NLPR3 inflammasome inhibition alleviates hypoxic endothelial cell death in vitro and protects blood–brain barrier integrity in murine stroke

Local Leukocyte Invasion during Hyperacute Human Ischemic Stroke

(2020) Alexander M. Kollikowski et al.   ANNALS OF NEUROLOGY

HIF-1α is involved in blood–brain barrier dysfunction and paracellular migration of bacteria in pneumococcal meningitis

(2020) Gayatri Devraj et al.   ACTA NEUROPATHOLOGICA

NLRP3 inflammasome in endothelial dysfunction

(2020) Baochen Bai et al.   Cell Death & Disease

The NLRP3 inflammasome drives inflammation in ischemia/reperfusion injury after transient middle cerebral artery occlusion in mice

(2020) Maximilian Franke et al.   BRAIN BEHAVIOR AND IMMUNITY

Recent advances in the mechanisms of NLRP3 inflammasome activation and its inhibitors

(2019) Yang Yang et al.   Cell Death & Disease

Targeting Platelet GPVI Plus rt-PA Administration but Not α2β1-Mediated Collagen Binding Protects against Ischemic Brain Damage in Mice

(2019) Michael K. Schuhmann et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

NLRP3 inflammasome in ischemic stroke: As possible therapeutic target

(2019) Masoumeh Alishahi et al.   International Journal of Stroke

Thrombo-inflammation in acute ischaemic stroke — implications for treatment

(2019) Guido Stoll et al.   Nature Reviews Neurology

A Canine Model of Hemorrhagic Transformation Using Recombinant Tissue Plasminogen Activator Administration After Acute Ischemic Stroke

(2019) Run-Hao Jiang et al.   Frontiers in Neurology

Endothelial cell senescence in aging-related vascular dysfunction

(2018) Guanghong Jia et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Gasdermin Family: a Promising Therapeutic Target for Stroke

(2018) Sheng Chen et al.   Translational Stroke Research

Blocking of platelet glycoprotein receptor Ib reduces “thrombo-inflammation” in mice with acute ischemic stroke

(2017) Michael K. Schuhmann et al.   Journal of Neuroinflammation

Serum matrix metalloproteinase-9 levels and prognosis of acute ischemic stroke

(2017) Chongke Zhong et al.   NEUROLOGY

Selective NLRP3 (Pyrin Domain–Containing Protein 3) Inflammasome Inhibitor Reduces Brain Injury After Intracerebral Hemorrhage

(2017) Honglei Ren et al.   STROKE

The role of the inflammasome in patients with autoinflammatory diseases

(2016) Hal M. Hoffman et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death

(2015) Jianjin Shi et al.   NATURE

A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases

(2015) Rebecca C Coll et al.   NATURE MEDICINE

Assessment of Blood–Brain Barrier Disruption in Stroke

(2015) Andrea Kassner et al.   STROKE

Endothelial dysfunction

(2014) Zhen Chen et al.   CURRENT OPINION IN LIPIDOLOGY

CD28 Superagonist-Mediated Boost of Regulatory T Cells Increases Thrombo-Inflammation and Ischemic Neurodegeneration during the Acute Phase of Experimental Stroke

(2014) Michael K Schuhmann et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Canonical Nlrp3 Inflammasome Links Systemic Low-Grade Inflammation to Functional Decline in Aging

(2013) Yun-Hee Youm et al.   Cell Metabolism

TRPM2 links oxidative stress to NLRP3 inflammasome activation

(2013) Zhenyu Zhong et al.   Nature Communications

Alzheimer's dementia begins as a disease of small blood vessels, damaged by oxidative-induced inflammation and dysregulated amyloid metabolism: implications for early detection and therapy

(2011) Vincent T. Marchesi   FASEB JOURNAL

Animal Research: Reporting in vivo Experiments—The ARRIVE Guidelines

(2011) Carol Kilkenny et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Blood–Brain Barrier Breakdown in Acute and Chronic Cerebrovascular Disease

(2011) Yi Yang et al.   STROKE

Expansion of the Time Window for Treatment of Acute Ischemic Stroke With Intravenous Tissue Plasminogen Activator

(2009) Gregory J. del Zoppo et al.   STROKE

Pericyte–endothelial cell interaction increases MMP-9 secretion at the blood–brain barrier in vitro

(2007) Alla Zozulya et al.   BRAIN RESEARCH