NLRP3) Inflammasome Activation and Podocyte Injury via Thioredoxin-Interacting Protein (TXNIP) during Hyperhomocysteinemia

(2014) Justine M. Abais et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Isoliquiritigenin is a potent inhibitor of NLRP3 inflammasome activation and diet-induced adipose tissue inflammation

(2014) Hiroe Honda et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Nitric oxide suppresses NLRP3 inflammasome activation and protects against LPS-induced septic shock

(2013) Kairui Mao et al.   CELL RESEARCH

The inflammasome: A remote control for metabolic syndrome

(2012) Mohamed Lamkanfi et al.   CELL RESEARCH

Inflammasomes in health and disease

(2012) Till Strowig et al.   NATURE

Chemotherapy-triggered cathepsin B release in myeloid-derived suppressor cells activates the Nlrp3 inflammasome and promotes tumor growth

(2012) Mélanie Bruchard et al.   NATURE MEDICINE

Some natural flavonoids are competitive inhibitors of caspase-1, -3, and -7 despite their cellular toxicity

(2011) J. Brandon White et al.   FOOD CHEMISTRY

Epigallocatechin-3-gallate prevents lupus nephritis development in mice via enhancing the Nrf2 antioxidant pathway and inhibiting NLRP3 inflammasome activation

(2011) Pei-Yi Tsai et al.   FREE RADICAL BIOLOGY AND MEDICINE

Colitis-associated cancer: the dark side of inflammatory bowel disease

(2011) S. Danese et al.   GUT

Effects of Flavonoids on Matrix Metalloproteinase-13 Expression of Interleukin-1β–Treated Articular Chondrocytes and Their Cellular Mechanisms: Inhibition of c-Fos/AP-1 and JAK/STAT Signaling Pathways

(2011) Hyun Lim et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Intestinal homeostasis and its breakdown in inflammatory bowel disease

(2011) Kevin J. Maloy et al.   NATURE

NLRP3 inflammasomes link inflammation and metabolic disease

(2011) Dominic De Nardo et al.   TRENDS IN IMMUNOLOGY

The Inflammasomes

(2010) Kate Schroder et al.   CELL

Colitis induced in mice with dextran sulfate sodium (DSS) is mediated by the NLRP3 inflammasome

(2010) C. Bauer et al.   GUT

Autophagy and the degradation of mitochondria

(2010) Scott J. Goldman et al.   MITOCHONDRION

Mitochondria and reactive oxygen species

(2009) Alicia J. Kowaltowski et al.   FREE RADICAL BIOLOGY AND MEDICINE

Lymphoproliferative disorders in patients receiving thiopurines for inflammatory bowel disease: a prospective observational cohort study

(2009) Laurent Beaugerie et al.   LANCET

The inflammasome: a caspase-1-activation platform that regulates immune responses and disease pathogenesis

(2009) Luigi Franchi et al.   NATURE IMMUNOLOGY

The NALP3 inflammasome is involved in the innate immune response to amyloid-β

(2008) Annett Halle et al.   NATURE IMMUNOLOGY

Innate Immune Activation Through Nalp3 Inflammasome Sensing of Asbestos and Silica

(2008) C. Dostert et al.   SCIENCE